294 results about "Enuresis" patented technology

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.

The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

This invention proposed applications of the extracted materials from shell of Xanthoceras sorbifolia Bunge to making drugs for enhancing brain functions. The extracted materials from the shell of X. sorbifolia include 2~10 percent of crude fats, 15~20 percent of crude protein, 15~25 percent of Bunkankasaponin A. B. C. D., 20~30 percent of sugar and 7~12 percent of water as well as two kinds of sterols of (3beta,5alpha,20R,24S)-stigmasta-7, trans-22-dien-3-ol and (3beta,5alpha,20R,24R)-stigmasta-7-en-3-ol. The applications of this invention shows evidently effective for curing diseases of mental retardation and deficiency, dementia, enuresis, and increasing body's ability of resistance to activity of glycosuria. The extracted materials can also be made of functional foods for increasing brain's functions.

The invention provides an intelligent sleep monitoring system for preventing kids from kicking quilts, comprising a control assembly, magnetic sensors, stretching motors, drive pulleys, pull ropes, a humidity-sensitive resistor, a thermal-sensitive resistor, magnets, temperature sensors, and a remote alarm assembly. The humidity-sensitive resistor and the thermal-sensitive resistor are arranged on the obverse side of a bed body. The magnetic sensors and the stretching motors are arranged in the corners of the bed body. The control assembly is connected to the humidity-sensitive resistor, the thermal-sensitive resistor, the magnetic sensors and the stretching motors. A quilt is connected to the stretching motors through the pull ropes. The temperature sensors are arranged on the quilt, and the temperature sensors are connected with the control assembly in a wireless communication mode. The control assembly is connected with the remote alarm assembly in a wireless communication mode. The intelligent sleep monitoring system of the invention has the functions of automatically covering a kid with a quilt, alarming for high fever and enuresis, and the like, and has a high level of intelligence. Long-term test shows that the intelligent sleep monitoring system can prevent kids from kicking quilts in sleep in a fully automatic way and improve the quality of sleep of both kids and parents.

This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are =O, -O(CH2)pO- or -S(CH2)pS-; W1 is either O or S; X1 and X2 are both H, or together are =O or =S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are -(CH2)n; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.

Methods and compositions containing bicifadine are provided for the prevention and treatment of lower urinary tract disorders in mammalian subjects. The methods and compositions may be used to prevent or treat urinary incontinence, urinary urgency, nocturia, and enuresis associated with neurogenic and non-neurogenic overactive bladder, interstitial cystitis, prostatitis, prostadynia, and benign prostatic hyperplasia, among other conditions. Additional compositions and methods are provided which employ bicifadine in combination with a second anti-incontinence agent, or a different therapeutic agent to yield more effective anti-incontinence treatment tools, and / or dual activity therapeutic methods and formulations useful to prevent or reduce urinary incontinence and one or more additional symptoms such as urinary urgency, overflow, frequency, or pain in mammalian subjects.

This invention provides novel compounds according to general formula (1) wherein A is a bicyclic or tricyclic azepine derivative, V1 and V2 are both H, OMe or F, or one of V1 and V2 is Br, Cl, F, OH, OMe, OBn, OPh, O-acyl, N3, NH2, NHBn or NH-acyl and the other is H, or V1 and V2 together are ═O, —O(CH2)pO— or —S(CH2)pS—; W1 is either O or S; X1 and X2 are both H, or together are ═O or ═S; Y is OR5 or NR6R7; R1, R2, R3 and R4 are independently selected from H, lower alkyl, lower alkyloxy, F, Cl and Br; R5 is selected from H and lower alkyl; R6 and R7 are independently selected from H and lower alkyl, or together are —(CH2)n—; n=3, 4, 5, 6; and p is 2 or 3. The compounds are agonists at the vasopressin V2 receptor and are useful as antidiuretics and procoagulants. The invention further comprises pharmaceutical compositions incorporating these vasopressin agonists, which compositions are particularly useful in the treatment of central diabetes insipidus, nocturnal enuresis and nocturia.

This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attached to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

Novel compounds of Formula (I)and pharmaceutically acceptable salts thereof, and pharmaceutical formulations containing such compounds which are useful as anti-aquaretic agents in the treatment of nocturnal urinary enuresis, nocturnal urinary urgency, and / or similar conditions.

This invention provides a composition comprising extracts from the husk of Wenguanguo and a process of producing the combined extract comprising the following steps: extracting Wenguanguo husks with an organic solvent to form an organic extract; removing the organic solvent from the extract to form aqueous extracts; and drying and sterilizing the aqueous extracts to form the combined extracts. The extracts can be used to make medicines or health foods for preventing cerebral aging, improving memory, improving cerebral functions and curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease and other diseases caused by cerebral dysfunction. The combined extracts contain saponin, saccharides, proteins and others.

The invention discloses an external plaster for pediatric deficiency cold and preparation method thereof. Aim at the physiological and pathological characteristics of children and the pathogenic factors and pathogenesis of pediatric deficiency cold, 8 Chinese crude drugs ccontaining white atractylodes rhizome, clove, chinese magnoliaving, nutmeg and so on, is processed by decocting, condensing, crushing, concocting and the other steps to form plaster. The inventive plaster has functions of invigorating qi and yang, supplementing huo and eliminating han. The principle indications are pediatric deficiency cold, sickness, hiccup, diarrhea, cllic, cough, night cry, enuresis, pale complexion, coldness of the body and limbs, tiredness, inappetence, pale lips, whitish tongue and thin white tongue, etc. The external plaster is safe and convenient in use, with remarkable effect. It solves the probleme of fearing the needle and repelling the drugs of the children, furthermore convenient for controling quality and favourable to large-scale industrialization and continuous production.

The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5-HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

The invention discloses an urination sensing detection method and an urination sensing detection device. The method comprises the following steps of: acquiring original bladder impedance information and an original electrocardiosignal; extracting urination sensing characteristic parameters comprising an electrocardio approximate entropy, an electrocardio high and low frequency energy ratio, an impedance approximate entropy and an impedance high and low frequency energy ratio; establishing a neural network urination sensing detection model, using the urination sensing characteristic parameters as input vectors of a neural network, training the neural network and determining neural network parameters; and detecting the urination sensing degree of tested personnel by utilizing the trained neural network and outputting a detection result. The urination sensing detection method and the urination sensing detection device utilize the electronic technology to implement urination sensing detection and urination awakening on an enuresis patient, are safe and effective and have no any side effects.

The present invention discloses a Chinese medicine for effectively curing infantile enuresis with obvious therapeutic effect. Said Chinese medicine is made up by using 9 Chinese medicinal materials of lyceum berry, psoralea seed, alpinia fruit, mantis egg-case, rubus berry, jujube and others through a certain preparation process.

The invention relates to a Chinese medicine for treating enuresis and urinary incontinence and effectively solves the problem that the Chinese medicine for treating enuresis and urinary invontinence is unavailable. The technical scheme is that the Chinese medicine is prepared from 16 to 20g of ginseng, 22 to 26g of sharpleaf galangal fruit, 15 to 25g of ginkgo seed, 22 to 30g of astragalus, 18 to25g of mantis egg case, 25 to 35g of oyster, 23 to 35g of cuttlebone, 8 to 10g of baked licorice, 15 to 22g of malaytea scurfpea fruit, 16 to 23g of dodder, 22 to 35g of raspberry, 16 to 22g of schisandra chinensis and 16 to 26g of medlar. The Chinese medicine for treating enuresis and urinary incontinence is prepared by crushing astragalus, sharpleaf galangal fruit, mantis egg case, baked licorice, dodder, raspberry, schisandra chinensis and medlar respectively, sieving, uniformly mixing to obtain fine powder for later use, adding water in an amount which is 6 to 8 times the total weight of the ginseng, oyster, cuttlebone, ginkgo seed and malaytea scurfpea fruit each time, decocting twice, 1.5 hours for each time, filtering to obtain decoction, mixing the decoction, concentrating to obtain extract for later use, mixing the fine powder and the extract to obtain medicinal lumps, preparing pills and coating sugar. The Chinese medicine has widely available raw materials and good effects,is easy to produce and manufacture, low in cost and convenient to take, and can effectively treat enuresis and incontinence of children, teen-agers and elderly people.

The invention relates to methods of treating or slowing the onset of overactive bladder or urinary incontinence, or a symptom thereof selected from urinary frequency, urinary urgency, nocturia, or enuresis comprising identifying and administering to a subject in need of treatment a therapeutically effective amount of a compound according to Formulae I-V, as defined herein.

Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.

The invention relates to a Chinese medicinal formula for tonifying yang and reinforcing kidney, liver and lung. According to the Chinese medicinal formula, a Chinese medicine comprises the following components by weight: 25 to 45 grams of astragalus, 12 to 25 grams of cornus fruit, 15 to 60 grams of cherokee rose fruit, 15 to 60 grams of epimedium, 15 to 35 grams of south dodder seed, 25 to 45 grams of desertliving cistanche, 10 to 25 grams of glossy ganoderma, 10 to 25 grams of medicinal indianmulberry root, 15 to 50 grams of human placenta and the like. By the Chinese medicinal formula for tonifying yang and reinforcing the kidney, the liver and the lung, yang can be tonified, the kidney, the liver and the lung also can be reinforced, so the Chinese medicine is both a health-care produce and a medicine and has effects on the following diseases such as deficiency of the kidney of men and women, asthma, trachitis, various kinds of pain caused by hepatitis B night sweat and spermatorrhea, frequent urine at night, persistent cold of bladder, stranguria due to chyluria, weakness injury, extreme weakness, abnormal menstruation, poor appetite, vomiting and diarrhoea, leucorrhea, enuresis, frequent micturition, metrostaxis and ulcer subcutaneous nodule; and the Chinese medicine is taken in a health-care amount for a long time, so that an effect is ideal.

A Chinese medicine for treating child enuresis caused by dampness and heat in the liver channel pertains to a Chinese medicine for treating child enuresis. The components contain: 3g of Japanese gentian root, 8g of hill gardenia, 10g of baical skullcap root, 6g of radix bupleuri; 10g of oriental waterplantain rhizome, plantain seed and angelica respectively, and 4g of liquorice. The dosage materials in the prescription are all made from natural traditional Chinese herbal medicines by the traditional processing method. The materials can be easily gotten; the prescription and the preparation method are simple; the expense for preparing the medicine is low. The compatibility of the traditional Chinese herbal medicines is simple; the medicines used in the medicine prescription are all natural herbal medicines which can be conveniently gotten and used; the manufacturing method is simple; the curative effect after being taken is good; the medicine price is cheap, and the medicine is especially fit for people who live at the remote small villages away from villages and towns to use. The treatment expense for the patient with the disease of the child enuresis caused by dampness and heat in the liver channel is low, which solves the treatment problem, which is caused by low family income, poor living and lack of local medical treatment condition.

The invention discloses a Chinese traditional medicine for treating infantile nocturnal enuresis, which is prepared from ichih fruit, Chinese ephedra, Cinnamomum cassia, dodder seed, chicken's gizzard-skin, ginkgo nut, the preparing process consists of boiling, concentrating, charging findings or volatile fluid for palletizing.

The invention discloses an anti-stroke pill for treating cerebral apoplex and the sequela thereof, which comprises the main drug ingredients based on weight parts: 80-140 of astragaloside, 6-20 of angelica, 6-30 of red paeony root, 6-20 of szechuan lovage rhizome, 6-20 of peach seed, 6-20 of safflower. The preparing method includes: extracting solvent with water and alcohol, adding concentrated alcohol to deposit protein, resin, and glycan, and then enriching flavone and glycoside of the drug liquor by a n-butylalcohol extraction method and a resin column separation method, wherein the content change is measured in each step, and finally carrying out quality standard test, stability test, and fingerprint test. The preparation of the invention is advanced, the quality is controlable and stable, the effect is defined. The pill of the invention is suitable for treating diseases of slobbering, slurred speech, limb numbness, enuresis, hemiplegia, or the like, caused by cerebral apoplex and the sequela thereof.

The invention discloses honeycomb vinegar and a preparation method thereof and relates to a vinegar seasoning product. The vinegar comprises the following components in parts by weight: 0-8 parts of myotonin, 0-8 parts of black rice, 0-2 parts of red dates and 2-12 parts of honeycomb. The honeycomb vinegar is prepared by an acetic fermentation method of liquid backflow or solid fermentation. In the invention, the honeycomb, the myotonin, the black rice and the dates are used as raw materials, thus the vinegar has effective active substances of the honeycomb, the myotonin, the black rice and the dates. The product has good curative effect in the aspects of improving the immunity and treating the bronchitis, the rhinitis, the scirrhus, pain subcutaneous ulcer pyogenic infections, the benignprostatic hyperplasia, the arthritis, the hepatitis B, obstetrical and gynecological diseases, the impotence, the enuresis, the bone tuberculosis, stomach diseases, the pertussis and foot ringworms and has no toxic and side effects. Compared with the traditional table vinegar, the honeycomb vinegar has the advantages of gentle vinegar smell, pleasant fragrance and clear brownish red color. With the honeycomb vinegar, people can enjoy delicious food and also achieve the effect of medical health care.

Pharmaceutical compositions comprising azelastine or a pharmaceutically acceptable salt of azelastine and alprazolam are disclosed. Methods of using the pharmaceutical compositions for treating patients suffering from one or more psychiatric disorders such as major depressive disorder, generalized anxiety disorder, panic disorder, agitation, social anxiety disorder, mild chronic depression, obsessive-compulsive disorder, premenstrual dysphoric disorder, seasonal affective disorder, dysthymia, childhood enuresis, bipolar disorder, posttraumatic stress disorder, sleep disorder related to anxiety, are also disclosed.

The invention relates to health care food, in particular to dietary therapy food capable of regulating the entire function of the human body. The dietary therapy food can remarkably improve the situations of blood pressure, blood fat, blood sugar and blood viscosity and the entire physical function. Components selected for the food are all from 'New Resource Food Catalog' and 'Affinal Drug and Diet Catalog' approved by Ministry of Health, China. A patient taking the food evacuates stubborn stool in 24 hours, the intestines and stomach are improved, sleep quality gets better, nocturnal enuresis is reduced, the patient feels vigorous, and 1-2 months later, the situations of blood pressure, blood fat, blood sugar and blood viscosity and the entire physical function are all remarkably improved.

The invention discloses a traditional Chinese medicine warming patch for warming the uterus of women. The warming patch is composed of a warming patch and a traditional Chinese medicine ointment applied to the warming patch, wherein the traditional Chinese medicine ointment is prepared from the following components in parts by weight: 10-30 parts of herba leonuri, 2-3 parts of saffron crocus, 6-12 parts of angelica sinensis, 3-9 parts of polygala tenuifolia, 3-9 parts of cordyceps sinensis, 6-12 parts of fructus lycii, 15-30 parts of herba cistanche, 10-30 parts of radix rehmanniae praeparata, 1-5 parts of cornu cervi, 10-15 parts of astragalus membranaceus, 15-25 parts of fetus cervi and 3-15 parts of fructus cnidii, wherein the components are extracted by camellia oil and mixed with pharmagel. The warming patch has a remarkable effect for treating cold hands and feet, fatness, waist soreness, menstrual disorder, frequent urination and enuresis, frigidity, abortion and other symptoms caused by cold uterus of females, and is capable of solving the problems that a traditional warming patch easily causes high-temperature scalds when being directly applied to skin, traditional hot compress administration wastes time and labor, and an existing patch has slight effective ingredient infiltration and does not have remarkable medical effect since medicines are not heated.

The invention relates to a Chinese traditional medicine preparation, in particular to an oral Chinese drug for treating asthenic type enuresis in children. The drug is prepared by the following raw materials with different parts by weight, namely, radix codonopsitis and Chinese Taxillus Twing, each 10-12 g; Barbary Wolfberry Fruit, oyster, Ootheca Mantidis and Cherokee Rose Fruit Extract, each 5-6 g; Liquoric Root 3-4 g. The invention is characterized by unique prescription, low cost, convenient preparation and evident effect.

The invention relates to a single-cavity air sac quasi-elliptic catheter, and belongs to the technical field of medical auxiliary apparatus. The catheter is characterized in that: the radial section of a catheter body is quasi-elliptic; the end part of the head end of the catheter body is provided with an oblate ellipsoidal bulge; a quasi-elliptic and oblate ellipsoidal long axis is longitudinal; the upper half part of the head end of the catheter body is provided with an air sac; and an inclined surface is arranged below the end part of the head end of the catheter body from front to back. The invention has the advantages that: the end part of the catheter is smooth, the shape of the catheter is similar to that of an external orifice of a urethra and a urethra on a prostatic part of a human body, and the discomfort of a patient is obviously reduced; the longitudinal long axis is positioned between the quasi-elliptic catheter and the urethra, and a large gap is formed between two sides, so that urethral discharge is smoothly drained; a water inlet hole is at the lowest position, so that urine in a urinary bladder is emptied, and the infection rate of a urinary system and the enuresis possibility of the urethral orifice are reduced; and the upper part of the head end of a single-cavity prostatic catheter is elliptic, a slightly expanded part on the lower part of the catheter is lifted at the bladder neck of a patient with prostatic hyperplasia, and the head part of the catheter can be guided into the bladder along a hyperplastic middle lobe.