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127results about How to "Promote dissolution" patented technology

Method for extracting toosendanin from cortex meliae

InactiveCN103450324APromote rupturePromote dissolutionSteroidsBiophysicsDual frequency ultrasound
The invention relates to a method for extracting toosendanin from cortex meliae. The method comprises the following processing steps: cleaning dry mature cortex meliae and then crushing the mature cortex meliae by a pulverizer, grinding the mature cortex meliae into powder, drying the powder and adding a 60% ethanol solvent; adjusting the pH value of the solution to 4-6, and adding cellulase for enzymolysis; putting the extracting solution into a double-frequency ultrasonic extractor to obtain an enzymatic hydrolysate; carrying out high-temperature inactivation on the enzymatic hydrolysate to obtain an extracting solution; centrifuging, taking supernate, extracting by use of chloroform, and drying by use of anhydrous sodium sulfate; carrying out suction filtration, concentrating, adding ethanol and heating for dissolving; dropping petroleum ether until the mixture becomes a turbid matter; stewing for separating out a flavescent solid, namely the toosendanin. According to the method, the cortex meliae is taken as the raw material; the stacking effect of enzymolysis and a double-frequency ultrasonic wave is fully utilized; the toosendanin in the cortex meliae is dissolved to the greatest extent; the high-purity toosendanin can be obtained by virtue of extraction and crystallization. The method has the advantages of being simple in equipment, low in extraction cost, high in extraction efficiency, mild in reaction condition, less in solvent consumption, free of pollution and the like.
Owner:NANJING TONGZE AGRI SCI & TECH

Method for preparing peptide calcium by using fish bone

The invention discloses a method for preparing peptide calcium by using fish bone. The method comprises the following steps: by taking fish bone as a raw material, treating the fish bone by using subcritical water under an acid condition, performing super-fine comminution on the fish bone by using dynamic high-pressure micro jet, performing enzymolysis on the fish bone by using pepsase and composite flavourzyme, treating enzymatic hydrolysate by using a microwave technique, and performing spray drying, thereby obtaining a peptide calcium product. As a mixture of the fish bone and hydrochloric acid is treated by using the subcritical water technique, the speed of softening the fish bone can be effectively increased, and calcium ion digestion can be promoted; due to high-pressure micro jet, the granules of the fish bone can be greatly reduced, and later fish bone enzymolysis efficiency can be improved; the pepsase and the composite flavourzyme are adopted for enzymolysis on the fish bone after super-fine comminution, then conversion of proteins to polypeptide is promoted, and a mixed liquid of peptide and calcium can be formed; due to microwave heating, the chelation efficiency of the peptide and the calcium can be promoted, and the product quality can be improved; by adopting the method, the purpose of utilizing the proteins and the calcium in the fish bone simultaneously can be achieved, and the utilization values of the byproduct, namely the fish bone generated in minced fillet processing, can be increased.
Owner:JIANGXI NORMAL UNIVERSITY

Preparation method for safflower care-free tablet

The invention discloses a preparation method for a safflower care-free tablet, and relates to a preparation method for a traditional Chinese medicinal preparation. The method comprises the following steps: (1) extracting volatile oil of three traditional Chinese medicines, namely, Chinese angelica, bighead atractylodes rhizome and mint, by the method of steam distillation; (2) dissolving the herbresidue obtained in step (1) together with white peony root, Poria cocos, safflower, spina gleditsiae, herba bupleuri and licorice in water and obtaining water extract of the solution with supersonicwave; (3) including the volatile oil with beta-cyclodextrin so as to obtain volatile oil beta-cyclodextrin inclusion complex; (4) adding the water extract obtained in step (2) and the volatile oil beta-cyclodextrin inclusion complex obtained in step (3) into starch, carrying out granulation to form tablets and coating the tablets with thin film so as to obtain safflower care-free tablets. The invention enables effective ingredients in cells of the above-mentioned medicinal materials to dissolve rapidly and chemical constructions of the effective ingredients not to be destroyed, and therefore a high recovery rate is obtained. According to the invention, beta-cyclodextrin inclusion technique is employed to add the volatile oil, which effectively improves the retention index of volatile components of the above-mentioned medicinal materials in the preparation.
Owner:JIANGXI POZIN PHARMA

Method for detecting content of active calcium oxide and non-active calcium oxide in lime

The invention discloses a method for detecting the content of active calcium oxide and non-active calcium oxide in lime. The method comprises the steps of crushing lime until the particle diameter is less than or equal to 0.150mm, and drying at 105-110 DEG C for 1.5-2.5 hours; taking 0.5000g of a test sample, and mixing with a blend of 4g of anhydrous sodium carbonate and boric acid, fusing at 880-920 DEG C for 16-24 minutes, putting the fused blocks into 60ml of 8% hydrochloric acid and dissolving at 100-110 DEG C, enabling the volume of a solution to be constant by a 250ml volumetric flask so as to obtain a test solution a; taking 0.5000g of a test sample additionally, adding 5g of saccharose and 45-55ml of water which is boiled firstly and then cooled, vibrating closely for 18-22 minutes, enabling the volume of the solution to be constant by a 250ml volumetric flask so as to obtain a test solution b; removing 50.00ml of the test solution a and the test solution b, and respectively adding 5ml of triethanolamine and 20% potassium hydroxide or sodium hydroxide, so that the pH value of the test solution is greater than or equal to 12.5; then adding 4-5 drops of 1mg/ml magnesium oxide standard solution and 2-3 drops of calconcarboxylic acid, titrating the test solution by an EDTA standard solution until the test solution turns blue from red. The content of the active calcium oxide is calculated according to the following formula as shown in the specification, and the content of the non-active calcium oxide is calculated according to the following formula as shown in the specification, wherein W does not refer to CaO=WTCaO_WfCaO. The method is used for rapidly and accurately detecting the content of the active calcium oxide and non-active calcium oxide in a lime test sample, and is high in popularization and application value.
Owner:WUKUN STEEL

Supercritical water/supercritical carbon dioxide combined treatment method for arsenic-contaminated soil

The invention relates to a supercritical water/supercritical carbon dioxide combined treatment method for arsenic-contaminated soil, and belongs to the technical field of soil remediation. The supercritical water/supercritical carbon dioxide combined treatment method comprises: placing arsenic-contaminated soil in a high-temperature and high-pressure reaction kettle I, adding a metal binder, introducing carbon dioxide gas, carrying out heating pressurizing to achieve the supercritical state of the carbon dioxide, and carrying out contact extraction for 15-120 min to obtain repaired soil and the extracted product, wherein the temperature of the carbon dioxide in the supercritical state is 40-80 DEGC, and the pressure is 10-45 MPa; and adding the extracted product, water and an excess oxidant to a high-temperature and high-pressure reaction kettle II, uniformly mixing to obtain a reaction system, carrying out heating pressurizing on the reaction system in the high-temperature and high-pressure reaction kettle II under a closed condition until the reaction system achieves a water supercritical state, and carrying out a reaction for 5-45 min to obtain the reaction product system, wherein the temperature of the supercritical state is 380-650 DEGC, and the pressure is 23-55 MPa. According to the present invention, arsenic is gently extracted by supercritical carbon dioxide so as to repair contaminated soil while recover the arsenic in the form of arsenic trioxide.
Owner:KUNMING UNIV OF SCI & TECH

Solid dispersion prepared from magnolol, honokiol or mixture of magnolol and honokiol and preparation method of solid dispersion by hot-melt extrusion

The invention belongs to the field of pharmaceutical preparations and particularly discloses solid dispersion prepared from magnolol, honokiol or a mixture of the magnolol and the honokiol and a preparation method of the solid dispersion by hot-melt extrusion. The solid dispersion is mainly characterized in that polyethylene glycol, copovidone S-630, hydroxy propyl cellulose, acrylic resin or polyethylene caprolactam-polyvinyl acetate-polyethylene glycol grafted copolymer serves as a main adjuvant of a dispersion supporter, a sugar alcohol adjuvant is added to serve as a plasticizer when necessary, and the HME (hot-melt extrusion) technology serves as the preparation technology, so that medicines are dispersed in the adjuvant of the supporter in an amorphous state, dissolution rate of the medicines is increased, and bioavailability of the medicines is improved. Compared with a conventional solid dispersion preparation technology, the hot-melt extrusion technology adopted in the preparation method has the advantages of nonuse of organic solvents, safety, no pollution, stable process, continuous operation and easiness for enlarged industrialized production.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Washing machine timer capable of controlling circulating water flow and double-barrel washing machine

The invention discloses a washing machine timer capable of controlling circulating water flow and a double-barrel washing machine. The total working time of the timer contains soaking and washing time and continuous washing time; and at least the soaking and washing time is synchronized with an internal circulating water flow washing time for controlling periodical and intermittent circulation of a water discharging pump. The timer comprises an input end, an output end and a manual converter, wherein the output end is provided with two groups of washing contacts connected with a washing motor; one washing contact of the output end is selected for connection by switching of the manual converter; the input end is provided with two groups of contacts which respectively control a power supply and the water discharging pump; the timer is also provided with a cleaning cam for switching on and off the power supply in a timing manner to control the continuous washing time and the soaking and washing time and an internal circulating cam for switching on and off the water discharging pump in a timing manner to control the internal circulating water flow washing periodically, intermittently and circularly. According to the timer disclosed by the invention, the starting and stopping of the water discharging pump can be controlled for the internal circulation of the washing water flow, so that the dissolving performance and the washing performance of washing powder are improved. The double-barrel washing machine has the characteristic of saving water and power.
Owner:QINGDAO HAIER WASHING MASCH CO LTD

Extraction method of phyllanthus emblica polyphenol

The invention discloses an extraction method of phyllanthus emblica polyphenol. The extraction method comprises the following steps: removing stalks of obtained phyllanthus emblica fresh fruit, cleaning with deionized water, draining water, removing kernels, adding the phyllanthus emblica fresh fruit to a precooling acetone solution, pounding, homogenizing, carrying out magnetic force oscillation, centrifuging, taking supernatant, repeating the steps so as to extract precipitates for two to three times, combining supernatant, and recycling acetone, thus obtaining a total extracting solution; filtering the total extracting solution by using a pretreated hollow fibrous membrane; purifying a hollow fibrous membrane filtering medium by using a polyamide chromatographic column, collecting eluant, recycling alcohol, concentrating, and carrying out freeze drying, thus obtaining the phyllanthus emblica polyphenol. Compared with a conventional heat extraction method, the extraction method disclosed by the invention has the advantages that the extraction temperature is low, a technology is simple and easy to operate, the extraction effect is good, the extraction rate of the phyllanthus emblica polyphenol reaches above 95%, and the purity of the phyllanthus emblica polyphenol finished product reaches above 99%.
Owner:HEFEI KANGLING HEALTH TECH

Levofloxacin composition freeze-dried orally disintegrating tablets and preparation method thereof

The invention provides levofloxacin composition freeze-dried orally disintegrating tablets and a preparation method of the orally disintegrating tablets, relates to the field of a medicine and a medicine preparation method technology and mainly solves the problems in the prior art that the ordinary preparation prepared by levofloxacin is poor in curative effect and not suitable for children and the patients who are difficult to swallow. The levofloxacin composition freeze-dried orally disintegrating tablets are prepared from the following components by weight: 10-24% of levofloxacin, 24-50% of mannitol, 2-4% of gelatin, 32-74% of hydroxypropyl-beta-cyclodextrin with medium substitution degree, 0.1-0.2% of trichlorosucrose and 50-70% of purified water. The levofloxacin composition freeze-dried orally disintegrating tablets prepared by the above components are easy in preparation process, and simple in components, and mainly meet the administration requirements of children and the patients who are difficult to swallow; moreover, the levofloxacin composition freeze-dried orally disintegrating tablets have the advantages of being fast to disintegrate, convenient to take, and good in taste; and the tablets take effect quickly and are fully absorbed, and the first pass effect of the liver is avoided.
Owner:HAINAN WEI KANG PHARMA QIANSHAN
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