174 results about "Ultrasonic emulsification" patented technology

The invention provides a pregabalin slow-release type dissolving microneedle patch based on PLGA microspheres as well as a preparation method and application thereof. The method comprises the following steps: dissolving pregabalin and hyaluronic acid in deionized water to form an inner water phase (W1); dissolving PLGA in dichloromethane to form an organic phase (O); performing ultrasonic emulsification on the internal water phase and the organic phase to form W / O primary emulsion; rapidly adding the primary emulsion into an external water phase (W2) containing PVA and NaCl to form a W1 / O / W2 type multiple emulsion, and then carrying out solvent evaporation curing, centrifugal washing and freeze drying to obtain PLGA (at) PG microspheres; and uniformly dispersing the PLGA (at) PG microspheres in a hyaluronic acid solution, adding into a microneedle mold, vacuumizing, centrifuging, drying, and demolding the microneedle to obtain the dissolution type microneedle patch. By optimizing microsphere preparation, drug sustained release and microneedle patch preparation technologies are realized, and an efficient, safe and continuous local delivery platform is provided.

The invention relates to the field of surgical robots, and particularly discloses an intraoperative risk assessment system for a cataract surgical robot, comprising: a patient biomechanical monitoring unit for collecting a contact force between an instrument and an eye tissue, and calculating an anterior chamber equivalent pressure value according to an axial force component of the contact force and a contact area between the instrument and a cornea; the patient optical imaging monitoring unit is used for collecting microstructure images of the cornea and the lens capsule and quantifying the energy release density of ultrasonic emulsification; the robot motion parameter monitoring unit is used for collecting joint motion resistance, instrument tail end three-dimensional coordinates, motion speed and attitude angle of the robot; the multi-mode joint reasoning unit is used for identifying a high-risk operation state when the contact force is higher than a first preset value and the energy release density is higher than a second preset value; by adopting the technical scheme of the invention, multi-dimensional real-time monitoring can be realized, and a dynamic risk prediction model can be established by fusing heterogeneous data through an intelligent algorithm.

The invention relates to a preparation method of core-shell nanoparticles with photo-thermal-phase change dual functions and intracellular delivery application of the core-shell nanoparticles, and belongs to the field of nano materials and cell delivery. The invention provides a photothermal-phase change bifunctional core-shell nanoparticle applied to intracellular delivery of biomacromolecules, the nanoparticle is of a core-shell structure, a high-molecular polymer is taken as a shell, liquid fluorocarbon and a photothermal material are taken as a core, the nanoparticle is prepared by an ultrasonic emulsification method, and the preparation method is simple. The boiling point of the liquid fluorocarbon is low, and the photo-thermal material has good photo-thermal conversion performance, so that the core-shell nanoparticles can quickly generate photo-thermal steam microbubbles under laser induction. Under the synergistic effect of laser and core-shell nanoparticles, generated steam microbubbles are induced to generate micropores in plant cell walls and cell membranes or animal cell membranes, so that the physical barrier of the cell walls and the cell membranes is overcome, and the efficiency of delivering exogenous functional biomacromolecules into cells is remarkably improved.

The invention relates to the technical field of wound care, in particular to a responsive release microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: S1, dissolving a polylactic acid-glycolic acid copolymer in an organic solvent, adding an emulsifier, and carrying out ultrasonic emulsification to form a water-in-oil emulsion; s2, mixing a polyphenol compound, elastin, vegetable fat and probiotic suspension to form a quaternary mixed solution, slowly dropwise adding the quaternary mixed solution into the water-in-oil emulsion, continuing ultrasonic emulsification to form multiple emulsion, and evaporating to remove an organic solvent to obtain a quaternary system active component mixed solution; and S3, dissolving PDMAEMA in deionized water, adding a cross-linking agent, stirring, slowly dropwise adding the quaternary system active component mixed solution, carrying out a cross-linking reaction, and freeze-drying to obtain the responsive release microcapsule. The microcapsule can accurately release corresponding active ingredients according to pH value changes in different stages of wound healing, effectively shorten the wound healing time, improve the healing quality and reduce scar formation.

The invention relates to a targeted supramolecular BAPs-PLGA nanoparticle as well as a preparation method and an application of the targeted supramolecular BAPs-PLGA nanoparticle. The nanoparticle is prepared through a microfluidic technology and an ultrasonic emulsification technology, PLGA is used as an oil phase, supramolecular BAPs is used as a water phase to form a primary emulsion, and then the primary emulsion and a water phase containing an emulsifier and supramolecular RGD form a multiple emulsion. According to the technology, the BAPs and the eutectic solvent (TG-DES) are combined to form a stable supramolecular structure, so that the solubility and the stability of the BAPs are remarkably improved. The supramolecular RGD is attached to the surface of the nanoparticle and endows the nanoparticle with targeting property, and the cellular uptake ability of the BAPs can be improved through NRP-1 mediated transendocytosis. According to the invention, the bioavailability of the BAPs can be improved, and a new solution is provided for a drug delivery system and skin penetration enhancement. In addition, the preparation method of the nanoparticles is simple, controllable in process, suitable for industrial production and wide in application prospect.

The utility model discloses a negative pressure suction device for taking a dislocated intraocular lens. The negative pressure suction device mainly comprises a suction catheter, a catheter seat, a butt joint seat, an extension tube, a negative pressure generation device and a negative pressure control device, wherein the combined structure of the suction catheter and the catheter seat can be realized by directly adopting a 22G venous indwelling needle catheter, the combined structure of the suction catheter and the catheter seat is connected to the extension tube through the butt joint seat, the combined structure of the negative pressure generation device and the negative pressure control device can be realized by directly adopting an ultrasonic emulsification and vitreous body cutting machine and a matched pedal controller, and the extension tube is in butt joint with a negative pressure port of the extension tube. The negative pressure is adjusted through the pedal controller, the intraocular lens dislocated to the vitreous cavity is attracted to the pupil area, and damage to the retina in an operation is avoided. The device has the advantages of simplicity and convenience in operation, controllable negative pressure, small trauma and the like, is suitable for minimally invasive extraction or reduction of a dislocated intraocular lens in clinic, and is wide in adaptability.

The invention discloses a core-shell nano-enzyme composite spray gel dressing and a preparation method and application thereof.The dressing comprises a component A prepared from sodium alginate, N-isopropylacrylamide PNIPAM, core-shell nano-enzyme and curcumin and a component B of a divalent metal salt solution, and the component A and the component B are sprayed at the same time to form the core-shell nano-enzyme composite spray gel dressing. The preparation method of the core-shell nano enzyme comprises the following steps: mixing potassium ferrocyanide, ferric trichloride and polyvinylpyrrolidone to obtain a Prussian blue nano particle precursor solution; carrying out ultrasonic emulsification treatment and replacement on the curcumin core solution and the Prussian blue nanoparticle precursor solution; and freeze-drying to obtain the core-shell nano-enzyme. Through rapid ionic crosslinking of sodium alginate and divalent metal ions and the temperature-sensitive phase change characteristic of the temperature-sensitive polymer poly (N-isopropylacrylamide), the gel dressing is rapidly formed, the damaged skin is effectively covered and protected, the excellent antioxidant, anti-inflammatory and antibacterial capabilities are achieved, and the healing cycle of the radiodermatitis wound can be remarkably shortened.

The invention relates to the technical field of water-absorbent resin, in particular to salt-resistant water-absorbent resin and a preparation method thereof. The preparation method comprises the following steps: weighing acrylic acid, acrylamide, sulfobetaine methacrylate, hexadecyl dimethyl allyl ammonium chloride, sodium alginate, a cross-linking agent, an initiator, an antioxidant, an emulsifier, polyethylene glycol diacrylate and nano montmorillonite; carrying out ultrasonic emulsification on hexadecyl dimethyl allyl ammonium chloride and an emulsifier in ethanol; mixing neutralized acrylic acid, acrylamide and sulphobetaine methacrylate, and introducing nitrogen to remove oxygen; adding sodium alginate for dissolving, and injecting the microemulsion and the organic montmorillonite; adding a cross-linking agent and polyethylene glycol diacrylate, and adding an initiator and an antioxidant; and cross-linking, drying and sieving to obtain a finished product. According to the invention, by reducing the proportion of the ion-sensitive components and forming a salt-resistant interpenetrating network through the organic montmorillonite, the salt resistance of the water-absorbent resin is ensured.

In one embodiment, a phacoemulsification system includes a phacoemulsification probe configured to be inserted into an eye, and including a needle, a horn configured to support the needle, and an ultrasonic actuator connected to the horn and configured to vibrate the needle to emulsify a lens of the eye, an aspiration line partially disposed in the needle, a pumping sub-system connected to the aspiration line and configured to remove fluid and waste matter from the eye via the aspiration line, a valve disposed in the aspiration line and configured to control fluid connectivity in the aspiration line, a sensor configured to provide a signal indicative of a fluid metric in the aspiration line, and a controller configured to find an activation status of the ultrasonic actuator, and selectively control the valve responsively to the fluid metric and the activation status of the ultrasonic actuator.

The invention discloses a layered volatilization sleep-aiding essential oil product based on lavender essential oil and sandalwood essential oil and a preparation method of the layered volatilization sleep-aiding essential oil product. The preparation method comprises the following steps: mixing a high-volatility essential oil component and a low-volatility essential oil component with a natural emulsifier according to a specific ratio, carrying out an ultrasonic emulsification technology to obtain a nano-emulsion, and drying the nano-emulsion to prepare the microcapsule essential oil particles. According to the invention, different volatile components are coated by a specific emulsification method to reduce the volatilization loss and improve the stability, and layered slow release with synchronous starting and controllable speed is realized by utilizing the difference between high and low volatility; wherein the high-volatility component is quickly released in the early stage to provide an instant tranquilizing and allaying excitement effect, and the low-volatility component is slowly released in the later stage to provide a continuous sleep aiding effect. The layered volatile sleep-aiding essential oil product based on the lavender essential oil and the sandalwood essential oil provided by the invention is good in stability, has the advantages of rapid effect taking, lasting controlled release, uniform volatilization, good skin compatibility and the like, and can be used for preparing more sleep-aiding and nerve-soothing products.

The preparation method of the high-temperature-creep-resistant nano-composite pressure vessel steel comprises the following steps that a lead sulfide precursor is dissolved in an organic solvent, and heating reaction is conducted under the inert gas condition to generate lead sulfide quantum dots; mixing quantum dots with amphiphilic molecules, and performing ultrasonic emulsification to form a quantum dot colloidal solution; mixing the quantum dot colloidal solution with supercritical carbon dioxide to form a homogeneous fluid phase; the steel matrix is placed in a high-pressure reaction kettle, the homogeneous fluid phase is introduced, permeation is conducted for 2-4 h under the conditions that the pressure is 10-15 MPa and the temperature is 50-70 DEG C, and a steel billet is obtained; the steel billet is placed in hot isostatic pressing equipment, heat preservation and pressure maintaining are conducted for 1-2 h in the inert gas environment under the conditions that the pressure ranges from 150 MPa to 200 MPa and the temperature ranges from 800 DEG C to 900 DEG C, and then the steel billet is cooled to the room temperature; semiconductor quantum dots are introduced into a metal matrix, atomic-scale interface strengthening is achieved through the quantum effect and the supercritical fluid permeation technology, and the steady-state creep rate of the material at the temperature of 600 DEG C can be reduced to 1 / 10 of that of a traditional process by combining the microcosmic strengthening advantage of the quantum dots and the macroscopic permeation advantage of supercritical fluid.

The invention mainly relates to a bovine rotavirus inactivated vaccine and a preparation method thereof, and according to the preparation method of the bovine rotavirus inactivated vaccine, ultrasonic emulsification conditions are as follows: the ultrasonic frequency is 24-28 kHz, the power density is controlled within the range of 0.6-0.8 W / cm, the single pulse time is 8-12 seconds, the ultrasonic time is 60-120 seconds, ultrasonic emulsification is carried out in a refrigerant bath at the temperature of 2-5 DEG C, the temperature fluctuation is + / -0.5 DEG C, and the ultrasonic time is 60-120 seconds. The virus content in the inactivated vaccine is greater than or equal to 5 * 10 < 5.0 > TCID50 / ml, and the neutralizing antibody titer within 21-49 days after secondary immunization is greater than or equal to 900. The prepared bovine rotavirus inactivated vaccine is subjected to ultrasonic emulsification, a generated neutralizing antibody can completely neutralize an RVA / Bovine-tc / CHN / SHH2023001 / 2023 / G10P [11] virus strain, the titer is high (the titer can reach 1700 or above at most), the duration time is long, the G10P [11] type bovine rotavirus is the most common virus infected in a dairy cow group, and the G10P [11] type bovine rotavirus can be used for preparing the vaccine. Therefore, the vaccine can be used as an alternative vaccine for preventing calves from being infected with bovine rotavirus.

This invention belongs to the field of manganese dioxide recovery, and particularly relates to a polymeric flocculant and its preparation method. The method includes: (1) mixing an inorganic polymeric coagulant, a linear polymeric polymer, and silica in a certain proportion to form a mixture, dissolving it in water, and adding an initiator to carry out a low-temperature thermal reaction to prepare a precursor; (2) mixing a crosslinking agent, ethanol, nitric acid, and polymeric aluminum iron silicate in a certain proportion, drying and grinding to prepare a prepolymer; (3) mixing the precursor and the prepolymer in a certain proportion, ultrasonically emulsifying to prepare a polymeric flocculant. This invention has a good flocculation and adsorption effect, and can effectively remove impurities in electrolyte raw materials, especially metal ion impurities, while avoiding the loss of manganese ions during the removal of metal ion impurities.

The invention discloses an efficient flame-retardant fire extinguishing agent for rapidly extinguishing a lithium battery fire and a preparation formula, and relates to the technical field of fire fighting. The fire extinguishing agent is composed of a liquid-phase component and a solid-phase component, wherein the liquid-phase component comprises ethylene glycol, triethanolamine, fluoroalkyl betaine, sodium dodecyl benzene sulfonate, a phosphate flame retardant, an orange peel extracting solution and purified water; the solid-phase component comprises dodecyl sulfate, ammonium phosphate, potassium perchlorate, sodium carboxymethyl cellulose, polyacrylamide, benzotriazole and the like. The method comprises the following steps: drying and activating solid-phase components after graded crushing, and stirring in a nitrogen atmosphere; carrying out segmented treatment on liquid-phase components, and carrying out ultrasonic emulsification on an orange peel extracting solution; and after solid-liquid mixing, carrying out vacuum defoaming, high-speed shearing dispersion and homogenization treatment. According to the lithium battery fire extinguishing agent, component particle sizes with different dissolution rates are matched through graded crushing, nanoscale dispersion is achieved through ultrasonic emulsification, the bubble residual rate is reduced through vacuum defoaming, and the problems that a traditional lithium battery fire extinguishing agent is low in insulativity, low in cooling efficiency and insufficient in flame retardant efficiency are solved.

The utility model discloses a high-frequency ultrasonic fat emulsification instrument which comprises a high-frequency ultrasonic host, an ultrasonic emulsification treatment knife and a radio frequency electrode, the radio frequency electrode is connected with a high-frequency output interface, the ultrasonic emulsification treatment knife is connected with an ultrasonic output interface through a transducer, a plurality of annular grooves are formed in a knife head of the ultrasonic emulsification treatment knife, and the ultrasonic output interface is connected with the ultrasonic output interface through a transducer. The front end of the scalpel head is hemispherical, and a plurality of electrodes distributed in an array are arranged on the contact surface of the treatment head of the radio frequency electrode; a temperature sensor is also arranged in the treatment head of the radio frequency electrode; the scalpel head is not provided with a cutting edge, damage to normal tissue cannot be caused in the using process, the annular groove can increase the contact area, the emulsification effect is higher, and the treatment time is shorter; according to the radio frequency electrode provided by the utility model, radio frequency current can be more uniformly and fully distributed in tissues; according to the utility model, the radio frequency equipment and the ultrasonic equipment are combined on one high-frequency ultrasonic host, so that the occupied volume of the instrument is effectively reduced.

The invention relates to the technical field of mineral flotation dosing devices, in particular to an ultrasonic multi-stage rapid mixing, stirring and dosing device. Through the combination of the stirring impeller and the ultrasonic emulsification device, a medicament can be effectively stirred and ultrasonically emulsified, so that the medicament is mixed more uniformly and dispersed more meticulously, and the activity of the medicament is improved; and the spiral flow deflector on the inner wall of the atomization channel can enable the medicament to rotate in the flowing process, so that the mixing effect and the atomization degree of the medicament are further enhanced, the dosing efficiency and accuracy are improved, the dosing quality is ensured, and the use requirements of different working conditions are met.

The present invention discloses a method and device for preparing electronic slurry for multilayer ceramic capacitor electrodes with uniform particle size distribution, high yield and production efficiency, and good continuity of the slurry layer after sintering and film formation. The method for preparing electronic slurry for multilayer ceramic capacitor electrodes specifically includes the following preparation steps: (1) ultrasonic emulsification dispersion; (2) grinding dispersion; (3) centrifugal classification; (4) filtration; (5) stirring replacement; and (6) distillation concentration. The device used in the preparation method includes an ultrasonic emulsification kettle, a grinder, a rotary vibrating screen, a centrifuge, a filter, a stirring kettle, and an evaporation concentration device connected by a pipeline. A peristaltic pump is installed on the pipeline connecting the ultrasonic emulsification kettle and the grinder, and a peristaltic pump is installed on the pipeline connecting the rotary vibrating screen and the centrifuge. The evaporation concentration device includes a heating kettle, a condenser, a storage tank, and a vacuum pump connected by pipelines in sequence. The outer layer of the ultrasonic emulsification kettle is provided with a jacket.

The utility model relates to a lens posterior capsule protection pad used in cataract super breast surgery, which comprises a folding intraocular lens protection pad and a traction rope, the folding intraocular lens protection pad is arc-shaped, can be folded and curled and is injected between a lens nucleus and a posterior capsule through an intraocular lens injector, and the traction rope is arranged between the lens nucleus and the posterior capsule. One end of the traction rope is fixedly connected with the folding intraocular lens protection pad, and the other end of the traction rope is fixed outside the eye. The foldable intraocular lens protection pad can be folded and curled and injected between a lens nucleus and a posterior capsule through the intraocular lens injector, the intraocular lens injector is an existing device, a special implanter is not needed, the production cost is greatly reduced, after the foldable intraocular lens protection pad is implanted, the injector does not need to be continuously used, and the production cost is greatly reduced. The surgical operation time is shortened, the risk that the protection pad cannot be smoothly recycled through an injector is reduced, and the foldable intraocular lens protection pad can be taken out from the anterior chamber through a traction rope after ultrasonic emulsification is completed.

The application discloses an ultrasonic emulsification perfusion assembly, which comprises a metal connector, a plastic needle tube arranged in the metal connector, a metal perfusion sleeve provided with a water inlet and a perfusion port, and a plastic clamping perfusion sleeve which is sleeved outside the metal perfusion sleeve and forms a liquid storage space, wherein the water inlet is arranged in the liquid storage space. The application has the following beneficial effects: the slender needle head of the plastic needle tube can improve the stability of the anterior chamber and reduce the probability of surge occurrence; the relatively soft plastic needle head tip can also reduce the probability of puncturing the lens capsule; the metal perfusion sleeve effectively separates the ultrasonic emulsification needle tube body from the extrusion of the incision, greatly reduces or even eliminates the incision burn caused by ultrasonic friction; the relatively hard metal perfusion sleeve effectively prevents the perfusion liquid from being reduced or blocked due to the extrusion or distortion of the incision, thereby improving the stability of the anterior chamber and reducing the probability of surge occurrence.

The application provides a preparation method and application of resveratrol-polylactic acid microspheres, and relates to the technical field of biological agents, quantitative resveratrol is dissolved in methanol as O1 phase; quantitative polylactic acid is dissolved in an oil phase solution (ethyl acetate, dichloromethane, trichloromethane) as O2 phase; ammonium bicarbonate, sodium bicarbonate, sodium chloride and hydrogen peroxide are used as a porogen; O1 phase, O2 phase and the porogen solution are subjected to ultrasonic emulsification to obtain O / O primary emulsion; the O / O primary emulsion is added to a polyvinyl alcohol aqueous solution under stirring to obtain O / O / W multiple emulsion; the obtained O / O / W multiple emulsion is subjected to mechanical stirring to remove the oil phase solution in the O / O / W multiple emulsion, and then is subjected to standing, centrifugation, washing, drying and the like to obtain resveratrol-polylactic acid microspheres with uniform size. The resveratrol-polylactic acid microspheres of the application break through the bottleneck of poor water solubility of resveratrol, can effectively prolong the drug action time, and have good antibacterial effect.

The application relates to the field of food preservation, in particular to a natural bacteriostatic material and a preparation method and application thereof, and a preparation method of the natural bacteriostatic material, which comprises the following steps: mixing natural gelatin and dextran with deionized water, stirring, and freeze-drying to obtain a gelatin-dextran mixture powder, wherein the mass ratio of the natural gelatin to the dextran is 1-2:1-4, and the molecular weight of the dextran is 150-200 kDa; performing a glycosylation reaction on the gelatin-dextran mixture powder to obtain a gelatin-dextran conjugate; dissolving the gelatin-dextran conjugate in a buffer solution to obtain an emulsifier; and homogenizing edible essential oil, the emulsifier and deionized water, and performing ultrasonic emulsification to obtain the natural bacteriostatic material. The preparation method is simple, the conditions are simple, the prepared natural bacteriostatic material has good stability, and the shelf life of food can be prolonged.

The invention relates to a composite hydrogel slow-release adhesive as well as a preparation method and application thereof, and relates to the technical field of natural high polymer materials. The preparation method comprises the following steps: (1) dissolving tripterine with a solvent to obtain a tripterine solution; (2) mixing the tripterine solution with a polyethyleneimine aqueous solution, and carrying out ultrasonic emulsification to obtain a tripterine-polyethyleneimine nano suspension; and (3) adding a hydrogel material into the tripterine-polyethyleneimine nano suspension, so as to prepare the hydrogel slow-release adhesive. According to the preparation method disclosed by the invention, a novel medicine carrying material for effectively repairing the infected wound surface by carrying the tripterine is realized, the medicine is continuously applied to act on the infected wound surface, and the tripterine is lastingly and slowly released to repair the infected wound surface while the wound surface is effectively protected and ulcerative focuses are sealed.

Provided is a preparation method for an adiposome, comprising the following steps: S1) subjecting polar lipids and neutral lipids to intermittent ultrasonic emulsification in a buffer solution to obtain a crude emulsion; and S2) purifying the crude emulsion to obtain the adiposome. Compared with the prior art, the present invention uses an ultrasonic emulsification method to prepare the adiposome, so that the quality of the adiposome prepared in different batches is controllable, and the preparation of the adiposome can be efficiently completed. Moreover, high-energy mechanical vibration and ultrasonic cavitation effects of ultrasonic waves are utilized in the ultrasonic emulsification method to widen the selection of raw materials for adiposomes, so that the method can be used to not only prepare an adiposome with unsaturated fatty acid chain phospholipids and neutral lipids as raw materials, but also synthesize an adiposome with saturated fatty acid chain phospholipids, neutral lipids, or high-melting-point lipids as raw materials. In addition, the utilization of raw materials can be improved, and the scale of adiposome production can be expanded.

The present invention discloses a microelectronic device temperature control and heat dissipation system based on vapor-liquid phase change nanoemulsion boiling heat transfer, which relates to the field of thermal management technology of microelectronic devices, including a fan radiator, a circulating water pump, a controllable ultrasonic emulsification module and a heat exchanger connected in sequence. The water-cooled heat dissipation system adopts a vapor-liquid phase change nanoemulsion with phase change function (ultrapure water as a continuous phase and a low-boiling organic fluoride as a dispersed phase) as a heat exchange medium, and the configured emulsion is pre-filled into the pipeline of the water-cooled heat dissipation system. The controllable ultrasonic emulsification module is used to perform real-time online regulation of the emulsion parameters to match the heat dissipation requirements of the microelectronic device. By replacing the heat exchange medium of the water-cooled heat dissipation system, the heat dissipation performance is significantly improved compared with single-phase flow heat exchange under the same pump work and the same flow conditions, and the efficient temperature control and heat dissipation requirements of microelectronic devices with a junction temperature not exceeding 85°C are met, and the safe and stable operation of the microelectronic devices under the trend of miniaturization and high integration is guaranteed.

1. The name of the design product: ultrasonic emulsification instrument for ophthalmology. 2. The use of the design product: used in ophthalmic operating room, the operation equipment for cataract lens core fragmentation, perfusion and suction and anterior segment vitrectomy and electrocoagulation. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view 1.

The invention belongs to the technical field of biological medicine, and particularly relates to a Pickering emulsion with stable protein-polyphenol coating modified particles and a preparation method and application thereof.The preparation method comprises the following steps that protein and polyphenol are used for modifying solid particles, and the protein-polyphenol coating modified particles are obtained; dispersing the protein-polyphenol coating modified particles in water to obtain a dispersion liquid of the protein-polyphenol coating modified particles; and mixing the dispersion liquid with an oil phase, and carrying out high-speed homogenization or ultrasonic emulsification to obtain the Pickering emulsion. By adopting the preparation method to effectively modify the solid particles, not only can the inherent properties of the solid particles and the structure and function of protein be maintained, but also the Pickering emulsion prepared from the modified particles is uniform in droplet size and has excellent storage stability, and the service life of the Pickering emulsion is prolonged. The antioxidant and anti-inflammatory characteristics of polyphenol and the catalysis functions of protein are realized.

In certain embodiments, a surgical handpiece system includes a phacoemulsification tip, a fluid management system, an ultrasound drive system, and a controller. The phacoemulsification tip is attached to the shaft. The fluid management system is configured to manage inflow and outflow of fluid from an ocular surgical site. The ultrasonic drive system is configured to generate torsional and longitudinal vibrations in the phacoemulsification tip. The controller is configured to analyze a voltage and a current applied to the ultrasonic drive system using fast Fourier transform (FFT), and tune an application frequency of the torsional vibration and the longitudinal vibration according to at least one resonant frequency.

The embodiment of the invention provides PSO / PTX targeted composite nanoparticles as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a phospholipid composition in a first organic solvent, adding water and an emulsifier after dissolving, and uniformly mixing to obtain a water phase; the phospholipid composition comprises phospholipid and modified phospholipid, dissolving PLGA in a second organic solvent, adding PTX, PSO and SPIONs (at) OA after dissolving, and uniformly mixing to obtain an organic phase; and adding the organic phase into the water phase, carrying out ultrasonic emulsification, evaporating to remove the organic solvent, and filtering to obtain the PSO / PTX targeted composite nanoparticles. According to the PSO / PTX targeted composite nanoparticles prepared by the embodiment of the invention, the fact that psoralen and paclitaxel are co-loaded on the superparamagnetic polymer lipid nanoparticles is proposed for the first time, and the PSO / PTX targeted composite nanoparticles have the functions of magnetic targeting, long circulation and slow release, so that the PSO / PTX targeted composite nanoparticles have a good application prospect in preparation of the medicines for treating the breast cancer.

The invention discloses long-acting slow-release antibacterial preservative paper based on Pickering emulsion and a preparation method of the long-acting slow-release antibacterial preservative paper. The long-acting slow-release antibacterial preservative paper comprises a paper-based carrier and an antibacterial functional layer, wherein the surface of the paper-based carrier is coated with the antibacterial functional layer; the antibacterial functional layer is formed by mixing a Pickering emulsion and a polyvinyl alcohol / gelatin composite base material to form a film; the Pickering emulsion is prepared by taking Tempo oxidized nanocellulose and ethyl lauroyl arginate hydrochloride water suspension as a water phase and performing ultrasonic emulsification on the water phase and origanum vulgare essential oil according to an oil-water volume ratio of 1: 9; wherein the mixing ratio of the Pickering emulsion to the composite base material is (30 to 50): 50; the mass percent concentration of the Tempo oxidized nanocellulose in the water-phase suspension liquid is 0.2 wt%, and the mass percent concentration of the ethyl lauroyl arginate hydrochloride in the water-phase suspension liquid is 0.01 wt%. Through material innovation and process optimization, the antibacterial property, the slow release property, the environmental protection property and the industrial application are remarkably superior to those of the prior art, and an efficient and reliable solution is provided for green packaging in the fields of food, medicine and the like.

The invention discloses a microemulsion collecting agent for flotation of high-mud-content and high-oxidation molybdenite and preparation and application of the microemulsion collecting agent and belongs to the technical field of mineral processing, kerosene, xanthate or black powder collecting agents, a main emulsifier, a cosurfactant and water are mixed according to a certain proportion and then subjected to ultrasonic emulsification treatment, and the microemulsion collecting agent is obtained. According to the micro-emulsion collecting agent prepared through the method, after one-time roughing and two-time scavenging are conducted, the molybdenum recovery rate is remarkably increased compared with the molybdenum recovery rate when a kerosene collecting agent is singly used, the micro-emulsion collecting agent is simple in preparation method, high in emulsion stability, high in dispersity in ore pulp and free of slime interference, and the separation and recovery problem of high-argillization molybdenite is well solved.