2 results about "Alprazolam" patented technology

Methods of using a pharmaceutical composition comprising ebastine and alprazolam for treating patients suffering from one or more psychiatric disorders, such as major depressive disorder, generalized anxiety disorder, mild chronic depression, premenstrual dysphoric disorder are disclosed.

The application discloses a preparation method of small-granularity alprazolam crystal form I and belongs to the technical field of crystal preparation. Coarse alprazolam is dissolved in an alcohol solvent, and stirring and dissolving are carried out at 60-90 DEG C to obtain an alprazolam solution, and insoluble substances are removed by filtration; crystal seeds are added into water at 15-30 DEG C; the alprazolam solution is added into the water containing the crystal seeds, the temperature is controlled to be 15-30 DEG C, and ultrasonic treatment is carried out by introducing ultrasonic waves; the system is cooled to 0-5 DEG C, and the constant temperature is maintained for 1-3 h for crystal growth; and filtration, washing and drying are carried out to obtain the small-granularity alprazolam crystal form I. The prepared alprazolam realizes the preparation of the small-granularity alprazolam crystal form I on the basis of not changing the medicinal crystal form of the alprazolam, the particle size distribution is uniform, and the solubility is better; and the preparation method is simple, reproducible and easy for industrial production.