The invention relates to the technical field of drug residue detection and aims at providing a method for detecting residue of 18 illegally-added blood-glucose-reducing and antihypertensive drugs in ahealth product, which has the characteristics of rapidness, accuracy, simplicity and low cost. According to the technical scheme, the method for detecting the residue of the 18 illegally-added blood-glucose-reducing and antihypertensive drugs in the health product comprises the following steps: (1) preparing homemade extract, namely refluxing a mixture of methyl alcohol, ethyl acetate and decyl alcohol polyoxyethylene ether for 30 minutes at the temperature of 60-65 DEG C, and cooling for later use; (2) taking health product tablets, capsules or granules, breaking, accurately weighing 3-10g of sample, putting into a centrifugal tube provided with a plug, then adding 20-60mL of homemade extract, mixing, carrying out ultrasonic extraction for 2-10 minutes, carrying out centrifugal separation, then taking 1mL of supernatant, carrying out blow drying with nitrogen, and redissolving with 1mL of 50% acetonitrile aqueous solution; and (3) filtering the redissolved solution by virtue of a 0.22 microns microporous membrane, and carrying out HPLC-MS/MS (high performance liquid chromatography+mass spectroscopy+secondary mass spectroscopy detection) determination on filtrate.