The invention discloses a plaster for treating neck-shoulder and lumbocrural pain and a preparation method of the plaster. The plaster consists of the following components: flos carthami, radix aconiti kusenzoffii, radix aconiti, radix achyranthis bidentatae, lycopodium clavatum, tuberculate speranskia herb, sappan wood, eucommia bark, rhizoma drynariae, radix dipsaci from Sichuan of China, borax, semen strychni, cornu cervi, obscured homalomena rhizome, dadix veratri, clove, radix angelicae, herba piperis puberuli, herba asari, cassia bark, rhizoma arisaematis, unprocessed rhizoma pinelliae, rhizoma ligustici wallichii, rhizoma atractylodis, raw pangolin scales, ground beetles, cuttle bone, radix fici simplicissimae, Japanese onion herb, rhizoma of aconitum kongboense lauener, cassia bark, rhizoma seu radix notopterygii, radix angelicae pubescentis, mylabris radix asparag, honeysuckle flowers, caulis sinomenii, darura stramonium linn, panax notoginseng, cortex albiziae, fructus cnidii, chrysanthemum morofolium ramat, agkistrodon halys, roasted rhizoma atractylodis macrocephalae, root of samp soniihance, paniculate swallowwort root, radix clematidis, rhizoma corydalis, long-noded pit viper, zaocys dhumnade, sambucus williamsii hance, anise, red psychotria branchlet and leaf, parthenocissus tricuspidata, scorpio, centipede, dragon's blood, frankincense, myrrh, musk, dried ginger, gum tragacanth, beeswax and honey. The preparation method comprises the following steps: selecting, cleaning and soaking materials; and decocting the materials, and spreading the materials so as to obtain the plaster. The plaster provided by the invention has beneficial effects that the plaster is practical to use and the plaster is prepared from pure natural Chinese herbal medicines.