127results about How to "Promote dissolution" patented technology

A bilayer tablet comprises a first layer formulated for instant release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix and a second layer formulated for instant release of the calcium channel blocker amlodipine from a disintegrating or eroding tablet matrix.

The invention relates to an additive, especially relates to an additive used for limestone-gypsum method flue gas desulfurization. The technical problem solved by the invention is in order to provide an additive capable of preventing desulfurization absorption tower scaling, and slurry overflowing, avoiding demister blockage, and improving desulfurization efficiency. In order to solve the above problem, the technical proposal taken by the invention adopts organic acid substance 30-70, metal oxide 10-30, salt substance 5-20, oxidation catalyst 15-35, and antifoaming agent 5-15. The technical proposal has obvious effect in defoaming, scaling reduction, demister blockage, slurry overflowing prevention, and desulfurization efficiency improvement.

The invention relates to a method for extracting toosendanin from cortex meliae. The method comprises the following processing steps: cleaning dry mature cortex meliae and then crushing the mature cortex meliae by a pulverizer, grinding the mature cortex meliae into powder, drying the powder and adding a 60% ethanol solvent; adjusting the pH value of the solution to 4-6, and adding cellulase for enzymolysis; putting the extracting solution into a double-frequency ultrasonic extractor to obtain an enzymatic hydrolysate; carrying out high-temperature inactivation on the enzymatic hydrolysate to obtain an extracting solution; centrifuging, taking supernate, extracting by use of chloroform, and drying by use of anhydrous sodium sulfate; carrying out suction filtration, concentrating, adding ethanol and heating for dissolving; dropping petroleum ether until the mixture becomes a turbid matter; stewing for separating out a flavescent solid, namely the toosendanin. According to the method, the cortex meliae is taken as the raw material; the stacking effect of enzymolysis and a double-frequency ultrasonic wave is fully utilized; the toosendanin in the cortex meliae is dissolved to the greatest extent; the high-purity toosendanin can be obtained by virtue of extraction and crystallization. The method has the advantages of being simple in equipment, low in extraction cost, high in extraction efficiency, mild in reaction condition, less in solvent consumption, free of pollution and the like.

The invention provides a dispersible tablet of maca. The dispersible tablet is prepared by the following components of: 48%-78% of maca powder, 3%-20% of crospolyvinylpyrrolidone, 0.1%-35% of maltodextrin, 5%-30% of microcrystalline cellulose, 0.03%-1% of sodium lauryl sulfate, 0.1%-3% of aspartame, 0.5%-3% of magnesium stearate and a proper amount of bonding agent. The prepared dispersible tablet of the maca has the advantages that the tablet is high in disintegration and high in dispersing uniformity, has obvious functions for relieving the physical fatigue and improving the sexual function, is good in drug compliance, and is especially applicable to old people and patients with difficulty in swallowing. A preparation method of the dispersible tablet of the maca has the advantages that the process is simple, the operation is controllable, new equipment does not need to be added, and the suitability for industrial and large-scale production is achieved.

The invention provides an amoxicillin lipidosome solid preparation and a new application thereof. Certain amounts of yolk lecithin, cholesterin, natrium glycocholicum, tween 80 and an active ingredient amoxicillin are combined and are prepared into amoxicillin lipidosome by film dispersion technology, and the amoxicillin lipidosome is mixed with the certain accessories to prepare various solid preparations. The amoxicillin lipidosome solid preparation not only can solve the problems of poor dissolution rate and poor quality stability of the amoxicillin, increases the medical effect and the bioavailability of the preparation, can treat bacterial liver abscess and obtain good invention effect.

The invention relates to a process for preparing gelatin, in particular to a process for producing high-viscosity cowhide alkaline gelatin by a batch and alkaline (BATALK) method. The process comprises pretreatment, rubber extraction, filtration, ion exchange, concentration, high temperature sterilization, drying, crushing, mixing, metal detection and formation of a finished product. The process is characterized in that: the pretreatment process is the BATALK method. By the process, the consumption of water and the consumption of sulfur acid can be reduced; and the gelatin obtained by the process has high viscosity.

The invention provides a preparation method of a cassia twig extractive. According to the preparation method, ethanol is used to extract cassia twigs under the support of ultrasonic waves. The preparation method can further comprise ethyl acetate extraction and silica gel column purification. The invention further provides the cassia twig extractive prepared by the preparation method provided by the invention, and an application of the cassia twig extractive to preparation of a medical composition for inhibiting citrus postharvest pathogens. The cassia twig extractive has the stronger inhibition effect on the citrus postharvest pathogens, has no chemical residues after being used for keeping the freshness of citruses, has no damages to the health of a human body, has no pollution to the environment and hardly generates drug resistance.

The invention discloses an orlistat-containing tablet and a preparation method thereof. The orlistat-containing tablet is prepared by directly tabletting a silicon dioxide-containing orlistat phospholipid composition and pharmaceutic adjuvants, wherein the weight ratio of orlistat to phospholipid to silicon dioxide which are contained in the silicon dioxide-containing orlistat phospholipid composition is 1:(0.5-1.5): (0.5-3). The orlistat-containing tablet disclosed by the invention solves the problems of tabletting sticking and poor storage stability of the conventional process of the orlistat and enhances the in-vivo dissolvability of the orlistat.

The invention discloses a method for preparing peptide calcium by using fish bone. The method comprises the following steps: by taking fish bone as a raw material, treating the fish bone by using subcritical water under an acid condition, performing super-fine comminution on the fish bone by using dynamic high-pressure micro jet, performing enzymolysis on the fish bone by using pepsase and composite flavourzyme, treating enzymatic hydrolysate by using a microwave technique, and performing spray drying, thereby obtaining a peptide calcium product. As a mixture of the fish bone and hydrochloric acid is treated by using the subcritical water technique, the speed of softening the fish bone can be effectively increased, and calcium ion digestion can be promoted; due to high-pressure micro jet, the granules of the fish bone can be greatly reduced, and later fish bone enzymolysis efficiency can be improved; the pepsase and the composite flavourzyme are adopted for enzymolysis on the fish bone after super-fine comminution, then conversion of proteins to polypeptide is promoted, and a mixed liquid of peptide and calcium can be formed; due to microwave heating, the chelation efficiency of the peptide and the calcium can be promoted, and the product quality can be improved; by adopting the method, the purpose of utilizing the proteins and the calcium in the fish bone simultaneously can be achieved, and the utilization values of the byproduct, namely the fish bone generated in minced fillet processing, can be increased.

The invention discloses a preparation method for a safflower care-free tablet, and relates to a preparation method for a traditional Chinese medicinal preparation. The method comprises the following steps: (1) extracting volatile oil of three traditional Chinese medicines, namely, Chinese angelica, bighead atractylodes rhizome and mint, by the method of steam distillation; (2) dissolving the herbresidue obtained in step (1) together with white peony root, Poria cocos, safflower, spina gleditsiae, herba bupleuri and licorice in water and obtaining water extract of the solution with supersonicwave; (3) including the volatile oil with beta-cyclodextrin so as to obtain volatile oil beta-cyclodextrin inclusion complex; (4) adding the water extract obtained in step (2) and the volatile oil beta-cyclodextrin inclusion complex obtained in step (3) into starch, carrying out granulation to form tablets and coating the tablets with thin film so as to obtain safflower care-free tablets. The invention enables effective ingredients in cells of the above-mentioned medicinal materials to dissolve rapidly and chemical constructions of the effective ingredients not to be destroyed, and therefore a high recovery rate is obtained. According to the invention, beta-cyclodextrin inclusion technique is employed to add the volatile oil, which effectively improves the retention index of volatile components of the above-mentioned medicinal materials in the preparation.

The invention relates to the field of medicine, and especially relates to a febuxostat tablet and a preparation method thereof. The core tablet of the febuxostat tablet is composed of following raw materials in parts by weight: 5 to 30 parts of febuxostat, 30 to 90 parts of stuffing agent, 2 to 20 parts of disintegrating agent, 0.5 to 15 parts of adhesive, 0.5 to 5 parts of lubricant and a right amount of wetting agent. The preparation method comprises following steps: weighing, mixing the febuxostat, stuffing agent, disintegrating agent and adhesive together, then grinding the mixture, filtering for two times, granulating, drying, filtering the dry particles, then adding the disintegrating agent and lubricant to mix with the dry particles, pressing into tablets, and finally coating. The febuxostat tablet promotes the dissolution of the febuxostat and improves the biological utilization, the components of the formula are few, extra surfactant is not needed to assist the dissolution, the auxiliary materials are available, and the technology is simple and operable.

The invention discloses an imatinib mesylate tablet and a preparation method thereof. The imatinib mesylate tablet comprises 8-30% of crospovidone and 8 to 40% of silica. The preparation method comprises the following steps of carrying out granulation of imatinib mesylate and a waterless organic solvent, drying the granules, uniformly mixing the granules, crospovidone, silica, a filler and a lubricant, and carrying out tabletting. The preparation method solves the problem of a slow dissolution rate of a preparation obtained by the prior art.

The invention discloses a method for detecting the content of active calcium oxide and non-active calcium oxide in lime. The method comprises the steps of crushing lime until the particle diameter is less than or equal to 0.150mm, and drying at 105-110 DEG C for 1.5-2.5 hours; taking 0.5000g of a test sample, and mixing with a blend of 4g of anhydrous sodium carbonate and boric acid, fusing at 880-920 DEG C for 16-24 minutes, putting the fused blocks into 60ml of 8% hydrochloric acid and dissolving at 100-110 DEG C, enabling the volume of a solution to be constant by a 250ml volumetric flask so as to obtain a test solution a; taking 0.5000g of a test sample additionally, adding 5g of saccharose and 45-55ml of water which is boiled firstly and then cooled, vibrating closely for 18-22 minutes, enabling the volume of the solution to be constant by a 250ml volumetric flask so as to obtain a test solution b; removing 50.00ml of the test solution a and the test solution b, and respectively adding 5ml of triethanolamine and 20% potassium hydroxide or sodium hydroxide, so that the pH value of the test solution is greater than or equal to 12.5; then adding 4-5 drops of 1mg/ml magnesium oxide standard solution and 2-3 drops of calconcarboxylic acid, titrating the test solution by an EDTA standard solution until the test solution turns blue from red. The content of the active calcium oxide is calculated according to the following formula as shown in the specification, and the content of the non-active calcium oxide is calculated according to the following formula as shown in the specification, wherein W does not refer to CaO=WTCaO_WfCaO. The method is used for rapidly and accurately detecting the content of the active calcium oxide and non-active calcium oxide in a lime test sample, and is high in popularization and application value.

The invention discloses a method for extracting maize germ oil assisted by ethyl alcohol and steam explosion and belongs to the technical field of elaborate processing of the agricultural and sideline products. The method comprises the steps of after using low-concentration citric acid solution to immerse the maize, adopting the steam explosion method to greatly shorten the thermal processing time; adopting ethyl alcohol solution as oil extracting medium and adopting a demulsifier to substitute plenty of enzymes used in the traditional aqueous enzymatic method so as to save the production cost and modify the quality of the product. The method used in the invention has the advantages of high oil extracting efficiency, low cost and high quality, and solves the problems of low oil extracting efficiency, high cost and long period of maize germ oil extracting process in the traditional aqueous enzymatic method.

The invention relates to a method for preparing shenkangning capsules, which belongs to a preparation method of a Chinese herb preparation and comprises the following steps that: medicinal materials are crushed, sieved and extracted through ultrasonic waves to obtain ethanol extract extractum; medicinal dregs are extracted through ultrasonic waves again to obtain water extract extractum; the ethanol extract extractum and the water extract extractum are mixed and concentrated into thick paste, and compound Chinese herb extracts are obtained through drying; and starch are added for uniform mixing and granulation. The method has the beneficial effects that an ultrasonic wave extraction method is adopted, effective ingredients in medicinal material cells can be fast dissolved out, in addition, the destruction to the effective ingredients of the medicinal materials under the severe conditions of heating, decoction and the like is omitted, and the advantages of high effective ingredient extraction rate, short extraction time, energy saving, environment protection and the like are reached.

The invention relates to a supercritical water/supercritical carbon dioxide combined treatment method for arsenic-contaminated soil, and belongs to the technical field of soil remediation. The supercritical water/supercritical carbon dioxide combined treatment method comprises: placing arsenic-contaminated soil in a high-temperature and high-pressure reaction kettle I, adding a metal binder, introducing carbon dioxide gas, carrying out heating pressurizing to achieve the supercritical state of the carbon dioxide, and carrying out contact extraction for 15-120 min to obtain repaired soil and the extracted product, wherein the temperature of the carbon dioxide in the supercritical state is 40-80 DEGC, and the pressure is 10-45 MPa; and adding the extracted product, water and an excess oxidant to a high-temperature and high-pressure reaction kettle II, uniformly mixing to obtain a reaction system, carrying out heating pressurizing on the reaction system in the high-temperature and high-pressure reaction kettle II under a closed condition until the reaction system achieves a water supercritical state, and carrying out a reaction for 5-45 min to obtain the reaction product system, wherein the temperature of the supercritical state is 380-650 DEGC, and the pressure is 23-55 MPa. According to the present invention, arsenic is gently extracted by supercritical carbon dioxide so as to repair contaminated soil while recover the arsenic in the form of arsenic trioxide.

The invention discloses a rivaroxaban-containing composition and a preparation method thereof. The composition contains rivaroxaban and cyclodextrin with a weight ratio of (1: 1) to (1: 20). The composition disclosed by the invention is wide in process application range, and capable of improving rivaroxaban dissolution and guaranteeing no influences of a preparation process on the bioavailability.

The invention discloses a preparation method of a polypropylene composition and belongs to the technical field of materials. The composition at least comprises 100 parts of polypropylene, 0.05-0.15 part of a primary antioxidant, 0.1-0.3 parts of an auxiliary antioxidant and 0.05-0.2 parts of a halogen absorbent. Supercritical carbon dioxide is used for assisting in extrusion; heat and oxygen degradation of polypropylene is effectively inhibited in an extrusion process; at the same time, dissolution of micromolecular volatile matters is greatly accelerated; and the micromolecular volatile matters are removed in a pressure release extraction manner in front of a neck mold of an extruder. The method is simple in technology, wide in application scope and low in production cost.

The invention belongs to the field of pharmaceutical preparations and particularly discloses solid dispersion prepared from magnolol, honokiol or a mixture of the magnolol and the honokiol and a preparation method of the solid dispersion by hot-melt extrusion. The solid dispersion is mainly characterized in that polyethylene glycol, copovidone S-630, hydroxy propyl cellulose, acrylic resin or polyethylene caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymer serves as a main adjuvant of a dispersion supporter, a sugar alcohol adjuvant is added to serve as a plasticizer when necessary, and the HME (hot-melt extrusion) technology serves as the preparation technology, so that medicines are dispersed in the adjuvant of the supporter in an amorphous state, dissolution rate of the medicines is increased, and bioavailability of the medicines is improved. Compared with a conventional solid dispersion preparation technology, the hot-melt extrusion technology adopted in the preparation method has the advantages of nonuse of organic solvents, safety, no pollution, stable process, continuous operation and easiness for enlarged industrialized production.

The invention discloses a washing machine timer capable of controlling circulating water flow and a double-barrel washing machine. The total working time of the timer contains soaking and washing time and continuous washing time; and at least the soaking and washing time is synchronized with an internal circulating water flow washing time for controlling periodical and intermittent circulation of a water discharging pump. The timer comprises an input end, an output end and a manual converter, wherein the output end is provided with two groups of washing contacts connected with a washing motor; one washing contact of the output end is selected for connection by switching of the manual converter; the input end is provided with two groups of contacts which respectively control a power supply and the water discharging pump; the timer is also provided with a cleaning cam for switching on and off the power supply in a timing manner to control the continuous washing time and the soaking and washing time and an internal circulating cam for switching on and off the water discharging pump in a timing manner to control the internal circulating water flow washing periodically, intermittently and circularly. According to the timer disclosed by the invention, the starting and stopping of the water discharging pump can be controlled for the internal circulation of the washing water flow, so that the dissolving performance and the washing performance of washing powder are improved. The double-barrel washing machine has the characteristic of saving water and power.

The invention discloses a rivaroxaban tablet. The rivaroxaban tablet is prepared by dissolving rivaroxaban, hydroxypropyl-[beta]-cyclodextrin and deoxycholic acid in ethyl acetate; then, granulating an obtained solution with the addition of a pharmaceutically acceptable carrier; drying obtained granules; and adding a lubricating agent, and conducting mixing and tableting. In comparison with the prior art, the rivaroxaban tablet provided by the invention is simple in preparation process, uniform in drug dispersion, smooth in production process and rapid in drug dissolution.

The invention discloses an efficient chemical oxidation repairing method for organic polluted soil. The efficient chemical oxidation repairing method for the organic polluted soil comprises the following steps: mixing the organic polluted soil and water to prepare a slurry-state soil mixed solution; adding a binary compound organism-nonionic surfactant into the slurry-state soil mixed solution andthen adding an oxidizing agent; and performing oscillation in an oscillator and degrading the organic pollutant in the soil after oscillation treatment, wherein the oxidizing agent is SPC and the binary compound organism-nonionic surfactant is GLDA and Tween80. The efficient chemical oxidation repairing method for the organic polluted soil has the advantages of simple process condition, low operation requirement, high treatment efficiency and the like, and is suitable for repairing various kinds of organic polluted soil.

The invention discloses an extraction method of phyllanthus emblica polyphenol. The extraction method comprises the following steps: removing stalks of obtained phyllanthus emblica fresh fruit, cleaning with deionized water, draining water, removing kernels, adding the phyllanthus emblica fresh fruit to a precooling acetone solution, pounding, homogenizing, carrying out magnetic force oscillation, centrifuging, taking supernatant, repeating the steps so as to extract precipitates for two to three times, combining supernatant, and recycling acetone, thus obtaining a total extracting solution; filtering the total extracting solution by using a pretreated hollow fibrous membrane; purifying a hollow fibrous membrane filtering medium by using a polyamide chromatographic column, collecting eluant, recycling alcohol, concentrating, and carrying out freeze drying, thus obtaining the phyllanthus emblica polyphenol. Compared with a conventional heat extraction method, the extraction method disclosed by the invention has the advantages that the extraction temperature is low, a technology is simple and easy to operate, the extraction effect is good, the extraction rate of the phyllanthus emblica polyphenol reaches above 95%, and the purity of the phyllanthus emblica polyphenol finished product reaches above 99%.

The invention relates to a method for extracting notopterygium root volatile oil. The method is characterized by comprising the following steps: airing and grinding notopterygium root, allowing the notopterygium root to pass through a sieve with the granularity of 20 meshes, performing cellulase fermentation, adding 20-50% ethanol which is in an amount of 5-7 times that of the raw materials into the fermented raw materials, extracting in an ultrasonic-microwave extractor, filtering, performing vacuum concentration on the filtrate at the temperature of 30-50 DEG C, extracting the concentrated solution by using an organic solvent, drying by using anhydrous sodium sulfate, and performing vacuum concentration at the temperature of 50 DEG C to remove the organic solvent, thereby preparing the notopterygium root volatile oil. The method is easy to operate and obvious in technical effect, and damage to structures of the volatile oil components can be reduced.

The invention discloses a non-toxic electroplating liquid. The non-toxic electroplating liquid consists of a hydrogen peroxide stabilizer, a silicon removing agent and a color fixing agent, wherein the hydrogen peroxide stabilizer is a polyethylene polyamine salt; the silicon removing agent is magnesium silicate; the color fixing agent is epoxy chloropropane; the polyethylene polyamine salt accounts for 41 to 42 percent of the total weight of the non-toxic electroplating liquid; the magnesium silicate accounts for 31 to 32 percent of the total weight of the non-toxic electroplating liquid; the epoxy chloropropane accounts for 26 to 27 percent of the total weight of the non-toxic electroplating liquid. The non-toxic electroplating liquid provided by the invention has the advantages of being non-toxic, high in stability and suitable for continuous operation.

The invention discloses a manidipine hydrochloride solid dispersion, which comprises manidipine hydrochloride and a dispersing medium PEG6000, wherein a weight ratio of the manidipine hydrochloride to the PEG6000 is 10:90-40:60. The invention further discloses a manidipine hydrochloride solid dispersion preparation, which comprises the manidipine hydrochloride solid dispersion, lactose, microcrystalline cellulose, magnesium stearate, and PVPK30. The invention further discloses preparation methods for the solid dispersion and the solid dispersion preparation. According to the present invention, the manidipine hydrochloride is prepared into the manidipine hydrochloride solid dispersion to accelerate the drug release so as to provide an effective method, such that the dissolution of the manidipine hydrochloride can be improved, the bioavailability of the manidipine hydrochloride can be improved, the stability of the manidipine hydrochloride can be increased, and the drug is easily stored; the manidipine hydrochloride solid dispersion preparation prepared by using the manidipine hydrochloride solid dispersion has characteristics of high dissolution rate, high bioavailability, easy storage, and convenient large-scale application.

The invention relates to a method for improving the content of resveratrol in a wine base. The method comprises the following steps: dissolving resveratrol crystals having a purity of above 85% in a wine having an alcoholic strength of above 20%vol, wherein the ratio of the resveratrol crystals to the wine is 1:50-150(g/ml); preparing a resveratrol-containing wine concentrate; and adding the resveratrol-containing wine concentrate into a wine base. The method has the advantages of simple technology, low cost, strong controllability, good reappearance, suitableness for processing various wines, no obvious change of the mouthfeel and the flavor of the blended wine, high commercial value, and suitableness for industrialized production.

The invention relates to a method for extracting proteins from peony seed meal, and belongs to the technical field of plant extraction. The method comprises six steps: degreasing, enzymatic hydrolysis, ultrasonic alkali extraction, obtaining of a crude peony seed meal protein, purification and obtaining of the peony seed meal protein. Enzymatic hydrolysis and ultrasonic alkali extraction are cooperatively used for extracting the protein from the peony seed meal, and various process conditions in the extraction process are set reasonably to ensure high protein extraction rate. The method is simple and easy to operate, low in cost and suitable for industrialized production and promotes the development of peony seed oil and deep processing industrialization.

The invention discloses a detergent box of a washing machine, and belongs to the technical field of household appliances. The detergent box comprises a detergent box, a softener box, a washing powder box and an end cover, wherein heating wire tubes are adhered to bottoms of the detergent box, the softener box and the washing powder box; an assistant dissolving device is mounted inside the washing powder box; the heating wire tubes are uniformly arranged in the length direction of the detergent box and are fixed at the bottom of the detergent box through heat conduction adhesive; the assistant dissolving device comprises a transverse shaft which is fixedly mounted with the washing powder box and a three-claw type dissolving wheel which is connected with the transverse shaft in a sleeving manner. The detergent box has the advantages that as the heating wire tubes are additionally arranged at the bottom of the detergent box of the washing machine, and the assistant dissolving device is arranged inside the washing powder box, the washing powder can be dissolved rapidly, the washing activity of the detergent is improved, and a better washing and stain reduction effect can be achieved.

The invention provides levofloxacin composition freeze-dried orally disintegrating tablets and a preparation method of the orally disintegrating tablets, relates to the field of a medicine and a medicine preparation method technology and mainly solves the problems in the prior art that the ordinary preparation prepared by levofloxacin is poor in curative effect and not suitable for children and the patients who are difficult to swallow. The levofloxacin composition freeze-dried orally disintegrating tablets are prepared from the following components by weight: 10-24% of levofloxacin, 24-50% of mannitol, 2-4% of gelatin, 32-74% of hydroxypropyl-beta-cyclodextrin with medium substitution degree, 0.1-0.2% of trichlorosucrose and 50-70% of purified water. The levofloxacin composition freeze-dried orally disintegrating tablets prepared by the above components are easy in preparation process, and simple in components, and mainly meet the administration requirements of children and the patients who are difficult to swallow; moreover, the levofloxacin composition freeze-dried orally disintegrating tablets have the advantages of being fast to disintegrate, convenient to take, and good in taste; and the tablets take effect quickly and are fully absorbed, and the first pass effect of the liver is avoided.