7 results about "Alprazolam" patented technology

The invention discloses an alprazolam nasal spray and a preparation method thereof, and provides the alprazolam nasal spray which is good in stability, small in irritation, convenient, quick to take effect and extremely small in side effect, so that the medication compliance of a patient and the convenience of clinical medication are improved, and the preparation process is simple to operate, safe, environment-friendly and suitable for industrial mass production.

Methods of using a pharmaceutical composition comprising ebastine and alprazolam for treating patients suffering from one or more psychiatric disorders, such as major depressive disorder, generalized anxiety disorder, mild chronic depression, premenstrual dysphoric disorder are disclosed.

The invention relates to a detection method and application of an illegal additive cyclopropyl flualprazolam, and the detection method comprises the following steps: 1) adding methanol into a sample to be detected, extracting, centrifuging, and taking supernate for detection; (2) preparing a standard working solution from the standard substance cyclopropyl flualprazolam for qualitative detection or / and making of a standard curve; (3) respectively detecting the treated to-be-detected sample solution and the treated standard working solution by using a liquid chromatography-tandem mass spectrometry method; and 4) according to the obtained chromatogram of the standard working solution, correspondingly judging and detecting the chromatogram of the to-be-detected sample solution so as to obtain qualitative and quantitative results of the cyclopropyl flualprazolam in the to-be-detected sample. The method comprises the following steps: adding a to-be-detected sample into methanol for ultrasonic extraction, effectively dissolving the to-be-detected illegal additive into a to-be-detected solution, performing chromatographic column separation, and performing qualitative and quantitative analysis according to a liquid chromatograph-mass spectrometer. And optimization and methodological verification are carried out on different food matrix pretreatment methods, so that the quantitative accuracy of the method is ensured.

Methods of using a pharmaceutical composition comprising ebastine and alprazolam for treating patients suffering from one or more psychiatric disorders, such as major depressive disorder, generalized anxiety disorder, mild chronic depression, premenstrual dysphoric disorder are disclosed.

The present invention discloses a method for preparing alprazolam and its impurity LAP. The method uses 7-chloro-5-phenylbenzodiazepine as a starting material, undergoes an acylation reaction with acetyl chloride, and then undergoes a cyclization reaction with hydrazine hydrate to obtain an alprazolam finished product. The method can avoid the production of impurity LAP, while avoiding the use of phosphorus pentasulfide and the risk of poisoning caused by the generation of hydrogen sulfide during the reaction, thereby greatly improving the safety of the process. The present invention uses 7-chloro-5-phenylbenzodiazepine as a starting material, reacts with chloroacetic acid, and then undergoes a cyclization reaction with hydrazine hydrate under the catalysis of a condensing agent N,N'-carbonylbis(1,2,4-triazole) to obtain the impurity LAP. The method can be widely used in the quality research of alprazolam raw materials and their preparations, thereby improving the safety, effectiveness and quality controllability of the drug. #imgabs0#

The application discloses a preparation method of small-granularity alprazolam crystal form I and belongs to the technical field of crystal preparation. Coarse alprazolam is dissolved in an alcohol solvent, and stirring and dissolving are carried out at 60-90 DEG C to obtain an alprazolam solution, and insoluble substances are removed by filtration; crystal seeds are added into water at 15-30 DEG C; the alprazolam solution is added into the water containing the crystal seeds, the temperature is controlled to be 15-30 DEG C, and ultrasonic treatment is carried out by introducing ultrasonic waves; the system is cooled to 0-5 DEG C, and the constant temperature is maintained for 1-3 h for crystal growth; and filtration, washing and drying are carried out to obtain the small-granularity alprazolam crystal form I. The prepared alprazolam realizes the preparation of the small-granularity alprazolam crystal form I on the basis of not changing the medicinal crystal form of the alprazolam, the particle size distribution is uniform, and the solubility is better; and the preparation method is simple, reproducible and easy for industrial production.

Disclosed is a pharmaceutical composition comprising ebastine and alprazolam. Also disclosed is a method of using a pharmaceutical composition for treating a patient suffering from insomnia.