52 results about "Osmotic pump" patented technology

The present invention discloses a tofacitinib citrate sustained-release tablet preparation and a preparation method thereof, which belongs to the technical field of pharmaceutical preparations. The sustained-release tablet comprises a double-layer core and a coating layer; the double-layer core comprises a drug-containing layer and a push layer; wherein the drug-containing layer comprises: tofacitinib citrate, an adhesive, polyethylene oxide, a glidant and a lubricant; the push layer comprises: mannitol, an adhesive, red iron oxide, polyethylene oxide, a glidant and a lubricant; the coating layer comprises: cellulose acetate, a pore-forming agent, a plasticizer, water and acetone. The sustained-release tablet preparation of the present invention solves the technical problems existing in the prior art by adopting a double-layer osmotic pump prescription design, adopting non-hygroscopic materials such as mannitol, adopting a standard round tablet design, preparing a sustained-release coating layer without using methanol, and adopting a coating machine for coating and curing.

The invention relates to the technical field of drug delivery systems. The invention provides an osmotic pump drug release system based on a fenerenone solid dispersion and a preparation method of the osmotic pump drug release system. According to the fenerenone solid dispersion prepared by adopting a hot melt extrusion technology and the osmotic pump drug release system based on the fenerenone solid dispersion, the solubility and the bioavailability of the fenerenone in the solid dispersion can be improved, and drug absorption can be accelerated; the sustained and stable release of the fenerenone can be realized, the drug release rate is optimized, the effectiveness and safety of the drug in the treatment process are ensured, the chemical stability of the fenerenone is improved, and the validity period of the drug is prolonged. Various challenges of the fenerenone in the using process are effectively solved, a more effective and safer treatment scheme is provided for patients suffering from chronic kidney diseases complicated with type 2 diabetes, and important practical value and wide market prospects are achieved.

The invention relates to the technical field of pharmaceutical preparations, in particular to a rapamycin multiphase release or osmotic pump type weekly-effect oral controlled-release composition and a preparation method thereof, and the rapamycin multiphase release or osmotic pump type weekly-effect oral controlled-release composition comprises a quick release layer, a slow release layer and an osmotic pump structural design. According to the application, staged or constant-rate release of rapamycin within 168 hours is realized through a multi-phase release technology or an osmotic pump technology, and the problems that an existing preparation is large in blood concentration fluctuation, high in administration frequency and low in bioavailability are solved. The composition is suitable for treating hypertrophic cardiomyopathy of cats, significantly improves cardiac functions and reduces side effects and risks, is administered once a week, and is convenient to use. The invention further provides a storage method, and the product stability is ensured. The technical scheme has remarkable clinical advantages and application prospects.

A water treatment plant or system for the production of permeate includes a reverse osmosis stage and a permeate stage. The reverse osmosis stage can include a piping system having a supply line for process input water, a reverse osmosis pump, and a reverse osmosis tank. The reverse osmosis tank has an inlet for process input water coming from the reverse osmosis pump, a membrane, and an outlet for permeate. The permeate stage, which can have a line system forming a circuit, can include a permeate tank, a permeate pump, and a tapping point for connecting at least one consumer or user of permeate. The reverse osmosis stage and the permeate stage can be connected to one another via a connecting line in such a way that the reverse osmosis stage feeds the permeate stage with permeate. The circuit of the permeate stage can include a sterile filter.

The invention discloses a topiromilast osmotic pump tablet and a preparation method thereof. The topiromilast osmotic pump tablet comprises a tablet core composed of a drug layer and a pushing layer, a semipermeable membrane coating outside the tablet core, and a single drug release small hole and an isolation coating on the surface of a controlled release tablet on one side of the drug layer. Compared with topiromilast tablets on the market at present, the topiromilast osmotic pump controlled release tablet prepared by the invention can realize continuous and stable constant-speed release of drugs. After a patient takes the medicine, the medicine in the medicine release layer cannot be released immediately, and the tablet can rhythmically release the medicine, maintain the steady-state blood concentration, delay the peak time and prolong the half-life period of the medicine within more than ten subsequent hours under the action of the pushing layer, so that the bioavailability is improved, and the slow release effect of more than 12 hours is achieved. Due to the adoption of a double-layer osmotic pump controlled release technology, compared with a single-layer tablet, the double-layer osmotic pump controlled release tablet has the advantages of stronger controllability, more complete release and higher availability.

The invention discloses an osmotic pump sampler, and relates to the technical field of underwater samplers, an upper end cover and a lower end cover are respectively arranged at the upper end and the lower end of a cylinder body, a drainage pipe is arranged at the upper part of the upper end cover and is communicated with the cylinder body, and a water sample storage coil pipe is arranged at the lower part of the lower end cover and is communicated with the cylinder body; the rotary driving part is arranged on the lower portion of the upper end cover, a power output shaft of the rotary driving part is in threaded connection with the connecting frame, the lower portion of the connecting frame is connected with a piston, and the piston is attached to the inner wall of the barrel and can move up and down relative to the barrel; the piston is provided with a limiting through hole and a plurality of mounting through holes, the lower end of the sliding rod is arranged on the upper portion of the lower end cover, the upper end of the sliding rod penetrates through the limiting through hole and extends to the position above the piston, a plurality of permeable membranes are arranged on the lower portion of the piston, and each permeable membrane corresponds to one mounting through hole in position. According to the osmotic pump sampler, rapid collection of samples is realized, and the problems of low sampling speed and limited application scenarios are solved.

Disclosed are systems and methods for facilitating the cooling of electronic devices. In one embodiment, a cooling system includes a pump coupled to a gas accumulator. The pump can be operationally coupled to a heat exchanger in a fluid circuit. The gas accumulator can be coupled to a core. In some embodiments, the pump is an electro-osmotic pump, and the core is a metal core printed circuit board. In certain embodiments, the gas accumulator is coupled to the pump with a thermal fitting. In one embodiment, the pump, gas accumulator, and heat exchanger are mounted on a surface of the core.

The invention discloses a tofacitinib citrate sustained-release tablet preparation and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the sustained-release tablet comprises a double-layer tablet core and a coating layer; the double-layer tablet core comprises a medicine-containing layer and a pushing layer; wherein the medicine-containing layer comprises tofacitinib citrate, an adhesive, polyoxyethylene, a flow aid and a lubricant; the pushing layer comprises mannitol, an adhesive, red iron oxide, polyoxyethylene, a flow aid and a lubricant; the coating layer comprises cellulose acetate, a pore-foaming agent, a plasticizer, water and acetone. According to the sustained-release tablet preparation disclosed by the invention, the technical problems in the prior art are solved by adopting a double-layer osmotic pump prescription design, mannitol and other non-hygroscopic materials, a standard round tablet design, no methanol for preparing a sustained-release coating layer, a coating machine for coating, curing and the like.

An osmotic pump controlled-release tablet of an insoluble drug includes a tablet core, a semi-permeable membrane coating and a drug-release hole, wherein the tablet core includes a solid dispersion of the insoluble drug and a penetration enhancer, the solid dispersion of the insoluble drug includes the insoluble drug and a carrier, the insoluble drug is selected from nicardipine, nifedipine and felodipine and pharmaceutically acceptable salts thereof, and the carrier is selected from organic acids. Compared with other tablets, the drug solubility of the osmotic pump controlled-release tablet of the insoluble drug is improved, a large amount of penetration enhancers or other excipients do not need to be used in the tablet core, the drug-loading capacity is improved, and the tablet core is not too large; the degree of release in vivo is improved.

An electro-osmotic pump according to an embodiment of the present disclosure includes: a membrane that allows fluid movement; and a first electrode and a second electrode respectively provided on both sides of the membrane. The first electrode and the second electrode are formed of an impermeable substrate material and an electrode material coated thereon and have at least one fluid pathway. The impermeable substrate material is a plate-shaped substrate including at least one of a conducting material, a semiconducing material and a non-conducting material.

The invention relates to a glipizide controlled-release tablet, the controlled-release tablet comprises a sustained-release pellet and pharmaceutically acceptable auxiliary materials, the sustained-release pellet comprises (a) a blank pellet core, (b) a drug coating layer wrapping the blank pellet core, and (c) a sustained-release coating layer wrapping the drug coating layer; the in-vitro release degree similarity factor f2 of the controlled release tablet and a commercially available glipizide osmotic pump tablet, namely, reiligenin, is greater than or equal to 50. According to the glipizide controlled release tablet, the defects that in the preparation process of commercially available glipizide osmotic pump tablets, a large amount of acetone is used as a coating solvent, and laser drilling has high requirements on production equipment and technological process are overcome, the production process is simple, and the product reproducibility is good.

Main requirement: Water treatment plant for the production of permeate, especially for dialysis therapy, comprising • a reverse osmosis stage (137) with a piping system comprising a supply line (131) for process inlet water (100), a reverse osmosis pump (103) and a reverse osmosis tank (130), wherein the reverse osmosis tank (130) has an inlet (143) for the process inlet water (100) coming from the reverse osmosis pump (103), a membrane (104) and an outlet (144) for permeate (108), • a permeate stage (139) with a circulating piping system comprising a permeate tank (112), a permeate pump (114) and a take-off point (134) for connecting at least one consumer or user of permeate (108), wherein the reverse osmosis stage (137) and the permeate stage (139) are connected to each other via a connecting line (138) such that the reverse osmosis stage (137) feeds the permeate stage (139) with permeate (108), and wherein the circuit of the permeate stage (138) comprises a sterile filter (116).

The invention provides a nicotine osmotic pump tablet and a preparation method thereof, the nicotine osmotic pump tablet is suitable for the oral cavity, the nicotine osmotic pump tablet comprises a tablet core, the tablet core comprises a drug-containing layer and a boosting layer, the drug-containing layer contains nicotine, and the ratio of the viscosity of the drug-containing layer to the viscosity of the boosting layer is 1: 1.5-1: 2; the tablet core is coated with the semi-permeable membrane; and the release hole can release nicotine after the semipermeable membrane permeates into the liquid. By adopting the nicotine osmotic pump tablet, nicotine is released at an approximately constant rate, the problems that oral mucosa and even stomach are stimulated to cause nausea and the like due to too fast release of nicotine are avoided, and meanwhile, sticky feeling or foreign body sensation is avoided during oral administration.

The application provides a tivozanib hydrochloride osmotic pump controlled-release tablet, which is characterized in that the tablet comprises a tablet core, and the tablet core comprises 100 parts of tivozanib hydrochloride, 30-60 parts of a retarder, 40-80 parts of a disintegrant and / or an osmotic pressure promoter, 40-90 parts of a cosolvent and 8-15 parts of a pore-forming agent in terms of weight fraction. The tivozanib hydrochloride osmotic pump controlled-release tablet can realize zero-order release and has a 24-hour cumulative release degree of more than 96%, so that the bioavailability of tivozanib in vivo is improved, and the frequency or dosage of oral solid preparations of tivozanib is reduced.

The invention relates to a detachable multi-organ chip co-culture device, and relates to the technical field of biological tissue engineering. Comprising an upper-layer fluid channel layer chip, a lower-layer micro-pit cell culture layer chip and an osmotic pump, the upper-layer fluid channel layer chip and the lower-layer micro-pit cell culture layer chip are respectively divided into five independent functional units, and the structures of the independent functional units are mutually independent; each independent functional unit of the upper fluid channel layer chip comprises a fluid channel structure; each independent functional unit of the lower-layer micro-pit cell culture layer chip comprises a micro-pit array structure and a micro-cavity, and the micro-pit array structure is arranged at the bottom of the micro-cavity; the upper-layer fluid channel layer chip and the lower-layer micro-pit cell culture layer chip are detachably combined and connected through a tenon-and-mortise structure; the osmotic pump is connected to the outlet end of the culture device and is used for constructing a dynamic perfusion culture environment. According to the invention, high-throughput culture of multiple organs can be realized, and the cell viability and proliferation state are good under a dynamic perfusion condition.

An osmotic pump tablet, its preparation method and use. The osmotic pump tablet comprises a tablet core and a coating film wrapping the tablet core, the coating film has a drug release hole, the tablet core comprises a drug-containing layer, the drug-containing layer comprises a drug active ingredient, a hydrophilic polymer and a surfactant, the hydrophilic polymer comprises hydroxypropyl cellulose and the surfactant comprises poloxamer; or the drug-containing layer comprises a drug active ingredient and a hydrophilic polymer but does not contain a surfactant; the hydrophilic polymer comprises povidone K29 / 32; or the osmotic pump tablet comprises a drug-containing immediate-release outer coating, the drug-containing immediate-release outer coating comprises a drug active ingredient and a pharmaceutical excipient, and the pharmaceutical excipient is a binder.

In some example embodiments, there may provided a system that includes an osmotic pump; a fluidics structure coupled to the osmotic pump, and at least one sensor configured to measure a concentration of at least a first analyte in a biofluid collected using the system.

The invention relates to an osmotic pump tablet as well as a preparation method and application thereof. The osmotic pump tablet comprises a tablet core and a coating film wrapping the tablet core, the coating film is provided with drug release holes, the tablet core comprises a drug-containing layer, the drug-containing layer comprises active pharmaceutical ingredients, a hydrophilic polymer and a surfactant, the hydrophilic polymer comprises hydroxypropyl cellulose, and the surfactant comprises poloxamer; or the drug-containing layer comprises a drug active ingredient and a hydrophilic polymer, but does not contain a surfactant; the hydrophilic polymer is prepared from povidone K29 / 32; or the osmotic pump tablet contains the drug-containing quick-release outer coating, the drug-containing quick-release outer coating contains the active pharmaceutical ingredient and the pharmaceutic adjuvant, and the pharmaceutic adjuvant is an adhesive. The invention further provides a preparation method and application of the compound. The osmotic pump tablet disclosed by the invention is high in drug loading capacity and can well play a treatment effect.

The invention relates to a nicotine osmotic pump tablet for oral cavity and a preparation method thereof. The nicotine osmotic pump tablet for the oral cavity comprises a tablet core, the tablet core comprises a medicine layer and a boosting layer, the medicine layer comprises nicotine and a hydrophilic polymer, and the boosting layer comprises an osmotic pressure accelerant, an insoluble expanding agent and a hydrophilic polymer; the semipermeable membrane covers the tablet core, the weight of the semipermeable membrane accounts for less than 10% of the weight of the tablet core, the semipermeable membrane comprises a base material and a pore-foaming agent, and the weight of the pore-foaming agent accounts for 10%-20% of the weight of the semipermeable membrane; and the release hole can release the nicotine after the semipermeable membrane permeates into the liquid. The nicotine osmotic pump tablet for the oral cavity can adapt to the oral cavity environment, meets the core requirement of applying nicotine to the oral cavity, has no rupture condition in the nicotine dissolution process, is better in mechanical property, and can be accurately, rapidly and completely released in the oral cavity environment in a short time in a staged manner.

The utility model provides a rejecting device of osmotic pump tablet perforating machine, including carrier, blowing assembly and material channel box, the carrier is provided with a plurality of material grooves for filling tablets that are arranged in array, the blowing assembly is arranged below the carrier and includes a plurality of blowing needles that are controlled independently, and the blowing needle is connected with the material channel box. Air blowing ports of the air blowing needles are arranged in one-to-one correspondence with material grooves in a carrier; the material channel box is arranged above the carrier, a plurality of material channels corresponding to the blowing needles one to one are arranged on the material channel box, one end of each material channel is an inlet which covers the position over one material groove, the other end of each material channel is an outlet which is communicated with the defective product bin, and the inlet of the material channel, the material grooves and the blowing openings of the blowing needles which are correspondingly arranged are arranged on the same straight line from top to bottom. According to the utility model, a plurality of products can be rejected at one time, the blowing and rejecting channels are independent and do not influence each other, the influence of the blowing needle on the adjacent troughs during blowing can be avoided, and the rejecting effect is ensured while the rejecting efficiency is ensured.

The utility model relates to the technical field of water body samplers, in particular to a nanofiltration osmotic pump sampler which comprises an osmotic pump, the osmotic pump comprises a water inlet cavity, a water outlet cavity and an osmotic membrane, the water inlet cavity is filled with deionized water, anion exchange resin and cation exchange resin, and the water outlet cavity is filled with saturated draw liquid and solid draw substances. The solid absorbing substance is used for maintaining the concentration of the penetrating fluid after being dissolved, so that osmotic pressure is formed on the two sides of the osmotic membrane, water molecules enter the water outlet cavity from the water inlet cavity through the osmotic membrane, and the osmotic membrane is a nanofiltration membrane with the pore diameter being more than 1 nanometer; and substances formed after the solid-state absorbing substances are decomposed are bivalent and above high-valence ions or the outer diameter of the substances is greater than the aperture of the nanofiltration membrane. Water flow velocity on two sides of the osmotic membrane is increased by increasing the aperture of the osmotic membrane, so that water sampling speed is increased, types of drawn liquid are correspondingly changed, pressure difference on two sides of the osmotic membrane is maintained, and flow velocity of the osmotic pump is maintained.

The invention discloses a preparation method of a theophylline controlled-release tablet and the theophylline controlled-release tablet. The preparation method comprises the following steps: S1, dry granulation of a medicine layer: preparing medicine layer particles from theophylline, a slow-release hydrophilic polymer material, a moisture absorbent, a flow aid and a lubricant; s2, performing dry granulation on the boosting layer: preparing boosting layer particles from a coloring material, an expansive high polymer material, a moisture absorbent, a flow aid and a lubricant; s3, tabletting of double-layer tablets: adding the medicine layer particles and the boosting layer particles into a double-layer tablet press for tabletting; s4, semi-permeable membrane coating: adding the theophylline double-layer tablet chip and a semi-permeable membrane coating solution into a coating machine; and S5, laser drilling: drilling holes in the theophylline double-layer semi-permeable membrane coating tablets through a laser drilling machine. The osmotic pump controlled release technology is utilized to control the constant-speed release of the medicine, the medicine effect is more lasting, the plasma concentration is stable, the adverse reaction of the medicine is effectively reduced, the medicine taking frequency is reduced, the medicine taking compliance of a patient is improved, and the clinical treatment effect of the medicine is improved.

Main claim: Water treatment plant for the production of permeate, in particular for dialysis therapy, comprising: • a reverse osmosis stage (137) with a piping system comprising a supply line (131) for process inlet water (100), a reverse osmosis pump (103) and a reverse osmosis tank (130), wherein the reverse osmosis tank (130) has an inlet (143) for the process inlet water (100) coming from the reverse osmosis pump (103), a membrane (104) and an outlet (144) for permeate (108), • a permeate stage (139) with a circulating piping system comprising a permeate tank (112), a permeate pump (114) and a discharge point (134) for connecting at least one consumer or user of permeate (108), wherein the reverse osmosis stage (137) and the permeate stage (139) are connected to each other via a connecting line (138) such that the reverse osmosis stage (137) feeds the permeate stage (139) with permeate (108),and wherein the permeate stage circuit (138) includes a sterile filter (116).

The utility model provides a cabinet type high-speed osmotic pump laser-beam drilling machine, which relates to the technical field of laser-beam drilling machines, and comprises a cabinet body, the top of the cabinet body is fixedly connected with a workbench close to the center, and the top of the workbench is fixedly provided with a protective cover along the peripheral direction. Sliding grooves are formed in the edges of the two sides of the outer surface of the front side of the protective cover, sliding doors are slidably connected into the two sliding grooves, the sliding doors are connected with the protective cover in a matched mode, and fixing blocks are fixedly connected to the edges, close to the opposite sides, of the outer surfaces of the front sides of the two sliding doors. The laser-beam drilling machine solves the problems that when a traditional laser-beam drilling machine is used for drilling, strong light stimulation exists, irritant harm is generated to eyes, certain safety danger exists when the device is used, the using effect of the device is reduced, and the using cost of the device is reduced. And when an existing laser-beam drilling machine conducts drilling, calibration drilling is needed one by one, time is wasted, and the use efficiency of the device is reduced.

A biological treatment system comprising: a treatment vessel; a plurality of filter housings; a feed pump for moving fluid between the processing vessel and the filtration assembly; and a retention valve within the retention line. The retention valve includes a fluid passage to selectively direct movement of a fluid to at least one of the plurality of filter housings; an osmotic valve is arranged in the osmotic pipeline between the filter shell and the osmotic pump; a pressure sensor disposed in the permeate line, and a controller coupled to the pressure sensor, the retention valve, and the permeate valve. A controller actuates the retention valve and the osmotic valve to direct flow between the processing vessel and the one or more filter housings based on information received from the flow sensor and the pressure sensor, and direct osmotic flow from the filter housings to the osmotic pump.

The present application relates to a kind of poorly soluble drug osmotic pump controlled-release tablets and its preparation method, the osmotic pump controlled-release tablets include tablet core, semi-permeable membrane coating and release hole, the tablet core includes solid dispersion of poorly soluble drug and penetration agent, the solid dispersion of poorly soluble drug includes poorly soluble drug and carrier, the poorly soluble drug is selected from nicardipine, nifedipine, felodipine and their pharmaceutically acceptable salt, the carrier is selected from organic acid substance.Compared with prior art, the poorly soluble drug osmotic pump controlled-release tablets of the present application greatly improves the drug solubility, without using a large amount of penetration agent or other excipients in tablet core, drug loading is increased, and tablet core will not be too large;In vivo release greatly improves;Preparation process is simple, equipment requirement and cost are low, and easy to industrialization.

The invention discloses a gentiopicroside microporous osmotic pump tablet and a preparation method thereof, and the preparation method comprises the following steps: 1) preparing a medicine-containing tablet core: weighing 40-50% of gentiopicroside, 20-30% of osmotic pressure active substance, 20-39% of filler and 1-2% of lubricant according to weight ratio, granulating and tabletting to obtain the medicine-containing tablet core; 2) preparing a coating solution: weighing 2%-4% of ethyl cellulose, 0.2% of a plasticizer and 1%-3% of a pore-foaming agent according to a weight ratio, and dissolving in an organic solvent to prepare the coating solution; and 3) coating, wherein the weight of the coating is increased by 5-15% of the weight of the tablet-containing core. According to the gentiopicroside microporous osmotic pump tablet disclosed by the invention, the coating film controls the release of the medicine, the permeability of the coating film is changed by adding the pore-foaming agent, so that the medicine is released from the coating film, and the dosage of the pore-foaming agent determines the medicine release rate; according to the dosage form, the retention time of gentiopicroside in the body can be prolonged, and the treatment effect of gentiopicroside can be fully exerted.

The present application provides a kind of felodipine osmotic pump controlled-release tablets and preparation method thereof, the osmotic pump controlled-release tablet is composed of osmotic pump controlled-release tablet core and water-insoluble coating layer (single side laser punching), the weight percentage of the felodipine osmotic pump controlled-release tablet contains immediate-release coating layer, controlled-release coating layer, propelling coating layer, water-insoluble coating layer is (5~20) :(5~30) :(10~50) :(5~30).The present application also provides a kind of preparation method of felodipine osmotic pump controlled-release tablet and its application in treating hypertension.The formulation of the felodipine osmotic pump controlled-release tablet of the present application is reasonable, and production process is simple and easy to control;By replacing traditional controlled-release tablet polyethylene oxide with different povidone, the controllability of felodipine osmotic pump controlled-release tablet preparation is significantly improved, and the difficulty of cleaning in production is reduced.

The invention relates to a water treatment device for producing a permeate, in particular for dialysis treatments, comprising: a reverse osmosis stage having a line system comprising an input line for process input water, a reverse osmosis pump and a reverse osmosis container, wherein the reverse osmosis vessel has an inlet for process input water from a reverse osmosis pump, a membrane and an outlet for permeate; the invention relates to a reverse osmosis system comprising a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage, a reverse osmosis stage and a reverse osmosis stage, the reverse osmosis stage supplies permeate to the permeate stage, and wherein the loop of the permeate stage comprises a sterile filter.

The utility model relates to the technical field of water treatment, in particular to a highly integrated pure water treatment device which comprises an integrated frame, a precision filter, a water inlet header pipe, a first-stage reverse osmosis pump, a first-stage RO membrane, a second-stage reverse osmosis pump and a second-stage RO membrane are arranged in the integrated frame, an inlet of the precision filter is communicated with the water inlet header pipe, and an outlet of the precision filter is communicated with the water inlet header pipe. An outlet of the precision filter is connected with a first-stage reverse osmosis pump, an outlet of the first-stage reverse osmosis pump is connected with a first-stage RO membrane, a concentrated water outlet of the first-stage RO membrane is communicated to a trench through a pipeline, a pure water outlet of the first-stage RO membrane is connected with a second-stage reverse osmosis pump, and an outlet of the second-stage reverse osmosis pump is communicated with a second-stage RO membrane; a pure water outlet of the second-stage RO membrane is connected between the first-stage RO pump and the water inlet header pipe through a pipeline, a pure water outlet of the second-stage RO membrane is connected to the pure water tank through a water pipe, and a control system is arranged in the integrated frame, so that the effects that the occupied space of the pure water treatment device is smaller, and the pure water preparation rate is higher are achieved.