76 results about "Diacerein" patented technology

Methods and compositions for treating and / or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.

The present invention provides methods of treating type II diabetes using combinations of diacerein or its derivatives with other antidiabetic agents. The methods may also allow improving glycemic control of type II diabetes patients and / or reducing side effects and / or cardiovascular risks of antidiabetic agents.

The invention provides diacerein injection type thermo-sensitive gel. The diacerein injection type thermo-sensitive gel comprises diacerein, poloxamer 407, poloxamer 188 and HPMC (hydroxypropyl methylcelluloses). A concentration ratio (w / v) of the diacerein to the P-407 to the P-188 to the HPMC is 0.5%:17-22%:1-5%:0.3-1.0%. A method for preparing the diacerein injection type thermo-sensitive gelincludes preparation steps of swelling the HPMC by the aid of water at the room temperature to obtain HPMC solution; uniformly scattering the poloxamer P-407 and the poloxamer P-188 on the surface ofthe HPMC solution and carrying out overnight swelling and dissolving to obtain blank thermo-sensitive gel solution; sufficiently dissolving the diacerein by the aid of DMSO (dimethyl sulfoxide) to obtain diacerein solution and then adding the diacerein solution into the blank thermo-sensitive gel solution to obtain diacerein thermo-sensitive gel solution. The diacerein injection type thermo-sensitive gel and the method have the advantages that the diacerein injection type thermo-sensitive gel prepared by the aid of the method is prepared from water-soluble high-polymer materials, is excellentin histocompatibility and bio-adhesion, is long in detention time at medication positions, can be slowly released and is long-acting, and the purpose of reducing side effects on gastrointestinal tracts can be achieved.

The invention relates to a diacerein composition with good leaching property, and preparation and a use thereof. The diacerein composition consists of diacerein and pharmaceutically acceptable adjuvants. The pharmaceutically acceptable adjuvants are selected from one or more from starch, microcrystalline cellulose, lactose, a disintegrating agent, a lubricant, an edulcorant and an adhesive. The diacerein composition quickly enters a blood circulation system more easily than an imported diacerein capsule, has better storage stability and is suitable for application to preparing drugs for preventing and treating arthritis, nephritis, glomerulonephritis and psoriasis as well as an interleukin-1 inhibitor.

A once-daily controlted-release formulation of diacerein for treating inflammatory or autoimmune diseases or their complications, with reduced adverse side effects and methods of treating such diseases are disclosed.

The present invention provides methods of treating type II diabetes using combinations of diacerein or its derivatives with other antidiabetic agents. The methods may also allow improving glycemic control of type II diabetes patients and / or reducing side effects and / or cardiovascular risks of antidiabetic agents.

The present invention provides methods of treating type II diabetes using combinations of diacerein or its derivatives with other antidiabetic agents. The methods may also allow improving glycemic control of type II diabetes patients and / or reducing side effects and / or cardiovascular risks of antidiabetic agents.

The invention relates to the field of pharmaceutical preparations, in particular to a diacerein solid dispersion preparation and a preparation method thereof. The diacerein solid dispersion preparation is prepared from diacerein, povidone, a specific lubricating agent, a specific disintegrating agent and a diluent. The dissolution effect, bioavailability and stability of the diacerein solid dispersion preparation are beneficial to the industrial production of the diacerein solid dispersion preparation.

The invention provides a diacerein composition and a preparing method thereof. The diacerein composition is characterized by being prepared from the following raw materials in parts by weight: 1 part of diacerein, 0.01-0.1 part of poloxamer, 0.001-0.1 part of sodium benzoate, 0.3-6 parts of a filler, 0-0.5 part of a disintegrant, 0.01-0.5 part of an adhesive, 0-0.8 part of a moistening agent and 0.01-0.5 part of a lubricant. The diacerein composition not only can improve the solubility and the bioavailability of medicine, but also can reduce side effect generated when a patient takes the medicine.