13 results about "Round window" patented technology

This invention discloses the application of HuR and its encoding gene in the preparation of drugs for treating age-related hearing loss, belonging to the field of genetic engineering technology. It provides the application of the HuR encoding gene in the preparation of drugs for the prevention or treatment of age-related hearing loss. The nucleotide sequence of the HuR encoding gene is shown in SEQ ID NO.1. The amino acid sequence of HuR is shown in SEQ ID NO.2. This invention is the first to discover the use of HuR in the prevention or treatment of age-related hearing loss. The HuR encoding gene, after being packaged with adeno-associated virus (AAV), is injected into the inner ear through a round window, causing it to be widely overexpressed in various types of cells in the inner ear. This can resist or delay the onset of age-related hearing loss, thus providing a theoretical basis for the prevention and improvement of hearing loss in patients with age-related hearing loss in clinical practice.

The invention relates to the technical field of biological medicine, in particular to liposome dispersion liquid and ear drops capable of penetrating through tympanic membrane and inner ear round window membrane. The invention designs the liposome dispersion liquid which can effectively penetrate through a complete path of the tympanic membrane and the round window membrane of the inner ear after being dripped into the ear through the external auditory canal in a non-invasive manner, so that tympanic membrane perforation caused by injection in a tympanic chamber can be avoided, and the pain and discomfort of a patient can be relieved. The liposome dispersion liquid disclosed by the invention is good in stability, and the prepared ear drops can realize efficient delivery of targeted inner ear medicines, have the characteristics of noninvasiveness and convenience, and have a wide application prospect in the medical field.

Systems and methods can be employed to access the middle ear through the tympanic membrane for the delivery of therapeutic agents to, for example, the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otologic procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair, and ossicular chain repair.

The present application relates to the technical field of otological microsurgery instruments, and discloses a cross-shaped round window membrane incision knife with depth control for otological minimally invasive surgery, which comprises a knife rod, a cross-shaped knife head is arranged at the operating end of the knife rod, a detachable depth control mechanism is arranged on the outside of the knife rod behind the cross-shaped knife head, a grip type handle assembly is arranged at the end of the knife rod away from the cross-shaped knife head, and the grip type handle assembly comprises a grip type handle, and a thimble is arranged at the end of the grip type handle close to the knife rod. In the present application, the cross-shaped symmetrical blade edge realizes multi-point stable support, effectively avoids the slippage of the knife head on the surface of the wet round window membrane, and the incision position is accurate; the sharp symmetrical cutting forms a regular cross-shaped incision, there is no disorganized tearing, the incision edge is neat, and this is beneficial to postoperative healing and electrode implantation sealing; the annular flange type depth control mark block forms physical limiting, the cutting depth is locked in a safe range, and overcutting damage to the inner ear is avoided in structure.

The invention discloses application of cimicifugin in preparation of a medicine for preventing or treating inner ear hair cell injury, and belongs to the technical field of biological medicine. According to the invention, it is found for the first time that a natural compound cimifugin has a definite inner ear hair cell protection effect. By inhibiting hair cell apoptosis and reducing hearing synapse loss and hearing nerve fiber injury, the cimicifugin effectively relieves hair cell injury and hearing function decline caused by cis-platinum and other drugs, noise exposure and aging. The protection mechanism is related to inhibition of activation of a pro-apoptosis signal. The preferred administration mode is local administration, especially delivery through a round window membrane, and the dosage form can be a solution, a suspension or a sustained release preparation. Cell, in-vitro hair cell tissue and animal model experiments prove that the cimicifugin can obviously relieve hair cell damage and improve the auditory function. The invention provides a new drug candidate scheme for preventing and treating sensorineural hearing loss, and has important clinical application value.

The invention discloses application of Stab2 protein or coding nucleic acid thereof in preparation of a medicine for treating hearing loss, belongs to the technical field of biological medicine and gene therapy, and aims to solve the problem that in the prior art, an effective repairing means for cochlea banding synapse injury is lacked. The medicine mainly comprises a recombinant virus vector (preferably a lentiviral vector) carrying a Stat2 coding sequence, and the recombinant virus vector is suitable for being delivered to the inner ear through round window injection after being prepared; experiments show that overexpression of Stab2 protein in cochlea can significantly promote regeneration of banding synapses of inner hair cells after noise damage, and the number of synapses is effectively increased; meanwhile, the hearing brainstem reaction threshold value can be remarkably reduced, and the ABR I wave amplitude representing the nerve conduction function is improved; by repairing damaged synaptic junctions, noise-induced hearing loss and implicit hearing loss can be effectively treated, tinnitus, auditory allergy and speech resolution disorder are improved, and good clinical transformation prospects are achieved.

The present application relates to the technical field of biological medicine, and more particularly to a liposome dispersion liquid and ear drops for penetrating the tympanic membrane and the inner ear round window membrane. The present application designs a liposome dispersion liquid which can effectively penetrate the complete path of the tympanic membrane and the inner ear round window membrane after non-invasive ear drops through the external auditory canal, so as to avoid the tympanic membrane perforation caused by intratympanic injection and reduce the pain and discomfort of patients. The liposome dispersion liquid of the present application has good stability, the prepared ear drops can realize efficient delivery of targeted inner ear drugs, has the characteristics of non-invasive and convenience, and has a wide application prospect in the medical field.

1. Name of the product in this design: Tent (Octagonal Double-Layer Round Window). 2. Purpose of this design: a tent for users to camp or rest. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This item is a resin amulet characterized by a circular window made of a half-mirror. While this window functions as a mirror in typical indoor environments, because it is a half-mirror, it allows visibility through to the opposite side in outdoor environments or when the light source is brighter on the other side. Various shapes or characters can be placed inside the dashed lines within the solid lines of the window. These shapes or characters can be placed on either the front, back, or both sides.

A method for the treatment of an auditory disease or condition in a human subject is provided comprising administering a therapeutic agent into a bony cavity of a cochlea of the subject that contains neural structures via the Round Window membrane of the cochlea. Also provided are therapeutic agents for use in such methods, as well as method for the delivery of therapeutic agents via the Round Window membrane of the cochlea.

Systems and methods can be employed for trans-tympanic membrane access to the middle ear for delivery of a therapeutic agent, for example, to the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otological surgical procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair and ossicular chain repair.

The utility model relates to the technical field of medical instruments, and provides a robot for measuring the pressure of an artificial cochlea implantation operation, which comprises a movable chassis, a support body, a connecting arm, a tail end steering handle, a pitching joint and a clamping bracket, and is characterized in that the bottom of the support body is arranged at the top of the movable chassis; the near end of the connecting arm is arranged on the top of the supporting body, and the position of the far end of the connecting arm in the space can be adjusted. The tail end steering handle is connected with the far end of the connecting arm; the pitching joint is rotatably arranged on the tail end steering handle and is connected with the near end of the connecting rod; the clamping support is detachably fixed to the far end of the connecting rod and used for fixing the pressure guide wire catheter and the pressure guide wire. The pressure guide wire can be accurately guided to the round window membrane of a human body, accurate positioning is achieved, the shaking problem caused by holding the guide wire by hand can be avoided, measurement errors are greatly reduced, and the pressure guide wire has the advantages of being convenient to operate and observe and convenient and fast to mount and dismount.

The invention discloses a construction method of a viral deafness mouse model, and relates to an animal model construction technology, the method comprises the following steps: (1) narcotizing a mouse, cutting the skin after ears, separating subcutaneous tissues, and exposing the stethoblister of the mouse; (2) preparing an opening in the stethoscope bubble to expose a cochlea round window; (3) puncturing and injecting a solution containing viruses into the cochlear lymph through the round window membrane of the round window; (4) sealing the operation area; according to the method, a round window membrane local micro-injection technology is adopted, the blood-lost barrier is effectively broken through, the technical problems that a traditional systemic infection model is high in death rate and unstable in model forming are solved, the model constructed through the method has the remarkable advantages of being high in survival rate, high in model forming rate and stable in phenotype, the pathological characteristics of human viral deafness are accurately simulated, and the method is suitable for large-scale popularization and application. And a standardized ideal experimental platform is provided for deafness-causing mechanism research and drug screening.