Polylactic acid-capsaicin nano-capsule and preparation method thereof

Abstract

The invention discloses a polylactic acid-capsaicin nano-capsule and preparation method thereof. The method comprises the following steps: (1) preparing a dichloromethane solution of polylactic acid and capsaicin; (2) preparing a polyvinyl alcohol aqueous solution; (3) adding the solution in step (1) into the solution in step (2) and performing ultrasonic emulsification to obtain an emulsion; (4) heating the emulsion in step (3) to 40-50 DEG C to obtain a white emulsion and filtering the emulsion by a 100 nm microporous filter membrane to obtain a colloidal solution; (5) centrifuging the colloidal solution in step (4) to obtain a solid and vacuum drying the solid to obtain a polylactic acid nano-capsule. The polylactic acid nano-capsule of the present invention has a small particle size with a distribution of 30-90 nm; and the raw materials are biodegradable, is benefic to environment protection; the preparation process is simple, of low production cost, and easy to carry out. The prepared polylactic acid nano-capsule of capsaicin is applicable to adhesives, paints, electrical wires, cables, communication facilities, medicine, etc.

Description

technical field [0001] The invention relates to a polylactic acid nanocapsule containing capsaicin and a preparation method thereof. Background technique [0002] Capsaicin is an alkaloid containing vanillamide. Natural capsaicin consists of capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, homocapsaicin and other similar species, of which trans-8-methyl-N-vanillyl-6- Nonenylamide has the most intense spicy taste and pungency, and is the main spicy chemical component in pepper fruit. In places where rodents are rampant, wires, cables, communication facilities, packaging materials, grains, etc. are often damaged. In the past, toxic rodent repellents were used, but they not only damage the environment, but also have poor safety, especially for feed, food, For food packaging materials, safe and non-toxic materials must be used. In addition, capsaicin has a strong inhibitory effect on Botrytis cinerea, so it can be used to prevent and control pests and d...

AI Technical Summary

Problems solved by technology

[0007] However, in the above-mentioned method, there is an obvious defect that the core material is not dissolved in water, but forms an aqueous solution in a suspension state, and its particle size directly affects the final capsule particle size, so the prepared capsule particle size is relatively large. The proportion of nanoparticles is small, the distribution is wide, and the encapsulation effect is poor, and the drug loading is low