3 results about "Nitrendipine" patented technology

The application relates to application of a dihydropyridine compound or a salt thereof in preparation of a medicine for preventing and / or treating HPV infection, and belongs to the technical field of medicines and pharmaceutical preparations. The application provides application of the dihydropyridine compound or the salt thereof in preparation of the medicine for preventing and / or treating HPV infection, wherein the dihydropyridine compound is selected from one or more of nifedipine, amlodipine, lercanidipine, nimodipine, nitrendipine, nisoldipine, felodipine, benidipine, lacidipine and azelnidipine. The application scheme first reports the application of the dihydropyridine compound or the salt thereof in prevention and / or treatment of HPV, and in-vitro cell experiments are carried out through azelnidipine in the dihydropyridine compound, and further, the inhibiting effect of the dihydropyridine compound on HPV virus is verified through medicine administration of a mouse intradermal virus inoculation model and medicine administration of a mouse vaginal virus inoculation model.

The invention provides a candidate medicine for promoting the embryo implantation efficiency of an endometritis type RIF patient, and belongs to the technical field of embryo implantation. In order to solve the problem of how to discover potential intervention drugs aiming at the endometritis type RIF pathological mechanism, a five-step efficient drug screening strategy based on an in-vitro implantation model of the endometritis type RIF is adopted, so that the reliability and function correlation of a screening result are ensured. According to the invention, a candidate drug screened by adopting a five-step method efficient drug screening strategy comprises any one of the following drugs: evocamide, choline, nitrendipine, megestrol acetate, pranoprofen, oxaliplatin, adenine, ensorizole, baicalin and diacerein. Evocamide, choline and nitrendipine in the candidate drugs are three drugs with the best implantation promotion efficiency for patients with endometritis type RIF.

The invention relates to a nitrendipine tablet and a preparation method thereof. The nitrendipine tablet is prepared from the following components in parts by weight: 1 part of nitrendipine, 7.5 to 8.5 parts of lactose, 1.8 to 2.2 parts of sodium carboxymethyl starch, 2.6 to 3.4 parts of microcrystalline cellulose, 1.8 to 2.2 parts of povidone K30 and 0.1 to 0.2 part of magnesium stearate. The tablet provided by the invention is beneficial to uniform distribution of the content of nitrendipine by adjusting the components and the proportion. According to the method provided by the invention, the dissolution rate of the nitrendipine tablet meets the requirement by designing the charging sequence and mode of each auxiliary material.