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Compound reserpine medicine composition for treating hypertension and preparation method of compound reserpine medicine composition

A technology of compound reserpine and its composition, which is applied in the field of pharmacy, can solve the problems of short drug effect duration, poor drug treatment effect, and long onset time, and achieve long drug effect duration, quality assurance and curative effect, and onset of effect. short-term effect

Inactive Publication Date: 2015-12-30
ZHENGZHOU TAIFENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the treatment of hypertension, conventional antihypertensive drugs have large blood pressure fluctuations in the process of reducing blood pressure in hypertension, poor drug treatment effect, large side effects, long onset time, and short drug effect duration

Method used

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  • Compound reserpine medicine composition for treating hypertension and preparation method of compound reserpine medicine composition
  • Compound reserpine medicine composition for treating hypertension and preparation method of compound reserpine medicine composition
  • Compound reserpine medicine composition for treating hypertension and preparation method of compound reserpine medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 compound reserpine tablet and preparation method thereof

[0037] Dissolve the prescribed amount of reserpine, pentathiazine and hydroxypropyl cellulose in ethanol first, add the other auxiliary materials except the lubricant into the fluidized bed granulation coating machine, and spray them into the above-mentioned After the ethanol solution is granulated, it is dried, after the granulation is sized, a lubricant is added, mixed evenly, and tabletted.

[0038] (1) Composition prescription

[0039] Reserpine 0.3g, hydralazine hydrochloride 10g, pentathiazide 0.25g, hydrochlorothiazide 15g, promethazine hydrochloride 20g, potassium chloride 300g, rutin 50g, chloroquine phosphate 25g, vitamin B110g, vitamin B610g, fumaric acid 50g, lactose 613g, croscarmellose sodium 36g, hydroxypropyl cellulose 50g and magnesium stearate 10g.

[0040] (2) Preparation process

[0041] Weigh the prescribed amount of reserpine and pentathiazine, add them into 1000ml of 95% e...

Embodiment 2

[0044] Embodiment 2 compound reserpine tablet and preparation method thereof

[0045] Basically the same as Example 1, the difference is:

[0046] The prescription of compound reserpine tablet of the present invention consists of:

[0047] Reserpine 0.6g, Hydralazine Hydrochloride 20g, Cyclopenthiazine 0.5g, Hydrochlorothiazide 30g, Promethazine Hydrochloride 40g, Potassium Chloride 600g, Rutin 100g, Chloroquine Phosphate 50g, Vitamin B120g, Vitamin B620g, Fumaric Acid 120g, lactose 130g, croscarmellose sodium 70g, hydroxypropyl cellulose 100g, magnesium stearate 30g.

[0048] Explanation: The purified water and ethanol added in this example are prepared through the preparation method and finally dried to obtain the product, and the added purified water and ethanol are all evaporated;

[0049] The preparation process of the compound reserpine tablet of the present invention is the same as that in Example 1.

Embodiment 3

[0050] Embodiment 3 compound reserpine tablet and preparation method thereof

[0051] Basically the same as Example 1, the difference is:

[0052] The prescription of compound reserpine tablet of the present invention consists of:

[0053] Reserpine 0.3g, hydralazine hydrochloride 10g, pentathiazide 0.25g, hydrochlorothiazide 15g, promethazine hydrochloride 20g, potassium chloride 300g, rutin 50g, chloroquine phosphate 25g, vitamin B110g, vitamin B610g, fumaric acid 50g, lactose 315g, microcrystalline cellulose 315g, croscarmellose sodium 35g, hydroxypropyl cellulose 50g, micronized silica gel 5g and magnesium stearate 10g.

[0054] Explanation: The purified water and ethanol added in this example are prepared through the preparation method and finally dried to obtain the product, and the added purified water and ethanol are all evaporated;

[0055] The preparation process of the compound reserpine tablet of the present invention is the same as that in Example 1.

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Abstract

The invention belongs to the field of pharmacy, and particularly relates to a compound reserpine medicine composition for treating hypertension and a preparation method of the compound reserpine medicine composition. The compound reserpine medicine composition comprises raw materials in parts by weight as follows: 0.03 parts of reserpine, 1 part of hydralazine hydrochloride, 0.025 parts of cyclopenthiazide, 1.5 parts of hydrochlorothiazide, 2 parts of promethazine hydrochloride, 30 parts of potassium chloride, 5 parts of rutin, 2.5 parts of chloroquine phosphate, 1 part of vitamin B1, 1 part of vitamin B6, 2-10 parts of a stabilizer fumaric acid and other pharmaceutical adjuvants. Experiment results show that the medicine composition takes effect quickly, has long-lasting medicine efficacy, facilitates long-term treatment of a patient and is safe to take; besides, the formula has a high technological stability and is not influenced by environmental temperature and humidity, differences between different bathes of preparations are remarkably reduced, and the stability of samples is improved.

Description

technical field [0001] The invention relates to pharmaceutical preparation technology in the field of pharmacy, in particular to a compound reserpine pharmaceutical composition for treating hypertension and a preparation method thereof. Background technique [0002] Reserpine is an adrenergic neuron-blocking antihypertensive drug, which achieves antihypertension, slows heart rate and inhibits blood pressure by depleting adrenaline at peripheral sympathetic nerve endings, catecholamines and serotonin in heart, brain and other tissues. The role of the central nervous system. Widely used in the treatment of mild and moderate hypertension; antihypertensive and stable drugs, the antihypertensive effect is slow, but the effect is long-lasting, and the effect disappears slowly after stopping the drug, especially when combined with thiazide diuretics, it has a good effect , is one of the main components of commonly used compound antihypertensive drugs. Hyalalazine hydrochloride is...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/20A61K47/12A61P9/12A61K31/4415A61K31/4706A61K31/51A61K31/502A61K31/5415A61K31/549A61K31/7048
Inventor 任逢晓
Owner ZHENGZHOU TAIFENG PHARMA CO LTD
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