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2 results about "Cholecystokinin" patented technology
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Cholecystokinin (CCK or CCK-PZ; from Greek chole, "bile"; cysto, "sac"; kinin, "move"; hence, move the bile-sac (gallbladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin, officially called pancreozymin, is synthesized and secreted by enteroendocrine cells in the duodenum, the first segment of the small intestine. Its presence causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively, and also acts as a hunger suppressant.
Oat oligopeptides, preparation thereof and use thereof in the preparation of products for modulating the expression of brain appetite suppressors
The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).
Owner:UNIV OF SHANGHAI FOR SCI & TECH
Social disorder animal model construction method based on basal lateral amygdaloid nucleus-screen nucleus neural circuit and application thereof
ActiveCN122030335Aclear mechanismPeptide/protein ingredientsGenetic material ingredientsLateral amygdaloid nucleusViral vector
The invention provides a social disorder animal model construction method based on a basal lateral amygdaloid nucleus-screen nucleus neural circuit and application thereof, and belongs to the technical field of animal model construction. The method comprises the following steps: injecting a viral vector carrying a photosensitive protein gene or a photosuppressive protein gene into amygdaloid nucleus on the outer side of an animal basal to express neurons of cholecystokinin or neurons of CaMKII alpha; embedding an optical fiber above the screen-shaped core; first light stimulation is applied through an optical fiber to activate nerve projection from amygdaloid nucleus on the outer side of the substrate to the screen nucleus, and a social disorder animal model is obtained; or applying a second photostimulus to inhibit the projection, resulting in a social disorder relief animal model. According to the invention, specific photogenetic regulation and control of the BLACCK +-CLA neural circuit is realized for the first time, social behaviors can be accurately regulated and controlled without interfering with movement and anxiety levels, and a reliable experimental tool is provided for mechanism research and drug screening of social obstacles.
Owner:SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI