65 results about "Saccharin" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a pirfenidone eutectic crystal and a preparation method, a pharmaceutical composition and application thereof. The pirfenidone eutectic provided by the invention is prepared from pirfenidone and a eutectic ligand, and the eutectic ligand is selected from one of pimelic acid, cinnamic acid and saccharin. The pirfenidone eutectic crystal provided by the invention not only can improve the acute pancreatitis relieving effect of pirfenidone, but also can improve the safety of pirfenidone.

The invention relates to a method for producing notoginsenoside and ginsenoside by utilizing panax notoginseng cotyledon embryos, and belongs to the technical field of plant adventitious root tissue culture. The method comprises the following steps: inducing embryogenic calluses by utilizing immature zygotic embryos of panax notoginseng; proliferating the panax notoginseng embryogenic callus on a plate culture medium; s2, putting the pseudo-ginseng embryogenic callus obtained in the step S2 into a liquid culture medium, carrying out cell dispersion, and sieving by using a sieve with the aperture of 24-30 meshes; a mechanical stirring type bioreactor is filled with a liquid culture medium, and the globular embryo and the heart-shaped embryo are placed in the mechanical stirring type bioreactor to be cultured; s3, recovering the filtrate in the step S3, filtering by using a screen with the aperture of 30-80 meshes and 80-150 meshes to obtain uniform panax notoginseng embryogenic cells, and differentiating the panax notoginseng embryogenic cells in a triangular flask for the step S4; and drying the cotyledon embryo obtained in the step S4 at 45 DEG C, and grinding into powder. According to the method, large-scale generation of cotyledon embryos can be completed only in 4-6 weeks, the production process is remarkably accelerated, the method is suitable for industrial batch production requirements, and the production efficiency is high.

One aspect of the present invention relates to a method for producing a purified liquid having an increased purity of a separation target substance, or a purification kit for purifying a separation target substance, and the method for producing a purified liquid having an increased purity of a substance α is a method for producing a purified liquid having an increased purity of the substance α from a sample solution containing a separation target substance (substance α) or a substance containing the substance α (substance β), the method including: (1) the following step 1 and step 2-1; or (2) the following step 1 and step 2-2 (here, the substance α in the substance β is a protein, a nucleic acid, a lipid, or a saccharide), in which a container (i) including a first chamber having an opening in an upper portion and a second chamber partitioned from the first chamber by a filter and having an opening in an upper portion is used. Step 1: a step of obtaining a container (ii) having a carrier to which the substance α or the substance β in the sample solution is adsorbed, in the first chamber. Step 2-1: a step of obtaining a purified liquid having an increased purity of the substance α by bringing a liquid capable of releasing the substance α from the carrier into contact with the carrier and releasing the substance α from the carrier, in the container (ii). Step 2-2: a step of obtaining a purified liquid having an increased purity of the substance α by bringing a liquid capable of releasing the substance α from the carrier into contact with the carrier and releasing the substance α from the carrier. (here, the filter does not allow the carrier to pass therethrough.)

The invention relates to the technical field of organic fertilizers, particularly belongs to the patent classification number C05G3 / 00, and discloses a potamogeton crispus fermentation liquor-containing fertilizer and a preparation method thereof. Comprising the following steps: cleaning potamogeton crispus, cutting the potamogeton crispus into pieces, adding a compound enzyme preparation for enzymolysis treatment to obtain enzymatic hydrolysate, inoculating mixed bacteria liquid into the enzymatic hydrolysate for fermentation to obtain potamogeton crispus fermentation liquid, adding humic acid composite microspheres into the fermentation liquid, and enabling the humic acid composite microspheres to fully absorb nutritional ingredients in the fermentation liquid to obtain humic acid sustained-release microspheres. Uniformly mixing the humic acid sustained-release microspheres, urea, monoammonium phosphate and potassium sulfate to obtain the potamogeton crispus fermentation liquor-containing fertilizer. According to the method, the water caltrop is turned into wealth, and the fermentation liquor is rich in various nutrients and beneficial components through enzymolysis of the compound enzyme preparation and fermentation of the mixed bacterial liquid, so that comprehensive nutrients can be provided for plants.

The present invention provides a method for preparing Aconitum kusnezoffii using Yunnan Agarwood extract, belonging to the technical field of traditional Chinese medicine preparation. The present invention discloses for the first time a method for preparing Aconitum kusnezoffii using Yunnan Agarwood alcohol extract, wherein Aconitum kusnezoffii slices are soaked in Yunnan Agarwood alcohol extract for 24 to 72 hours, dried, and a Yunnan Agarwood processed Aconitum kusnezoffii product is obtained. The total amount of diester-type alkaloids in Aconitum kusnezoffii prepared by the method is less than 0.04%, and the content of aconitine is less than 15% of the content level of Aconitum kusnezoffii. The method is simple and green, can be operated on a large scale, and is easy to promote.

The invention discloses a formula and a preparation method of a glutinous rice sausage. The preparation method comprises the following steps: stir-frying glutinous rice and salted meat; the stir-fried glutinous rice comprises glutinous rice, fried lard oil, minced garlic, trehalose, refined salt and monosodium glutamate; the salted meat comprises pork, chopped salted fat dices, water, white granulated sugar, refined salt, monosodium glutamate, sodium tripolyphosphate, sodium pyrophosphate and auxiliary materials; the preparation of the stir-fried glutinous rice comprises hot frying and cold frying. The flavor of the glutinous rice sausages is remarkably improved, the glutinous rice in the sausages absorbs grease of the stuffing, particles are full, the taste is fragrant, sweet, soft and glutinous, and the overall flavor is richer and more harmonious.

Disclosed herein are formulations (including sweet proteins and rare sugars) for improving the sweetness of low glycemic index rare sugars without altering the texture and flavor of the rare sugars and methods for improving the sweetness of rare sugars. More specifically, the present invention discloses methods for improving the sweetness of rare sugars without altering the sweetness profile, texture and flavor of the primary sugars. The invention also discloses the addition of Brazitame protein with liquid rare sugars at different temperatures during the synthesis of the rare sugars, before crystallization or before or after caramelization of the rare sugars, to increase sweetness. The Brazilian sweet protein increases the sweetness of rare sugars, but is not limited to D-psicose, D-tagatose, D-allose, isomaltulose, trehalose, sorbose, pinose, leucobiose and the like. The invention also provides for the evaluation of non-nutritional sweeteners (such as aspartame, acesulfame, sodium cyclamate, neotame, saccharin, sucralose, stevioside, etc.), as each has a limitation of taste quality if used with rare sugars. However, the use of Brazilian sweet protein does not alter the flavor and texture of rare sugars, and the taste profile matches sucrose.

Composition including an artificial sweetener (e.g. ace-K, saccharin, sucralose, cyclamate, sugar alcohol (e.g. xylitol, mannitol, sorbitol, erythritol, maltitol, lactitol)) or a derivative thereof in

The utility model relates to the technical field of beverage bottle caps, and discloses a beverage bottle and a bottle cap, the beverage bottle comprises a beverage bottle, a threaded pipe is fixedly installed in the middle of the top of the beverage bottle, the surface of the threaded pipe is in threaded connection with the bottle cap, a closing assembly is arranged at the top of the bottle cap, and a guide pipe is fixedly installed at the top of the closing assembly. A diamond cover is arranged on the top of the guide pipe, and the beverage bottle is transparent. According to the beverage bottle and the bottle cap, through the arrangement of the bottle cap, the closing assembly, a guide pipe and a diamond cap, when a person uses the beverage bottle, the diamond cap is twisted, then the guide pipe drives a rotating cap to rotate, the rotating cap drives a limiting rod to slide in a sliding rail, and the limiting rod drives a closing plate to slide towards the two sides when moving; concentrated fruit juice or saccharin and other seasonings in the diamond cover can enter the beverage bottle along the sliding block, and therefore the purpose that different tastes of beverages can be combined is achieved.

A fire retardant formulation includes a first flame retardant agent consisting of corn syrup, com molasses, sorghum molasses, pomegranate molasses, carob molasses, date molasses, a waste concentrate of alcohol distilling industry, sacharinic acid, a lignosulfonate, steepwater solubles formed using a wet milling process for corn, whey, a wine-making residue, brewers' condensed solubles, desugared corn symp, desugared com molasses, desugared (brown) rice syrup, desugared maple symp, desugared sorghum molasses, desugared agave symp, desugared pomegranate molasses, desugared carob molasses, desugared date molasses and admixtures thereof exhibiting flame retardant properties, and a second agent selected from a group consisting of a flame retardant colorant, an additional flame retardant agent and mixtures thereof. A method of suppressing a wild fire or forest fire includes the step of applying an effective amount of the fire retardant formulation to (a) the wild fire, (b) the forest fire, (c) an area to be protected from the wild fire or the forest fire or (d) combinations thereof.

The invention relates to a beverage containing a) sucralose, saccharin and cyclamate, b) water, c) malic acid and d) lactic acid. The invention also relates to a beverage containing a) one or more high potency sweeteners, b) water, and c) 0,001 to 0,2 wt.-% malic acid and / or d) 0,05 to 0,6 wt.-% lactic acid. Furthermore, the invention addresses the use of lactic acid and malic acid and optionally citric acid in combination in a beverage containing high potency sweeteners for reducing or masking the sweet aftertaste or lingering effect of said high potency sweeteners or for improving the sensory profile of said beverage containing high potency sweeteners. The invention is also about the use of lactic acid and malic acid and optionally citric acid in combination in a beverage containing high potency sweeteners and at least one flavour compound for enhancing or prolonging the flavour impression of said flavour compound.

The invention relates to a sweetening composition comprising a naturally sweet carbohydrate, a stevia compound, rubusoside, and tannin, wherein component d) is present in an amount on the scale of 1 mg / l to 400 mg / l; the invention also relates to a sweetening composition comprising a naturally sweet carbohydrate, a stevia compound, rubusoside, tannin, and oak extract or pomegranate extract; the invention further relates to a sweetening composition comprising acesulfame or aspartame, sucralose, a stevia compound, saccharin or cyclamate, neohesperidin, and tannin in an amount on the scale of 1 mg / l to 400 mg / l; furthermore, the invention relates to a sweetening composition comprising a) 0.1 to 50 g / l of a naturally sweet-tasting carbohydrate, b) 40 to 120 g / l of a naturally sweet-tasting carbohydrate other than a), and c) 30 to 300 mg / l of rubusoside; and, the invention relates to the use of said sweetening compositions for sweetening and preparing beverages.

The invention belongs to the technical field of crystal form medicine molecules, and particularly relates to a preparation method and application of a baricitinib-saccharin eutectic crystal. Compared with eutectic crystals disclosed in the prior art, the baricitinib-saccharin eutectic crystal disclosed by the invention is high in stability, good in solubility and simple in preparation process. The bioavailability of the baricitinib can be obviously improved, and the baricitinib has a relatively good medical industrial application prospect.

A strain of Acanthopanax senticosus endophytic fungus HASZ2 producing isofraquinone and protocatechuic acid and its application, relating to the field of microorganisms, the Acanthopanax senticosus endophytic fungus HASZ2 is Rhodotorula glutinosus HASZ2, which has been preserved in the China Center for Type Culture Collection, the preservation address is Wuhan University, Wuhan, the preservation date is May 16, 2024, and the preservation number is CCTCC NO: M2024973. The strain has good antioxidant activity. After secondary metabolite analysis of its fermentation broth, it was found that the strain can produce isofraquinone and protocatechuic acid. The present invention is used for anti-oxidation and production of Acanthopanax senticosus secondary metabolites.

The invention discloses a device and an extraction method for extracting flavonoids from Sophora japonica with a nano-ultrafiltration membrane, and belongs to the technical field of extracting flavonoids from Sophora japonica. The device for extracting flavonoids from Sophora japonica with a nano-ultrafiltration membrane comprises a crushing and screening component, a fine crushing component and a dissolving component, wherein the crushing and screening component comprises a coarse crushing device, wherein the coarse crushing device coarsely crushes Sophora japonica, and a screening device is installed at the bottom of the coarse crushing device. The invention uses the peel and endosperm of Sophora japonica as raw materials, greatly reducing the impurities that need to be separated when extracting flavonoids from Sophora japonica, and at the same time, the raw materials are completely crushed by fine crushing, and the microparticles of the raw materials are contacted with water vapor particles in a molecular collision mode, so that the flavonoids in the raw materials are quickly and completely integrated into the water vapor, greatly improving the extraction rate of the flavonoids in the raw materials, thereby improving the extraction efficiency and extraction effect of the nano-ultrafiltration membrane on the flavonoids from Sophora japonica.

The invention discloses a high-precision electroplating grinding wheel which comprises a base body and a grinding layer arranged on the outer layer of the base body. The preparation method of the electroplating grinding wheel comprises the steps that the base body is subjected to oil removal; shielding and clamping; preparing an electroplating solution; and electroplating and forming. The electroplating device is provided with an automatic abrasive compensation device and a vibration device; when the grinding layer is electroplated, a more efficient electroplating system is adopted, lauryl sodium sulfate, boric acid, saccharin and 1, 4-butanediol are added into the electroplating system, and the electroplating efficiency is improved; the automatic compensation device is used for adding the grinding material with the same amount of electroplating consumption into the electroplating liquid, so that the proportion of the grinding material to the electroplating system is kept constant, and the electroplated grinding material is more uniform.

The invention belongs to the field of bioengineering, and relates to an engineering strain, in particular to a bacillus for degrading sclareol and application. The preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) The bacillus for degrading the sclareol can convert the ambergris intermediate product sclareol into a Yunxiang substance, the degradation rate of the sclareol within 72 h is 65.99% or above, and when the bacillus is used for fermenting tobacco leaves, the quality of the tobacco leaves can be improved, and the sensory quality of cigarettes can be improved.

A novel compound complex that has no side effects on a liver and is used to alleviate the toxicity of an acetaminophen (APAP) drug to the liver. The composition of the compound consists of (a) acetaminophen in a pharmaceutically effective amount and (b) a commonly-used safe and pharmaceutically acceptable excipient that can be combined with one or more of two drugs to reduce the toxicity of a drug metabolized by the hepatic enzyme CYP2E1 in the liver.The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, S100 acrylic resin, sodium carboxymethylcellulose, polyoxyethylene polyoxyethylene, menthol, low-substituted propylcellulose hydrocarbon, pregelatinized starch, Dextrates NF hydrate, citric acid, polyoxyethylene castor oil, colloidal silicon, aliphatic polyethylene glycol monostearate ester, sorbic acid, lemon oil, hydroxypropylcellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, Peg 4000, PEG 2000, and the like, so as to reduce the side effects caused by acetaminophen on the liver.

Non-aspartame sweetener compositions, systems and methods for predicting the sweetness intensity of confectionery products, and coating compositions comprising rebaudioside M are disclosed herein. A non-aspartame sweetener composition may include one or more of an unencapsulated high intensity sweetener other than a steviol glycoside, an agglomerated rebaudioside, an agglomerated high intensity sweetener other than a steviol glycoside, and a mixture of steviol glycosides. The composition may also include at least one of a first encapsulated high intensity sweetener and a second encapsulated high intensity sweetener different from the first encapsulated high intensity sweetener, wherein each of the first encapsulated high intensity sweetener and the second encapsulated high intensity sweetener is one of saccharin and its salts, acesulfame and its salts, or another high intensity sweetener other than a steviol glycoside.

The invention provides traditional Chinese medicine formula essential oil for improving or treating insomnia, and relates to the technical field of traditional Chinese medicine essential oil. The traditional Chinese medicine formula essential oil is prepared from radix bupleuri essential oil, longan aril essential oil, tuber fleeceflower stem essential oil, allium macrostemon essential oil, angelica sinensis essential oil and borneol. The traditional Chinese medicine formula essential oil can significantly improve the sleep quality of drosophila melanogaster; through sniffing administration on an insomnia model mouse, the insomnia state of the insomnia model mouse can be obviously improved, the behavior activity of the model mouse can be recovered, the sleep rate of the mouse can be obviously increased, the sleep latency period can be obviously shortened, the sleep time can be obviously prolonged, the levels of hypothalamic homogenate 5-HT, GABA and Glu of the mouse can be obviously increased, and the level of hypothalamic homogenate DA can be obviously reduced; the traditional Chinese medicine composition has a remarkable treatment effect on insomnia model mice. The traditional Chinese medicine formula essential oil provided by the invention has a relatively good application prospect in preparation of aromatherapy medicines for treating insomnia.

The purpose of the present invention is to provide a satin nickel plating solution and a plating method with which it is possible to form, in a manner that is stable over a long period of time, a plating film having a uniform and excellent appearance.　The satin nickel plating solution is characterized by containing saccharin and / or a saccharin salt, at least one acidic polysaccharide, at least one neutral polysaccharide, and at least one surfactant. The plating method is characterized in that treatment is performed using the aforementioned plating solution. The surfactant preferably contains a non-ionic surfactant, and more preferably also contains an anionic surfactant.

The invention belongs to the technical field of food, and provides a method for preparing cyperus esculentus oil oleogel from an edible polymer. The method comprises the following steps: S1, mixing an edible polymer and water to obtain an edible polymer solution; s2, mixing the edible polymer solution and the cyperus esculentus oil to obtain a mixture; and S3, mixing the mixture with a cross-linking agent, and carrying out gelation treatment to obtain the cyperus esculentus oil gel. According to the scheme provided by the invention, the steps are simple, and the prepared oleogel has excellent stability, is not easy to layer and oxidize, can keep the original quality for a long time, and provides a novel high-stability oleogel product for the food industry.

The application belongs to the technical field of medicines, and particularly relates to a pirfenidone co-crystal, a preparation method thereof, a pharmaceutical composition and application. The pirfenidone co-crystal is prepared from pirfenidone and a co-crystal ligand, and the co-crystal ligand is selected from one of heptanedioic acid, cinnamic acid and saccharin. The pirfenidone co-crystal can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The present invention relates to the technical field of food processing, and discloses a low-sugar sponge cake and a preparation method thereof, wherein the low-sugar sponge cake comprises the following ingredients in parts by weight: 220g of whole eggs, 120g of sugar-free applesauce, 65g of almond powder, 65g of whole wheat flour, 3g of baking powder, 1g of vanilla extract, 1g of salt, 2g of cinnamon powder and 0.6-0.8g of mogroside. The low-sugar sponge cake and the preparation method thereof, by using sugar-free applesauce to replace part of the sugar, make the sugar content in the cake lower, suitable for people who need to control blood sugar, such as diabetics and people who lose weight, and no oil is added, so as to reduce the intake of saturated fat, reduce calories, and be more suitable for healthy diet, whole wheat flour and almond powder are rich in dietary fiber, which helps digestion, increases satiety, and controls weight, almond powder and whole eggs provide high-quality plant and animal proteins, which help body repair and immune function, and the unsaturated fatty acids contained in the almond powder are beneficial to cardiovascular health and can reduce the level of bad cholesterol.

A sweetener according to exemplary embodiments comprises: a core including one selected from erythritol, xylitol, sorbitol, maltitol, mannitol, inositol, lactitol, isomalt, and allulose; and a shell surrounding at least a portion of the core and including one selected from stevia, enzyme-treated stevia, steviol glycoside, mogroside, thaumatin, sucralose, aspartame, saccharin, acesulfame potassium, and neotame, wherein a content ratio of the shell to the core may be 0.002 to 0.05. The sweetener has a core-shell structure, wherein the core and the shell are each made into a single raw material without any separate additives (e.g. excipients), and thus is close to zero calories.

The invention relates to a composition and a method for preventing or treating fat pancreas and improving pancreatic lesions, diabetes mellitus or other related diseases caused by the fat pancreas. Specifically, the invention relates to the use of a compound for preparing a composition for reducing pancreatic fat content, preventing or treating fat pancreas or improving pancreatic lesions or other related diseases caused by fat pancreas in an individual, and the compound is selected from the group consisting of eriodictyol, menthol, sucralose, mannitol, saccharin and any combination thereof.

Disclosed are compositions and methods relating to variant alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

The invention relates to a minty medicinal and edible vitamin energy beverage. The tea powder, the maca powder, the rhizoma polygonati powder, the ginseng powder, the fructus lycii concentrated juice, the compound nutrition enhancer, the citric acid monohydrate, the sodium citrate, the sodium cyclamate, the acesulfame potassium, the sucralose and the potassium sorbate serve as main raw materials, the flavoring agent is matched, all the components are reasonably matched, various vitamins needed by the human body can be effectively supplemented, and the maca health-care beverage has various tastes and is suitable for being eaten by people. Meanwhile, the product does not contain heat and fat, and the added medicinal and edible components enable the product to have higher nutritional value. Due to the good taste and the nutritional value, the product better meets the market requirements, and application and popularization are facilitated.

1. The name of the product of this design: Bottle sticker (Roxbirica roxburghii immune enhancement tablets). 2. Purpose of this design product: used for packaging products. 3. The design key point of this appearance design product lies in the pattern. 4. The picture or photo that best illustrates the key points of the design: main view. 5. This appearance design product is a thin product, and the left view, right view, top view and bottom view are omitted.

The present invention belongs to the technical field of chemical medicines. Disclosed are a salt form of a PARP inhibitor-fused heterocyclic deuterated compound, and a preparation method therefor and the use thereof. Provided in the present invention are various salt forms of a compound of formula (1), and a preparation method therefor and the use thereof. The present invention provides support for dosage form study by means of studying various salt forms of the compound, such as fumarate, tartrate, various sulfonates such as 2-naphthalenesulfonate, p-toluenesulfonate and methanesulfonate, and saccharin co-crystal, and studying crystal forms of each salt form, thereby more effectively preventing / treating PARP-related diseases, and meeting different clinical medication requirements.