Yao medicine composition for treating urinary tract infection, preparation and preparation method thereof

Abstract

The invention discloses a Yao medicine composition for treating urinary tract infection, a preparation and a preparation method thereof. The Yao medicine composition comprises 10-20 parts of lysimachia christinae hance, 10-20 parts of lygodium japonicum, 10-20 parts of sweetmoss, 5-15 parts of ludwigia octovalvis, 5-15 parts of salvia sclarea, 5-15 parts of ground beetle, 3-9 parts of cinnamon, 3-9 parts of rhizoma anemarrhenae and 3-9 parts of golden cypress. The Yao medicine composition can be prepared into various medicinal preparations according to a conventional process, and the composition and the preparations thereof can be used for treating urinary tract infection, quickly relieving clinical symptoms such as frequent urination, urgent urination, urinary ketones and hematuria of urinary tract infection patients and reducing the recurrence rate.

Description

Technical Field

[0001] The present application relates to the field of traditional medicine, and specifically to a Yao medicine composition, preparation and preparation method thereof for treating urinary tract infection. Background Art

[0002] Urinary tract infection is a general term for infections in various parts of the urinary system. It is one of the most common bacterial infections in the world, with more than 150 million cases each year worldwide. It is the second most common infectious disease after respiratory tract infection and the main reason for prescribing antibiotics. Women and the elderly in my country are still the key populations for the prevention and control of urinary tract infections, and the incidence rate in women is much higher than that in men. The probability of re-infection within one year is high, and the incidence rate increases with age.

[0003] Urinary tract infection is divided into upper urinary tract infection and lower urinary tract infection according to the site of infection; it is divided into simple and complicated urinary tract infection, urosepsis, male reproductive system infection, etc. according to the state of the urinary tract when the infection occurs. Among them, simple urinary tract infection refers to urinary tract infection in patients with normal anatomical and functional structure of the urinary system and without complications such as diabetes or immunodeficiency. It can be cured by short-term antibacterial drug treatment and usually does not affect renal function. The 2019 edition of the "Guidelines for the Diagnosis and Treatment of Urological and Men's Diseases in China" recommends the classification method of the American Infectious Diseases Society and the American Society for Healthcare Epidemiology. Among them, simple urinary tract infection is equivalent to uncomplicated urinary tract infection, which is an occasional or recurrent lower urinary tract infection and (or) upper urinary tract infection, without abnormalities in the anatomy or function of the urinary system and other complications. The main clinical manifestations are frequent urination, urgency, dysuria, discomfort in the suprapubic bladder area or perineum, and burning sensation in the urethra. Modern medicine believes that bacteria, fungi, chlamydia, mycoplasma, viruses, etc. can all cause disease, but bacteria are the most common pathogens of urinary tract infection. Treatment mainly focuses on inhibiting and killing bacteria, but it is easy to recur and develop drug resistance.

[0004] Zhuang-Yao medicine is a unique ethnic medicine that has been accumulated, summarized and gradually formed by the Zhuang and Yao people in their long-standing labor practice and experience in fighting diseases. It has unique advantages and ethnic characteristics. Urinary tract infection belongs to the category of "Stranguria", which is a disease with frequent and short urination, stinging pain, and lower abdominal cramps and pain as the main symptoms. It was first seen in the "Inner Canon of Medicine"; later generations summarized the pathogenesis of "Stranguria" as "heat in the lower jiao" and "all stranguria is caused by kidney deficiency and bladder heat". In terms of the course of the disease, the initial onset of "Stranguria" is mostly due to internal dampness and heat, which turns from real to virtual over time, or a mixture of virtual and real; in terms of the location of the disease, "Stranguria" is located in the kidney and bladder, and has a certain relationship with the liver and spleen; in terms of pathogenesis, the views of ancient doctors are mostly "kidney deficiency as the root and bladder dampness and heat as the symptom", and most modern doctors believe that "dampness and heat" and "kidney deficiency" are the main causes and pathogenesis. Both Western medicine and Yao medicine can effectively treat urinary tract infections, and Yao medicine has obvious advantages in preventing and treating urinary tract infections and complicated urinary tract infections. Giving full play to the advantages of Yao medicine in treating urinary tract infections can not only effectively reduce the use of antibacterial drugs, but also reduce the emergence of drug resistance of pathogenic bacteria to a certain extent. Summary of the invention

[0005] The purpose of this application is to provide a safe and reliable Yao medicine composition, preparation and preparation method for treating urinary tract infection. To this end, this application adopts the following technical solutions:

[0006] In a first aspect, the present application provides a Yaoyao composition for treating urinary tract infection, comprising the following components in parts by weight:

[0007] 10-20 parts of Golden Money Wind, 10-20 parts of Golden Sand Vine, 10-20 parts of Sweeping Pinus, 5-15 parts of Lotus Root, 5-15 parts of Glehnia littoralis, 5-15 parts of Dalbergia odorifera, 3-9 parts of Cinnamon Bark, 3-9 parts of Anemarrhena Rhizome, and 3-9 parts of Phellodendron Amurense.

[0008] In at least one embodiment, the Yao medicine composition comprises the following components in parts by weight:

[0009] 15 parts of Rhizoma Anemarrhenae, 15 parts of Rhizoma Cibotii, 15 parts of Rhizoma Pinifoliae, 10 parts of Rhizoma Dioscoreae, 10 parts of Rhizoma Dioscoreae, 6 parts of Rhizoma Cinnamomi, 6 parts of Rhizoma Anemarrhenae, and 6 parts of Rhizoma Phellodendri.

[0010] In a second aspect, the present application provides a pharmaceutical preparation, which is prepared using the above-mentioned Yao medicine composition as the raw material.

[0011] In at least one embodiment, the pharmaceutical preparation further comprises a pharmaceutically acceptable excipient.

[0012] In at least one embodiment, the dosage form of the pharmaceutical preparation is a decoction, oral solution, drops, ointment, pills, powder, tablets or capsules.

[0013] On the third aspect, the present application provides a first method for preparing the above-mentioned pharmaceutical preparation, which is to first obtain an extract by water extraction of the raw material, and the extract can be used as a pharmaceutical preparation, or the extract can be made into other Chinese patent medicine dosage forms.

[0014] In at least one embodiment, the water extraction method is to boil the raw material twice with water, and finally combine the decoctions obtained twice.

[0015] In at least one embodiment, the decoction method is: the amount of water added for each decoction is 5-15 times the total weight of the raw material, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling in water for 10 minutes.

[0016] The present application can at least achieve the following beneficial effects: the Yao medicine composition and preparation provided in the present application can be used for the treatment of urinary tract infection, quickly relieve clinical symptoms such as frequent urination, urgency, ketones in urine, hematuria, etc. in patients with urinary tract infection and reduce the recurrence rate. The raw materials are all medicinal materials or edible foods that are both medicinal and edible, without toxic materials, and are safe and reliable. DETAILED DESCRIPTION

[0017] The present application will be described in detail below with reference to exemplary embodiments. However, it should be understood that the present application can be implemented in a variety of different forms and should not be construed as being limited to the embodiments described herein. These embodiments are provided here to make the disclosure of the present application more complete and to fully convey the concept of the present application to those skilled in the art.

[0018] First, the present application provides a Yao medicine composition for treating urinary tract infection, which includes the following components in parts by weight: 10-20 parts of Jinxunfeng, 10-20 parts of Jinshateng, 10-20 parts of Sweeping Pinus, 5-15 parts of Cuscuta australis, 5-15 parts of Glehnia littoralis, 5-15 parts of Dracaena sylvestris, 3-9 parts of cinnamon bark, 3-9 parts of Anemarrhena asphodeloides, and 3-9 parts of Phellodendron chinense.

[0019] The above composition is most commonly prepared as a decoction, and the dosage of the medicine in the prescription can be flexibly adjusted according to the individual conditions of the patient. Here, the inventor also provides a most commonly used ratio, that is, the Yao medicine composition for treating urinary tract infection, which includes the following components by weight: 15 parts of golden money wind, 15 parts of golden sand vine, 15 parts of sweeping pine, 10 parts of lotus root, 10 parts of yellow flower ginseng, 10 parts of ground drill, 6 parts of cinnamon bark, 6 parts of anemarrhena, and 6 parts of phellodendron.

[0020] The above components are common Chinese medicinal materials in this field and are also conventional medicinal materials in Zhuang and Yao medicine. Their general sources are as follows:

[0021] Jinqianfeng: also known as Jinbeng, it is the root and rhizome of Phyllodium pulchellum (Linn.) Desv. of the Leguminosae family; light, astringent, flat, it is a medicine for both wind and fire; it clears away heat and detoxifies, dispels wind and dampness, promotes blood circulation and relieves blood stasis, relieves pain and is a diuretic; it is used for Halun (meaning "cold and fever" in Yao dialect; similar annotations are used in other places in the following text), Lanxu (hepatitis), Lanbangchuiwenglu (hepatosplenomegaly), Lanyingzhongweng (ascites due to cirrhosis), Buxingxuan (nephritis edema), Kaximen (epigastric pain), Lageimeidui (irregular menstruation), Biedaibing (leucorrhea), Guwabuduan (uterine prolapse), Yuejiaojianglabei (bladder stones), Bengbimen (rheumatism, rheumatoid arthritis), Bochong (trauma) and Pengnao (fracture).

[0022] Japonicum japonicum: also known as Mu Gu Sui, it is the aerial part of Japonicum japonicum (Thunb.) Sw. of the Japonicum family; bitter, astringent, flat, and a wind medicine; diuretic, relieving stranguria, dispersing nodules, detoxifying, cooling blood, and stopping bleeding; used for urinary tract infection, urinary tract stones, nephritic edema, pyelonephritis, biaosha (cold), gu a pumping and nu ha (pneumonia in children), gu a zhao pa (sequelae of polio), peng nao (fracture), bigang (epistaxis) and chong cui zang (traumatic bleeding).

[0023] Sweeping pine: Also known as broom, it is the branches and leaves of Baeckea frutescens L., a plant of the Myrtaceae family. It is bitter, astringent, cold, and belongs to the category of wind medicine. It clears away heat and dampness, kills insects and relieves itching, promotes diuresis and detoxification, dispels wind and dredges the meridians, and helps digestion and relieves stagnation. It is used to treat fever, abdominal pain, enteritis and diarrhea, urinary incontinence, indigestion, rheumatic pain, rheumatism, and rheumatoid arthritis, and rheumatic heart disease. The branches and leaves are used externally to treat cystic eczema (venomous snake bites), eczema, itchy skin, and trichomonas vaginitis.

[0024] Guotang lotus root: also known as Quelangmi, is the rhizome or whole herb of Saururus chinensis (Lour.) Baill. of the family of the euphorbiaceae. It is sweet and spicy, cold in nature, and belongs to the category of wind medicine. It can clear away heat and detoxify, promote diuresis and relieve stranguria, remove rot and promote tissue regeneration, and consolidate the body. It is used to treat urinary tract infection, urinary tract stones, nephritis edema, beriberi edema, leucorrhea, halunuha (cough due to tuberculosis), dysentery, bruises (gastric and duodenal ulcers), furuncle (swollen toxicity), skin eczema, and venomous snake bites.

[0025] Yellow flower ginseng: also known as Jieduanbang, the root of Polygala falax Hemsl., a plant of the Polygalaceae family; sweet, slightly bitter, flat, belongs to the wind medicine. Nourishes the liver and kidneys, nourishes blood and regulates menstruation, strengthens the spleen and eliminates dampness; used for Rongguwaliuxinhei (postpartum weakness), Benzangbogongmeng (anemia and dizziness), Lanxu (acute and chronic hepatitis), Halunuha (cough due to tuberculosis), Buxingxuan (edema due to nephritis), Lageimeidui (irregular menstruation), Lagemen (dysmenorrhea), Biedaibing (leucorrhea), Nizhuigaimun (kidney deficiency and low back pain), Lanbangchuiwenglu (hepatosplenomegaly), Guwabuduan (uterine prolapse), Gangtuo (rectal prolapse) and Jiangmo (milk moth, tonsillitis).

[0026] Ground drill: also known as ground drill, is the root of the leguminous plant Flemingia philippinensis Merr.et Rolfe or large-leaf ground drill Flemingia macrophylla (Willd.) Prain; sweet, slightly astringent, warm, belongs to the wind medicine; strengthens tendons and bones, strengthens the waist and tonifies the kidney, invigorates the spleen and digests food, dispels wind and dampness; used for uterine bleeding (rheumatism, rheumatoid arthritis), gaimianbeng (stroke hemiplegia), xingxuan (edema), pumping heinuha (lung deficiency and long-term cough), hajin (chronic bronchitis), nizhuiwu (chronic nephritis), guaqianggong (infantile malnutrition), guwabuduan (uterine prolapse), clothuan (gastric ptosis), gaimeiyan (impotence, spermatorrhea) and other leucorrhea (leucorrhea, leucorrhea, excessive red discharge).

[0027] Cinnamon (Zheng Gui): It is the dried bark of Cinnamomum cassia Presl, a plant of the Lauraceae family; it tastes pungent and sweet, and is very hot in nature; it has the effects of replenishing fire and supporting yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians; it is used for impotence, cold uterus, cold pain in the waist and knees, asthma due to kidney deficiency, floating of false yang, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, abdominal pain due to cold hernia, and dysmenorrhea and amenorrhea.

[0028] Anemarrhena: It is the dried rhizome of Anemarrhena asphodeloides Bunge., a plant of the Liliaceae family; it tastes bitter and is cold in nature; it clears away heat and purges fire, nourishes yin and moistens dryness; it is mainly used to treat fever, thirst, dry cough due to lung heat, hot flashes due to bone steaming, internal heat and polydipsia, and constipation due to dry intestines.

[0029] Phellodendron chinense Schneid. or Phellodendron amurense Rupr. of the Rutaceae family; bitter in taste, cold in nature; has the effects of clearing away heat and dampness, purging fire and removing steaming, detoxifying and treating sores; used for damp-heat diarrhea, jaundice and red urine, leucorrhea and vulvar itching, hot stranguria and painful stranguria, beriberi and paralysis, bone steaming and fatigue fever, night sweats, spermatorrhea, sores and swelling, eczema and wet sores.

[0030] The above composition can be used as a raw material medicine to make not only decoctions, but also other common Chinese patent medicine preparations according to conventional processes. The Chinese patent medicine preparations include liquid preparations, semisolid preparations or solid preparations. These forms of pharmaceutical preparations contain the Yao medicine composition or its extract of the present application as an active ingredient, and may also contain pharmaceutically acceptable excipients. The active ingredient can be compounded with commonly used non-toxic pharmaceutical excipients to make decoctions, oral liquids, drops, ointments, pills, powders, tablets or capsules and any dosage forms that can be used. The excipients of the pharmaceutical preparation of the present application include, but are not limited to, solvents, propellants, solubilizers, cosolvents, emulsifiers, colorants, adhesives, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adhesive agents, integrities, penetration enhancers, pH regulators, buffers, plasticizers, surfactants, foaming agents, defoamers, thickeners, inclusion agents, humectants, absorbents, diluents, flocculants and deflocculating agents, filter aids, release retardants, etc. More specifically, the excipients include, but are not limited to, talc, water, ethanol, glucose, honey, lactose, gum arabic, gelatin, mannitol, starch, magnesium trisilicate, keratin, colloidal silicon, and the like.

[0031] Secondly, the present application provides a method for preparing the above-mentioned pharmaceutical preparation, which is to first obtain an extract by water extraction of the raw material drug, that is, to add water to the raw material drug and decoct it twice, and finally combine the decoctions obtained twice. The decoction method is: the amount of water added for each decoction is 5-15 times the total weight of the raw material drug, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling the water for 10 minutes.

[0032] The present application adopts the above-mentioned specific components and proportions, which have a synergistic effect. In the prescription: Jinqianfeng and Jinshateng clear away heat and detoxify, promote diuresis and relieve stranguria, cool blood and stop bleeding; assisted by broomstick and lotus root, they strengthen the effects of clearing heat and detoxifying, promoting diuresis and relieving stranguria; Huanghuagin and Dizhen nourish the liver and kidney, strengthen the tendons and bones, combine tonification and purgation, eliminate evil without hurting the body, and strengthen the body without leaving evil; assisted by cinnamon to guide fire back to the origin; Phellodendron chinense and Anemarrhena asphodeloides clear away heat and purge fire, nourish yin and moisten dryness; together they play the role of clearing heat and detoxifying, promoting diuresis and relieving stranguria, and nourishing the liver and kidney.

[0033] The Yao medicine composition and preparation of the present application can be used for the treatment of urinary tract infection, quickly relieve the clinical symptoms of urinary frequency, urgency, urine ketones, hematuria, etc. in patients with urinary tract infection and reduce the recurrence rate.

[0034] In addition, the present application also provides a number of specific embodiments, further illustrating the composition and preparation method of the raw materials of the above-mentioned pharmaceutical preparation for treating urinary tract infection, specifically:

[0035] Example 1

[0036] 1) Weigh the following raw materials by weight: 15 parts of golden coin wind, 15 parts of golden sand vine, 15 parts of sweeping pine, 10 parts of lotus root, 10 parts of yellow ginseng, 10 parts of ground drill, 6 parts of cinnamon bark, 6 parts of anemarrhena, and 6 parts of phellodendron;

[0037] 2) The raw material medicine is decocted twice with water, and the decoctions obtained twice are finally combined to obtain a decoction; the decocting method is as follows: the amount of water added for each decoction is 10 times the total weight of the raw material medicine, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling in water for 10 minutes.

[0038] Example 2

[0039] 1) Weigh the following raw materials by weight: 10 parts of golden coin wind, 14 parts of golden sand vine, 20 parts of sweeping pine, 5 parts of lotus root, 10 parts of yellow ginseng, 15 parts of ground drill, 3 parts of cinnamon bark, 6 parts of anemarrhena, and 9 parts of phellodendron;

[0040] 2) The raw material medicine is decocted twice with water, and the decoctions obtained twice are finally combined to obtain a decoction; the decocting method is as follows: the amount of water added for each decoction is 5 times the total weight of the raw material medicine, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling in water for 10 minutes.

[0041] Example 3

[0042] 1) Weigh the following raw materials by weight: 15 parts of golden coin wind, 20 parts of golden sand vine, 10 parts of sweeping pine, 12 parts of lotus root, 15 parts of yellow flower ginseng, 5 parts of ground drill, 5 parts of cinnamon bark, 9 parts of anemarrhena, and 3 parts of phellodendron;

[0043] 2) The raw material medicine is decocted twice with water, and the decoctions obtained twice are finally combined to obtain a decoction; the decocting method is as follows: the amount of water added for each decoction is 10 times the total weight of the raw material medicine, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling in water for 10 minutes.

[0044] Example 4

[0045] 1) Weigh the following raw materials by weight: 20 parts of golden coin wind, 10 parts of golden sand vine, 15 parts of sweeping pine, 15 parts of lotus root, 5 parts of yellow flower ginseng, 10 parts of ground drill, 9 parts of cinnamon bark, 3 parts of anemarrhena, and 5 parts of phellodendron;

[0046] 2) boiling the raw material medicine twice with water, and finally combining the decoctions obtained twice to obtain a decoction; the decoction method is: the amount of water added for each decoction is 15 times the total weight of the raw material medicine, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling in water for 10 minutes.

[0047] Clinical trials

[0048] 1. Research subjects

[0049] A total of 120 patients with urinary tract infection were treated in the emergency department of the First Affiliated Hospital of Guangxi University of Chinese Medicine. The selected patients were divided into an observation group and a control group according to a random number table, with 60 cases in each group.

[0050] 2. Case selection

[0051] All patients met the diagnostic criteria of western medicine for clinical trials, referring to the diagnostic criteria of "urinary tract infection" in the 2014 edition of "Guidelines for the Diagnosis and Treatment of Urological Diseases in China"; the diagnostic criteria of traditional Chinese medicine refer to the "Syndrome Section of Clinical Diagnosis and Treatment Terminology of Traditional Chinese Medicine" and "Internal Medicine of Traditional Chinese Medicine". Exclusion criteria: ① Participation in other clinical trials within 3 months; ② Allergy to Sanjin tablets or quinolones; ③ Previous insensitivity to levofloxacin; ④ Complicated urinary tract infection; ⑤ Combined with severe cardiopulmonary, liver and kidney diseases or other serious or progressive diseases of the system; ⑥ Combined with mental illness and unable to cooperate; ⑦ Combined use of other antibacterial drugs; ⑧ Lactating women or those who have plans to have children in the near future

[0052] 3. Treatment options

[0053] Intervention measures of the observation group: oral administration of Yao medicine, drug composition: 15g of golden coin wind, 15g of golden sand vine, 15g of sweeping pine, 10g of lotus root, 10g of yellow flower ginseng, 10g of ground drill, 6g of cinnamon bark, 6g of rhizoma anemarrhenae, and 6g of phellodendron. Control group: oral administration of levofloxacin tablets, 0.5g times / day. The course of treatment is 1 week.

[0054] 4. Observation indicators

[0055] The observation indicators include basic clinical routine examination indicators such as blood routine and urine analysis, as well as efficacy evaluation such as disease severity assessment and TCM symptom score. Among them, the efficacy evaluation standard is formulated with reference to the "Guidelines for Clinical Research of Antimicrobial Drugs for Simple Urinary Tract Infection" and the "Technical Guidelines for Clinical Trials of Antimicrobial Drugs".

[0056] The severity of the disease includes: mental state, chills and other systemic symptoms, signs and related examinations, as well as local symptoms, signs and related examinations such as frequent urination and urgency. The quantification of TCM symptoms includes: major symptoms such as frequent urination and urgency; minor symptoms such as yellow and dark urine, abdominal distension and discomfort. See Table 1 for details.

[0057] Table 1. Classification of severity of illness (points)

[0058]

[0059] 5. Statistical methods

[0060] SPSS 18.0 software was used for statistical analysis. The comparison between two sample means was performed by t test; the comparison between multiple samples was performed by one-way ANOVA, and the comparison between two samples was performed by SNK-q test. P<0.05 was considered statistically significant.

[0061] 6. Results

[0062] The comparison of the efficacy between the observation group and the control group is shown in Table 2. The total effective rate of the observation group is better than that of the control group. The comparison of the indicators between the two groups after treatment is shown in Table 3. The degree of symptom relief in the observation group is better than that in the control group.

[0063] Table 2. Comparison of efficacy

[0064]

[0065] Table 3. Comparison of symptom indicators between the two groups after treatment

[0066]

[0067] Clinical trials have shown that the Yao medicine prescription provided by the present invention has clear effects of clearing away heat, detoxifying, promoting the removal of dampness and relieving stranguria, can effectively relieve the symptoms of urinary tract infection and reduce the recurrence rate of patients, and is a good medicine for treating urinary tract infection.

Claims

1. A Yao medicine composition for treating urinary tract infection, characterized in that: The composition comprises the following components in parts by weight: 10-20 parts of Golden Money Wind, 10-20 parts of Golden Sand Vine, 10-20 parts of Sweeping Pinus, 5-15 parts of Lotus Root, 5-15 parts of Glehnia littoralis, 5-15 parts of Dalbergia odorifera, 3-9 parts of Cinnamon Bark, 3-9 parts of Anemarrhena Rhizome, and 3-9 parts of Phellodendron Amurense.

2. The Yao medicine composition according to claim 1, characterized in that: The composition comprises the following components in parts by weight: 15 parts of Rhizoma Anemarrhenae, 15 parts of Rhizoma Cibotii, 15 parts of Rhizoma Pinifoliae, 10 parts of Rhizoma Dioscoreae, 10 parts of Rhizoma Dioscoreae, 6 parts of Rhizoma Cinnamomi, 6 parts of Rhizoma Anemarrhenae, and 6 parts of Rhizoma Phellodendri.

3. A pharmaceutical preparation, characterized in that The Yao medicine composition according to claim 1 or 2 is used as the raw material medicine.

4. The pharmaceutical preparation according to claim 3, characterized in that: Also contains pharmaceutically acceptable excipients.

5. The pharmaceutical preparation according to claim 3, characterized in that: The pharmaceutical preparations include decoctions, oral liquids, drops, ointments, pills, powders, tablets or capsules.

6. A method for preparing the pharmaceutical preparation according to claim 3, characterized in that: First, the raw material drug is extracted by water to obtain an extract, and the extract is used as a pharmaceutical preparation, or the extract is made into other Chinese patent medicine dosage forms.

7. The preparation method according to claim 6, characterized in that: The water extraction method comprises decocting the raw material medicine with water twice, and finally combining the decoctions obtained twice.

8. The preparation method according to claim 7, characterized in that: The decoction method is as follows: the amount of water added for each decoction is 5-15 times the total weight of the raw material medicine, and the decoction time is to keep boiling for 15 minutes after boiling; during the first decoction, cinnamon is added after boiling in water for 10 minutes.

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