18 results about "Frequent urination" patented technology

The purpose of the present invention is to provide a novel medical application using pluripotent stem cells in regenerative medicine. The present invention provides a cell formulation and pharmaceutical composition that are for amelioration and therapy for frequent urination and bladder pain caused by the inflammation of the bladder and that contain SSEA-3 positive pluripotent stem cells isolated from cultured mesenchymal cells or a mesenchymal tissue of a living organism. The cell formulation according to the present invention is considered to be based on a mechanism in which, for example, Muse cells are administered against interstitial cystitis having the abovementioned disorders to be successfully engrafted into affected bladder tissue, whereby the disorders are ameliorated and treated.

This invention provides a traditional Chinese medicine composition, preparation method, and application for treating frequent urination with incontinence in various postmenopausal symptoms. The traditional Chinese medicine composition, by weight, consists of the following raw materials: Astragalus membranaceus 10-20 parts, Codonopsis pilosula 10-15 parts, Atractylodes macrocephala 7.5-10 parts, Ziziphus jujuba var. spinosa 10-15 parts, Mantis religiosa ootheca 4-5 parts, Paeonia lactiflora 7.5-15 parts, Rehmannia glutinosa 6-10 parts, Angelica sinensis 7.5-10 parts, Cinnamomum cassia 1.5-2.5 parts, Poria cocos 6-7.5 parts, Lindera strychnifolia 5-6 parts, Schisandra chinensis 5-6 parts, Psoralea corylifolia 4-6 parts, Alpinia oxyphylla 4-6 parts, Citrus reticulata 4-6 parts, Polygala tenuifolia 3-4 parts, Cane sucrose (peeled) 10-30 parts, Zingiber officinale (peeled) 5-7.5 parts, Ziziphus jujuba 5-7.5 parts, and Glycyrrhiza uralensis (processed) 3-4 parts. The traditional Chinese medicine composition of the present invention has definite curative effect, is safe to use, and has no obvious toxic side effects.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating kidney-deficiency enuresis of elderly women by collapse, which comprises the following components: yam rhizome, sharpleaf galangal fruit, grassleaf sweelflag rhizome, combined spicebush root, peach kernel, safflower, white paeony root and the like, and paste is formed by a specific preparation method and is used for treating collapse. According to the application, the traditional Chinese medicine theory and modern pharmacological research are combined, the medicine compatibility and the operation process are optimized, and the symptoms such as frequent urination, urgent urination and frequent urination at night are remarkably improved by adopting a method of matching wet compress with TDP therapeutic apparatus irradiation. Key technical links comprise accurate control of medicine crushing particle size, yellow wine blending proportion and irradiation conditions, and safety and curative effect are ensured. The application has the advantages of high drug pertinence, simplicity and convenience in operation, low cost, high patient compliance and the like, is suitable for being popularized in primary medical institutions, and provides a new method for treating kidney deficiency enuresis of old women.

This invention relates to the field of traditional Chinese medicine technology, specifically to a granule for promoting urination and eliminating stones, its preparation method, and its application. The granule comprises the following ingredients: *Lysimachia christinae*, *Pyrrosia lingua*, *Cynanchum paniculatum*, talc, stir-fried chicken gizzard lining, *Polygonum aviculare*, *Dianthus superbus*, *Plantago asiatica*, *Tetrapanax papyriferus*, *Poria cocos*, *Coix lacryma-jobi*, *Paeonia lactiflora*, vinegar-processed *Corydalis yanhusuo*, *Astragalus membranaceus*, and *Achyranthes bidentata*. The entire formula integrates clearing heat and promoting urination, dissolving stones, tonifying qi and relieving pain, and guiding the medicine downwards. It primarily focuses on purging while supplementing with tonifying, achieving the combined effects of clearing heat and promoting diuresis, and dissolving stones. It is used for damp-heat accumulation, stone accumulation, or combined with deficiency of vital energy leading to urinary tract infections, stones, or hematuria. Symptoms include frequent urination, burning and stinging pain, yellow or reddish urine, abdominal cramps, difficulty urinating or stones in the urine, red tongue with yellow or greasy coating, and a slippery and rapid pulse. This composition has the effects of clearing heat and promoting diuresis, relieving strangury and expelling stones. It is used for heat strangury, stone strangury and hematuria caused by damp-heat accumulation, with symptoms such as frequent urination, burning and stinging pain, yellow or reddish urine or blood in urine, lower back and abdominal colic, difficulty in urination or gravel in urine, red tongue with yellow or yellow and greasy coating, and slippery and rapid pulse.

The application discloses a traditional Chinese medicine composition for treating overactive bladder (OAB) with kidney yang deficiency, a preparation method and application thereof. The composition is composed of three medicinal materials of fennel, cherokee rose and stir-baked dodder seed, and is formulated according to an optimal ratio. The composition improves the symptoms of frequent urination caused by OAB according to the TCM syndrome differentiation and treatment concept. The composition has the advantages of simple prescription, exact curative effect, no obvious toxic and side effects, simple medicine, easy quality control, low cost, reduced medical burden of patients, saved traditional Chinese medicine resources, and the like. The composition can obviously improve the urination indexes, OABSS scores and TCM syndrome scores of patients, improve the life quality of patients, has few adverse reactions, good tolerance and no drug dependence, and can significantly repair the bladder function of model rats and reduce the urination frequency. The product is prepared by adopting a volatile oil inclusion, alcohol extraction and water extraction combination and spray drying granulation process. The product contains 42 kinds of chemical components, mainly flavones and phenolic acids, has obvious comprehensive advantages, and has good industrialization and clinical application prospects.

The invention provides a traditional Chinese medicine compound preparation for treating vaginitis and urethritis and a preparation method thereof. The preparation is prepared from nine traditional Chinese medicines including coptis chinensis, scutellaria baicalensis, radix sophorae flavescentis, cortex dictamni, fructus kochiae, fructus cnidii, rhizoma smilacis glabrae, gallnut and alum according to a specific weight ratio. The prescription is scientific in compatibility, has the remarkable effects of clearing away heat and drying dampness, detoxifying and killing insects, astringing and arresting leucorrhea, dispelling wind and arresting itching, and has the remarkable effect on symptoms such as pruritus vulvae, abnormal leucorrhea, frequent micturition and urgent micturition. The preparation disclosed by the invention can be prepared into a plurality of external dosage forms such as washing liquid and effervescent tablets, is safe and convenient to use, definite in curative effect and low in recurrence rate, and has a good clinical application prospect and market value.

The application discloses a traditional Chinese medicine composition for auxiliary treatment of prostatic hypertrophy and a preparation method thereof. The traditional Chinese medicine composition is prepared from Uncaria, ethanol extract of Dehaasia bibracteata, Akebia quinata, Nelumbo nucifera, Crossandra infundibuliformis, Rosmarinus officinalis, Prunus armeniaca, Cinnamomum cassia and Salvia officinalis by processing. The traditional Chinese medicine composition has the effect of treating prostatic hypertrophy. The traditional Chinese medicine composition is mainly used for prostatic hypertrophy, and the symptoms include frequent urination, urgent urination and incomplete urination. The traditional Chinese medicine composition can reduce the prostate index of a patient with prostatic hypertrophy, regulate the sex hormone level, reduce the prostate phosphatase activity, and has a remarkable effect on treating the problems of frequent urination, urgent urination and incomplete urination caused by prostatic hypertrophy. Meanwhile, the composition is prepared from traditional Chinese medicines as raw materials, is safe to use, has high bioavailability, and has no any toxic and side effects.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a Miao medicine composition for prostate health care. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of bulbophyllum, 8-15 parts of phryma leptostachya, 5-12 parts of sambucus chinensis, 3-8 parts of pseudo-ginseng and 2-6 parts of ethanol. The Miao medicine composition is prepared by the following steps: washing, drying and mixing the sambucus chinensis, the phryma leptostachya, the sambucus chinensis and the pseudo-ginseng, adding an ethanol water solution for soaking, and filtering to obtain an extracting solution, namely the Miao medicine composition. The Miao medicine composition can be used for relieving symptoms such as frequent micturition, urgent urination and unsmooth urination caused by benign prostatic hyperplasia and chronic inflammation, and can be used for improving local blood circulation and microcirculation; the powerful targeting effect on deep target tissue prostate is realized, so that the enhanced curative effect of treating both symptoms and root causes is achieved; the traditional Chinese medicine composition has the advantages of quick response, remarkable and lasting curative effect, high safety and good patient comfort and acceptability.

Devices, systems, and methods are claimed for the treatment of male urinary frequency disorders using volumetric tissue heating, e.g., via radiofrequency (RF) or ultrasound (US) energy applied to pelvic floor tissue or penile tissue. In one embodiment, a device for the non-invasive treatment of urinary frequency disorders is disclosed, the device being applicable externally to a perineal region of a male individual, the device comprising: at least one radiofrequency (RF) generator configured to generate RF energy; at least one RF electrode suitable for placement on a target perineal surface; and at least one control circuit connected to the RF generator, wherein the at least one control circuit is operable to cause the RF energy to selectively heat a portion of a urethra, a portion of one or more pelvic floor muscles, a portion of a prostate gland, or a portion of a urinary bladder.

A urine exosome marker panel for detecting bladder cancer and the use thereof. The provided biomarker panel comprising IGF2, KRT20, SPAG5, NRP1 and DHRS2 is used for detecting bladder cancer patients. The marker panel is used to construct a prediction model, and the model is trained by means of a training set and optimized by means of a test verification set, so as to finally obtain an early diagnosis prediction model for bladder cancer. The provided exosome marker panel and prediction model enable relatively accurate early screening of clinical samples from patients clinically suspected of having bladder cancer, presenting with symptoms such as hematuria, frequent urination, urgent urination, and dysuria, and for whom cystoscopy is recommended by clinical diagnosis, wherein the optimal marker panel is IGF2+KRT20+SPAG5+NRP1, with an AUC of 0.902, a sensitivity of 86.8%, a specificity of 83.0%, and an accuracy of 84.8%, demonstrating favorable clinical diagnostic value.

The invention discloses a traditional Chinese medicine composition for treating prostatitis, frequent urination, urgent urination and anuresis, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from the following raw materials in parts by weight: 3-10 parts of Chinese prickly ash, 4-20 parts of radix clematidis, 2-18 parts of mineral salt, 3-8 parts of calcined escargots and 3-22 parts of sedum sarmentosum. The invention also discloses a preparation method and application of the compound. The traditional Chinese medicine composition is simple in formula, has the effects of warming and activating meridians, softening hardness to dissipate stagnation, clearing heat and promoting diuresis and relieving swelling and pain by being applied to the navel (Shenque acupoint), and is used for treating prostatitis and related urinary system symptoms. The traditional Chinese medicine is quick in effect, short in treatment course, definite in curative effect, green, safe, free of side effects, convenient to use and low in cost, and provides an excellent external treatment choice for patients.

The invention belongs to the technical field of health food, and discloses a yang tonifying cake with kidney tonifying and yang supporting curative effects, which comprises the following raw material components by weight: 15g of male silkworm moth, 15g of gordon euryale seed and 10g of polygala tenuifolia. The effects of the male silkworm moth, the gordon euryale seed and the polygala tenuifolia cooperate with one another to achieve a conditioning effect, the male silkworm moth can achieve the effects of tonifying liver and stomach and tonifying Yang and arresting seminal emission, the gordon euryale seed can achieve the effects of tonifying kidney and securing essence and tonifying spleen, the polygala tenuifolia has the effects of tonifying kidney and supporting Yang and securing essence and reducing urination, and the three raw materials cooperate with one another to achieve the effects of tonifying kidney and supporting Yang, and securing essence and reducing urination. According to the traditional Chinese medicine composition, a mutually matched synergistic effect is formed from multiple dimensions of tonifying liver, tonifying kidney, tonifying spleen, supporting yang, securing essence and reducing urination, the symptoms of soreness and weakness of waist and knees, intolerance of cold and cold limbs, fatigue, frequent micturition at night and sexual dysfunction caused by kidney-yang deficiency can be comprehensively conditioned, the problems that the effect of a single raw material is limited, and various discomforts related to kidney-yang deficiency are difficult to cover are effectively avoided, and the traditional Chinese medicine composition is suitable for clinical application. The kidney-tonifying, yang-supporting and conditioning effects are ensured to be more comprehensive and more targeted.

The present invention relates to a medical device, and specifically relates to a urinary catheter with a urinary catheter top end made of a multi-layer composite material. The technical problem to be solved by the present invention is that the material used in the existing urinary catheters is relatively hard for the bladder mucosa, and the relatively hard top end of the urinary catheter may press and stimulate the bladder wall to cause bladder stimulation symptoms such as frequent urination, urgent urination, abdominal pain, and intense sensation of holding back urine. According to the present invention, the top end of the urinary catheter is made of a multi-layer composite material and is formed by nesting two or more layers of materials with different hardness, wherein the innermost layer is an inner lining layer, and the inner lining layer is continuous with the wall of the remaining urinary catheter but has a smaller thickness. A soft cushion layer is nested on the surface of the inner lining layer, the soft cushion layer is made of a softer material than the inner lining layer, and one or more film layers may be additionally disposed on the outer side of the soft cushion layer to wrap the soft cushion layer inside a closed cavity. The present invention has the beneficial effects that the top end of the urinary catheter is of a layered structure, and the hardness of different layers of materials is different, wherein the part of the outer layer in direct contact with the bladder wall is made of a super-flexible material so as to reduce the compression on the bladder mucosa, and the inner layer and other parts of the urinary catheter are made of relatively hard materials so as to ensure the support degree of the urinary catheter.

The present application provides a kind of lactobacillus gasseri LN32 and lactobacillus crispatus LN70 containing probiotic composition and application in reducing the risk of vaginal infection, belong to microbial application technical field.Containing 4 strains of probiotics, including lactobacillus plantarum LN66, lactobacillus rhamnosus LN56, lactobacillus gasseri LN32 and lactobacillus crispatus LN70.The probiotic composition is realized by oral route, vaginal flora reconstruction, inhibit the reproduction of gardnerella vaginalis and candida albicans, increase lactobacillus colonization, eliminate abnormal leucorrhea, vaginal burning and itching, frequent urination, urgency and pain.The probiotic composition is combined with conventional carrier, applied to prepare food, dietary supplement or drug for preventing and / or treating vaginal and urethral microecological disorder, bacterial vaginitis, mycotic vaginitis and urethral infection, and then the present application realizes inhibiting harmful bacteria in vagina, reconstructing vaginal flora to reduce the risk of vaginal infection and reduce the risk of urethral infection.

The invention relates to the technical field of biological materials, in particular to a polydopamine coating as well as a preparation method and application thereof. According to the specific technical scheme, a dopamine solution and a hydrogen peroxide aqueous solution are mixed on the surface of a base material to be coated, and the polydopamine coating is generated. The prepared polydopamine coating can effectively improve the lower urinary symptoms such as pathological bladder mucous membrane barrier damage, erosion, bleeding, pain, frequent urination and urgent urination, mucous membrane repair is accelerated, and the life quality of a patient is improved. The technical scheme provided by the invention has a wide application prospect in the field of chemical cystitis treatment.

1. The name of the design product: photon therapy instrument. 2. The use of the design product: for treating prostate-related diseases, such as frequent urination, urinary urgency, hematuria, and prostate hyperplasia. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The invention discloses a traditional Chinese and western medicine synergetic postpartum pelvic repair technique and device. The mechanical balance of pelvic floor is intervened and reconstructed through a systematic technique. The method integrates the traditional Chinese medicine meridian theory and the western medicine anatomy structure, comprises a targeted stimulation scheme of key structures such as vulva vestibular glands, anus external sphincter and piriformis, can effectively improve symptoms such as postpartum sexual intercourse pain, vagina blowing, frequent urination and urgent urination in combination with a biomechanical feedback regulation mechanism, and has the characteristics of being simple and convenient to operate, noninvasive and safe.

This invention discloses a method for preparing a tortoise and snake wine that nourishes Yin and tonifies the kidneys, and its application in products that improve frequent urination at night and benign prostatic hyperplasia, belonging to the field of traditional Chinese medicine health wine technology. The method employs a combined process of "soaking in water + low-temperature marinating with ginger juice and cooking wine" to remove the fishy smell. Extraction is performed stepwise at 35-45℃ and 25-35℃ respectively, targeting the characteristics of tortoise and snake meat and traditional Chinese medicinal materials, with a secondary extraction of the medicinal residue. After mixing the extracts, honey and citric acid are added to adjust the taste. The mixture is then aged in a sealed container at 15-20℃, followed by a three-stage clarification process of "low-temperature refrigeration sedimentation + coarse filtration with diatomaceous earth + fine filtration with a 0.22μm microporous membrane" to obtain the finished product. This invention solves the problems of low extraction rate, strong fishy smell, and poor stability in existing tortoise and snake wines. It increases the raw material utilization rate by 25%-35%, and the product shows no turbidity or sedimentation after 18 months of storage at room temperature. The overall effective rate for symptoms of frequent urination at night and benign prostatic hyperplasia reaches over 85%. The process is simple and suitable for industrial production.