112 results about "Upper urinary tract infection" patented technology

The ureter and urine bag comprises a urine bag body, a spiral pipe, a connecting pipe, a threaded connector pipe and a urine guiding pipe, the threaded connector pipe comprises a pipe body and an insertion pipe, internal threads with the thread pitch being 1.8-2.2 mm are machined on the inner wall of the pipe body, external threads matched with the internal threads are machined on the outer wall of the insertion pipe, and the spiral pipe is connected with the connecting pipe. Two groups of wing plates are symmetrically arranged on the outer wall of the cannula to provide rotating acting points, and a collecting assembly is integrated on the side wall of the urine bag and used for aseptically collecting urine samples. Traditional plug-pull type connection is replaced by a precise thread fit structure, a clear rotating force application point is provided for medical staff, operation is labor-saving and convenient, connector pollution is avoided, the urinary tract infection risk is effectively reduced, and the nursing comfort of a patient is improved.

The invention discloses a bacterial cluster motion single image detection method and system based on deep learning, and the method and system are used for quickly and automatically distinguishing the states of cluster motion, swimming and the like of bacteria. According to the method, high-precision classification is realized by acquiring a long-exposure single blurred image of bacteria in a circular limited space and extracting spatial-temporal characteristics by using a dense connected neural network (DenseNet) with an attention module. The kit is suitable for a high-throughput environment, can be integrated into portable equipment, and is used for early diagnosis and treatment evaluation of diseases such as urinary system infection (UTI) and inflammatory bowel disease (IBD).

The invention discloses a health-care food for delaying ovarian aging, which belongs to the technical field of health-care foods and comprises a composition for improving the levels of anti-mullerian test tube hormone and superoxide dismutase and functional auxiliary materials, the composition for improving the anti-muller test tube hormone and superoxide dismutase level is prepared from the following components in parts by weight: 2 to 5 parts of pyrroloquinoline quinone PQQ, 30 to 80 parts of cranberry powder and 40 to 100 parts of an isoflavone extract, and the content of the pyrroloquinoline quinone PQQ is 2 to 5 parts, the content of the cranberry powder is 30 to 80 parts, and the content of the isoflavone extract is 40 to 100 parts. The pyrroloquinoline quinone PQQ, the cranberry powder and the isoflavone extract in a specific formula have the effect of synergistically improving the levels of anti-muller test tube hormone and superoxide dismutase, and the health food prepared from the pyrroloquinoline quinone PQQ, the cranberry powder and the isoflavone extract can improve sleep, improve urinary tract infection of middle-aged women, delay ovarian aging and the like.

The gynecological urethral catheterization pain management integrated workstation comprises a main control terminal, a self-adaptive urethral catheterization support with force feedback, a three-dimensional navigation module, a consumable management module and a complication early warning system. The main control terminal is connected with the self-adaptive urinary catheterization support, the three-dimensional navigation module, the consumable management module and the complication early warning system through a network. By means of the AR dynamic navigation and pressure feedback linkage function, the operation time is effectively shortened, the operation efficiency is improved, and the qualified rate of independent operation of new nurses is increased. In the aspect of pain management, the individualized NRS evaluation module evaluates the pain, timely intervention is performed, and the pain of the patient is reduced. The complication prevention and control effect is obvious, the damage to the urethra is reduced, and the urinary tract infection incidence rate is reduced. Meanwhile, complete tracing of consumables is achieved through the RFID consumable management and electronic medical record docking function, and data support is provided for continuous improvement of nursing quality.

The invention discloses a traditional Chinese medicine composition for treating recurrent urinary tract infection as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from 30-90 parts of astragalus membranaceus, 3-9 parts of cordyceps mycelia, 12-36 parts of rhizoma anemarrhenae, 10-30 parts of golden cypress and 6-18 parts of cinnamon. According to the pathogenesis characteristics of recurrent urinary tract infection and the principle of treatment based on syndrome differentiation of traditional Chinese medicine, the optimal raw material composition and dosage part ratio are obtained through screening, simplification and optimization of a large number of experiments, and the traditional Chinese medicine composition can remarkably improve the frequent micturition symptom, bacterial load and bladder pathological injury of rUTI mice. In addition, the drug-containing serum can promote migration of the SV-HUC-1 cells and reduce the level of inflammatory factors secreted by co-culture of the SV-HUC-1 cells and the UTI89 cells; the adhesion and internalization of the UTI89 to the cells are reduced. In addition, according to different bacterial strains and mouse modeling results, it is found that the modeling rate is obviously increased in a mode of enhancing infection every 24 hours, a recurrent urinary tract infection model of UTI89 infected C57BL / 6J is constructed, and a stable model is provided for screening drugs for treating recurrent urinary tract infection.

This utility model relates to the field of urine collection bag technology and discloses a urine collection bag for bladder irrigation in urological patients. It includes a lifting arm and a urine collection bag. A hook is fixedly connected to the middle of the upper surface of the lifting arm, and a warning light is installed in the middle of one side of the lifting arm. A power supply is installed inside the lifting arm. Slides are formed on both sides of the lifting arm. A conductive block is fixedly connected to one side of the bottom wall of the slide, and a spring is fixedly connected to the other side of the bottom wall of the slide. An inlet pipe is fixedly connected to one side of the upper surface of the urine collection bag, and a drain pipe is fixedly connected to the middle of the lower surface of the urine collection bag. This urine collection bag for bladder irrigation, through the design of an observation window and built-in scale lines, reduces the interference of bag deformation and light refraction on readings. Nursing staff can intuitively and accurately read the volume of irrigation waste fluid, ensuring accurate recording of intake and output balance, and providing reliable data support for assessing the patient's bladder irrigation effect, bleeding, and renal function recovery.

The invention provides an electrical stimulation catheter and a preparation method thereof, and belongs to the technical field of medical instruments.The electrical stimulation catheter comprises a catheter body, the outer wall of the catheter body is sequentially provided with a substrate layer, a liquid metal layer and a packaging layer from inside to outside, the liquid metal layer comprises a plurality of electrode connecting discs and wires connected with the electrode connecting discs, and the electrode connecting discs are connected with the packaging layer. The electrode terminal pad is formed by printing liquid metal, and an electrode contact covers the electrode terminal pad. The problem that the antibacterial effect of the catheter is not lasting can be solved, and catheter-related urinary tract infection is reduced.

The invention relates to the field of traditional Chinese medicines and discloses a traditional Chinese medicine composition for treating damp-heat downward flow type balanitis and urinary tract infection as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 8 to 12 parts of rhizoma anemarrhenae, 8 to 12 parts of cortex phellodendri, 8 to 12 parts of honeysuckle flower, 13 to 17 parts of radix scrophulariae, 8 to 12 parts of rhizoma paridis, 4 to 6 parts of radix gentianae, 4 to 6 parts of radix angelicae, 5 to 7 parts of cicada slough, 25 to 35 parts of semen coicis, 5 to 7 parts of wintersweet flower, 8 to 12 parts of cortex moutan, 13 to 17 parts of radix paeoniae rubra, 8 to 12 parts of cyrtomium rhizome, 13 to 17 parts of herba patriniae, 8 to 12 parts of radix pulsatillae and 8 to 12 parts of liquorice root. The traditional Chinese medicine composition can effectively improve symptoms such as red and swollen glans penis, astringent and painful urination and scorching urethra, remarkably improve the treatment effective rate and effectively control infection, has good safety and low cost, and is suitable for long-term or repeated attack patients to use.

The invention discloses a specific primer group for simultaneously detecting 54 urinary tract infection-related pathogens and 26 drug-resistant genes and a related detection method thereof, which is characterized in that the specific primer group aiming at the 54 urinary tract infection-related pathogens and 26 key drug-resistant genes is designed and is combined with an ultra-multiplex PCR (Polymerase Chain Reaction) and high-throughput sequencing technology, so that the specific primer group can be used for simultaneously detecting the 54 urinary tract infection-related pathogens and 26 key drug-resistant genes, and the specific primer group can be used for simultaneously detecting the 54 urinary tract infection-related pathogens and 26 key drug-resistant genes. One-stop synchronous detection is achieved, the limitation that traditional pathogen culture is long in period and difficult to culture and the detection rate of pathogens is low is broken through, and the defects that in an existing molecular detection technology, target spot coverage is small, and pathogens and drug-resistant genes cannot be analyzed synchronously are overcome. The method provides key technical support for clinically and rapidly formulating a precise anti-infection treatment scheme, reducing blind medication and delaying development of drug resistance, meanwhile, reduces diagnosis and treatment cost and time cost caused by multiple times of detection, and has extremely high clinical application value.

Embodiments are directed to a UPEC conjugate peptide including a self-assembling peptide and at least one UPEC epitope. The UPEC conjugate peptide may self-assemble into a nanofiber or fibril. Compositions including the UPEC conjugate peptide may be used to treat a bacterial infection such as a urinary tract infection (UTI). The compositions and methods may be specific for pathogenic bacteria. The compositions and methods may treat the infection without altering the gut microbiome.

The present invention is directed to phage therapy for the treatment and control of bacterial infections, in particular urinary tract infections caused by Escherichia coli. More specifically, the present invention is directed to novel bacteriophage strains, cocktails thereof and variants thereof; and to methods using the same in the treatment, reduction or prevention of bacterial infections. The cocktail is used as a first line treatment against urinary tract infections, in particular in cancer patients, diabetic patients, or patients with a weakened immune system. Disclosed herein is a pharmaceutical composition comprising one or more purified strains of bacteriophage, each purified strain having a genome with at least 98% sequence identity to a nucleotide sequence selected from SEQ. ID No. 1, SEQ ID NO. 4, SEQ ID NO. 5 and SEQ ID NO. 6 and / or variants thereof. The pharmaceutical composition may also be used in combination with other therapies for urinary tract infections such as antibiotics. The pharmaceutical composition may also be used in a method of diagnosis of the causative agent of a bacterial infection. A bacteriophage comprising at least 95% sequence identity with SEQ. ID No. 1, SEQ ID NO. 5 or SEQ ID NO. 6 is also disclosed.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a pharmaceutical composition for recurrent urinary tract infection and a preparation method thereof. According to the invention, a compound extract for warming yang, promoting diuresis and activating blood and baicalin are synergistically compounded in an ion composite network formed by sodium alginate and chitosan, and are subjected to shear dispersion or homogenization treatment to form ion composite nanoparticles, and then the ion composite nanoparticles are subjected to calcium chloride cross-linking solidification and chitosan coating to prepare a multi-layer synergistic carrier design of the pellet; the dispersion uniformity, the forming strength, the pH response release and the storage stability of the ionic composite nanoparticles under the condition of high drug loading capacity are realized, and the core contradiction that the mechanical strength, the in-vivo swelling response release and the low-water-content storage and transportation stability are difficult to consider at the same time in the existing calcium alginate carrier system is solved; the method has wide clinical application value in comprehensive prevention and treatment of recurrent urinary tract infection.

The invention relates to a cat magnesium ammonium phosphate calculus model and a construction method and application thereof, and belongs to the technical field of medical animal models. The construction method of the cat magnesium ammonium phosphate calculus model comprises the following steps: inserting a sterile catheter into the bladder of a modeling animal through the urethra; the proteus mirabilis bacterial liquid is injected into the bladder of the modeling animal through the catheter, the catheter is pulled out, and when it is observed that magnesium ammonium phosphate crystals and / or magnesium ammonium phosphate stones exist in the bladder and / or urine of the modeling animal, the cat magnesium ammonium phosphate stone model is obtained. The modeling method aims at safely and effectively simulating the key pathological process of cat struvite urolithiasis induced by upstream urinary tract infection (proteus mirabilis infection), and the defects that due to operator factors, the individual severity degree difference is large, other complications are difficult to control, repeatability is poor and the like can be overcome.

The application discloses a urinary catheter for urology, and relates to the technical field of medical devices.The urinary catheter comprises a catheter main body, a urinary lumen, a medicine dropping lumen and a flushing lumen are arranged in the catheter main body; the urinary lumen is used for draining urine in a bladder; the medicine dropping lumen is used for adding medicine; and the flushing lumen is used for flushing the bladder; a connecting pipeline is connected with the catheter main body at a first end; a urinary head, a medicine dropping head and a flushing head are arranged at a second end of the connecting pipeline and are independent of each other; the urinary head is communicated with the urinary lumen; the medicine dropping head is communicated with the medicine dropping lumen; and the flushing head is communicated with the flushing lumen.The urinary catheter can drain urine or perform bladder perfusion treatment, add medicine into a patient's body, improve treatment effect and reduce the risk of complications such as urinary tract infection.

The invention discloses a nursing bed for preventing bedsores and cleaning excreta in time, a massage structure is arranged on a nursing bed body, and a urination opening is formed in the edge of the massage structure. The invention relates to the technical field of nursing beds, and has the beneficial effects that a negative pressure suction device and a matched drying function enable urine of a patient to be removed in time, so that the skin wetting time is shortened, the occurrence rate of urinary tract infection and perineum dermatitis is reduced, the cost of adult diapers is reduced, and the defects caused by the adult diapers are overcome. Automatic massage and electrical stimulation solve the problem of passively preventing bedsores, the electrical stimulation is particularly suitable for completely paralyzed patients, muscle atrophy can be effectively delayed, the effect of promoting blood circulation is achieved, and the frequency of turning over is reduced.

Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).

The present invention relates to a composition for inhibiting crystallization and / or biofilm formation on an indwelling catheter. Likewise, the present invention relates to the use of a composition as provided herein for the preparation of a medicament for inhibiting crystallization and / or biofilm formation on an indwelling catheter. The composition applied according to the invention contains trimagnesium citrate and tripotassium citrate, and the application of the composition reduces the risk of catheter blockage, reduces the risk of catheter-related urinary tract infection, reduces the risk of bladder calculus formation, reduces the risk of urethral mucosa injury caused by replacement of the indwelling catheter, and reduces the risk of urinary tract mucosa damage caused by replacement of the indwelling catheter. And allows the catheter to be used over an extended period of time.

Among hospital–acquired infections, Pseudomonas aeruginosa-associated urinary tract infections (UTIs) are mainly caused by indwelling urethral catheters (catheter-associated UTIs or CAUTIs) and are difficult to treat, resulting in high rates of morbidity among hospitalized patients. While antibiotics can successfully treat bacteria in the bladder lumen, they are inefficient at crossing stratified urothelium plasma membranes to kill persistent intracellular bacterial communities (IBCs). Herein, UTI IBCs are targeted by locally delivering the antibiotic gentamicin and / or the steroid hormone estradiol via polymeric nanogels conjugated with a cell-penetrating peptide Cys-Gly-Lys-Arg-Lys (CGKRK - SEQ ID NO:1). This approach delivered more intracellular gentamicin compared to drug delivered in solution in vitro and more estradiol compared to conventional methods. In an acute UTI murine model, the nanogel cell-penetrating peptide drug delivery system facilitated the transport of gentamicin into the urothelium and resulted in > 90% clearance of a uropathogenic P. aeruginosa clinical strain in vivo.

This application provides a method and system for predicting urinary tract infections related to urodynamic examinations. It addresses the limitations of current preventative measures, where methods with high evidence levels and good efficacy, including antibiotic intravesical instillation and weekly oral cyclic antibiotic therapy, inevitably require antibiotic use. The method includes: acquiring urodynamic examination data from a target patient; analyzing the curve information in the urodynamic examination data to obtain a curve numerical sequence corresponding to a time axis; extracting a urodynamic feature set based on the curve numerical sequence; constructing a medical history feature set based on the target patient's medical history data; inputting the urodynamic feature set and the medical history feature set into a urinary tract infection risk prediction model to output a risk prediction result for urinary tract infection after urodynamic examination. The risk prediction result includes at least a risk score or risk stratification result.

The application provides a catheterization device with an adjusting function, comprising: a catheter, one end of the catheter is provided with a catheter head for guiding urine into the catheter head, and the other end of the catheter is provided with an adjusting switch body for adjusting the rate and on-off of the urine discharged from the other end of the catheter; a balloon, the balloon is arranged on the outer peripheral wall of the catheter close to the catheter head, and the balloon can be filled with a medium to fix the catheter in the bladder of a human patient; two electrodes with opposite polarities, one end of each of the two electrodes penetrates through the catheter and extends into the catheter head along the length direction of the catheter, and the two electrodes are respectively used for connecting the positive electrode and the negative electrode of an electrophysiological monitoring device at the end outside the catheter; wherein the catheter, the catheter head and the balloon are all made of an electrically charged silicone rubber material. The application accelerates the recovery of the self-urination ability of the patient and reduces the risk of urinary tract infection of the patient through the adjustment of the adjusting switch body and the electrodes.

The invention belongs to the technical field of biological medicines, and particularly discloses a nano drug-loaded catheter coating material based on TUBA1C gene expression regulation and a preparation method thereof. The coating material is composed of siRNA (small interfering ribonucleic acid) loaded with TUBA1C and PLGA (poly (lactic-co-glycolic acid)) / chitosan nanoparticles loaded with antibacterial peptide GL13K. The sequences of the siRNA are as shown in SEQ ID NO: 1 and SEQ ID NO: 2. Nanoparticles are prepared through a multiple emulsion-solvent evaporation method, and the surface of the catheter is coated with the nanoparticles. The coating provided by the invention can synergistically exert gene silencing and antibacterial effects, and siRNA silences a TUBA1C gene in urethral mucosa cells in a targeted manner and inhibits inflammatory response and fibrosis; the antibacterial peptide GL13K can kill pathogenic bacteria and prevent the formation of biological membranes. The coating material has antibacterial, anti-inflammatory and anti-biofilm functions, can effectively prevent and treat catheter-related urinary tract infection, and reduces the risk of long-term complications such as urethrostenosis.

Disclosed are instillable compositions in the form of aqueous solutions comprising hyaluronic acid or a salt thereof and a complex of diclofenac or a salt thereof with 2-hydroxypropyl-beta- cyclodextrin and use thereof in the prevention of urinary tract infections.

A dietary supplement, as a single-dose oral suspension, comprising lactoferrin, xyloglucan, proanthocyanidins and simethicone as active ingredients, useful in the joint prevention of gastrointestinal and urinary tract infections. The dietary supplement ingredients are stored in a container with a storage closure and in a vial, wherein the storage closure contains a composition in solid powdered form comprising lactoferrin, xyloglucan and cranberry extract, while the vial contains a flavoured simethicone suspension. The composition in solid powdered form of lactoferrin, xyloglucan and cranberry extract in the closure storage cap and the flavored simethicone suspension contained in the vial are mixed in a direct process, just before use, forming a flavored single-dose oral suspension that can be used directly from its container.

Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.

The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and / or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect.