307 results about "Upper urinary tract infection" patented technology

The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA 5 molecules, RNA-LNPs and compositions for the prevention of E. coli infection, including urinary tract infection.

The ureter and urine bag comprises a urine bag body, a spiral pipe, a connecting pipe, a threaded connector pipe and a urine guiding pipe, the threaded connector pipe comprises a pipe body and an insertion pipe, internal threads with the thread pitch being 1.8-2.2 mm are machined on the inner wall of the pipe body, external threads matched with the internal threads are machined on the outer wall of the insertion pipe, and the spiral pipe is connected with the connecting pipe. Two groups of wing plates are symmetrically arranged on the outer wall of the cannula to provide rotating acting points, and a collecting assembly is integrated on the side wall of the urine bag and used for aseptically collecting urine samples. Traditional plug-pull type connection is replaced by a precise thread fit structure, a clear rotating force application point is provided for medical staff, operation is labor-saving and convenient, connector pollution is avoided, the urinary tract infection risk is effectively reduced, and the nursing comfort of a patient is improved.

The invention relates to the technical field of rapid detection methods, in particular to a one-step detection method for urinary tract infection escherichia coli with a non-disease diagnosis or non-treatment purpose. According to recombinase polymerase amplification provided by the invention, target DNA is specifically amplified through primers, CRISPR / Cas12a specifically recognizes a target sequence through crRNA, and through double screening of RPA and CRISPR / Cas12a, the target sequence is specifically recognized through crRNA; the rapid, sensitive and specific detection on the Escherichia coli infected with the urinary tract can be realized. Meanwhile, an RPA primer, crRNA and reaction conditions are optimized, so that an RPA reaction system and a CRISPR / Cas12a reaction system can be premixed in a tube, and the reaction can be completed only by a one-step method. The method can specifically detect urinary tract infection escherichia coli and has no cross reaction with common pathogenic bacteria, optimized conditions can avoid the competitive effect of CRISPR / Cas12a and RPA, the reaction rate and sensitivity are guaranteed, and meanwhile, the risk of nucleic acid aerosol pollution is also avoided due to the fact that a cover does not need to be opened.

The invention discloses a method for rapidly detecting common candida of urinary tract infection based on a nucleic acid mass spectrometry technology. The method comprises the following steps: extracting total nucleic acid from a urine sample of a patient; amplifying the extracted total nucleic acid by adopting a PCR (Polymerase Chain Reaction) technology to obtain an amplification product containing a target sequence; analyzing a characteristic peak map of the amplification product containing the target sequence by using a single-base extension primer and a matrix-assisted laser desorption / ionization time flight mass spectrometry technology; and determining whether specific candida exists in the sample according to the characteristic peak map. According to the invention, a set of detection system suitable for common candida is obtained through sequence screening and optimization of the amplification primers and the single-base extension primers, five common candida of UTI are detected based on the system, and a nucleic acid mass spectrometry technology is combined, so that the result can be clearly distinguished, a complex traditional detection means is avoided, and the detection efficiency is improved.

A system (or apparatus) for supporting a disabled, immobilized, injured, sick, or partially or fully paralyzed pet or animal in a standing or substantially standing position so as to facilitate various activities, care, diagnosis, or treatment is disclosed. The system may include a foundation or frame to which one or more slings and / or stirrups may be selectively attached or tied using one or more strips in order to support the animal in a standing or substantially standing position. The front of the frame may be substantially open. Different slings (e.g., seat-like slings) and / or stirrups may be attached to the frame or bathrub depending on the individual needs, purpose, and support needed for the pet or animal. The frame and sling may be configured and sized to accommodate pets or animals of different shapes, sizes, and / or weights, and may be ideal for, but not limited to, medium-sized dogs. Because the system supports the animal in a natural standing or substantially standing position rather than laying on its side, the owner or handler can advantageously use both hands freely to work on the animal. The ability to use both hands to express the bladder and / or bowels of the animal, while in a normal standing or substantially standing position, results in a more complete emptying of the animal's bladder and / or bowels, which provides health benefits for the animal such as prevention of urinary tract infection and consequent infectious diseases, which are common in disabled animals. In addition, the use of both hands freely allows the owner or handler to clean the animal and / or change its diapers in a more clean and efficient manner. The system is versatile and may also be suitable for use in one or more additional exemplary applications such as physical therapy rehabilitation (especially for in-home use), the stretching of muscles, exercise through placement over a small, portable treadmill, improving circulation (especially when there is a need to manipulate the limbs), massage therapy, chiropractic treatment, acupuncture treatment, wrapping of bandages, support for bathing in a bathtub, diagnostic evaluations, etc. such that the system or aparatus is adapted for use over a treadmill for rehabilitation. An aluminum frame, when selected, allows easy lifting and placement on an elevated surface, such as a bed, making it easier and more comfortable for the owner or caregiver to work with the animal at approximately waist height rather than in an uncomfortable position on the floor or ground.

The invention discloses a bacterial cluster motion single image detection method and system based on deep learning, and the method and system are used for quickly and automatically distinguishing the states of cluster motion, swimming and the like of bacteria. According to the method, high-precision classification is realized by acquiring a long-exposure single blurred image of bacteria in a circular limited space and extracting spatial-temporal characteristics by using a dense connected neural network (DenseNet) with an attention module. The kit is suitable for a high-throughput environment, can be integrated into portable equipment, and is used for early diagnosis and treatment evaluation of diseases such as urinary system infection (UTI) and inflammatory bowel disease (IBD).

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

The invention discloses a health-care food for delaying ovarian aging, which belongs to the technical field of health-care foods and comprises a composition for improving the levels of anti-mullerian test tube hormone and superoxide dismutase and functional auxiliary materials, the composition for improving the anti-muller test tube hormone and superoxide dismutase level is prepared from the following components in parts by weight: 2 to 5 parts of pyrroloquinoline quinone PQQ, 30 to 80 parts of cranberry powder and 40 to 100 parts of an isoflavone extract, and the content of the pyrroloquinoline quinone PQQ is 2 to 5 parts, the content of the cranberry powder is 30 to 80 parts, and the content of the isoflavone extract is 40 to 100 parts. The pyrroloquinoline quinone PQQ, the cranberry powder and the isoflavone extract in a specific formula have the effect of synergistically improving the levels of anti-muller test tube hormone and superoxide dismutase, and the health food prepared from the pyrroloquinoline quinone PQQ, the cranberry powder and the isoflavone extract can improve sleep, improve urinary tract infection of middle-aged women, delay ovarian aging and the like.

The invention relates to the technical field of urinary tract infection detection, and discloses a phage-based rapid and accurate urinary tract infection detection method, which comprises the following steps: S1, constructing a CRISPR / Cas9 system; s2, constructing a homologous recombinant plasmid; s3, constructing three plasmids BL21; s4, constructing, screening, verifying and reporting a phage T4:: Nluc; according to the detection method, a CRISPR / Cas9 system is combined with a homologous recombination technology, so that the efficiency of bacteriophage gene editing is remarkably improved, based on the report bacteriophage T4:: Nluc, rapid, sensitive, specific, accurate, simple and convenient detection on clinical urinary tract infection escherichia coli is realized, and the method can be used for detecting an escherichia coli urinary tract infection sample which is not pretreated, and has a wide application prospect. The kit shows excellent detection timeliness and specificity, is a powerful tool for identifying clinical urinary tract infection escherichia coli, and provides a new technical path for timely and accurate diagnosis and effective treatment of clinical urinary tract infection.

An uropathogenic escherichia coli recombinant protein composition LS, a construction, expression and purification method therefor, and a use thereof, relating to the technical field of genetic engineering. The method comprises: carrying out PCR amplification on LpcA and SurA genes, and respectively inserting the LpcA and SurA genes into multiple cloning sites of a cloning vector to construct a recombinant vector; then converting the recombinant vector into an escherichia coli expression protein; and finally, carrying out purification to obtain a composition LS of an LpcA protein and an SurA protein, wherein the composition LS can be used in a urinary tract infection vaccine. The present invention has the following advantages: a protein vaccine can induce relatively strong cell and humoral immune response of animals; and animal challenge experiments show that the protein vaccine has the protection effect of reducing the bacterial loads of the bladder and the kidney.

The gynecological urethral catheterization pain management integrated workstation comprises a main control terminal, a self-adaptive urethral catheterization support with force feedback, a three-dimensional navigation module, a consumable management module and a complication early warning system. The main control terminal is connected with the self-adaptive urinary catheterization support, the three-dimensional navigation module, the consumable management module and the complication early warning system through a network. By means of the AR dynamic navigation and pressure feedback linkage function, the operation time is effectively shortened, the operation efficiency is improved, and the qualified rate of independent operation of new nurses is increased. In the aspect of pain management, the individualized NRS evaluation module evaluates the pain, timely intervention is performed, and the pain of the patient is reduced. The complication prevention and control effect is obvious, the damage to the urethra is reduced, and the urinary tract infection incidence rate is reduced. Meanwhile, complete tracing of consumables is achieved through the RFID consumable management and electronic medical record docking function, and data support is provided for continuous improvement of nursing quality.

The invention discloses a traditional Chinese medicine composition for treating recurrent urinary tract infection as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 30-90 parts of astragalus membranaceus, 3-9 parts of cordyceps mycelia, 12-36 parts of rhizoma anemarrhenae, 10-30 parts of golden cypress and 6-18 parts of cinnamon. According to the pathogenesis characteristics of recurrent urinary tract infection and the principle of treatment based on syndrome differentiation of traditional Chinese medicine, the optimal raw material composition and dosage part ratio are obtained through screening, simplification and optimization of a large number of experiments, and the traditional Chinese medicine composition can remarkably improve the frequent micturition symptom, bacterial load and bladder pathological injury of rUTI mice. In addition, the drug-containing serum can promote migration of the SV-HUC-1 cells and reduce the level of inflammatory factors secreted by co-culture of the SV-HUC-1 cells and the UTI89 cells; the adhesion and internalization of the UTI89 to the cells are reduced. In addition, according to different bacterial strains and mouse modeling results, it is found that the modeling rate is obviously increased in a mode of enhancing infection every 24 hours, a recurrent urinary tract infection model of UTI89 infected C57BL / 6J is constructed, and a stable model is provided for screening drugs for treating recurrent urinary tract infection.

This utility model relates to the field of urine collection bag technology and discloses a urine collection bag for bladder irrigation in urological patients. It includes a lifting arm and a urine collection bag. A hook is fixedly connected to the middle of the upper surface of the lifting arm, and a warning light is installed in the middle of one side of the lifting arm. A power supply is installed inside the lifting arm. Slides are formed on both sides of the lifting arm. A conductive block is fixedly connected to one side of the bottom wall of the slide, and a spring is fixedly connected to the other side of the bottom wall of the slide. An inlet pipe is fixedly connected to one side of the upper surface of the urine collection bag, and a drain pipe is fixedly connected to the middle of the lower surface of the urine collection bag. This urine collection bag for bladder irrigation, through the design of an observation window and built-in scale lines, reduces the interference of bag deformation and light refraction on readings. Nursing staff can intuitively and accurately read the volume of irrigation waste fluid, ensuring accurate recording of intake and output balance, and providing reliable data support for assessing the patient's bladder irrigation effect, bleeding, and renal function recovery.

The invention provides an electrical stimulation catheter and a preparation method thereof, and belongs to the technical field of medical instruments.The electrical stimulation catheter comprises a catheter body, the outer wall of the catheter body is sequentially provided with a substrate layer, a liquid metal layer and a packaging layer from inside to outside, the liquid metal layer comprises a plurality of electrode connecting discs and wires connected with the electrode connecting discs, and the electrode connecting discs are connected with the packaging layer. The electrode terminal pad is formed by printing liquid metal, and an electrode contact covers the electrode terminal pad. The problem that the antibacterial effect of the catheter is not lasting can be solved, and catheter-related urinary tract infection is reduced.

The invention relates to the field of traditional Chinese medicines and discloses a traditional Chinese medicine composition for treating damp-heat downward flow type balanitis and urinary tract infection as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 8 to 12 parts of rhizoma anemarrhenae, 8 to 12 parts of cortex phellodendri, 8 to 12 parts of honeysuckle flower, 13 to 17 parts of radix scrophulariae, 8 to 12 parts of rhizoma paridis, 4 to 6 parts of radix gentianae, 4 to 6 parts of radix angelicae, 5 to 7 parts of cicada slough, 25 to 35 parts of semen coicis, 5 to 7 parts of wintersweet flower, 8 to 12 parts of cortex moutan, 13 to 17 parts of radix paeoniae rubra, 8 to 12 parts of cyrtomium rhizome, 13 to 17 parts of herba patriniae, 8 to 12 parts of radix pulsatillae and 8 to 12 parts of liquorice root. The traditional Chinese medicine composition can effectively improve symptoms such as red and swollen glans penis, astringent and painful urination and scorching urethra, remarkably improve the treatment effective rate and effectively control infection, has good safety and low cost, and is suitable for long-term or repeated attack patients to use.

The invention discloses a specific primer group for simultaneously detecting 54 urinary tract infection-related pathogens and 26 drug-resistant genes and a related detection method thereof, which is characterized in that the specific primer group aiming at the 54 urinary tract infection-related pathogens and 26 key drug-resistant genes is designed and is combined with an ultra-multiplex PCR (Polymerase Chain Reaction) and high-throughput sequencing technology, so that the specific primer group can be used for simultaneously detecting the 54 urinary tract infection-related pathogens and 26 key drug-resistant genes, and the specific primer group can be used for simultaneously detecting the 54 urinary tract infection-related pathogens and 26 key drug-resistant genes. One-stop synchronous detection is achieved, the limitation that traditional pathogen culture is long in period and difficult to culture and the detection rate of pathogens is low is broken through, and the defects that in an existing molecular detection technology, target spot coverage is small, and pathogens and drug-resistant genes cannot be analyzed synchronously are overcome. The method provides key technical support for clinically and rapidly formulating a precise anti-infection treatment scheme, reducing blind medication and delaying development of drug resistance, meanwhile, reduces diagnosis and treatment cost and time cost caused by multiple times of detection, and has extremely high clinical application value.

The utility model discloses a pressure-measuring anti-reflux urine bag device, and relates to the technical field of urine bag devices, the pressure-measuring anti-reflux urine bag device comprises a urine bag body and an alarm, the upper end of the urine bag body is fixedly connected with a drainage tube, and one end, far away from the urine bag body, of the drainage tube is provided with a urine tube connector. According to the pressure-measuring anti-reflux urine bag device, the anti-reflux valve, the sensor outer shell, the alarm and the like are arranged, the urine bag body is connected with the urethra pipeline through the drainage tube, so that urine flows into the urine bag body through the drainage tube, urine reflux is avoided through the anti-reflux valve, and urinary tract infection caused by urine reflux is avoided; when the urine bag body is replaced, the urine bag body can be sensed by the non-contact type liquid level sensor, then information is sent to the alarm, personnel are prompted to handle the information in time, meanwhile, the sensor outer shell is installed on the drainage tube in a clamped mode through the connecting piece, when the urine bag body is replaced, the sensor outer shell is detached, repeated use can be achieved, waste is avoided, and practicability is improved.

Embodiments are directed to a UPEC conjugate peptide including a self-assembling peptide and at least one UPEC epitope. The UPEC conjugate peptide may self-assemble into a nanofiber or fibril. Compositions including the UPEC conjugate peptide may be used to treat a bacterial infection such as a urinary tract infection (UTI). The compositions and methods may be specific for pathogenic bacteria. The compositions and methods may treat the infection without altering the gut microbiome.

The present application provides a urinary catheter structure, including an outer sheath tube with a drainage port, an inner core inserted in the outer sheath tube, and a balloon arranged at the distal end of the inner core, the balloon being positioned in the patient's bladder, and the outer sheath tube being able to be axially moved relative to the inner core by an external force, wherein when the drainage port of the outer sheath tube is located between the patient's sphincter and the bladder, the urine in the patient's bladder directly flows into the drainage port and is discharged, so as to provide an involuntary urination function, and when the drainage port of the outer sheath tube is located between the patient's sphincter and the external urethral opening, the urine in the bladder flows through the sphincter and enters the urethra, and then flows into the drainage port to be discharged through the urinary catheter passage, so as to provide an autonomous urination function. Thus, the present application can switch between providing autonomous urination and involuntary urination functions according to the actual use needs of the patient, and can effectively alleviate the patient's urinary tract irritation symptoms and reduce the risk of urinary tract infection.

The present invention is directed to phage therapy for the treatment and control of bacterial infections, in particular urinary tract infections caused by Escherichia coli. More specifically, the present invention is directed to novel bacteriophage strains, cocktails thereof and variants thereof; and to methods using the same in the treatment, reduction or prevention of bacterial infections. The cocktail is used as a first line treatment against urinary tract infections, in particular in cancer patients, diabetic patients, or patients with a weakened immune system. Disclosed herein is a pharmaceutical composition comprising one or more purified strains of bacteriophage, each purified strain having a genome with at least 98% sequence identity to a nucleotide sequence selected from SEQ. ID No. 1, SEQ ID NO. 4, SEQ ID NO. 5 and SEQ ID NO. 6 and / or variants thereof. The pharmaceutical composition may also be used in combination with other therapies for urinary tract infections such as antibiotics. The pharmaceutical composition may also be used in a method of diagnosis of the causative agent of a bacterial infection. A bacteriophage comprising at least 95% sequence identity with SEQ. ID No. 1, SEQ ID NO. 5 or SEQ ID NO. 6 is also disclosed.

The disclosure provides a tebipenem pivoxil HBr formulation in the form of a tablet core comprising at least 70% (w / w) tebipenem pivoxil HBr, and in certain embodiment more than 80% (w / w) tebipenem pivoxil HBr. The disclosure provides a tebipenem pivoxil HBr tablet core comprising at least 70% w / w tebipenem pivoxil HBr, 5-25% w / w of a diluent, 0.5 to 5% w / w of a glidant, 0.5 to 5% w / w of a lubricant, and optionally 0.5 to 5% w / w of disintegrant. The disclosure provides methods of treating a patient who has a bacterial infection such as complicated urinary tract infection (cUTI), acute and chronic pyelonephritis, an upper or lower respiratory infection, or bacteremia by administering a formulation of the disclosure to the patient.

The invention relates to the technical field of traditional Chinese medicine composition preparation and application, and discloses a traditional Chinese medicine composition for improving urinary tract infection and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from radix bupleuri, radix scutellariae, raw radix astragali, radix salviae miltiorrhizae, the root of Chinese pulsatilla, herba patriniae, polygonum aviculare, chingma abutilon seeds, the root of three-nerved spicebush, fennel, cinnamon and juncus roemerianus. The traditional Chinese medicine composition comprises the following components in parts by mass: 14-16g of radix bupleuri; 9 to 11 g of radix scutellariae; 19 to 21 g of raw radix astragali; 29 to 31 g of red sage root; 13-17g of Chinese pulsatilla root; 28-32 g of herba patriniae; 14-16 g of polygonum aviculare; 13 to 16 g of chingma abutilon seeds; 7-9g of combined spicebush root; 7-9g of fennel; 5-7g of cinnamon; according to the traditional Chinese medicine composition for strengthening the body resistance, clearing heat and promoting diuresis, the clearing curative effect on RUTI drug-resistant bacteria is better than that of antibiotics, the symptoms of a patient are obviously improved, the recurrence rate is lower than that of an antibiotic group, and the treatment principle and purpose of traditional Chinese medicine are completely different from those of antibiotic treatment; the traditional Chinese medicine composition disclosed by the invention considers recovery and improvement of the overall functional state of a patient instead of purely removing pathogenic bacteria.

A catheter insertion lubricating device relates to the field of medical instruments and comprises a sterilizing tube and a fixing plate, the fixing plate is arranged at the penetrating-out end of the sterilizing tube, one end of the fixing plate is connected with the sterilizing tube, the sterilizing tube is composed of a first connecting plate and a second connecting plate, and one side of the first connecting plate is hinged to one side of the second connecting plate; the other side of the first connecting plate and the other side of the second connecting plate are fixed through a buckle, and medical sponges for adsorbing a lubricating liquid and an iodophor solution are arranged in the first connecting plate and the second connecting plate; the urethral catheter disinfection device is high in practicability and very convenient to use, the lubricating cavity is formed in the disinfection tube, the surface of the urethral catheter is lubricated, and the pain degree of a patient during insertion is reduced; the disinfection cavity is formed in the disinfection tube, so that the surface of the catheter is disinfected when the catheter is inserted, and the urinary tract infection of a patient caused by bacteria is prevented; by arranging the fixing plate, the disinfection tube is fixed when the catheter is inserted, and medical staff can operate conveniently.

The present invention provides a medicinally active extract obtained from the plant Polyspora axillaris ( Polygala japonica Houtt. ), which contains flavonol compounds of the following formula (I) as the first active ingredient, and optionally contains xanthone compounds of the following formula (II) as the second active ingredient and glycolipid compounds of the following formula (III-1) or (III-2) as the third active ingredient. Animal experiments have confirmed that the drug of the present invention is significantly superior to potassium sodium hydrogen citrate in typical test indexes such as calcium oxalate crystal aggregation, renal interstitial inflammatory cell infiltration and renal tubular dilation lesions, indicating that it has extremely good potential and market prospects in the treatment of urinary system lithiasis and urinary tract infections or kidney injuries caused by urinary system lithiasis, and as an adjuvant drug after surgical treatment of urinary system lithiasis. (I) (II) (III).

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a pharmaceutical composition for recurrent urinary tract infection and a preparation method thereof. According to the invention, a compound extract for warming yang, promoting diuresis and activating blood and baicalin are synergistically compounded in an ion composite network formed by sodium alginate and chitosan, and are subjected to shear dispersion or homogenization treatment to form ion composite nanoparticles, and then the ion composite nanoparticles are subjected to calcium chloride cross-linking solidification and chitosan coating to prepare a multi-layer synergistic carrier design of the pellet; the dispersion uniformity, the forming strength, the pH response release and the storage stability of the ionic composite nanoparticles under the condition of high drug loading capacity are realized, and the core contradiction that the mechanical strength, the in-vivo swelling response release and the low-water-content storage and transportation stability are difficult to consider at the same time in the existing calcium alginate carrier system is solved; the method has wide clinical application value in comprehensive prevention and treatment of recurrent urinary tract infection.

An apparatus, system and method device for monitoring for an internal infection, such as a urinary tract infection. Included may be: a dispensing unit capable of receiving a continuous feed of color-changing infection test strips, comprising two compartments, one serving as a pass through for unused ones of the test strips, and the other configured to receive a used one of the test strips, and at least two gears capable of urging the continuous feed of the test strips from the unused compartment to the used compartment; a connection module capable of receiving a urine feed from a patient and having a window facing the dispensing unit; and a sensing module having an optical path facing the window and a urine reservoir for interfacing with the window to receive urine and including slits on either side thereof to feed the used ones of the test strips to the used compartment.

The invention relates to a cat magnesium ammonium phosphate calculus model and a construction method and application thereof, and belongs to the technical field of medical animal models. The construction method of the cat magnesium ammonium phosphate calculus model comprises the following steps: inserting a sterile catheter into the bladder of a modeling animal through the urethra; the proteus mirabilis bacterial liquid is injected into the bladder of the modeling animal through the catheter, the catheter is pulled out, and when it is observed that magnesium ammonium phosphate crystals and / or magnesium ammonium phosphate stones exist in the bladder and / or urine of the modeling animal, the cat magnesium ammonium phosphate stone model is obtained. The modeling method aims at safely and effectively simulating the key pathological process of cat struvite urolithiasis induced by upstream urinary tract infection (proteus mirabilis infection), and the defects that due to operator factors, the individual severity degree difference is large, other complications are difficult to control, repeatability is poor and the like can be overcome.

The present application relates to the technical field of biological medicine, and particularly relates to an antibacterial synergistic peptide targeting bacterial G-quadruplex and application thereof. The antibacterial synergistic peptide is an amino acid sequence shown in SEQ ID NO:1, a modified sequence or a pharmaceutically acceptable salt of the polypeptide. The amino acid sequence (GR17) is shown in SEQ ID NO:1. The antibacterial synergistic peptide has low antibacterial activity, but can enter the intracellular bacteria by means of polymyxin antibiotic-mediated bacterial membrane permeabilization, combine with bacterial G-quadruplex and interfere with nucleic acid-related processes and protein synthesis, thereby enhancing the antibacterial activity of polymyxin antibiotics on enterobacteriaceae pathogens such as clinical extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) and the like. E. coli The antibacterial synergistic peptide can also be used in combination with polymyxin B to continuously inhibit bacterial growth and recovery, inhibit bacterial biofilm formation, and improve the treatment effect on lung infection and catheter-related urinary tract infection.