Antihypertensive peptides and antihypertensive proteins and applications thereof

A blood pressure-lowering peptide and blood-pressure-lowering technology, which is applied in blood-pressure-lowering peptides and blood-pressure-lowering proteins and their application fields, can solve problems such as blood pressure rise, and achieve a synergistic blood pressure-lowering effect

Active Publication Date: 2016-12-07
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bradykinin has the function of dilating blood vessels, but when bradykinin is in an in...

Method used

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  • Antihypertensive peptides and antihypertensive proteins and applications thereof
  • Antihypertensive peptides and antihypertensive proteins and applications thereof
  • Antihypertensive peptides and antihypertensive proteins and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Embodiment 1: antihypertensive drug tablet

[0104] The antihypertensive drug tablet of this embodiment contains 5wt% of hypotensive peptide and 95wt% of excipients. The hypotensive peptide is the first hypotensive peptide, and the excipients are starch and magnesium stearate.

[0105]In fact, the hypotensive peptide can also be any one or several of the second hypotensive peptide, the third hypotensive peptide and the hypotensive protein. The auxiliary material can be any one or more of starch, sucrose and maltodextrin. The content of hypotensive peptide can be 1-20wt% and the content of auxiliary materials can be 80wt-99wt%.

Embodiment 2

[0106] Embodiment 2: antihypertensive health products

[0107] The antihypertensive drug tablet of this embodiment contains 15wt% of hypotensive peptide and 85wt% of excipients. The hypotensive peptide is the third hypotensive peptide, and the auxiliary materials are starch, honey, dietary fiber, arginine, and glutathione.

[0108] Wherein, the blood pressure-lowering peptide can also be any one or more of the first blood-pressure-lowering peptide, the second blood-pressure-lowering peptide and the blood-pressure-lowering protein. The content of hypotensive peptide can be 1-20wt% and the content of auxiliary materials can be 80wt-99wt%.

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Abstract

The invention discloses certain antihypertensive peptides and antihypertensive proteins and applications thereof. Amino acid sequences of the antihypertensive peptides are TTW, VHW and KAKW respectively; amino acid sequences of the antihypertensive proteins contain one or more of TTW, VHW and KAKW. The antihypertensive peptides and the antihypertensive proteins can restrain the activities of angiotensin converting enzymes so as to play roles in lowering blood pressure, and can be prepared into various antihypertensive drugs or healthcare products.

Description

technical field [0001] The invention belongs to the technical field of food or medicine, and relates to blood pressure lowering peptides, blood pressure lowering proteins and applications thereof. Background technique [0002] Angiotensin converting enzyme (ACE) is an enzyme that can cause blood pressure to increase, and it has the following two regulatory pathways. [0003] First, angiotensin-converting enzyme can cut off two amino acids (His-Leu) at the end of angiotensin I (AngiotensinI), thereby converting angiotensin I into angiotensin II (AngiotensinII). Wherein, the amino acid sequence of angiotensin I is Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, abbreviated as DRVYIHPFHL. The amino acid sequence of angiotensin II is Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, abbreviated as DRVYIHPF. Angiotensin II is a vasoconstrictor that promotes constriction of blood vessels, thereby raising blood pressure. [0004] Second, angiotensin-converting enzyme can excise two amino acids (Phe-Arg...

Claims

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Application Information

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IPC IPC(8): C07K5/083C07K5/11A61K38/06A61K38/07A61P9/12A23L33/18
CPCA61K38/00A23V2002/00A61P9/12A23L33/18C07K5/1019A23V2200/326A61K38/06A61K38/07
Inventor 谢静莉陈绪军朱巧莎吴俊杰周琰魏东芝
Owner EAST CHINA UNIV OF SCI & TECH
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