12 results about "Pyrrovinyquinium" patented technology

The application discloses application of pyrroloquinoline quinone (PQQ) or a derivative thereof in preparation of a product for relieving or preventing blue-green algae toxin poisoning of yellow catfish, and belongs to the technical field of aquatic animal feed. The PQQ or the derivative thereof can be used as an aquatic feed additive or a medicine, and is added in an amount of 3-6 mg / kg of feed to feed yellow catfish, so as to effectively relieve pathological damage of the liver of the yellow catfish caused by blue-green algae toxin through various ways such as improving key enzyme activity of liver function, inhibiting liver oxidative stress, relieving inflammatory reaction and reducing structural damage of tissues. The PQQ is a new food raw material approved in China in 2022, has advantages of high safety, good water solubility, moderate cost, similar dosage to that of feed vitamins and the like, and provides a safe, economical and convenient new nutritional intervention strategy for blue-green algae toxin poisoning of the yellow catfish, and has a wide industrial application prospect.

The utility model relates to a pyrrole quinolinone production technical field especially relates to a kind of recovery treatment system for pyrrole quinolinone salting-out mother liquor and crystallization mother liquor, including pyrrole quinolinone salting-out mother liquor conveying pipeline and pyrrole quinolinone crystallization mother liquor conveying pipeline, pyrrole quinolinone salting-out mother liquor conveying pipeline, first concentration kettle, first crystallization, first drying device, sodium chloride storage tank and series connection;Pyrrole quinolinone crystallization mother liquor conveying pipeline, second concentration kettle, dilution kettle, decoloring kettle, first resin column, first pH adjusting kettle, second resin column, second pH adjusting kettle, second crystallization kettle, second drying device, pyrrole quinolinone storage tank are connected in series in proper order.The above-mentioned recovery treatment system design is reasonable, can recycle and utilize sodium chloride in salting-out mother liquor and pyrrole quinolinone in crystallization mother liquor, avoids resource waste.

Disclosed are a self-emulsifying composition of a coenzyme Q10 with high bioavailability, and a method and device for preparing the same. The composition includes the following components in percentage by weight: 5-35% of a coenzyme Q10, 1-50% of an oil phase, 10-60% of a surfactant, 1-10% of a cosurfactant, 0-7% of an antioxidant, and 0.5-2% of pyrroloquinoline quinone disodium salt. The coenzyme Q10 medicinal liquid obtained can be kept in a clear and transparent solution state at room temperature, can be stably dispersed in water and self-emulsified to a transparent emulsion, significantly improves the bioavailability of the coenzyme Q10 by more than 4 times, and can be filled in capsules or softgels to swallow. The method disclosed by the disclosure includes two steps: material grinding and vacuum self-emulsifying. The method is concise in step and easy to control. Moreover, the device is simple in structure and low in cost.

Provided is a formulation that can prevent or treat pregnancy hypertension syndrome. A prevention or treatment agent for pregnancy hypertension syndrome is prepared, said agent containing an effective amount of one or more substances selected from the group consisting of pyrroloquinoline quinone, salts of pyrroloquinoline quinone, apple polyphenols, black rice, and black rice extracts.

This invention discloses a novel use of pyrroloquinoline quinone (PQQ) in improving conception rates after artificial insemination in beef cows, as well as compositions containing rumen-protected PQQ and their application methods, belonging to the field of animal nutrition and reproductive technology. Addressing the problem of low conception rates in beef cattle after artificial insemination due to early embryonic oxidative stress death, this invention proposes continuously adding an effective dose of rumen-protected PQQ to the cow's diet starting from the day of artificial insemination. This method significantly increases the conception rate of cows from approximately 40.00% in the control group to 80.00%. This invention is safe, effective, and easily applicable in large-scale farming.

The application discloses a synergistic anti-oxidation ergothioneine composition and application thereof in anti-fatigue beverages. In the application, a multi-level anti-oxidation defense system is constructed by the combination of ergothioneine and pyrroloquinoline quinone, from free radical scavenging to cell energy metabolism to form a complete protection chain. Ergothioneine can directly capture and neutralize active oxygen free radicals in cells, protect cell membranes, proteins and DNA from oxidative damage, and reduce the generation of hydroxyl radicals by chelating metal ions. Pyrroloquinoline quinone can activate the mitochondrial biosynthesis pathway, improve the cell energy metabolism efficiency, and enhance the activity of the cell's own antioxidant enzyme system, thereby reducing the generation of free radicals from the root. The synergistic effect of the two can not only quickly remove the formed free radicals, but also enhance the cell's anti-oxidation repair capacity.

This invention discloses a pyrroloquinoline quinone ionic liquid, its preparation method, and its applications, belonging to the field of new materials technology. The ionic liquid is composed of the pyrroloquinoline quinone anion represented by Formula I and any one of the cations from Formulas II to V. It is prepared by mixing pyrroloquinoline quinone or its sodium salt with the corresponding cation in a solvent at a molar ratio of 1:1 to 1:3, reacting, separating, and drying. This ionic liquid combines the excellent properties of PQQ with those of ionic liquids, and when used in the preparation of high-purity nuclides in nuclear medicine, it can solve problems such as the easy loss of PQQ and the use of toxic raw materials in existing separation materials. When loaded onto supports such as silica gel for column chromatography separation, it exhibits high selectivity and good recovery rates in the separation of zirconium-yttrium, strontium-yttrium, etc., thanks to the metal coordination ability of PQQ. The preparation conditions are mild and the purification is simple, showing broad application prospects in the separation of key nuclides in nuclear medicine.

To provide a new technology for suppressing off-flavors in beverages containing citral. [Solution] Use pyrroloquinoline quinone or a salt thereof.

The application provides an asymmetric total synthesis method of alkaloid martinellic acid. Compared with the prior art, the asymmetric total synthesis method provided by the application constructs a pyrroloquinoline skeleton through a transition metal catalyst catalyzed tandem asymmetric cyclization reaction, and realizes carbon chain growth and amine group introduction through an olefin hydroamination carbonylation reaction, raw materials are simple and easy to obtain, the synthesis route is simple, and the conversion efficiency is high, so that the application provides a new idea and platform for drug molecule design and modification.

The present application relates to the technical fields of enzyme engineering and biological feed additive, and discloses a preparation process of high-activity deoxynivalenol degrading enzyme, which comprises the following steps: firstly, obtaining F428D mutant deoxynivalenol degrading enzyme concentrate in an acetate buffer system; then, under the conditions of stirring and temperature reduction, adding zinc acetate or calcium acetate aqueous solution into the concentrate to perform a coordination reaction; after the reaction is completed, adding trehalose, maltodextrin and pyrroloquinoline quinone disodium salt as protective agents, stirring and dissolving to form a to-be-dried enzyme solution; finally, setting the air inlet temperature to 140-160 DEG C to perform spray drying, and collecting dry powder to obtain the product. The present application solves the problem that the enzyme is easy to be inactivated in spray drying by using the metal ion same ion effect and coordination effect under the acetate buffer environment and combining with specific auxiliary embedding, and has the advantages of short production cycle, low cost, high enzyme activity recovery rate and the like, and is suitable for large-scale industrialized preparation.

本发明涉及医药领域，特别是涉及吡咯喹啉醌在制备低温诱导药物中的应用。吡咯喹啉醌（Pyrroloquinoline quinone），简称PQQ，具有很好降温效应，低剂量就可以有效降低小鼠体温至亚低温状态，且通过调整药物剂量可以有效控制降温持续时间。PQQ诱导的低温可以显著改善脑出血小鼠运动功能和神经功能，促进脑内血肿吸收。本发明首次发现了PQQ降低体温的效应，并发现了PQQ诱导的低温可以有效降低出血性脑卒中损伤，为出血性脑卒中的治疗提供了一种新的有效方法，具有广泛的应用前景。

Disclosed is a method for treating a menstrual cycle disorder in a patient in need thereof, comprising: orally administering to the patient a therapeutically effective amount of pyrroloquinoline quinone (PQQ), or a pharmaceutically acceptable derivative thereof. Preliminary experimental data show that oral PQQ has a significant effect on preventing, alleviating, or treating menstrual cycle disorders compared with a placebo.