4 results about "Felodipine" patented technology

The application relates to application of a dihydropyridine compound or a salt thereof in preparation of a medicine for preventing and / or treating HPV infection, and belongs to the technical field of medicines and pharmaceutical preparations. The application provides application of the dihydropyridine compound or the salt thereof in preparation of the medicine for preventing and / or treating HPV infection, wherein the dihydropyridine compound is selected from one or more of nifedipine, amlodipine, lercanidipine, nimodipine, nitrendipine, nisoldipine, felodipine, benidipine, lacidipine and azelnidipine. The application scheme first reports the application of the dihydropyridine compound or the salt thereof in prevention and / or treatment of HPV, and in-vitro cell experiments are carried out through azelnidipine in the dihydropyridine compound, and further, the inhibiting effect of the dihydropyridine compound on HPV virus is verified through medicine administration of a mouse intradermal virus inoculation model and medicine administration of a mouse vaginal virus inoculation model.

The utility model discloses a non - furosemide reation kettle of protection structure, specifically at related to pharmaceutical preparation technical field, including the reation kettle, the reation kettle top is equipped with the sealing cover, the sealing cover top is fixedly connected with the feed pipe, the reation kettle top is provided with the heat exchange protection mechanism, the heat exchange protection mechanism includes the fixed box, the fixed box is fixed in the sealing cover top, the sealing cover top is fixedly installed with the heat exchange box in the fixed box one side, the utility model discloses through circulating pump drive coolant circulation, realizes the efficient heat exchange to the reation kettle, and the air release valve opens and makes the high -temperature gas through the air release pipe and enters the heat exchange box, and its heat is absorbed by coolant, reduces gas temperature and maintains the pressure stability in the reation kettle, ensures that non - furosemide production reaction is carried out under the suitable temperature and pressure condition, improves product quality and production efficiency, avoids the scald, fire and other safety problems that high -temperature gas direct emission brings, provides the protection effect.

The present application provides a kind of felodipine osmotic pump controlled-release tablets and preparation method thereof, the osmotic pump controlled-release tablet is composed of osmotic pump controlled-release tablet core and water-insoluble coating layer (single side laser punching), the weight percentage of the felodipine osmotic pump controlled-release tablet contains immediate-release coating layer, controlled-release coating layer, propelling coating layer, water-insoluble coating layer is (5~20) :(5~30) :(10~50) :(5~30).The present application also provides a kind of preparation method of felodipine osmotic pump controlled-release tablet and its application in treating hypertension.The formulation of the felodipine osmotic pump controlled-release tablet of the present application is reasonable, and production process is simple and easy to control;By replacing traditional controlled-release tablet polyethylene oxide with different povidone, the controllability of felodipine osmotic pump controlled-release tablet preparation is significantly improved, and the difficulty of cleaning in production is reduced.

The present application relates to the technical field of pharmaceutical preparation, and particularly discloses a felodipine enalapril tablet and a preparation method thereof. The felodipine enalapril tablet takes hydrochloric acid felodipine and maleic acid enalapril as active ingredients, and the auxiliary materials include lactose monohydrate, microcrystalline cellulose, crosslinked polyvinylpyrrolidone, sodium bicarbonate, povidone and magnesium stearate. The tablet is prepared through the processes of separate granulation, mixing, tabletting and coating. The felodipine enalapril tablet prepared by the present application has similar dissolution curve to the reference preparation, uniform content and good stability.