The application discloses irbesartan and hydrochlorothiazide tablets and a preparation method thereof. The tablet comprises irbesartan granules and hydrochlorothiazide granules. The irbesartan granules comprise irbesartan, hydroxyphenyl cellulose, glycerophosphoric acidcalcium, a disintegrant and a binder. The hydrochlorothiazide granules comprise hydrochlorothiazide, a diluent, a disintegrant and a binder. The tablet can solve the problems of easy agglomeration of irbesartan and hydrochlorothiazide, and difficulty in controlling the content uniformity due to the great difference in the dosage. Meanwhile, the tablet can effectively overcome the poor solubility of irbesartan and hydrochlorothiazide, and good dissolution effect is obtained.