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Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues

A technology for delivering drugs and equipment, applied in other medical devices, drug devices, hypodermic injection devices, etc., can solve the problems of unknown dosage of therapeutic agents and failure to control the delivery of therapeutic agents well.

Inactive Publication Date: 2009-09-09
NEUROSYSTEC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these conventional methods can ultimately deliver therapeutic agents to the inner ear (e.g., via implantation of the round window septum), therapeutic agent delivery is often poorly controlled and the dose of therapeutic agent reaching the inner ear is unknown

Method used

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  • Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
  • Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
  • Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues

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Embodiment Construction

[0048] A. Direct injection of therapeutic agents and other types of agents into the inner ear.

[0049] At least some embodiments of the present invention provide methods for treating inner ear disorders by injecting therapeutic agents (and other types) directly into the cochlea using a device. Direct injection into the cochlea overcomes many of the shortcomings of oral and other parenteral delivery methods. For example, drugs that reduce the symptoms of tinnitus and can achieve the same purpose by directly acting on the underlying molecular mechanism of tinnitus include: clonazepam, alprazolam, memantine (see US Patent No. 6,066,652), ring amygdalus Esters, caroverin (see US Patent No. 5,563,140), lidocaine, tocainide, gabapentin. These drugs target various receptors in the auditory system that are responsible for nerve signal transduction. Unfortunately, under the effective dose of tinnitus control, the use of these drugs has side effects, which limits their oral or systemic adm...

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Abstract

The present invention discloses an apparatus may include a needle for sustained delivery of drugs and other agents to the inner ear or other tissues of a human or an animal. The needle can include an insertion stop, and can be placed through the round window membrane or through a surgically-prepared hole in a bone. The needle can be in fluid communication with a port and / or with a micro-infusion or osmotic pump. A cochlear implant electrode can be used instead of a needle.

Description

[0001] Cross-references to related applications [0002] The present invention claims the rights of the following U.S. provisional applications: No. 60 / 665,368 (filed on March 28, 2005, entitled "Apparatus and method for delivering therapeutic agents to the inner ear"), No. 60 / 645,755 (January, 2005) Submitted on January 24, titled "Direct Cochlear NMDA Receptor Antagonist Injection Therapy for Inner Ear Disorders"), No. 60 / 645,757 (submitted on January 24, 2005, titled "Dextromethorphan Direct Cochlear Injection Therapy for Inner Ear Disorders") "), No. 60 / 645,756 (submitted on January 24, 2005, titled "Direct cochlear subtype specific NMDA receptor antagonist injection therapy for inner ear disorders"), and No. 60 / 645,606 (January 24, 2005 Submitted on Japan, titled "Direct Cochlear Therapeutic Drug Injection Therapy for Inner Ear Disorders"). All of the above applications are incorporated herein by reference. Background technique [0003] As we all know, if the local application...

Claims

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Application Information

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IPC IPC(8): A61M5/00A61M31/00A61M37/00
Inventor 托马斯·J·洛布尔斯蒂芬·J·麦科马克托马斯·H·R·莱纳兹约翰·V·施洛斯安娜·I·纳吉雅各布·E·帕纳南
Owner NEUROSYSTEC CORP
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