The invention relates to a medicament for treating acute radiation skin lesion on clinical care. The medicament is prepared from the following raw material medicines: pyrrosia lingua, limonium bicolor, angiospermae, sword bean, zornia diphylla pers, pansy, coriolus versicolor, root and leaf of affined conehead, clinopodium polycephalum, epipremum pinnatum, pericarpium arecae, honewort, hairyleaf litse fruit, sargentgloryvine stem, lygodium japonicum, dactylicapnos root, dryopteris lacera, rhizoma sparganii, selaginella uncinata, radix polygonati officinalis, malvastrum coromandelianum, folium mori, divaricate knotweed herb, pawpaw, parietaria root, schisandraceane, carallia diplopetala leaf, fewflower lysionotus herb, horsetail, manchurian catalpa bark, akebia fruit, aster subulatus, herba orostachyos, buckeye and gnaphalium. The medicament for treating acute radiation skin lesion on clinical care is reasonable in composition, and has characteristics of being precise in curative effect, safe and convenient, free of toxic and side effects and low in price.