51 results about "Ciclopentolato" patented technology

A process for the preparation of 1-[(cyano) aryl methyl] cyclohexanol of the general formula 1 (1a-d) by reacting cyclohexanone with the carbanions of an aryl acetonitrile of the general formula 3 (3a-d), a) R1=H, R2=H b) R1=OMe R2=H c) R1=OMe R2=OMe d) R1=OMe R2=cyclopentyloxy using a base, isolating the compound of formula I and purifying the compound of formula 1a-d by crystallisation is disclosed.

The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatment of diseases characterized by excessive lipofuscin accumulation in the retina.

The invention relates to a preparation method of (3R, 5R)-3,5-dihydroxy-6-methyl cyan-caproate (I) and belongs to the technical field of pharmaceutical chemistry. The preparation method concretely comprises the following steps of: firstly, carrying out asymmetric catalysis alcoholysis on 3-siloxy cyclopentane anhydride (II) to prepare (R)-3-siloxy-5-alkoxy-5-oxo-pentanoate (III); secondly, condensing the (R)-3-siloxy-5-alkoxy-5-oxo-pentanoate (III) and methyl cyanoacetate to prepare (R)-2-cyano-3-oxo-5-siloxy diethyl pimelate (IV); thirdly, carrying out decarboxylation on the (R)-2-cyano-3-oxo-5-siloxy diethyl pimelate (IV) to prepare (R)-3-hydroxy-5-oxo-6-benzyl cyanohexanoate (V) by using desilicication protective groups; and fourthly, carrying out asymmetric reduction on the (R)-3-hydroxy-5-oxo-6-benzyl cyanohexanoate to prepare a product of (3R,5R)-3,5-dihydroxy-6-methyl cyan-caproate (I). The preparation method is mild in reaction conditions, simple and convenient to operate, high in stereoselectivity, environment-friendly, and suitable for industrial production; and products have high yield, the used chiral catalyst is small in dosage and can be recovered with fix quantify, raw materials which are easily obtained are low in cost, and particularly hypertoxic cyanides are avoided.

The invention discloses an oil phase dispersion sunblocking concentrate of nanometer titania and a preparation method as well as application thereof. The concentrate of the invention comprises the following materials by weight: (a) 35-60% of nanometer titania; (b) 30-62% of organic solvent which is one or more of dimethyl polysiloxane, cyclopentasiloxane, alkyl benzoate, caprylic triglyceride and capric triglyceride; (c) 1-10% of dispersing accessory which is one or more of polyhydroxystearate, polyhydroxystearic acid and polyglyceryl polysiloxane. Characterized by uniformity and stability, small viscosity, high content of effective components, obvious blocking effect against ultraviolet rays and complete permeability to visible light, the concentrate provided in the invention is beneficial for the production and processing of various sunblocking cosmetics.

The present invention provides a polymer containing thienothiophene, benzothiadiazole and cyclopentadithiophene, a preparation method and an application thereof. The polymer is a polymer P having the following general formula, wherein R1 and R2 are the same or different H or C1-C12 alkyl, and n is a natural number of 5-60. According to the present invention, the three units such as thienothiophene, benzothiadiazole and cyclopentadithiophene in the polymer are combined to form the repeated unit having the acceptor-donor-acceptor-donor (A-D-A-D) form so as to enhance the charge transporting in the polymer molecule, reduce the band gap of the polymer, and expand the light absorption range of the polymer material, such that the polymer has characteristics of excellent sunlight matching property, excellent carrier mobility property and simple and controllable preparation method, and has good application prospects in the fields of polymer solar cells, organic electroluminescent devices and other optoelectronic materials. The polymer P is as the follow.

The invention provides a water-in-oil type emulsified cosmetic which is excellent in stability, isolation effect and skin feeling. The water-in-oil type emulsified cosmetic is prepared by comprising the following components: (A) 0.5-10wt% of a silicone elastomer, (B) 0.2-10wt% of dimethyl polysiloxane with the polymerization degree of more than 350 and less than 1500, (C) 3-28wt% of dimethyl polysiloxane and/or decamethyl cyclopentasiloxane with the polymerization degree of more than 1 and less than 6, (D) 0.5-25wt% of ethanol and (E) water. Furthermore, the invention also provides a skin care method which applies the water-in-oil type emulsified cosmetic provided by the invention to the skin and maintains the skin.

The invention provides a perfume mixture, preferably perfume oil, which comprises: (a) ethyl 2-(cyclopent-2-enyl)acetate (I); and (b) at least one perfume with a flowery olfactory note, comprising alcohols or aldehydes with a molar mass of = 210 g/mole; and/or (c) at least one perfume comprising ketones, ethers or esters with a molar mass of 190-250 g/mole.

The invention provides an application of a 3-[[2-[3-oxo-(1, 2-benzisoxazole-6-yl) methoxyl]-5-[(2-hydroxyl-4-cyclopentoxyl benzoyl)] phenyl] propionic acid (compound I) in preparation for treatment of connexin CX31 mediated skin disease. The connexin CX31 mediated skin disease comprises erythrokeratodermia variabilis or psoriasis. The pharmacological experiment proves that a low-dose group and a high-dose group of the compound I can remarkably reduce skin damage degree of a psoriasis animal sample; the content of TNF-alpha in murine serum can be restrained by the low-dose group of the compound I, then inflammatory cell infiltration is restrained, the inflammatory response is relieved, and the compound I has good psoriasis treatment effect and can be used for treating the connexin CX31 mediated skin disease.

The invention belongs to the field of pharmacy, and particularly relates to a compound reserpine medicine composition for treating hypertension and a preparation method of the compound reserpine medicine composition. The compound reserpine medicine composition comprises raw materials in parts by weight as follows: 0.03 parts of reserpine, 1 part of hydralazine hydrochloride, 0.025 parts of cyclopenthiazide, 1.5 parts of hydrochlorothiazide, 2 parts of promethazine hydrochloride, 30 parts of potassium chloride, 5 parts of rutin, 2.5 parts of chloroquine phosphate, 1 part of vitamin B1, 1 part of vitamin B6, 2-10 parts of a stabilizer fumaric acid and other pharmaceutical adjuvants. Experiment results show that the medicine composition takes effect quickly, has long-lasting medicine efficacy, facilitates long-term treatment of a patient and is safe to take; besides, the formula has a high technological stability and is not influenced by environmental temperature and humidity, differences between different bathes of preparations are remarkably reduced, and the stability of samples is improved.

The invention discloses a synthetic method of 5-nitryl-2,4-diphenyl cyclopentyl-2-ene-1,1-dinitrile and a derivative thereof, which comprises the following steps of: in the presence of a catalyst, adding substituted or non-substituted 1-bromine-1-nitryl-2-styrene and substituted or non-substituted 1,1-dinitrile-2-methyl-2-styrene into a reaction solvent for reaction, and post processing a reaction product to obtain the 5-nitryl-2,4-diphenyl cyclopentyl-2-ene-1,1-dinitrile and the derivative thereof. The method has the advantages of flexible reaction time, higher yield, low price and easy obtainment of most solvents, environmental protection, simple operation, wide application range and the like and is suitable for industrialized production. The invention also discloses the 5-nitryl-2,4-diphenyl cyclopentyl-2-ene-1,1-dinitrile and the derivative thereof, which have the following structural formulae; and the compound has better antibacterial and insecticidal actions.

The invention relates to the technical field of eyeliner refills, in particular to a waterproof eyeliner refill prepared from the following raw materials in parts by weight: 10-20 parts of a film-forming agent, 15-18 parts of a thickening agent, 5-10 parts of an emollient, 5-8 parts of a suspending agent, 10-12 parts of a filling agent, 8-15 parts of a coloring agent, 6-10 parts of a skin conditioner, 1-4 parts of a preservative and 2-5 parts of an antioxidant, wherein the film-forming agent comprises one or a compound of more of trimethylsiloxysilicate, cyclopentasiloxane, polypropylsilsesquioxane, a dimethiconol cross-linked polymer and isododecane. By adding the trimethylsiloxysilicate, the cyclopentasiloxane and the isododecane, the product has excellent transfer resistance and elutionresistance, is long-acting and durable, enhances the gloss and color strength of the product, is smooth but not sticky after being dried, and has excellent film-forming property and water resistance.

The invention provides a method for synthesizing butyrolactone which is shown as the molecular formula (1) and butyrolactone obtained by the method. The method is characterized by obtaining the butyrolactone by carrying out free radical addition of alcohol and 3-butenoic acid or ester thereof; in the formula (1), R1 is hydrogen, a methyl or an ethyl; and R2 is a propyl, a butyl, an amyl, a hexyl, a heptyl, an octyl, a nonyl, a phenyl, a benzyl, a cyclopentyl, a cyclopentylmethyl, a cyclohexyl or a cyclohexylmethyl. The method can realize clean production and obtain high yield.

The invention discloses shoe polish prepared from a wool fat extract and a preparation method of the shoe polish, and the shoe polish is prepared by taking the modified wool fat extract as a main raw material and simultaneously adding substances such as modified mixed wax, a regulator and an emulsifier. The modified wool fat extract is obtained by modifying a wool fat extract through a modifier, and the modifier is a mixture of sorbitan monooleate, fatty alcohol-polyoxyethylene ether and (1-fluoro-2-phenyl vinyl) (4-aminophenyl) thioether; and the modified mixture is prepared by taking liquid paraffin, microcrystalline wax and carnauba wax as raw materials and under the promotion action of an accelerant, and the accelerant is a mixture of 3, 4, 6-trihydroxy-5-oxo-5H-benzo [7] cyclopent-8-carboxylic acid propyl ester, bisphenol A glycerol dimethacrylate and 1, 2-epoxyhexyl-5-ene. The shoe polish prepared from the lanolin extract enables leather to have excellent glossiness and waterproofness, and meanwhile, the shoe polish has very high wiping resistance and durability and is wide in application range.

The invention belongs to the field of oilfield tracing, and particularly relates to an environment-friendly tracer controlled release capsule and a method thereof. Aiming at the problems of poor slowrelease and stability of an existing oilfield tracer, the invention provides the following scheme that the controlled release capsule is prepared from the following raw materials in parts by weight: 10 to 15 percent of a biological coloring agent, 10 to 15 percent of an acid-base regulator, 5 to 10 percent of methyl fluorobenzoate, 1 to 5 percent of potassium hydrogen sulfate, 2 to 7 percent of cyclobutylsiloxane, 1 to 5 percent of cyclopentasiloxane, 1 to 5 percent of polyvinyl alcohol, 1 to 5 percent of chitosan, 2 to 6 percent of sodium carboxymethylcellulose, 3 to 7 percent of polyethyleneglycol and 4 to 9 percent of di-iso-decylphthalate. The tracer controlled release capsule provided by the invention is injected into a target stratum along with fluid; when the tracer controlled release capsule is in contact with target fluid, a tracer component starts to be slowly released; and the tracer component is carried out by the target fluid; the concentration of the tracer component issampled and analyzed at a wellhead, so that the aim of monitoring the target fluid is fulfilled.

The invention discloses a synthesis method of a seven-membered cyclopenta [b] indole derivative, which is characterized in that an acetylenic ketone compound and a cyclohexanone ester compound are used as raw materials, and the seven-membered cyclopenta [b] indole derivative shown as a formula (b) (See the specification) is synthesized by adopting a 'one-pot method'. The synthesis method specifically comprises the following steps: step 1, promoting C-C bond insertion through alkali to realize an expansion reaction so as to obtain a seven-membered ring compound, and step 2, carrying out a nucleophilic addition reaction under the action of p-toluenesulfonic acid. The preparation method provided by the invention has the advantages of simple and easily available raw materials, good universality, simple and convenient post-treatment, good yield, environmental friendliness and the like. The invention also provides an application of the seven-membered ring cyclopenta [b] indole derivative shown in the formula (b) in medicines.

A skin protecting product that includes cyclopentasiloxane, disiloxane, octylacrylamide, acrylates, butylaminoethyl methacrylate copolymer, isopropyl myristate, hydroxypropyl gluconomide, hydroxyproply ammonium gluconate, phenoxyethanol, Cetearyl alcohol, cetyl alcohol, cetyl PPG, PPG-10/1 dimethicone, hydroxyethyl urea, zinc oxide, titanium oxide, fragrance such as perfumes or colognes, vitamin C, and isodecyl neopentanoate. The skin protecting product is applied daily along with sunscreen to help reduce the chance of skin damage related conditions and illnesses that result from sun exposure. The product is applied on hard to reach areas such as the scalp. The product is weightless, so the user is not bothered by the application of the product. The skin protecting product comes in various forms such as a spray, gel or lotion.