29 results about "Endometritis" patented technology

The invention discloses a degradable slow-release drug delivery device aiming at gynecological chronic inflammation and application, the degradable slow-release drug delivery device is of a hollow column-shaped or uterus-like structure matched with a gynecological physiological structure, the diameter of a hollow cavity of the hollow column-shaped structure is 2-5mm, and an arc-shaped bulge is arranged at the top end of the uterus-like structure; by replacing the drug delivery main body structure and adjusting the length of the catheter, treatment of various chronic inflammations such as cervicitis, endometritis and annexitis can be achieved, various devices do not need to be developed, the clinical use cost is reduced, the preparation process of each component of the device is the existing mature technology, the equipment investment cost is low, and the device is suitable for large-scale industrial production.

The current invention is in the field of molecular biology / pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and / or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention / reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

The invention discloses a method for constructing a chronic endometritis rat model based on Hungata (preservation number: DSM 13479), and belongs to the technical field of animal models. The bacterial strain is subjected to anaerobic culture to prepare a bacterial solution, 150 mu L vagina perfusion is performed twice every 3 days for 3 weeks, rat endometrial inflammation reaction is induced, and endometrial atrophy and endometrial inflammation cell infiltration are taken as pathological characteristics. According to the invention, the problems of high infection, high death rate and the like caused by traditional injection of lipopolysaccharide or pathogenic bacteria through the uterus horn are avoided, and an efficient experimental tool is provided for mechanism research and drug development of chronic endometritis.

The application belongs to the technical field of traditional Chinese medicine compound, and discloses a traditional Chinese medicine composition for treating endometritis and a preparation method thereof. The traditional Chinese medicine compound is composed of the following components: 15-25 parts of Astragalus membranaceus, 10-20 parts of Atractylodes, 10-20 parts of Sargentodoxa, 20-30 parts of Psychotria asiatica and 5-15 parts of Cyperus rotundus. The preparation method is as follows: the components are weighed and dissolved in 6 times of water for 40 minutes; the soaked components are boiled with a strong fire and then changed to a weak fire for 35 minutes, and then the medicinal liquid is taken out; 4 times of water is added, boiled with a strong fire and then changed to a weak fire for 30 minutes, and then the medicinal liquid is taken out; the two medicinal liquids are mixed and stored in a refrigerator for standby. The traditional Chinese medicine compound has the effects of benefiting qi, clearing heat and dampness, promoting blood circulation to remove blood stasis and regulating qi to stop pain, and is used for treating and preventing endometritis caused by deficiency of healthy qi, dampness-heat and blood stasis, has a remarkable effect, is mild in nature and has no toxic side effects.

The application belongs to the technical field of medicine, and particularly relates to preparation and application of an anti-endometritis and probiotic regulating gel. The preparation method comprises the following steps: adding poloxamer and inulin into a solvent, and stirring and reacting to obtain a gel solution. The temperature-sensitive gel has stable gel structure and good rheological property, can be precisely delivered in the uterus, can realize slow release of the drug after loading the drug, fully plays the anti-inflammatory effect, and can regulate the flora. The application has simple preparation process, good stability, good biocompatibility, and good application prospect.

The application discloses a traditional Chinese medicine composition for qi-blood deficiency, swelling and pain relieving and a preparation method thereof, which is prepared from honeysuckle stem, radix sargentiae, liquorice, red ginseng, pilose antler, prepared rehmannia root, dandelion, cortex moutan, red peony root, Chinese evodia fruit and prepared rhizoma corydalis according to certain proportions; compared with the prior art, the application has more reasonable prescription, and has remarkable curative effect on leukorrhagia and abdominal pain caused by menstrual irregularity, abdominal pain during menstruation, pelvic inflammation, adnexitis and endometritis and the like caused by qi-blood deficiency; the application has reasonable prescription, remarkable curative effect and no toxic and side effects.

The invention discloses a model building method based on animal endometrial epithelium organoid and application of the model building method, and relates to the technical field of cell engineering and organoid. According to the method, healthy cow endometrial tissue serves as a raw material, a model is built through the steps of pretreatment, enzymolysis, cell cleaning and screening, seed gum culture, passage, cryopreservation resuscitation and the like, and the model is built through Hamp; e, verifying morphological integrity through dyeing, and detecting E-cadherin expression through IHC dyeing to confirm cell specificity. The animal organ model restores the in-vivo three-dimensional microenvironment and species specificity, overcomes the limitation of traditional two-dimensional culture and mouse models, can accurately simulate the pathological process of endometritis, is applied to research on the pathogenesis of endometritis of dairy cows, can also efficiently screen anti-inflammatory drugs and evaluate the drug effect, and has a wide application prospect. A reliable in-vitro tool is provided for disease prevention and treatment, and healthy development of the dairy cow breeding industry is assisted.

This invention discloses a suppository for treating endometritis in cattle and sheep, its preparation method, and its application, belonging to the field of veterinary drug preparation technology. The suppository uses Salvia miltiorrhiza, Coptis chinensis, Forsythia suspensa, Carthamus tinctorius, Borneol, and Astragalus membranaceus as active ingredients. Coptis chinensis and Forsythia suspensa clear damp-heat, while Salvia miltiorrhiza and Carthamus tinctorius unblock stagnation. Astragalus membranaceus replenishes postpartum qi deficiency, promotes blood circulation, enhances blood circulation, strengthens the body's resistance to pathogens, prevents inflammation recurrence, harmonizes the cold properties of other herbs, and reduces side effects. Borneol, with its pungent and penetrating properties, guides the medicine directly to the lesion, promotes mucosal repair, increases mucosal permeability, relieves pain and itching, and synergistically provides anti-inflammatory and analgesic effects, improving the user experience. It is suitable for local suppository administration, aligning with the principles of traditional Chinese veterinary medicine for endometritis, simultaneously exerting the effects of clearing heat and dampness, promoting blood circulation and removing blood stasis, and tonifying qi and strengthening the body, addressing both the symptoms and the root cause. By adding a matrix and excipients and combining vaginal administration to treat endometritis in cattle and sheep, the local drug concentration is concentrated for rapid onset of action, achieving a balance between effectiveness, convenience, and safety.

This invention belongs to the field of biomedical technology and provides the application of carvacrol combined with astragaloside A in the preparation of drugs for treating endometritis. This invention confirms that carvacrol combined with astragaloside A is effective against *Ralstonia pinnatifida* (…). R. pickettii The combination of carvacrol and astragaloside A in this invention has significant therapeutic benefits in treating mouse endometritis: It exhibits a synergistic antibacterial effect, rapidly reducing body temperature and weight loss in mice, significantly decreasing the uterine index, alleviating tissue congestion and edema, and significantly downregulating pro-inflammatory factors such as TNF-α, IL-1β, and IL-6 while upregulating the anti-inflammatory factor IL-10, thus inhibiting excessive activation of inflammatory signals. Simultaneously, it reduces MDA, increases SOD and GSH levels, and alleviates oxidative stress damage. Therefore, the combination of carvacrol and astragaloside A in this invention can effectively repair the pathological structure of the uterus, with superior effects compared to single drugs, and is safe and has no significant toxicity, providing a safe and drug-free natural alternative for endometritis in livestock.

The present application relates to the use of substituted indazoles for treatment and / or prophylaxis of allergic and / or inflammatory diseases in animals, especially for treatment and / or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflammatory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory disease, mastitis and endometritis in animals.

This invention provides the application of a uterine-derived Sphingomonas DS-28 strain and its metabolites in the treatment of endometritis, relating to the field of microbial technology. The Sphingomonas DS-28 strain provided by this invention possesses uterine colonization ability, good niche adaptability, and significant efficacy in treating Escherichia coli-induced endometritis. Animal experiments show that the preparation of this strain can effectively alleviate uterine redness and swelling, reduce pathological damage, and significantly reduce [the condition / progression]. TNF-alpha , IL-6 , IL-8 It inhibits gene expression and suppresses the NF-κB signaling pathway, exhibiting superior anti-inflammatory and tissue repair effects compared to other Sphingomonas strains C3-25.1, C3-41.1, and C3-42.1. Furthermore, the metabiotic preparation of this strain can also alleviate Escherichia coli-induced endometritis in mice, improve uterine redness and swelling, and reduce pathological damage.

The present application relates to the use of substituted indazoles for treatment and / or prophylaxis of allergic and / or inflammatory diseases in animals, especially for treatment and / or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflammatory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory disease, mastitis and endometritis in animals.

An injectable hydrogel for pet endometritis is provided, belonging to the technical field of veterinary drug preparation. The injectable hydrogel includes the following raw materials: forsythiaside A, chitosan, sodium β-glycerophosphate, sodium hyaluronate, acetic acid, and water. By combining the technical advantages of thermosensitive gel with injectable gel, forsythiaside A is used in combination with the chitosan to obtain an injectable hydrogel with excellent antibacterial properties. Encapsulating forsythiaside A with the chitosan not only enhances an antibacterial effect of forsythiaside A, but also prolongs a release time of the drug and can effectively shorten a duration required for repairing inflammatory damages, thereby reducing the probability of secondary infection in the uterine cavity.

The invention relates to a capsule for treating gynecological diseases and a preparation method thereof. The capsule is prepared from polygonum cuspidatum, sargentgloryvine stem, coptis chinensis, rhizoma bletillae, radix gentianae, dragon's blood, cuttlebone, rheum officinale, aloe, catechu, astragalus membranaceus, chloramphenicol and purified water. The capsule is prepared through a powder preparation process, a conventional vaginal medicine filling method is adopted for administration, the capsule is dissolved by virtue of vaginal secretion to release medicine, and the medicine acts on the vagina, the cervix uteri and the endometrium and directly reaches a focus, so that the effects of diminishing inflammation, sterilizing, resisting viruses, diminishing swelling, removing stasis and repairing mucosa are achieved; the traditional Chinese medicine composition can be used for treating colpitis mycotica, infectious microbe vaginitis, cervical erosion, cervicitis, HPV infection and endometritis. The capsule is a proved recipe inherited by several generations, has a good curative effect, takes traditional Chinese medicines as main raw materials, is added with a small amount of western medicines, has the advantages of benefiting and eliminating disadvantages, has no side effect, no preservative and no irritation, has an effective rate of 99% and a cure rate of 98%, and is worthy of popularization.

The invention provides a traditional Chinese medicine compound suppository for treating endometritis of livestock and a preparation method of the traditional Chinese medicine compound suppository, and relates to the technical field of veterinary drugs. The traditional Chinese medicine compound suppository consists of povidone iodine, a traditional Chinese medicine composition and a slow-release high polymer material matrix carrier, wherein the traditional Chinese medicine composition is prepared from thirteen traditional Chinese medicine components including philippine flemingia root, common andrographis herb, zanthoxylum dissitum, Chinese angelica, suberect spatholobus stem, motherwort herb, baical skullcap root, honeysuckle flower, weeping forsythia capsule, white paeony root, nutgrass galingale rhizome, heartleaf houttuynia herb and swordlike atractylodes rhizome. Besides the matrix carrier, the traditional Chinese medicine compound suppository only contains povidone iodine and traditional Chinese medicine composition components, the content of the povidone iodine component is low, and side effects are reduced. The traditional Chinese medicine compound suppository is non-toxic, small in irritation to vaginal mucosa of livestock, high in effective rate of treating endometritis of the livestock and good in anti-inflammatory effect. In the preparation process of the traditional Chinese medicine compound suppository, no organic solvent is used, pollution to the environment is avoided, and the preparation process is simple, convenient and easy to implement and low in cost.

The invention discloses application of an inhibitor acting on NOS1 related ceRNA in relieving sheep endometritis caused by LPS and promoting embryo implantation, and relates to the field of bioengineering. The inhibitor is si-NOS1 (SEQ ID No.1) and / or si-TCONS00000014 (SEQ ID No.2), and by regulating and controlling a NOS1 / bta-miR-370 / TCONS00000014 signal axis, the endometrial oxidative stress excessive activation induced by LPS (lipopolysaccharide) is improved, the autophagy and apoptosis of cells are relieved, and the expression of a key implantation gene is recovered. Experiments prove that the inhibitor can significantly improve the sheep embryo implantation rate and reduce the embryo loss probability, provides a new target and strategy for preventing and treating LPS-induced sheep endometritis and embryo implantation disorder, and has important significance for improving the sheep breeding efficiency.

The disclosure is directed to glucocorticoids for the treatment of epithelial microbial infections in fluid-containing organ having a natural exterior orifice in mammals; this new therapeutic use finds particular interest in the treatment of epithelial microbial infections of ear (such as otitis extema), udder (such as mastitis), and uterus (such as endometritis).

A sustained release solid oral bolus that, once ingested, is capable of providing sustained release of a therapeutically effective amount of a non-steroidal anti-inflammatory drug (NSAID), and its use for treating fever, pain and / or inflammation, preferably caused by periparturient disorders, such as mastitis, lameness, endometritis, metritis, or subfertility.

The invention provides a candidate medicine for promoting the embryo implantation efficiency of an endometritis type RIF patient, and belongs to the technical field of embryo implantation. In order to solve the problem of how to discover potential intervention drugs aiming at the endometritis type RIF pathological mechanism, a five-step efficient drug screening strategy based on an in-vitro implantation model of the endometritis type RIF is adopted, so that the reliability and function correlation of a screening result are ensured. According to the invention, a candidate drug screened by adopting a five-step method efficient drug screening strategy comprises any one of the following drugs: evocamide, choline, nitrendipine, megestrol acetate, pranoprofen, oxaliplatin, adenine, ensorizole, baicalin and diacerein. Evocamide, choline and nitrendipine in the candidate drugs are three drugs with the best implantation promotion efficiency for patients with endometritis type RIF.

The invention provides application of uterus-derived sphingomonas DS-28 and a metagen thereof in treatment of endometritis, and relates to the technical field of microorganisms. The sphingomonas DS-28 provided by the invention has uterus colonization ability and good ecological niche adaptability, and also has a remarkable curative effect in treatment of Escherichia coli induced endometritis. Animal experiments show that the strain preparation can effectively relieve red and swollen uterus, relieve pathological damage, remarkably reduce gene expression of TNF-alpha, IL-6 and IL-8 and inhibit an NF-kappa B signal channel, and the anti-inflammatory and tissue repair effects of the strain preparation are superior to those of other sphingomonas strains C3-25.1, C3-41.1 and C3-42.1. Meanwhile, the metastatic preparation of the strain can also relieve mouse escherichia coli endometritis, improve red and swollen uterus and relieve pathological injury.

The pelvic inflammation therapeutic apparatus comprises a machine frame and a fixing frame, the fixing frame is fixedly connected to one side of the machine frame, a heating box is fixedly connected to the interior of the fixing frame, a medicine tank is placed in the heating box, and a control panel is fixed to one side of the machine frame. The first liquid pipe, the second liquid pipe, the third liquid pipe and the fourth liquid pipe are designed to be of a combined structure, when the liquid pipes need to be deeply cleaned in the using process, a rotary knob is rotated to drive a second threaded rod to rotate, and a movable sleeve is driven to move under the threaded connection effect; the clamping plates are synchronously driven to move to cancel limiting and fixing of the second connecting discs, so that rapid separation between the adjacent connecting discs and the liquid pipes can be facilitated, operation is easy, use is convenient and fast, and the interiors of the sectional liquid pipes can be conveniently and deeply cleaned through the design of the sectional liquid pipes, so that follow-up use is facilitated.

The invention discloses a phycocyanin hydrogel capable of resisting endometritis and promoting vaginal flora regulation as well as a preparation method and application of the phycocyanin hydrogel. The preparation method comprises the following steps: a, adding a polylactic acid high-molecular polymer material into a sterile solvent, and performing low-temperature stirring reaction to obtain a hydrogel solution; and b, adding phycocyanin powder into the hydrogel solution prepared in the step a, and carrying out low-temperature stirring reaction to obtain the phycocyanin hydrogel. The hydrogel is phycocyanin hydrogel formed by wrapping natural phycocyanin with a polylactic acid derivative, accurate delivery in the genital tract can be achieved, and meanwhile, the anti-inflammatory and anti-apoptosis effects of phycocyanin can be fully exerted by slow release of the phycocyanin in the hydrogel; and the hydrogel can maintain an acidic environment in the vagina and regulate vaginal flora. The phycocyanin hydrogel disclosed by the invention is expected to bring a new treatment means for patients with endometritis and vaginal dysbacteriosis.

The application discloses a traditional Chinese medicine compound for treating uterine endometritis of livestock and poultry and a preparation method and application thereof; raw materials of the traditional Chinese medicine compound include 25-35 parts of poria cocos, 15-25 parts of radix codonopsis, 10-20 parts of cyperus rotundus, 5-15 parts of white atractylodes, 15-25 parts of dried ginger, 5-15 parts of taraxacum and 15-25 parts of arctium lappa by weight percentage. The traditional Chinese medicine compound has a good treatment effect on uterine endometritis of livestock and poultry, and all the drugs used in the application are natural plants which can be fed and can effectively reduce side effects in the treatment of uterine endometritis.

The invention belongs to the technical field of veterinary drug preparation, and discloses a synergistic doxycycline hydrochloride effervescent tablet as well as a preparation method and application thereof. The effervescent tablet is prepared from the following raw and auxiliary materials in percentage by weight: 10-15% of doxycycline hydrochloride, 3-5% of composite essential oil microcapsules, 3-7% of bletilla striata polysaccharide, 7-10% of Arabic gum, 1-3% of lauryl sodium sulfate, 38-42% of an effervescing agent, 5-6% of an adhesive, 4-5% of a disintegrating agent, 2-3% of a lubricant and the balance of a filling agent, wherein the weight percentage of the raw and auxiliary materials is 100%. The effervescent tablet prepared by the invention can be completely disintegrated after encountering water, can generate a large number of bubbles and is high in disintegration speed, the contact area between the medicine and an inflammation part is effectively enlarged, the microcapsules can be well adhered to the inner walls of the uterus and the vagina after absorbing water and expanding, the retention time of the medicine is prolonged, and the medicine effect is more lasting. The effervescent tablet is applied to treatment of bovine vaginitis and endometritis, the cure rate can reach 90% or above, and the effervescent tablet is suitable for being applied to intensive large-scale farms.

The invention belongs to the technical field of biological medicine, and particularly relates to application of chitosan in preparation of endometritis diagnostic products, objective quantitative detection is achieved through electric signal response of a chitosan memristor, accurate recognition of early and latent inflammations is achieved by means of high-sensitivity response of a chitosan material to low-concentration inflammatory factors, and the application of the chitosan material in preparation of endometritis diagnostic products is achieved. The selective binding capacity of a chitosan material to specific pathogen metabolites in local endometrium is utilized, so that the detected tissue specificity is enhanced, and cross interference is reduced.

The application discloses a preparation method and application of a natural active ingredient compound nanogel agent for animals, and belongs to the technical field of veterinary drug preparations. The natural active ingredient compound nanogel agent disclosed by the application is composed of natural active ingredients, a gel matrix and additional agents, is reasonable in formula, simple in process, stable in property, convenient to use and safe and long-acting. The natural active ingredient compound nanogel agent contains two synergistically acting natural active ingredients, can inhibit the proliferation of endometritis pathogenic bacteria such as staphylococcus aureus and streptococcus, and reduce the expression of pro-inflammatory cytokines at an inflammation site; meanwhile, the natural active ingredient compound nanogel agent has a certain slow-release capacity, slowly releases natural active ingredient nanoparticles easy to be taken by cells, can realize long-time residence and high-efficiency absorption of drugs at a drug administration site, and thus can enhance the action time, reduce the drug administration frequency and improve the curative effect.

The utility model discloses a visual female rabbit artificial insemination insemination gun belongs to female rabbit insemination field. A visual female rabbit artificial insemination insemination gun, include: handle, still include: probe pipe, fixed setting in the upper side of handle, baffle ring, set up in the end of probe pipe, probe head, set up in the probe pipe, and the probe head is close to the upper side of probe pipe inner wall, micropump machine, set up in the handle, draw liquid pipe, set up between the draw liquid end of baffle ring and micropump machine, storage bottle, set up in the lower side of handle, liquid discharge pipe, set up between the liquid discharge end of storage bottle and micropump machine, button, set up in the handle, the utility model effectively carries out the cleaning to mucus, and female rabbit is more easily accepted to relative to the mode of air blowing, and convenient operation personnel real -time observation insemination position, facilitate observation endometrium state, exclude female rabbit who suffers from endometritis or vaginitis, improve female rabbit conception rate.

The invention discloses a microbubble prepared based on an in-situ gas generation method and a preparation method and application thereof. According to the method, the gas generating agent is entrapped in the microspheres, the triggering agent is used for activating reaction under mild conditions, gas is directly generated in situ in the microspheres, form conversion from the microspheres to the microbubbles is achieved, the gas is stably entrapped in the microbubbles, the size, density and release kinetics of the microbubbles can be accurately regulated and controlled, operation is simple, complex exogenous triggering conditions are avoided, and the method is suitable for large-scale industrial production. Therefore, a microbubble system capable of generating gas on demand is constructed, and a new strategy is provided for tumor microenvironment targeting, focus specific imaging and the like. The microbubble can be simultaneously modified with an anti-VCAM-1 antibody and entrapped with an endometritis treatment drug, a novel drug carrier which has focus targeting, drug long-acting slow release and ultrasonic visual tracking functions and is safer is provided for treatment of endometritis, and a novel solution can also be provided for precise long-acting treatment of endometritis.

The invention discloses an intrauterine anti-infection and anti-adhesion gel and a preparation method thereof, the intrauterine anti-infection and anti-adhesion gel comprises lactobacillus rhamnosus CGMCC 1.577 and lactococcus lactis CGMCC 1.15072, the fermentation product of lactobacillus rhamnosus CGMCC 1.577 has uniqueness, can generate a synergistic effect with the lactococcus lactis CGMCC 1.15072, and can have relatively excellent effects of reducing endometritis cell infiltration, interstitial and epithelial reactive changes, improving the anti-infection and anti-adhesion effects and improving the anti-infection and anti-adhesion effects. The number of infectious microbes is reduced, inflammatory factors are reduced, and the endometritis disease can be well improved.