35 results about "Round window" patented technology

The invention discloses an application of HuR and a coding gene thereof in preparation of a medicine for treating senile deafness, belongs to the technical field of gene engineering, and provides an application of the HuR coding gene in preparation of a medicine for preventing or treating senile deafness, and the nucleotide sequence of the HuR coding gene is shown as SEQ ID NO.1. According to the application of the HuR in preparation of the medicine for preventing or treating the senile deafness, the amino acid sequence of the HuR is shown as SEQ ID NO.2. The invention discovers the application of HuR in preventing or treating age-related hearing loss for the first time. The HuR coding gene is packaged by an adeno-associated virus (AAV) and then is injected into the inner ear through a round window, so that the HuR coding gene is widely overexpressed in various cells of the inner ear, the occurrence of the senile deafness can be resisted or delayed, and a theoretical basis is provided for clinically preventing and improving the hearing loss of a patient with the senile deafness.

The invention discloses application of a carrier carrying Pou4f3 genetic information in preparation of a medicine for treating DFNA15 deafness, and belongs to the technical field of gene therapy, the DFNA15 deafness is that POU4F3 is mutated, and the POU4F3 is mutated into POU4F3c. 337Cgt; the medicine for treating the T-type mutation DFNA15 deafness carries a carrier with Pou4f3 genetic information, the AAV carrier is a combination of AAV-Anc80L65 and a Myo15 promoter, and the AAV carrier is delivered to an inner ear through round window membrane injection, targets outer hair cells and compensates for insufficient haplodose of POU4F3. The invention verifies that AAV delivers POU4F3 gene to compensate c.337Cgt for the first time; deafness caused by dominant genetic mutation of DFNA15 can be corrected due to insufficient haplodose caused by T (p.Q113 *) mutation, the optimized AAV vector design breaks through the problem of insufficient hair cell targeting of a traditional vector, the treatment efficiency is remarkably improved, meanwhile, a P60-P180 dynamic monitoring system is established, it is proved that the curative effect is lasting, no side effect exists, and a reliable basis is provided for clinical transformation.

The invention discloses an artificial cochlea implantation automatic path planning method based on multi-objective optimization, and relates to the technical field of medicine, and the method comprises the steps: S1, key structure segmentation; s2, generating a candidate path; s3, performing path evaluation; and S4, solving an optimization problem: solving a multi-objective optimization problem by using a genetic algorithm, defining a fitness function and integrating a plurality of objectives, the optimization objectives including minimizing path length, minimizing deviation with an ideal bone surface angle, minimizing bone grinding distance and maximizing the shortest distance with a key structure. According to the artificial cochlea implantation automatic path planning method based on multi-objective optimization, a key anatomical structure is segmented through deep learning, a candidate path set from mastoid to a niche is generated, a multi-objective optimization problem is solved by using a genetic algorithm, and an optimal path meeting clinical constraints is selected. When the method is applied to preoperative planning of an artificial cochlea implantation operation, the safety and accuracy of the operation can be remarkably improved.

The invention relates to the technical field of auditory sense and neuroscience, and particularly discloses a drug delivery system of mononuclear magnetic mesoporous silica and a preparation method thereof, the drug delivery system comprises a delivery system completely or partially composed of mononuclear magnetic mesoporous silica; the silicon dioxide is generated by reaction of tetraethyl orthosilicate, and a mononuclear magnetic material is wrapped in the silicon dioxide; and the silicon dioxide coated with the magnetic material is coated with mesoporous silicon dioxide. The prepared mononuclear magnetic mesoporous silica drug delivery system is injected into the cochlea through a round window, and the drug in the mononuclear magnetic mesoporous silica is targeted to a specific position to be slowly released under the stimulation of a magnetic field, so that the auditory function is recovered. The mesoporous silica based on the mononuclear magnetic material takes the magnetic material and silica as raw materials, is easy to obtain, low in cost, safe and non-toxic, and combines the mesoporous nanotechnology, directional induction and magnetic stimulation to promote auditory function recovery.

The embodiment of the utility model discloses an externally-hung stainless steel circular-ring-shaped decoration installation device for a round window, which relates to the technical field of window decoration modeling and comprises a window frame, an adapter, glass and a decoration assembly. The window frame is used for being fixed on a wall body, the adapter piece is fixedly connected with the window frame, and the glass is clamped between the window frame and the adapter piece; one part of the adapter piece is embedded in the decoration assembly and is connected with the decoration assembly to fix the decoration assembly on the window frame, so that the problem of reliable installation of the externally hung decoration assembly can be solved in a limited space, the installation structure is attractive and simple, the connection structure is not exposed, the installation is ingenious and reliable, and various requirements and performances are considered.

This invention discloses the application of HuR and its encoding gene in the preparation of drugs for treating age-related hearing loss, belonging to the field of genetic engineering technology. It provides the application of the HuR encoding gene in the preparation of drugs for the prevention or treatment of age-related hearing loss. The nucleotide sequence of the HuR encoding gene is shown in SEQ ID NO.1. The amino acid sequence of HuR is shown in SEQ ID NO.2. This invention is the first to discover the use of HuR in the prevention or treatment of age-related hearing loss. The HuR encoding gene, after being packaged with adeno-associated virus (AAV), is injected into the inner ear through a round window, causing it to be widely overexpressed in various types of cells in the inner ear. This can resist or delay the onset of age-related hearing loss, thus providing a theoretical basis for the prevention and improvement of hearing loss in patients with age-related hearing loss in clinical practice.

The invention relates to the technical field of sustained-release preparation, in particular to a microcrystalline sustained-release preparation and a preparation method thereof.The sustained-release preparation comprises a core composed of edaravone rodlike microcrystals and a shell composed of 2-4 double layers, the shell comprises at least one polyethylene glycol-polylysine copolymer inner layer, and the polyethylene glycol-polylysine copolymer inner layer is a polyethylene glycol-polylysine copolymer outer layer. And at least one outer layer of hyaluronic acid modified with a CD44 targeting peptide. The CD44 targeting peptide modified by the shell layer can specifically recognize a CD44 receptor on the surface of an inner ear hair cell, so that the binding efficiency of a preparation, a round window membrane and a target cell is remarkably improved, the diffusion of a drug to non-target tissues is reduced, and the local drug concentration is improved.

1. Name of the Design Product: Medal (Round Window with Intertwined Floral Patterns Y4470). 2. Use of the Design Product: Used as a medal for awarding or a souvenir. 3. Design Key Points of the Design Product: Lies in the combination of shape and pattern. 4. Picture or Photo Most Indicating the Design Key Points: Perspective View 1. 5. Left View, Right View, Top View, and Bottom View are omitted.

1. The name of the design product: egg-shaped cabin (round window). 2. The use of the design product: for outdoor living. 3. The design points of the design product: in the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

Disclosed herein are methods and compositions for enhancing the delivery of therapeutics through the round window membrane into the inner ear; i.e., enhancing drug delivery to the inner ear.

The invention relates to the technical field of biological medicine, in particular to liposome dispersion liquid and ear drops capable of penetrating through tympanic membrane and inner ear round window membrane. The invention designs the liposome dispersion liquid which can effectively penetrate through a complete path of the tympanic membrane and the round window membrane of the inner ear after being dripped into the ear through the external auditory canal in a non-invasive manner, so that tympanic membrane perforation caused by injection in a tympanic chamber can be avoided, and the pain and discomfort of a patient can be relieved. The liposome dispersion liquid disclosed by the invention is good in stability, and the prepared ear drops can realize efficient delivery of targeted inner ear medicines, have the characteristics of noninvasiveness and convenience, and have a wide application prospect in the medical field.

1. Name of the design product: Sewing Needle Iron Box (105 Round Window). 2. Use of the design product: For containing items. 3. Design key points of the design product: The combination of shape and pattern. 4. Picture or photo that best shows the design key points: Perspective view. 5. Other circumstances that need to be explained: Other explanation: Part A is marked as transparent material.

This invention discloses a hair cell protectant based on a ferritin nanoplatform and its application in treating hearing loss, belonging to the field of biomedicine. The ferritin nanoparticles of this invention, loaded with cimicifugin, include ferritin (Fn) as a carrier and cimicifugin (Ci@Fn) loaded within the ferritin. By loading cimicifugin (Ci), an extract of cimicifugin, into ferritin, it is endowed with additional anti-inflammatory and tissue-protective functions, thereby achieving a more precise and effective therapeutic effect. After injection through the round window membrane (RWM) behind the ear, Ci@Fn is transported to the basement membrane along with the flow of perilymph and endolymph, ultimately targeting the inner ear hair cells (HCs). After entering the hair cells, Ci@Fn is taken up and degraded by lysosomes, releasing cimicifugin (Ci), thereby exerting a protective effect on the hair cells.

The invention discloses a photoelectric artificial cochlea, which comprises an extracorporeal machine and an implant, and is characterized in that the extracorporeal machine is configured to receive an original sound signal, process the original sound signal into a first analog signal or a conversion signal of the first analog signal, and transmit the first analog signal or the conversion signal to the implant; the implant comprises a stimulator, the stimulator comprises a photoelectric hybrid chip, the photoelectric hybrid chip is configured to receive an input signal and modulate a carrier optical signal by using the input signal to output a modulated carrier optical signal, the modulated carrier optical signal is an analog signal, and the input signal is a first analog signal or a conversion signal of the first analog signal; the implant comprises an optical fiber electrode, and the optical fiber electrode is implanted from the round window of the human ear, is arranged in the drum step, extends from the cochlea bottom to the cochlea top and directly acts on the auditory neuron, so that the high-frequency component of the modulated carrier optical signal is preferentially demodulated at the cochlea bottom, and the low-frequency component of the modulated carrier optical signal is preferentially demodulated at the cochlea top. Therefore, the photoelectric artificial cochlea system which is low in power consumption, high in fidelity and accurate in directional stimulation is realized.

According to the tent round window, the tent round window comprises a window frame, at least two outer ring flanges, at least two inner ring flanges, tempered glass and screws; the window frame is of an annular structure and comprises an outer frame and an inner frame, and the window frame is installed on a framework of the tent. The second outer ring flange is installed on the outer frame through screws and used for fixing an outer film of the tent. The thickness of the second outer ring flange is larger than that of the tempered glass, the center of the second outer ring flange can contain the tempered glass, and the first outer ring flange penetrates through the second outer ring flange through a screw to be installed on the outer frame so as to clamp the tempered glass and form a sealing structure. The second inner ring flange is fixedly mounted on the inner frame so as to fix the tent inner film; the first inner ring flange penetrates through the second inner ring flange through a screw to be installed on the inner frame and used for fixing the inner curtain of the tent. The problem that water enters the round window is solved, the cost and difficulty of part replacement and adjustment are reduced, the round window of the steel structure tent can be better installed and sold, and waste of labor and materials is reduced.

Systems and methods can be employed to access the middle ear through the tympanic membrane for the delivery of therapeutic agents to, for example, the round window niche adjacent to the cochlea under direct visualization. The systems and methods can also be used to improve accessibility and visualization for various otologic procedures, such as, but not limited to, cholesteatoma removal, tympanic membrane repair, and ossicular chain repair.

The present application relates to the technical field of otological microsurgery instruments, and discloses a cross-shaped round window membrane incision knife with depth control for otological minimally invasive surgery, which comprises a knife rod, a cross-shaped knife head is arranged at the operating end of the knife rod, a detachable depth control mechanism is arranged on the outside of the knife rod behind the cross-shaped knife head, a grip type handle assembly is arranged at the end of the knife rod away from the cross-shaped knife head, and the grip type handle assembly comprises a grip type handle, and a thimble is arranged at the end of the grip type handle close to the knife rod. In the present application, the cross-shaped symmetrical blade edge realizes multi-point stable support, effectively avoids the slippage of the knife head on the surface of the wet round window membrane, and the incision position is accurate; the sharp symmetrical cutting forms a regular cross-shaped incision, there is no disorganized tearing, the incision edge is neat, and this is beneficial to postoperative healing and electrode implantation sealing; the annular flange type depth control mark block forms physical limiting, the cutting depth is locked in a safe range, and overcutting damage to the inner ear is avoided in structure.

The invention discloses application of cimicifugin in preparation of a medicine for preventing or treating inner ear hair cell injury, and belongs to the technical field of biological medicine. According to the invention, it is found for the first time that a natural compound cimifugin has a definite inner ear hair cell protection effect. By inhibiting hair cell apoptosis and reducing hearing synapse loss and hearing nerve fiber injury, the cimicifugin effectively relieves hair cell injury and hearing function decline caused by cis-platinum and other drugs, noise exposure and aging. The protection mechanism is related to inhibition of activation of a pro-apoptosis signal. The preferred administration mode is local administration, especially delivery through a round window membrane, and the dosage form can be a solution, a suspension or a sustained release preparation. Cell, in-vitro hair cell tissue and animal model experiments prove that the cimicifugin can obviously relieve hair cell damage and improve the auditory function. The invention provides a new drug candidate scheme for preventing and treating sensorineural hearing loss, and has important clinical application value.

The invention relates to the technical field of auditory sense and neuroscience, and particularly discloses a stem cell-based bioactive artificial cochlea electrode and a preparation method thereof, and the stem cell-based bioactive artificial cochlea electrode comprises an artificial cochlea electrode completely or partially formed by stem cell combined I-type collagen conductive hydrogel; a conductive material is wrapped in the I-type collagen conductive hydrogel; stem cells are wrapped in the type I collagen conductive hydrogel. The hydrogel is implanted into the cochlea through the round window, and the stem cells in the hydrogel effectively regenerate functional auditory neurons under the electroacoustic stimulation of the artificial cochlea, so that the auditory function is recovered. The bioactive artificial cochlea electrode based on the conductive material takes the conductive material and the I-type collagen as raw materials, is easy to obtain, low in cost, safe and non-toxic, and combines factors for promoting nerve regeneration by a three-dimensional nanotechnology, directional induction and electroacoustic stimulation.

1. The name of this design product: Combined meter winder (round window). 2. Purpose of the product of this design: a watch winder used to wind a mechanical watch. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: Design 1 3D drawing. 5. Designate Design 1 as the base design.

The present invention discloses the use of a biological factor Sparcl1 in a drug that promotes the regeneration of inner ear hair cells, belonging to the field of gene technology for inner ear cell regeneration. The biological factor Sparcl1 is used to promote the regeneration of inner ear stem cells into hair cells. The amino acid sequence of the biological factor Sparcl1 is shown in SEQ NO.1. Compared with the prior art, this application explores the regenerative effect of the Sparcl1 gene on inner ear hair cells by combining gene regulation with the restoration of auditory function by inner ear stem cells. This patent uses AAV-ie as a viral vector for delivering the target gene, and then injects it through the round window of the ear of a newborn mouse. This method has the highest delivery efficiency and causes less damage to the cochlea, fundamentally avoiding the problems of low vector transfection efficiency and the choice of delivery method. Secondly, this patent uses human recombinant Sparcl1 protein, which can act directly on humans and therefore has important value and role in the regeneration of inner ear hair cells and the recovery of hearing loss in clinical practice.

The invention relates to the field of biological medicine, in particular to application of capsid protein to preparation of products for preventing or treating ear diseases or ear hair cell regeneration treatment products. The capsid protein disclosed by the invention comprises a peptide fragment of which the amino acid sequence is shown as any one of SEQ ID No.1-3. The adeno-associated virus containing the capsid protein can mediate a target gene to be specifically expressed in cochlear hair cells of an adult mouse under the condition of posterior semicircular canal injection of the adult mouse; under the condition of round window injection of the young mouse, the target gene is mediated to be specifically expressed in cochlea supporting cells of the young mouse, so that the adeno-associated virus disclosed by the invention can provide a safe, efficient and specific transduction tool for otologic gene therapy.

The invention discloses a personalized auxiliary implant for precisely delivering drugs to a round window niche. The personalized auxiliary implant comprises a main structure arranged in an external auditory canal; one bottom surface of the main structure is positioned in the middle of a bony external auditory canal and faces a tympanic membrane and a middle ear, and the other bottom surface is positioned at an opening of the external auditory canal; the shape contour of the side surface of the main structure is matched with and mechanically and fixedly connected with an anatomical structure of an external auditory canal of a patient; a hollow linear conveying channel is arranged between the two bottom faces of the main structure, and the extension line of the conveying channel is aligned with the round window niche of the inner ear structure. The main structure is made of a biocompatible flexible material. The problems of individual operation difference, dissection complexity influence and drug loss risk due to dependence on manual operation of doctors on tympanic membrane injection administration under guidance of a traditional endoscope can be solved, and the device can be widely applied to the fields of drug delivery, contrast agent and local anesthetic injection, gene therapy, biosensor or microelectrode implantation and the like.

The invention discloses application of Stab2 protein or coding nucleic acid thereof in preparation of a medicine for treating hearing loss, belongs to the technical field of biological medicine and gene therapy, and aims to solve the problem that in the prior art, an effective repairing means for cochlea banding synapse injury is lacked. The medicine mainly comprises a recombinant virus vector (preferably a lentiviral vector) carrying a Stat2 coding sequence, and the recombinant virus vector is suitable for being delivered to the inner ear through round window injection after being prepared; experiments show that overexpression of Stab2 protein in cochlea can significantly promote regeneration of banding synapses of inner hair cells after noise damage, and the number of synapses is effectively increased; meanwhile, the hearing brainstem reaction threshold value can be remarkably reduced, and the ABR I wave amplitude representing the nerve conduction function is improved; by repairing damaged synaptic junctions, noise-induced hearing loss and implicit hearing loss can be effectively treated, tinnitus, auditory allergy and speech resolution disorder are improved, and good clinical transformation prospects are achieved.

The present application relates to the technical field of biological medicine, and more particularly to a liposome dispersion liquid and ear drops for penetrating the tympanic membrane and the inner ear round window membrane. The present application designs a liposome dispersion liquid which can effectively penetrate the complete path of the tympanic membrane and the inner ear round window membrane after non-invasive ear drops through the external auditory canal, so as to avoid the tympanic membrane perforation caused by intratympanic injection and reduce the pain and discomfort of patients. The liposome dispersion liquid of the present application has good stability, the prepared ear drops can realize efficient delivery of targeted inner ear drugs, has the characteristics of non-invasive and convenience, and has a wide application prospect in the medical field.

1. Name of the product in this design: Tent (Octagonal Double-Layer Round Window). 2. Purpose of this design: a tent for users to camp or rest. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. Name of the Design Product: Seal (Round Window Reward). 2. Use of the Design Product: For stamping. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Perspective view.

The present invention discloses a construction method for a square and round window-type retaining wall, which belongs to the technical field of retaining wall. The present invention comprises: leveling the site; installing slope top and slope bottom components; installing a steel frame; installing a transport truss; installing a retaining wall hole mold; putting the mold in place; transporting and pouring concrete; cyclic pouring; installing vegetation bags. The present invention completes the reservation of retaining wall window holes and the pouring of concrete by divided area operations, which reduces the difficulty of installing and positioning the window-type reserved template, reduces the time for installing and disassembling the template, and realizes integrated and standardized operations; the present invention can realize the simultaneous installation of multiple retaining wall hole molds, and realizes the rapid adjustment of the position and elevation of the retaining wall hole molds through adjustable components, avoiding the cumbersome installation, adjustment and disassembly processes of traditional assembled templates, and improving construction efficiency.

The application discloses a round window membrane puncture state detection method based on a SlowFast algorithm and relates to the field of medical devices.The application solves the problem that the existing otological surgery robot is difficult to perceive in the injection puncture process due to the extremely small size of the micro-needle, and the problem of affecting the operation precision.The step one of the application is to realize the position detection of the round window and the micro-needle through a target detection module, so as to detect whether the micro-needle is in the round window area; if the micro-needle is in the round window area, the next step is performed; if the micro-needle is not in the round window area, the position detection of the round window and the micro-needle is continuously performed; the step two is to recognize the puncture state of the micro-needle through a state recognition module, and to determine whether the micro-needle is successfully punctured through a judgment algorithm; wherein the state recognition module adopts a SlowFast algorithm model which is trained and optimized to recognize the puncture state of the micro-needle; and the recognition of the SlowFast model is filtered through the judgment algorithm.The application is used for the round window membrane puncture state detection.

This item is a resin amulet characterized by a circular window made of a half-mirror. While this window functions as a mirror in typical indoor environments, because it is a half-mirror, it allows visibility through to the opposite side in outdoor environments or when the light source is brighter on the other side. Various shapes or characters can be placed inside the dashed lines within the solid lines of the window. These shapes or characters can be placed on either the front, back, or both sides.