41results about How to "Easily prepared" patented technology

Novel and efficient syntheses create novel piperazinone intermediates which facilitate the production and use of PNAs. Such syntheses and the products enhance the feasibility of a system which permits the rapid identification of PNA oligomers useful as therapeutics, diagnostics and/or gene characterization tools. A first component of the system is a universal PNA library that most preferably incorporates one or more universal nucleotide bases into carefully selected positions within each oligomer species thereby providing the library with the screening ability of a much larger library. The second component of the system is a high throughput screening system that includes a number of assays designed to provide information on the binding activities of the different PNAs to a target nucleotide sequence (generally, a DNA or RNA sequence). The third component is a software system especially designed to provide rapid analysis of the data collected from the high throughput screening system and to determine therefrom the sequence base identities and sequence lengths of PNA oligomers most likely to bind to and appropriately affect the target molecule.

An automated attendance monitoring system is disclosed. The system includes (i) identification tags, with wireless communication capabilities, for each potential attendee, (ii) scanners for detecting the attendees' tags as they enter a given room, (iii) at least one server in communication with the scanners, (iv) handheld computing devices for use by attendance trackers, such as teachers, to verify a provisional attendance report generated by the scanners and server, and (v) software running on the server for receiving and managing the attendance data received from the scanners, and for generating attendance reports. Although particularly well-suited for tracking attendance in schools, the present invention can also be used in variety of other setting where there is a need to track the whereabouts of a number of individuals.

PCT No. PCT/JP98/03304 Sec. 371 Date Mar. 25, 1999 Sec. 102(e) Date Mar. 25, 1999 PCT Filed Jul. 24, 1998 PCT Pub. No. WO99/06457 PCT Pub. Date Feb. 11, 1999There is provided graft copolymer particles prepared by graft-polymerizing a vinyl monomer to a coagglomerated rubber, wherein said rubber is prepared by coagglomerating rubber particles of mixed latexes obtained by mixing (A) a silicone rubber latex with (B) an acrylic rubber latex and/or a conjugated diene rubber latex in such an amount as a silicone content is from 1 to 90% by weight based on the total rubber component. A physical property of a thermoplastic resin is improved using the graft copolymer particles. The thermoplastic resin composition using the graft copolymer particles is excellent in impact resistance, weather resistance, processability, thermal discoloration resistance and appearance of molded products.

A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An immunogenic malarial epitope is expressed between residues 78 and 79 of the HBc immunogenic loop sequence. The chimer preferably contains a malaria-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.

The compound represented by formula (I)

(wherein D and G are cyclic group which may have a substituent(s) or alkyl which may have a substituent(s), W and Y are a bond or a spacer of which main chain has an atom number of 1-4, ringA and ringB are heterocyclic ring which may have a substituent(s), containing at least one carbon atom and one nitrogen atom and the ringA and ringB share one spiro carbon atom), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof. Since the compounds represented by formula (I), a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof have the affinity to MBR, they are useful for the prevention and/or treatment for disease caused by stress.

A cap device for bottles which contains an additive in an additive container thereof and discharges the additive from the additive container into a bottle according to a predetermined movement of a part of the cap device, thus introducing the additive into the bottle and thus mixing the additive with a bottled liquid to prepare a mixture and allowing a user to easily prepare the mixture just prior to consuming or using the mixture. The cap device has an actuating unit to actuate the additive container while movably supporting the additive container. The actuating unit includes a body provided on the cap body, with the additive container received in the body to be moved vertically relative to both the body and the cap body. At least one aim is coupled to the body, and a head is mounted on the body.

An activator comprising a biocompatible base and a known fungicide in the form of an acid salt are mixed together by the user shortly before being applied to the infection so as to react them chemically to produce the free base of the fungicide thereby rendering the composition capable of penetrating throughout the infected tissue. The free base form has been found to be much more lethal to the fungal infection, particularly in the treatment of onychomycosis. The activator is formulated to be mixed within a few days of or just before application with the fungicide, e.g., terbinafine hydrochloride (an acid salt). Although the free base is subject to degradation and has a shorter shelf life, it was found that mixing just prior to use eliminates problems that could be caused by degradation of an active ingredient. A preferred activator solution also contains a penetration enhancer and a tissue softener.

Provided is a method for preparing a hydrophobic silica aerogel by using a Soxhlet extraction, and a hydrophobic silica aerogel prepared by using the method. Since the preparation method according to the present invention may simultaneously perform washing and drying of a hydrophobic silica wet gel as well as solvent substitution and may remove an extraction solvent without an additional separation process, a hydrophobic silica aerogel having low tap density and high specific surface area may be easily prepared.

The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Highly fluorescent metallo-supramolecules based on terpyridine-based monomers and transition metals have been obtained. These robust supramolecules provide high quantum yields with emissions from violet to blue, green or yellow color. They have emerged as promising emitters for polymeric light-emitting diodes (PLEDs) due to desirable properties such as high luminance, high purity, low cost, and good thermal stabilities. The supramolecule has molecular structure represented by the formula

wherein M represents Group IB, IIB VIIA, VIIIA or lanthanide metals; R is independently in each occurrence and is selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, or recognized donor and acceptor groups; X is independently in each occurrence and is nitrogen or carbon atom; R is selected from alkoxy, aryloxy, heteroaryloxy, alkyl, aryl, heteroaryl, alkyl ketone, aryl ketone, heteroaryl ketone, alkylester, arylester, heteroarylester, alkylamide, arylamide, heteroarylamide, alkylthio, arylthio, fluoroalkyl, fluoroaryl, amine, imide, carboxylate, sulfonyl, alkyleneoxy, polyalkyleneoxy, or combination thereof; n is an integer of 1 to 100,000; Z is a counter ion and is selected from the group of acetate, acetylacetonate, cyclohexanebutyrate, ethylhexanoate, halide, hexafluorophosphate, hexafluoroacetylacetonate, nitrate, perchlorate, phosphate, sulfate, tetrafluoroborate or fluoromethanesulfonate; y is an integer of 0 to 4.

A highly stable aqueous solution having a molecular cluster with dimensions which are small enough to ensure substantial chemical-physical stability thereof for a relatively long time. To prepare the solution a fluid treatment device is used, which comprises at least one chamber (7) and at least one anode (4) and one cathode (3) arranged in the chamber (7). The anode (4) and cathode (3) are at least partly made of a first metallic material. At least one of the at least one cathode (3) and anode (4) comprises a coating of nanoparticles (5) of a second metallic material.

A chimeric West Nile live virus comprised of the NY99 and WN1415 strains and an infectious DNA recombinant construct encoding for the chimeric virus are provided, as well as immunogenic compositions and their method of use.

A disc brake caliper for braking a wheel if a vehicle includes an inboard wall, an outboard wall spaced laterally from the inboard wall, each wall having a leading hole spaced a first distance on a first side from a lateral axis and extending through the respective wall, a trailing hole spaced a second distance on a second side opposite the first side from the lateral axis and extending through the respective wall, and a bridge interconnecting the inboard wall and the outboard wall.

A coating composition for making a protein microarray, the composition comprising a gelling agent or a precursor to a gelling agent and microspheres; the microspheres containing a dye represented by Formula (I):

wherein: R1 and R2 independently reprresent substituted or unsubstituted alkyl, aryl, carbocyclic ring, heterocyclic ring, or amino; and R3 represents H, alkylamino, dialkylamino, hydroxy, or alkoxy.

It is intended to provide a novel convenient approach for DNA quantitative analysis that overcomes the disadvantages of conventional formulations. A standard DNA sample is prepared by introducing a single-base substitution into target DNA, and a predetermined amount thereof is mixed with a target DNA sample. The target and standard DNAs are amplified using the same primers designed to amplify a region comprising the single-base substitution site. To a hybridization product of a probe capable of binding to a site immediately before the single-base substitution site, ddATP, ddGTP, ddCTP, and ddTTP are sequentially added one by one to perform a complementary strand synthesis reaction. Luciferase reaction-induced luminescence derived from the formed pyrophosphoric acid is detected. The target DNA is quantitated from the amount of the detected luminescence and the amount of the added standard DNA sample.

The invention concerns a method for manufacturing nanoporous metal oxide or metal active sites frameworks in which the metal oxide precursor is distributed into the framework in the form of a metal soap surfactant.

The invention also covers a nanostructure framework comprising metal oxide active sites which are evenly distributed in the framework.

The present invention provides a coke resistant catalyst and process for sequestration of carbon dioxide via reforming of methane to synthesis gas (a mixture of CO and H₂). The process provides a direct single step selective vapour phase carbon dioxide reforming of methane to syngas over gadolinium promoted mesoporous Ni-ZSM catalyst. The process provides almost 11-95% conversion of methane with H₂ to CO ratio of 0.82 to 1.

A preparing apparatus of an NC machining program prepares an NC machining program including a position instruction of a cutting portion of a rotary tool on the basis of a two-dimensional workpiece coordinate system having a Z-axis and an X-axis as coordinate axes. An operator inputs a lead clearance α and a radial clearance β to the preparing apparatus via an input operation section. A processing section converts the NC machining program prepared on the basis of the two-dimensional workpiece coordinate system into an NC machining program including a position instruction of a three-dimensional workpiece coordinate system having the X-axis, a Y-axis and the Z-axis as the coordinate axes, on the basis of the lead clearance α and the radial clearance β.

An object of the present invention is to provide a highly practical electrolytic solution which has a high oxidative decomposition potential, enables the dissolution and precipitation of magnesium to stably repeatedly proceed, and is easy to prepare. The present invention relates to an electrolytic solution for a magnesium battery comprising: a compound represented by the general formula (I), a Lewis acid or a compound represented by the general formula (A), and a solvent; and to the compound represented by the general formula (I). In the formula (I), two X's each independently represent a halogeno group, and R¹ represents an alkyl group having 1 to 6 carbon atoms; an alkoxy group having 1 to 6 carbon atoms; a phenoxy group; a —OMgX group (X is the same as X described above); an aryl group having 6 to 18 carbon atoms which has, as a substituent, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a vinyl group, a phenyl group, a phenoxy group, a halogeno group or a —B(OMgX)₂ group (X is the same as X described above) or is unsubstituted; or a monocyclic or bicyclic heterocyclic group which has, as a substituent, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, a vinyl group, a phenyl group, a phenoxy group, a halogeno group, or a —B(OMgX)₂ group (X is the same as X described above) or is unsubstituted. In the general formula (A), four R⁶'s each independently represent an alkyl group having 1 to 6 carbon atoms, a perfluoroalkyl group having 1 to 6 carbon atoms, a phenyl group, or a perfluorophenyl group.

The present invention discloses a DNA vaccine and its method of preparation, which employs DNA recombination technique to co-incorporate a fragment of tumor-associated gene and a fragment of cytokine gene into a vector. The administration of such DNA vaccine may enhance the immune response of the host through the co-expression of tumor-associated antigen and cytokine, and thereby achieve the therapeutic effect of inhibiting or retarding tumor growth.

A polyion complex (PIC) or a PIC nanoparticle that may be easily prepared, and that is finally disappeared in vivo due to its suitable biodegradability while exhibiting high stability in vivo, an immunotherapy agent comprising the PIC nanoparticle to which various antigen proteins or peptides may be easily conjugated or incorporated and/or which may be easily mixed with the antigen proteins or peptides, as well as a process for preparing thereof are provided. Specifically, a polyion complex (PIC) comprising a hydrophobized poly(acidic amino acid) and a basic polypeptide, a nanoparticle thereof having a particle shape, an immunotherapy agent comprising the PIC nanoparticle, as well as a process for preparing the PIC, comprising steps of introducing a hydrophobic amino acid to a poly(acidic amino acid) to prepare a hydrophobized poly(acidic amino acid), and dissolving the hydrophobized poly(acidic amino acid) prepared to a buffer, and it is mixed with a basic polypeptide dissolved in a buffer.

A fully baked, deep dish pizza crust is provided having a water activity in the range of about 0.9 to about 0.95. The deep dish pizza crust is ideally suited for use in a refrigerated, ready-to-eat pizza kit. The deep dish pizza crust is of a convenient size and shape (generally square and about 4 by about 4 by about 0.75 in. deep) and is especially adapted as a single serving or snack food product. Also provided is a kit for preparing ready-to-eat deep dish pizza, the kit including one or more deep dish pizza crusts, pizza sauce, cheese, and one or more pizza toppings. The deep dish pizza crusts are designed so that they can be nested so as to reduce the volume requirements in the kit. Each of the components of the pizza kit, including the deep dish pizza crusts, is hermetically sealed from the other food items to substantially retard or prevent flavor, moisture, and microbial migration from one food item to another. The deep dish pizza crusts retain a soft, desirable texture throughout their anticipated shelf lives.

The present invention relates to a new transition metal compound based on cyclopenta[b]fluorenyl group, a transition metal catalyst composition containing the same and having high catalytic activity for preparing an ethylene homopolymer or a copolymer of ethylene and one α-olefin, a method of preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin using the same, and the prepared ethylene homopolymer or the copolymer of ethylene and α-olefin.

The present invention relates to a coating composition comprising

• • (a) at least one hydroxyl-containing compound (A),
  • (b) at least one compound (B) having free and/or blocked isocyanate groups, and
  • (c) at least one phosphate-containing catalyst (C) for the crosslinking of silane groups,
  • (d) at least one further catalyst (D),

one or more constituents of the coating composition containing hydrolyzable silane groups, wherein the catalyst (D) is a bicyclic amine.

An 8-hydroxyjulolidine compound, having the formula:(wherein R1 and R2 represent independently H, halogen, hydroxyl or alkyl) is prepared by the following chemical reaction:wherein X and Y represent independently halogen, acyloxyl, sulfonyloxyl or phosphoryloxyl and R1 and R2 are as defined above.

A method of preparing high refractive index nanoparticles includes adding a polymer stabilizer to a solvent, and forming high refractive index nanoparticles by adding high refractive index nanoparticle materials to the solvent and stirring the same. The high refractive index nanoparticle materials may have a refractive index equal to or greater than 1.8, and sizes of the high refractive index nanoparticles may be determined by adjusting a content of the polymer stabilizer to control an amount of the polymer stabilizer adsorbed to surfaces of the high refractive index nanoparticles.

Disclosed herein are a cocoon-based, dental barrier membrane for guided bone regeneration and a method for manufacturing the same. The cocoon-based, dental barrier membrane is manufactured by dividing a cocoon into two or more fragments in a predetermined form, the cocoon having a shell having a first thickness. The dental barrier membrane is biocompatible, has excellent tensile strength and porosity, and promotes osteogenesis in a bone defect.

A method and system for water-priming carbon micropore filter media using negative pressure. The method includes placing dry filter elements in a polymer bag, applying a vacuum of no more than approximately 33 kPa above zero pressure, and heat-sealing the bag using a heat-set bar; submerging, by a consumer, the vacuum-sealed bag with its the filter elements in water; the filters in the vacuum sealed bag are at least partially submerged, puncturing the bag to form one or more small openings in the bag below the water line. Breeching the vacuum causes the water to flow through the openings into the bag and the filter(s) to equalize the pressure between the water and the previously vacuum environment of the plastic bag, causing the surrounding water to quickly flow into the micro-pores of the filter media, thereby priming the carbon filter for use in the gravity-fed water-purification system.

The invention relates to a pharmaceutical composition for modulation of T cell and B cell responses by antigen- or allergen-specific immunotherapy in combination with peripheral tolerance-inducing phagocytosis, made of one or more preparations and comprising one or more matrices suitable for locally restricted sustained release of a physiologically effective dose of at least one antigen or allergen, liposomes tailored for effective phagocytosis, one or more immune modulators of phagocytosis, and one or more immune modulators suitable for enhancing the suppressive function of regulatory T cells at the site of antigen or allergen presentation.

In order to provide a transformant by which a high containment effect is obtained and which can be prepared by a simple procedure, a method for producing the transformant, and a method for detecting the presence of a reduced phosphorous compound with use of the transformant, a transformant in accordance with an embodiment of the present invention is a transformant which is defective in functions of a gene encoding a phosphate transporter protein and a gene encoding a phosphate ester transporter protein and into which a gene encoding a hypophosphite transporter protein is introduced.