56results about How to "Promote dissolution" patented technology

The application discloses a separation system for recycling leaf filter waste residue in an alumina production process, comprising a pressure separation device, a feed pump connected between a leaf filter waste residue slurry source and a feed inlet of the pressure separation device, an external tank dilution circuit, an overflow outlet of the pressure separation device connected to an inlet front end of the feed pump through a shunt pipeline, a underflow pump connected to an underflow outlet of the pressure separation device, a vacuum belt filter connected to an outlet of the underflow pump, a pulping tank arranged below a filter cake discharge outlet of the vacuum belt filter, and a conveying pump connected between an outlet of the pulping tank and a pre-desilication process of an alumina production system. Through the synergistic effect of high solid content mud layer sedimentation technology and external tank dilution technology, the industry problem that leaf filter waste residue is difficult to settle, concentrate and filter and separate due to easy hydrolysis under the condition of low caustic alkali concentration and low molecular ratio and a large amount of fine planktonic matter is effectively solved.

The application discloses a preparation method of a nitrogen-containing heterocyclic compound and an alkali metal salt of the nitrogen-containing heterocyclic compound, and steps of the preparation method of the nitrogen-containing heterocyclic compound comprise: (1) uniformly mixing trithiocyanic acid with a first solvent, introducing sulfuryl fluoride gas or adding an alkenyl sulfonyl fluoride to perform a reaction, and obtaining a crude product through a crude treatment after the reaction is finished; (2) purifying the crude product to obtain the nitrogen-containing heterocyclic compound shown in a structural formula 1; wherein R1, R2 and R3 are each independently selected from -H, -SO2F or -CH2-(CH2) n -SO2F, n is an integer selected from 1-10, and R1, R2 and R3 are not H at the same time. The preparation method of the nitrogen-containing heterocyclic compound and the alkali metal salt of the nitrogen-containing heterocyclic compound can be applied to a large amount of trithiocyanic acid in a lithium battery electrolyte, raw materials are easy to obtain, operation is simple, the yield is high, the condition is mild, the requirement for equipment is low, and the method is suitable for industrial production.

The application discloses a whitening and freckle-removing composition containing white tomato and chases yellow grass, a preparation method and application thereof, and belongs to the technical field of food, wherein the whitening and freckle-removing composition is composed of white tomato powder and chases yellow grass powder with a weight ratio of 1-3:2-7. The preparation method comprises the following steps: (1) beating, separating, concentrating and drying white tomatoes to obtain white tomato powder; (2) soaking chases yellow grass in acidic water, performing solid-liquid separation, concentrating and drying the obtained clear liquid to obtain chases yellow grass powder; and (3) mixing the white tomato powder and the chases yellow grass powder. The application utilizes the combination of white tomatoes and chases yellow grass, and improves the preparation process of chases yellow grass, so that the two components produce a synergistic effect in inhibiting tyrosinase activity and inhibiting melanin production.

This invention relates to an ultra-high performance concrete with added supersulfate cement and its preparation method, belonging to the field of concrete technology. This invention uses granulated blast furnace slag powder, desulfurized gypsum, and cement clinker as the supersulfate cement matrix, and introduces pre-carbonized dicalcium γ-silicate, CO2 nanobubble water, and triethanolamine as ternary synergistic components. The finished product is obtained through early sealed in-situ carbonization-hydration synergistic curing supplemented by standard curing. Pre-carbonized dicalcium γ-silicate provides heterogeneous nucleation sites to accelerate early hydration; CO2 nanobubbles achieve in-situ carbonization filling submicron pores; triethanolamine simultaneously enhances the carbonization and hydration reaction rates; and sealed curing protects hydration products from decalcification. Through multi-level synergistic effects, this invention significantly improves the early strength, compressive strength, and carbonation resistance of concrete. The concrete prepared by this invention exhibits carbonation resistance, high compressive strength, and excellent early strength.

The application discloses an olmesartan medoxomil and amlodipine besylate pharmaceutical composition and a preparation method thereof, and belongs to the technical field of medicines. The olmesartan medoxomil and amlodipine besylate pharmaceutical composition takes olmesartan medoxomil and amlodipine besylate as active ingredients, and is prepared into antihypertensive tablets by being matched with a disintegrant, a filler and a lubricant; wherein the filler is a mixture of pre-gelatinized starch and a co-processed product of microcrystalline cellulose and colloidal silicon dioxide. The preparation method adopts a direct compression process, and sequentially comprises the steps of mixing, whole-granulating, twice mixing, lubricating, tabletting and stomach-soluble film coating, and is simple in process and suitable for industrialized scale-up production. The application effectively solves the problem of low dissolution rate of the existing olmesartan medoxomil and amlodipine besylate tablets, and the prepared tablets have the advantages of high dissolution rate, similar dissolution curve to commercial preparations, high bioavailability, stable quality and good clinical application value.

The invention provides a method for recovering lithium from waste lithium iron phosphate black powder, which comprises the following steps: S1, heating, stirring and mixing ethylene glycol and ferric chloride hexahydrate to obtain a eutectic solvent; s2, adding waste lithium iron phosphate black powder into the eutectic solvent, and reacting to obtain reaction slurry; and S3, carrying out solid-liquid separation on the reaction slurry to obtain a lithium-containing leachate. According to the method, the lithium in the waste lithium iron phosphate black powder can be selectively leached, and the leaching rate of the lithium can be increased.

The invention relates to the technical field of blueberry wine brewing, in particular to a mixed bacteria fermentation blueberry wine brewing process and application thereof, and the mixed bacteria fermentation blueberry wine brewing process comprises the following steps: raw material pretreatment: unfreezing, picking and crushing blueberries to obtain blueberry pulp; performing enzymolysis: adding potassium metabisulfite and pectinase into the blueberry pulp, and performing enzymolysis at 48-52 DEG C for 1-2 hours; sugar adjustment: adjusting the sugar degree of the blueberry pulp to 14-22Bx, and adjusting the pH value to 3.5-4.5; inoculating yeast: inoculating activated mixed yeast strains into the blended blueberry pulp, wherein the mixed yeast strains are RW angel wine yeast and 71B yeast; fermentation and post-treatment: fermenting the inoculated blueberry pulp with residues, filtering after fermentation to obtain the blueberry fruit wine, and through synergistic fermentation of RW angel wine yeast and 71B yeast, generating aroma substances such as esters and alcohols richer than that of single-bacterium fermentation, so that the wine body has strong fruit aroma, mellow wine aroma and soft fermentation aroma, is full in layering sense, and has a good taste. The problems that traditional fruit wine is thin in taste and serious in homogenization are effectively solved.

The application relates to a binder applied to mine slag adhesion, which comprises the following components: 65-70 parts of mine slag, 8-12 parts of calcium aluminate cement, 3-5 parts of mine powder, 2-3 parts of phosphorus powder, 1.5-2.5 parts of water glass, 0.8-1.2 parts of sodium hydroxide, 0.6-0.8 parts of a retarder, and 2-5 parts of an alkaline additive; the alkaline additive comprises modified calcium hydroxide, sodium silicate and sodium carbonate; the modified calcium hydroxide comprises calcium hydroxide and sodium polyphosphate. The application has the effects of improving the cement solidification and adhesion performance, reducing heavy metal ion seepage, and improving the utilization rate of mine slag.

The application discloses a preparation method of high-purity carbon powder prepared by step-by-step pyrolysis of waste tires, comprising the following steps: S1, removing steel wires and fiber accessories from waste tires, crushing and screening to obtain 80-120 mesh tire rubber powder, placing the rubber powder in a vacuum drying box, drying for 2-4 hours to remove the surface adsorbed water and light volatile impurities of the rubber powder, and obtaining dry tire rubber powder, thus, the closed pressure control vacuum drying pretreatment process can isolate external water vapor and dust, eliminate secondary pollution of the material, efficiently remove the surface adsorbed water, residual oil and light volatile components of the rubber powder under constant temperature conditions, adopt a three-stage gradient series condensation process, separate heavy, medium and light oil gas components according to the boiling point difference of the oil gas components, effectively avoid the problems of incomplete oil gas condensation and component adhesion and mixing, and adopt a dilute hydrochloric acid pickling-weak alkali desulfurization-multiple pure water rinsing grading purification system, low-speed stirring in the desulfurization stage, and consideration of the desulfurization effect and the structural integrity of the carbon powder.

The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic as well as a preparation method and application thereof, and belongs to the technical field of pesticide preparation. The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic which is formed by combining 3, 5-dihydroxy-4'-pentylbiphenyl and betaine through an intermolecular hydrogen bond, and a preparation method of the 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic. According to the 3, 5-dihydroxyl-4 '-pentylbiphenyl-betaine eutectic and the preparation method thereof, the eutectic is formed by BP and BET, the solubility and the dissolution rate of BP are improved, the application amount of pesticide molecules is reduced, and the 3, 5-dihydroxyl-4'-pentylbiphenyl-betaine eutectic is applied to various plant pathogenic fungi. Results of the embodiment show that the co-crystals formed by BP and BET are combined through hydrogen bonds in a molar ratio of 1: 1, the dissolution effect of the co-crystals is superior to that of the medicine, and the dissolution effect is not affected by the pH environment. Compared with drugs with the same concentration and the drug eutecticum, the drug eutecticum shows the antibacterial activity advantage superior to that of original drug molecules.

This invention relates to an extraction method for enhancing the hypoglycemic activity of mulberry leaf peptides. Freshly harvested mulberry leaves are washed, crushed, and then water and alkaline protease are added for extraction. After extraction, the enzyme is inactivated to obtain the mulberry leaf peptide extract. The extract is then filtered through a plate and frame filter to obtain a clear liquid and a residue. The clear liquid is further fractionated using ultrafiltration and nanofiltration membranes to obtain components with different molecular weight ranges. These components are then concentrated, sterilized using filter cartridges, and spray-dried to obtain products with different molecular weight ranges. This invention utilizes a fractionation and purification technology in the mulberry leaf peptide extraction process, resulting in different grades of mulberry leaf peptide products suitable for various hypoglycemic cases and scenarios.

The invention discloses a method for continuously extracting and separating naringin and pectin in shaddock peel. The method comprises the following steps: mixing shaddock peel powder with an alcohol amine-alcohol eutectic solvent, ultrasonically extracting naringin, and centrifugally separating to obtain a naringin extracting solution; deionized water is added into the extracting solution, CO gas is introduced, double aqueous phases are formed, and naringin is enriched in the lower phase; collecting a lower-phase solution to obtain a crude extract, heating and dissolving with ethanol, filtering, crystallizing and drying to obtain naringin; the method comprises the following steps: washing and drying residues after naringin extraction, extracting pectin by using a citric acid solution, filtering, precipitating with ethanol, centrifuging, purifying and drying to obtain the pectin. According to the method, the alcohol amine-alcohol eutectic solvent is applied to green extraction of the naringin for the first time, CO is utilized to trigger two aqueous phases to achieve efficient separation and purification of the naringin, meanwhile, multi-component high-value co-production of the naringin and pectin is achieved, the method has the advantages of being green, efficient, simple and convenient and the like, and a new way is provided for high-value utilization of shaddock peel waste.

This invention relates to the field of comprehensive utilization of biomass resources, and discloses a pretreatment process for the efficient resource utilization of crop straw, comprising: mixing and impregnating crushed straw particles with a high-concentration solubility buffer; adding solid tetraacetylethylenediamine and flowing hydrogen peroxide solution for oxidation reaction; performing hot solid-liquid separation under no-cooling conditions, washing the filter cake to obtain cellulose enrichment, and combining the washing liquid with primary hot black liquor to obtain mixed black liquor; cooling the mixed black liquor to induce a phase change, separating lignin and cold mother liquor, discharging part of the cold mother liquor, and recycling the remaining mother liquor. This invention improves the separation efficiency of straw components by constructing a stable pretreatment reaction microenvironment through composition; prevents secondary lignin adhesion and achieves lignin precipitation by controlling the hot separation and cold phase change operations; and reduces the overall water and reagent consumption of the process by combining the mother liquor circulation design.

This invention provides a method for preparing a metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of traditional Chinese medicine components; step S2, enzymatic hydrolysis of the first group of traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-processing. This method synergistically combines extracts from seven traditional Chinese medicines—bitter melon, phellodendron bark, astragalus root, kudzu root, rehmannia root, ginseng, and privet fruit—with metformin hydrochloride to form a metformin compound hypoglycemic oral solution, balancing the synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.

The application discloses a kind of tea branch orange superfine powder with anti-inflammatory efficacy and a preparation method thereof.The tea branch orange superfine powder comprises the following raw material components by mass fraction: 15-30 parts of tea branch orange pericarp powder, 30-50 parts of tea branch orange pulp powder, and 4-8 parts of tea branch orange seed powder.By efficiently compounding different parts of tea branch orange, the best anti-inflammatory effect is achieved, and the efficient use of whole fruit is realized, which is conducive to reducing environmental pollution and resource waste and improving economic benefits.The preparation method is to sequentially use high-voltage pulsed electric field, pressure difference puffing and vacuum freeze drying to separate the pulp and seeds, and then dry low-temperature superfine grind tea branch orange pericarp, pulp and seeds, and compound the raw material components to obtain tea branch orange superfine powder with anti-inflammatory efficacy.The synergistic effect of multiple processing technologies significantly improves the dissolution of functional active substances such as anti-inflammatory components, and the tea branch orange superfine powder with good anti-inflammatory effect is obtained by combining component compounding.

The utility model discloses a raw material extraction device for electronic atomized liquid, which belongs to the technical field of extraction devices and comprises an extraction tank and a centrifugal filter, the centrifugal filter is mounted at the bottom of the extraction tank, a cover plate is arranged at the top of the extraction tank, and a plurality of ultrasonic transducers fixedly penetrate through the top of the cover plate. An amplitude-change pole is fixedly arranged at the bottom end of each ultrasonic transducer and comprises a longitudinal rod, a plurality of transverse rods are fixedly arranged on the outer wall of the longitudinal rod, the outer wall of the cover plate is sleeved with a fixing ring, the cover plate is connected with the fixing ring through a rotating mechanism, and the outer wall of the fixing ring is sleeved with a mounting frame. According to the utility model, mechanical vibration is generated through the plurality of ultrasonic transducers and is amplified by using the amplitude-change pole, so that the dissolution of target components in raw materials is accelerated, and the rotating mechanism is used for driving the amplitude-change pole to rotate and stir the raw materials and a solvent, so that the extraction efficiency of the electronic atomized liquid raw materials can be further improved; and carrying out solid-liquid separation by using a centrifugal filter to finish liquid extraction.

The utility model relates to extraction device technical field discloses a kind of ultrasonic wave circulation extraction devices for moss bacteriostatic agent, including the fixed connection of sediment cavity and stirring cavity from bottom to top, and the outer wall of sediment cavity and stirring cavity is connected with support, valve port is provided at the junction of sediment cavity and stirring cavity, the bottom end of sediment cavity is threadedly connected with sealing plug, the outside junction of sediment cavity and stirring cavity is provided with circulation mechanism, ultrasonic oscillator is provided at the valve port place of stirring cavity inner wall bottom end, stirring mechanism is provided in stirring cavity. The circulation mechanism in the utility model is provided with filter cleaning piece at the water inlet in sediment cavity;When circulation pump works, fluid drives rotary blade to rotate, drive arc plate to carry out sustained scraping and cleaning to the outer wall of filter head, prevent moss residue from adhering and accumulating, avoid the blockage of pipeline and pump body, to ensure the continuity and stability of circulation extraction operation, reduce equipment damage risk.

The invention discloses a traditional Chinese medicine beverage capable of soothing nerves, helping sleep and regulating emotion and a preparation method thereof, and particularly relates to the field of traditional Chinese medicine pharmaceutics. The beverage realizes sleep aiding through jujuboside, spinosin, eleutheroside, cyclic adenosine monophosphate and the like, regulates emotion through fingered citron lactone, rose volatile oil and the like, and tranquilizes and stabilizes mind by using hericium erinaceus, hawthorn flavone and the like. The preparation method comprises the following steps: carrying out differential pretreatment on raw materials; volatile oil, water-soluble functional components and flavor substances are obtained through circulating percolation extraction, dynamic countercurrent extraction and mild extraction by adopting a stepped directional extraction process; and precisely filtering and clarifying the extracting solution through a ceramic membrane, compounding with aromatic volatile oil, and sterilizing and filling by adopting a 550MPa ultrahigh-pressure cold sterilization technology. The method overcomes the defects of low extraction efficiency and easy loss of active components in the traditional process, realizes efficient synergistic extraction and complete retention of various active components, and has the advantages of fresh taste, stable character, long shelf life and accurate and controllable process parameters.

The invention relates to the technical field of traditional Chinese medicine concentrated pills and preparation thereof, in particular to traditional Chinese medicine concentrated pills for treating cardiovascular and cerebrovascular diseases and a preparation method of the traditional Chinese medicine concentrated pills. The concentrated traditional Chinese medicine pill is prepared from the following raw materials in parts by weight: radix astragali seu hedysari, ginseng under forest, radix ophiopogonis, fructus schizandrae, radix paeoniae rubra, semen persicae, cortex moutan, radix angelicae sinensis, poria cocos, rhizoma chuanxiong, saffron crocus, salvia miltiorrhiza bunge, pseudo-ginseng and the like, wherein the radix astragali seu hedysari, the salvia miltiorrhiza bunge and the ginseng under forest are prepared into standard fermented traditional Chinese medicine powder through a micro-fermentation process combining an ancient method and a modern method; and carrying out low-temperature full-wall-breaking superfine grinding on the other raw materials to obtain superfine powder. Through cooperation of low-temperature wall-breaking superfine grinding, controllable micro-fermentation and solid dispersion slow-release forming, effective components are released more sufficiently, absorption is more stable, batch-to-batch consistency is better, taking is more convenient, and better storage stability is achieved.

This invention provides a nematidine and ritonavir combination tablet and its preparation method. The nematidine and ritonavir combination tablet is prepared by double-layer compression of materials corresponding to the ritonavir layer and the nematidine layer. The nematidine layer is composed of the following raw materials: 280-320 parts of nematidine, 200-250 parts of compound dispersant, 60-100 parts of filler, 20-50 parts of disintegrant, 10-25 parts of binder, and 2-3 parts of lubricant. The ritonavir layer is composed of 90-110 parts of ritonavir, 30-60 parts of filler, 6-10 parts of coating material, 40-100 parts of filler, 3-5 parts of lubricant, and 200-300 parts of binder. The nematamide and ritonavir combination tablets of the present invention have small initial dissolution fluctuations, stable onset time and efficacy; at the same time, the excipients adsorb less of the active ingredients, resulting in high drug recovery rate, good efficacy and good stability.

The application discloses an extraction method of effective substances in liquorice, and particularly relates to a liquorice extract and a preparation method thereof. The preparation method comprises the following steps: (1) rapid pretreatment of alkali liquor; (2) extraction of liquorice residue flavones; (3) recovery of liquorice flavones; and (4) recovery of glycyrrhizic acid in alkali washing liquor. Finally, the precipitate is collected and dried to obtain a crude glycyrrhizic acid product, and the purity of glycyrrhizic acid in the crude product is 43-46% (v / v).

This utility model discloses an alumina leaching device, characterized in that: the raw ore slurry, after passing through a first heat exchanger, sequentially enters a second, third, fourth, and fifth heat exchanger, and then enters a heat-insulating retention tank. The heat-insulating retention tank is connected to a flash evaporator. The leached slurry from the flash evaporator is connected to a second heat exchanger, and then enters a dilution tank. The dilution tank is connected to a post-leaching tank via a first pump. This utility model, through optimized thermal energy design, reduces redundant flash evaporation and auxiliary processes in traditional processes, lowers equipment investment costs and operational complexity, and provides a device for optimizing the thermal energy utilization of the leaching system, while simultaneously achieving the goals of simplifying the leaching process and saving investment. Combining the leaching heat balance and the water distillation benefits from flash cooling, it ensures that the ore slurry achieves the best leaching effect and optimal economic benefits in the leaching system.

This invention relates to the field of deep processing technology of white hyacinth bean, specifically to a method for preparing a compound spleen-strengthening and dampness-removing white hyacinth bean paste. This invention utilizes low-temperature roasting to pretreat a specific ratio of dampness-removing medicinal herbs, including licorice, poria cocos, coix seed, and bitter almond, and prepares a compound decoction rich in dampness-removing components. This decoction is then used as a biological stressor to promote the germination of white hyacinth beans, with its concentration controlled to encourage moderate germination and the production of substances that resist adverse conditions. Simultaneously, leveraging the plant's water absorption capacity during germination, the invention incorporates the dampness-removing components of the compound decoction. Stable solid-state fermentation with pure Rhizopus further enhances the dampness-removing components of the compound white hyacinth bean and fermented soybean. This not only increases the content of major dampness-removing components such as polyphenols, proteins, and polysaccharides in the white hyacinth bean and fermented soybean, but also increases the content of trace dampness-removing substances such as rutin, quercetin, kaempferol, luteolin, and picolinic acid. It also promotes the dissolution of dampness-removing amino acids—alanine and glycine. The dampness-removing compound white hyacinth bean and fermented soybean components are clearly defined, and the content of spleen-strengthening and dampness-removing substances is richer.

The application provides an integrated water purification hydrogen production device, and belongs to the technical field of hydrogen water preparation. The device comprises a water purification tank, a hydrogen injection assembly, a first driving assembly, a hydrogen gas backfeeding assembly and a whipping assembly. One end of the hydrogen injection assembly extends to the outside of the water purification tank and is connected with a hydrogen generator, and the other end extends to the inside of the water purification tank. The first driving assembly is installed on the top of the water purification tank and is used to drive the hydrogen injection assembly to rotate in the water purification tank, so as to deliver hydrogen to different positions in the water body. Compared with the prior art, the embodiment of the application can whip and disperse the hydrogen bubbles delivered into the water body when hydrogen is produced in the water body, thereby improving the dissolution effect of hydrogen in the water body. After the hydrogen gas floats out of the water surface, the floated hydrogen gas can be backfed into the water body, so that the floated hydrogen gas participates in the hydrogen production process again, thereby reducing the waste of hydrogen and improving the utilization rate of hydrogen.

The present application relates to the technical field of cosmetic raw materials, and discloses a camellia flower composite oil, a preparation method and application thereof, and a cosmetic. The preparation method of the camellia flower composite oil comprises the following steps: (1) performing enzymatic reaction on camellia oil in the presence of lipase and a solvent, and separating to obtain enzymatic camellia oil; (2) performing extraction on camellia flower powder and the enzymatic camellia oil to obtain an extraction mixture; and (3) performing solid-liquid separation on the extraction mixture to obtain the camellia flower composite oil. The camellia flower composite oil provided by the present application has high polarity, high antioxidant property, high safety and good formulation application performance, and can significantly improve the water phase carrying capacity and long-term stability of a water-in-oil emulsion.

The invention discloses a method for preparing 4N8-grade high-purity quartz sand through external field enhanced acid leaching and cleaning equipment, and belongs to the technical field of high-purity quartz purification processes, the method comprises the following steps: S1, after a to-be-treated object is cleaned and dried, roasting and water quenching treatment are performed in sequence, and a first treated object is obtained; s2, mixing the first treated substance with the leachate, carrying out microwave external field enhanced high-temperature acid leaching treatment, and then cleaning a leached product to be neutral, so as to obtain a second treated substance; s3, the second treated matter is prepared into ore pulp, a collecting agent is added into the ore pulp for flotation treatment, after impurities are removed, concentrate obtained through flotation is cleaned to be neutral, and a third treated matter is obtained; s4, dehydrating and drying the third treated product, and performing magnetic separation and impurity removal under magnetic field intensity to obtain 4N8-grade high-purity quartz sand; the method for preparing the high-purity quartz sand is fluoride-free, nitrate-free, green and environment-friendly, and severe influence and pollution to human bodies and the environment caused by use of hydrofluoric acid are avoided.

This invention discloses an utpatinib sustained-release tablet and its preparation method, characterized by comprising the active ingredient utpatinib and excipients, wherein the excipients include filler 1, filler 2, a matrix material, a lubricant, a flow aid, and a coating material; filler 1 is a combination of different types of microcrystalline cellulose, filler 2 is mannitol or lactose, and the matrix material is a mixture of polyvinyl acetate and povidone (Kollidon® SR). The formulation prepared by this invention solves the degradation problem encountered in the preparation of utpatinib sustained-release tablets, simplifies the production steps and facilitates commercial production, and also solves the problem of utpatinib relying on pH adjusters to enhance solubility, and has good stability and high mixing uniformity.

This invention relates to a method for purifying imidazole cyclized liquid, comprising the following steps: adding an alkali and montmorillonite to an imidazole cyclized liquid to obtain a mixture; heating the mixture under vacuum to remove water, obtaining an imidazole concentrate; distilling the imidazole concentrate to collect the crude imidazole distillate; and crystallizing, centrifuging, and drying the crude imidazole distillate to obtain imidazole. This invention utilizes the addition of an alkali to effectively release free imidazole, promoting its dissolution, facilitating distillation, and increasing the imidazole distillation yield. Montmorillonite, used in the purification and distillation process of imidazole, effectively reduces the viscosity of the residue, facilitating heat and mass transfer and promoting complete distillation of imidazole. This invention can obtain a high-content imidazole concentrate at a lower distillation temperature, which, after further processing, yields high-purity imidazole. The method of this invention has the advantages of simple process, low cost, environmental friendliness, and high yield.

The present application relates to the technical field of deep processing of deer products, and discloses an enzyme-assisted high-activity ingredient extraction process of deer horn powder, which comprises the following steps: raw material pretreatment, composite enzymolysis, preparation of extraction liquid, ultrasonic-assisted extraction, separation and primary purification, adsorption purification, concentration and drying; the compact keratinization matrix structure of the deer horn powder is destroyed through defatting and decalcification treatment in the pretreatment step, which creates conditions for the release of subsequent active ingredients; the step of composite enzymolysis adopts step-by-step enzymolysis treatment, and the papain, acid protease, trypsin and cellulase are used for step-by-step enzymolysis in a controllable temperature oscillation reactor, which can hydrolyze the complex protein-polysaccharide composite structure in the deer horn, promote the dissolution of the internal high-value components, the multi-enzyme synergistic effect overcomes the limitations of single enzyme action, and thus the extraction sufficiency of the target ingredients and the breadth of the product spectrum are improved.

The present application relates to the technical field of tobacco processing, and particularly relates to a tobacco flavor substance extraction device and method. The device comprises an extraction barrel, a grinding assembly, a scraping assembly and a stirring assembly arranged in the extraction barrel. The grinding assembly comprises a grinding disc, a crushing wheel and a driving unit. The grinding disc is fixed in the extraction barrel. The driving unit comprises a motor, a driving gear, a driven gear and a rotating shaft. The motor is installed on the top of the extraction barrel. The scraping assembly comprises a scraper and an elastic force applying structure. The scraper is connected with the rotating shaft through the elastic force applying structure, and the scraper is in contact with the surface of the grinding disc. The stirring assembly comprises a support frame and a stirring member. The support frame is fixed on the lower part of the rotating shaft, and the stirring member is installed on the support frame. The present application solves the problem of low extraction efficiency caused by insufficient crushing and grinding in the prior art, and shortens the extraction time and improves the extraction efficiency per unit time.