92 results about "Nanocages" patented technology

The invention discloses a photosensitive metal-organic coordination nanocage material as well as preparation and application thereof. The photosensitive metal-organic coordination nanocage material comprises a photosensitive ligand, metal ions and counter anions. According to the metal-organic coordination nanocage material, pure water can be decomposed into hydrogen and hydrogen peroxide only through ultrasound and illumination under the condition that a sacrificial agent is not added, and the metal-organic coordination nanocage material has efficient piezoelectric electro-catalytic performance.

The invention discloses a ferrate nanocage superstructure material and a preparation method and application thereof, the preparation method comprises the following steps: preparing a zinc-iron Prussian blue nanocube precursor material, then dispersing the precursor material in deionized water, and standing and aging for 24-120 hours at 15-45 DEG C to obtain a zinc-iron Prussian blue nanocage; the preparation method comprises the following steps of: dispersing in diluted hydrochloric acid, adding metal salt, uniformly stirring, standing and reacting for 6-48 hours at the temperature of 50-120 DEG C, filtering, washing, drying, and annealing for 1-5 hours at the temperature of 300-500 DEG C; according to the invention, the zinc-iron Prussian blue nanocube is used as a precursor, the zinc-iron Prussian blue nanocage is obtained through aging, and the ferrite nanocage superstructure material is prepared through ion exchange and has excellent gas-sensitive characteristic.

The invention belongs to the field of electrochemical sensors, and relates to an electrochemical sensor for high-sensitivity detection of diuron and a preparation method of the electrochemical sensor. An HNT (halloysite nanotube)-CNC (carbon nanocage)-SWCNT (single-walled carbon nanotube) nanocomposite material prepared from a halloysite nanotube, a carbon nanocage (CNC) and an SWCNT (single-walled carbon nanotube) is modified on the surface of a GCE (glassy carbon electrode) to form an HNT-CNC-SWCNT / GCE working electrode. The method comprises the following steps: firstly, uniformly dispersing CNC and SWCNT which are equal in mass in an N, N-dimethylformamide solution through magnetic stirring in an ultrasonic environment; then, adding HNT into the solution, and carrying out ultrasonic dispersion to obtain a uniformly mixed HNT-coated CNC-coated SWCNT turbid liquid; and finally, dispensing the uniform turbid liquid on the surface of GCE, and drying under an infrared lamp to prepare the nano composite material modified HNT / CNC / SWCNT / GCE working electrode. Based on the synergistic interaction effect generated by HNT, CNC and SWCNT, the HNT / CNC / SWCNT / GCE sensor is high in sensitivity, the detection limit can reach 18.04 nM, and the diuron sensing detection performance is excellent.

The invention provides a cyclodextrin-based nano anti-tumor medicine preparation as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: preparing a graphene quantum dot deposition gold nanocage modified by a silane coupling agent, carrying out a Schiff base reaction on the graphene quantum dot deposition gold nanocage and aldehyde substituted-beta-cyclodextrin to prepare a composite carrier, and coating a targeted peptide-drug compound through the reaction, thereby preparing the cyclodextrin-based nano anti-tumor drug preparation. According to the cyclodextrin-based nano anti-tumor medicine preparation prepared by the invention, the anti-tumor medicine effect is obviously improved, meanwhile, the medicine resistance of the medicine can be reversed, the damage to normal tissues is reduced, the use amount of the medicine is reduced, the side effect after the medicine is used is reduced, the compliance of a patient is improved, and meanwhile, the stability and biocompatibility of the medicine can be improved; wide application prospects are realized.

The invention relates to a Raman probe for detecting hydrogen sulfide as well as a preparation method and application of the Raman probe. The gold and silver nanocage (AuAg NCs) is prepared, and after the gold and silver nanocage (AuAg NCs) is modified by a Raman signal molecule 4-ethynylaniline (4EA), it is found that the AuAg-4EANCs shows the strongest Raman enhancement effect at the position of 2010 cm <-1 > located in a cell silence zone. The SERS probe with the tumor targeting capability is developed through the functional modification of a mucoprotein 1 aptamer (MUin1aptamer, MUC1Apt) and polyethylene glycol (PEG), and the SERS probe with the tumor targeting capability is further developed through the functional modification of the mucoprotein 1 aptamer (MUin1aptamer, MUC1Apt) and the PEG (Polyethylene Glycol). In the presence of hydrogen sulfide (H2S) and oxygen, Ag in AuAg-4EANCs rapidly reacts with H2S to generate Ag2S with significantly reduced Raman enhancement performance, resulting in sharp attenuation of 4EA signal intensity. And along with the increase of the H2S concentration, the generation amount of Ag2S is increased, so that a quantitative detection model dependent on the H2S concentration is established.

The invention discloses a PtRu nanocage and a preparation method and application thereof, and the method comprises the following steps: (1) adsorbing ruthenium chloride and chloroplatinic acid to ZIF-8 to form a PtRu ZIF-8 composite material; (2) performing high-temperature calcination on the PtRu-ZIF-8 composite material in a hydrogen-argon reducing atmosphere to reduce the PtRu-ZIF-8 composite material into metal Ru and Pt, and forming an intermetallic compound by Zn generated by decomposition of ZIF-8, Ru and Pt to obtain a PtRuZn composite material; and (3) selectively etching the PtRuZn composite material by using a hydrochloric acid solution to remove Zn so as to obtain the PtRu nanocage with the cage-shaped structure. The method is easy and convenient to operate, the catalytic activity can be remarkably improved, and the Pt dosage can be greatly reduced. The material is suitable for AEMWE, and a new solution is provided for developing a low-cost and high-stability water electrolysis hydrogen production technology.

An antibody gold nanocage drug delivery system, a preparation method, and a use. LA-DOX-mPEG and a gold nanocage are first prepared independently; reaction between LA-DOX-mPEG and the gold nanocage is enabled to obtain DOX@GNC; then HS-PEG-COOH and an antibody are added for reaction to obtain the antibody gold nanocage drug delivery system. In addition to the advantages of nano drug delivery systems in the prior art, the gold nanocage drug delivery system further has the active targeting capability for tumor cells and can reduce the toxic and side effects of chemotherapeutic drugs on normal cells; pH responsive DOX drug release in an acidic tumor microenvironment can improve drug accumulation in tumor tissue. In addition, under the irradiation of near-infrared light, the gold nanocage converts light energy into heat energy, and the pH responsive drug release combined with high temperature enables rapid pulsed release of DOX carried by the gold nanocage, thereby achieving synergistic treatment of photothermal therapy and chemotherapy.

The invention discloses a chiral precious metal nanocage induced and synthesized by penicillamine and a preparation method and application thereof, precious metals in the chiral precious metal nanocage are palladium, platinum and gold, the molar ratio of palladium to platinum to gold is (16-18): (24-28): (56-59), and the chiral precious metal nanocage has three-dimensional chiral morphology characteristics induced by penicillamine chiral molecules. And the edge length is in a nanometer size. Chiral deposition growth of gold atoms in two palladium-platinum nanometer hollow frame structures (cubes and icosahedrons) is induced through chiral penicillamine molecules (D- / L-penicillamine), and a chiral precious metal palladium-platinum-gold three-element hollow nanometer cage structure is constructed. The structure shows excellent catalytic activity on selective catalytic oxidation of D-configuration glucose molecules. The invention provides an efficient, low-cost and high-reliability biomimetic catalytic material solution for glucose detection, and promotes the upgrading of diabetes management, biosensing and food quality control technologies.

The invention belongs to the technical field of preparation of adsorption separation functional materials, and discloses a controllable preparation method and application of a nano cage type thiourea-resorcinol-formaldehyde resin adsorbent. According to the method, silicon dioxide nanospheres are used as hard templates, thiourea and silicon dioxide are synchronously doped when a phenolic resin layer grows, and finally, the silicon dioxide templates are removed through etching, so that the cross-crumpled resin nanocage microspheres can be controllably prepared. The method not only realizes controllable morphology, but also greatly improves the adsorption performance. The method has important economic value in the field of precious metal recovery, the problems of precious metal resource waste and environmental pollution in electronic waste can be effectively solved, and meanwhile, a new thought is provided for designing a low-cost high-performance adsorbent.

The invention belongs to the technical field of oxygen reduction catalysts, and discloses a hollow nanocage loaded high-entropy alloy electrocatalyst and a preparation method and application thereof. The preparation method comprises the following steps: synthesizing PS balls through an emulsion polymerization method, mixing, stirring and aging a solution prepared from 2-methylimidazole, cobalt nitrate and zinc nitrate in methanol and the PS balls, then adding metal precursors of iron, nickel and copper, and carrying out washing, drying, heat treatment and concentrated nitric acid etching to prepare NC-CoZnFeNiCu. The high-entropy alloy is located on the carbon nanocage, multiple active sites are formed due to the compression strain caused by the ultra-small bending carbon layer and the good synergistic coordination effect of the high-entropy alloy, and the reaction potential barrier of oxygen reduction is effectively reduced. The oxygen reduction performance of the material is superior to that of commercial Pt / C, the half-wave potential is 0.896 V, and the dynamic current density is 31.88 mA / cm < 2 >. By combining the structures of the high-entropy alloy and the hollow nanocage, the electron conduction capability of the catalyst is enhanced, and the performance of the oxygen reduction reaction is remarkably improved.

Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.

The invention belongs to the technical field of nano materials, and particularly relates to a polyoxazoline coated gold nano cage and a preparation method thereof. According to the technical scheme, the preparation method comprises the following steps: (1) heating an ethylene glycol solution, then adding sodium hydrosulfide, hydrochloric acid, polyvinylpyrrolidone and silver trifluoroacetate for reaction, then standing the mixture to prepare silver nanocubes (AgNc), and washing the obtained AgNc with acetone and deionized water; (2) adding tetrachloroauric acid into the obtained AgNc solution, carrying out an electric replacement reaction to generate a gold nanocage (AuNc), and washing with ethanol and ultrapure water to remove impurities after the reaction is completed; and (3) adding 3-thiohydracrylic acid into the obtained AuNc solution to enable gold and sulfydryl to form a coordinate bond, and then adding poly (2-ethyl-2-oxazoline) to coat AuNc to form a final product, namely the polyoxazoline coated gold nanocage (AuNc (at) PEtOx). The preparation method of AuNc (at) PEtOx provided by the invention is simple, convenient and efficient; in addition, AuNc (at) PEtOx has good photo-thermal characteristics when exposed to laser with the wavelength of 808 nm.

The present invention relates to a hollow nanocage structured silver-doped nickel cobaltate / nickel oxide gas-sensitive material, and its preparation method and application. The method uses dimethyl imidazole cobalt as a structure-directing agent, combined with a nickel-cobalt layered double hydroxide derivatization method and a chemical reduction method, to simultaneously achieve triple optimization of the material's microstructure, interface energy band gap, and composition. The unique hollow nanocage structure of the prepared composite material greatly increases its contact area with the gas being detected; the interface heterojunction formed by nickel cobaltate and nickel oxide in the material accelerates the efficiency of interfacial electron transmission; and silver doping increases the number of electron transitions during the detection process. Gas-sensing experiments have shown that the composite material has high selectivity, sensitivity, and stability for the volatile organic gas n-butanol at a relatively low operating temperature, and is suitable for the detection of trace n-butanol in complex environments. The preparation method has mild conditions, low cost, and good industrialization prospects, and has broad application prospects in the field of gas-sensitive material preparation.

The invention discloses a nickel-based noble metal multi-shell nanocage material and a preparation method and application thereof, and relates to the technical field of nano functional materials.According to the nickel-based noble metal multi-shell nanocage material and the preparation method thereof, nickel nanoparticles serve as a core material, and the complexing and growth rate of noble metal is regulated and controlled by controlling the using amount of ligands; the technology of precious metal multi-step precise feeding, step-by-step programmed heating and system residual ligand reuse is combined, and precise epitaxial growth of multiple precious metals on the surfaces of the nickel nanoparticles is achieved. And carrying out carbon carrier loading and inorganic acid selective etching to accurately remove a part of nickel matrix and reserve a complete noble metal shell layer, thereby finally preparing the nickel-based noble metal multi-shell nanocage material with a hollow structure.

The invention particularly relates to a CdS-coated Cu3BiS3 composite material with a hollow nanocage structure as well as a preparation method and application of the CdS-coated Cu3BiS3 composite material. The CdS (at) Cu3BiS3 composite material with the hollow nanocage structure is prepared from a nano particle CdS and a hollow nanocage Cu3BiS3, the nano-particles CdS are uniformly attached to the surface of the hollow nano-cage Cu3BiS3, and the nano-particles CdS and the hollow nano-cage form a heterostructure. CdS and Cu3BiS3 are compounded to construct a p-n heterojunction, the absorption range and strength of visible light of the composite material are remarkably enhanced, separation / migration of photon-generated carriers is remarkably promoted, compounding of photo-generated electrons and holes in the transfer process is inhibited, and the obtained composite material shows excellent photocatalytic performance and an effect of degrading organic pollutants; various organic pollutants can be efficiently degraded, and the method is of great significance to improvement of degradation of organic dyes in water.

The invention discloses a photo-thermal regenerative carbon nanocage confinement lithium chloride low-temperature energy storage composite material, and preparation and application thereof, and belongs to the technical field of energy storage materials. The composite material takes a carbon nanocage with a micropore-mesopore-macropore hierarchical structure as a carrier, lithium chloride is loaded in a nano cavity and a pore channel of the carbon nanocage in a limited range to form a stable composite structure, and the problems of leakage and agglomeration of lithium chloride can be effectively inhibited; during preparation, the carbon nanocage is prepared through a chemical vapor deposition method, and the carbon nanocage can be obtained through drying, vacuum impregnation, suction filtration and freeze-drying shaping, the process is simple and controllable, and the graded pore mass transfer advantage of the carbon nanocage can be reserved; the composite material can stably work under the environment with the temperature of 20-40 DEG C and the relative humidity of 30%-60%, and the fit lt is achieved; the device can capture, store and release 100 DEG C low-grade heat energy, can be directly driven by solar energy to dehydrate and regenerate, has the advantages of high cycle stability and green regeneration, is suitable for adsorption type heat storage, solar photo-thermal energy storage and industrial waste heat recovery devices, and has remarkable industrial application value.

The invention discloses a uric acid biosensor electrode substrate and a preparation method and application thereof, and relates to the technical field of biosensors. The uric acid biosensor electrode substrate is prepared by modifying the surface of an electrode with a poly (3-methylthiophene) membrane and assembling a gold nanocage on the surface of the poly (3-methylthiophene) membrane. The electrode substrate is modified by using poly-3-methylthiophene, the assembly efficiency of the gold nanocage on the surface of the electrode is effectively improved, the poly3-methylthiophene and the gold nanocage are synergistically catalyzed, the redox peaks of interferents can be effectively separated, the uric acid detection effect is ensured, and the accuracy and feasibility of the detection technology are improved. The uric acid biosensor provided by the invention has the advantages of high accuracy, good selectivity, high sensitivity and the like, can realize quantitative detection of uric acid, and has important application value in the fields of clinical diagnosis and drug research of related diseases such as purine metabolic disorder and the like.

The invention relates to the technical field of battery materials, in particular to a multi-metal sulfide hollow nanocage composite material preparation method which comprises the following steps: S1, precursor preparation, S2, vulcanizing agent preparation and S3, composite preparation. According to the invention, the graphene oxide in the additive component is used as a conductive base material, can provide a macro-scale electron high-speed transmission channel, forms a three-dimensional cross-linked polymer conductive network, effectively fills gaps between graphene sheet layers, and physically prevents re-stacking caused by Van der Waals' force; the conductivity of a polyaniline molecular chain can be improved by doping phytic acid through rich phosphate groups, phytic acid molecules can also be intercalated between graphene sheets to prevent interlayer accumulation, the high specific surface area and a smooth ion transmission channel of the composite material are cooperatively maintained, and the conductivity of the composite material is improved. Therefore, the conductivity of the composite material is comprehensively improved.

The application discloses a ZnNiCo-LDH with a hollow nanometer cage structure, and a ZIF-67 with a regular dodecahedron structure is synthesized by taking cobalt nitrate and 2-methyl imidazole as raw materials; a ZIF-67@NiCo-LDH with a core-shell structure is prepared by ZIF-67 and Ni(NO3)2.6H2O; and the ZnNiCo-LDH with the hollow nanometer cage structure can be obtained by the reaction of zinc chloride and the ZIF-67@NiCo-LDH. The preparation method comprises the following steps: 1, preparation of the ZIF-67 with the regular dodecahedron structure; 2, preparation of the ZIF-67@NiCo-LDH with the core-shell structure; and 3, preparation of the ZnNiCo-LDH with the hollow nanometer cage structure. As the application of the super capacitor, the specific capacitance is 1900-2000 F / g when charging and discharging in the range of 0-0.5 V and the discharge current density is 1 A / g; and the capacitance retention rate reaches 73% at 10 A / g relative to the capacitance at 1 A / g.

The invention relates to a silver-doped nickel cobaltate / nickel oxide gas-sensitive material with a hollow nanocage structure and a preparation method and application thereof, and according to the method, dimethyl imidazole cobalt is used as a structure-directing agent, a nickel-cobalt layered double-layer hydroxide derivation method and a chemical reduction method are combined, and triple optimization of a material microstructure, an interface energy band gap and components is realized at the same time. The prepared composite material has a unique hollow nanocage structure, so that the contact area between the composite material and detected gas is greatly increased; an interface heterojunction formed by nickel cobaltate and nickel oxide in the material accelerates the interface electron transmission efficiency; the doping of silver increases the electron transition quantity in the detection process. A gas sensitive experiment proves that the composite material has high selectivity, sensitivity and stability on volatile organic gas n-butyl alcohol at a relatively low working temperature, and is suitable for detecting trace n-butyl alcohol in a complex environment. The preparation method is mild in condition, low in cost and good in industrialization prospect, and has extremely wide application prospect in the field of preparation of gas sensitive materials.

The invention discloses a preparation method and application of a Prussian blue nanocage, and the preparation method of the Prussian blue nanocage comprises the following steps: dispersing potassium ferricyanide and nickel salt in a citrate solution, and aging to obtain an iron-nickel Prussian blue nanocube; drying the iron-nickel Prussian blue nanocubes obtained in the step S1, dispersing the dried iron-nickel Prussian blue nanocubes in an acid solution of dihydric alcohol, and performing chemical etching to obtain the Prussian blue nanocage. According to the preparation method, the dihydric alcohol is used as a reducing agent and an auxiliary agent, the acid solution is used as an etching agent, conversion from the iron-nickel Prussian blue nanocube to the nanocage is successfully achieved, and compared with the nanocube, the specific surface area, the pore volume and the iron ion content of the nanocage are further improved; therefore, the peroxidase mimic activity is obviously enhanced, and the method can be used as a solution for enhancing the nano-enzyme activity.

The invention provides a lysosome endogenous zinc ion detection probe, a preparation method thereof and application in zinc level detection in an Alzheimer's disease biological model, the preparation method comprises the following steps: 1) modifying a hydrophobic group with a DNA nano structure to prepare a DNA nano cage which has cell lysosome targeting ability and contains a specific hydrophobic cavity; 2) providing a hydrophobic fluorescent dye with zinc ion responsiveness; and 3) mixing the DNA nanocage and the hydrophobic zinc ion responsive dye through oscillation or ultrasonic mixing, so that the hydrophobic dye enters a hydrophobic cavity of the DNA nanocage and is packaged in the hydrophobic cavity, thereby obtaining the lysosome endogenous zinc ion detection probe. The lysosome endogenous zinc ion detection probe prepared according to the method disclosed by the invention has higher sensitivity, better stability and good biological safety, can be used for carrying out imaging monitoring on endogenous lysosome zinc ions in an AD (Alzheimer's disease) biological model, and has a good medical application prospect.

The present application is directed to a nanocage of Formula (I): wherein A and R are as described herein. The present application is also directed to a process for preparation of a nanocage of Formula (I). Methods of utilizing the nanocage for detecting an analyte in a fluid and for functionalizing a polymer are also described.

A fusion protein comprising: a first nanocage monomer subunit of a nanocage monomer; and a bioactive moiety attached to the first nanocage monomeric subunit; wherein the fusion protein is self-assembled with a protein comprising a second nanocage monomer subunit to form a nanocage monomer.

This invention discloses an ultrasonic-responsive modular acoustic printing ink, a printing platform, and their applications, relating to the fields of biomedical engineering and biomanufacturing. The ultrasonic-responsive element of this invention is a hollow nanocage composed of fluorinated silk fibroin, and the critical response sound pressure can be set by adjusting the degree of fluorination. The modular acoustic printing ink includes this ultrasonic-responsive element, a biopolymer prepolymer matrix, and optional functional additives. The printing platform integrates a focused ultrasonic transducer, an ink application device, an ultrasonic imaging module, and a control system. This invention uses an ultrasonic triggering method, breaking through the depth limitations of traditional photopolymer printing, to achieve minimally invasive in-situ printing of subcutaneous tissues several centimeters deep. It also features high spatiotemporal resolution, good biocompatibility, and mechanical adaptability, and can flexibly realize functions such as conductivity and drug loading. It is suitable for scenarios such as bioelectrode preparation, visceral wound closure, and controlled drug release, providing a new tool for precision medicine.

The invention relates to a polypyrrole conductive material with a hollow nanocage structure and a preparation method and application thereof, and belongs to the technical field of preparation of nano conductive materials, the method comprises the steps that pyrrole is polymerized on the surface of nano zinc oxide in situ, the mass ratio of pyrrole to nano zinc oxide is (0.5-1.5): 1, and a PPy / ZnO composite material with a core-shell structure is obtained; and dispersing the PPy / ZnO composite material with the core-shell structure in an acid solution, and etching the nano zinc oxide through double decomposition reaction to obtain the polypyrrole conductive material with the hollow nano-cage structure. The process controllability is high, the prepared polypyrrole nanocage has an ultrathin shell layer and a clear hollow cavity, a large specific surface area and rich internal and external reaction interfaces are provided, rapid diffusion of electrolyte ions and charge storage are facilitated, and excellent electrochemical performance is shown when the polypyrrole nanocage serves as an electrode material.

This invention discloses a miR-141 / near-infrared light dual-response synergistic drug delivery system, relating to the fields of biomedicine and nanomedicine. The system uses DNA-modified gold nanocages as carriers, loading doxorubicin (a chemotherapy drug) and methylene blue (a photosensitizer). H-type DNA nanolocks formed by thiol-modified A and B chains achieve specific recognition of miR-141 and dual response to near-infrared light. miR-141 binding triggers initial unwinding of the nanolocks, followed by complete unwinding and drug release via 808nm near-infrared light irradiation (photothermal effect). A 650nm laser excites methylene blue to generate reactive oxygen species, simultaneously completing quantitative detection of miR-141 (fluorescence / SERS signal complementarity) and synergistic treatment in three modes: chemotherapy + photothermal + photodynamic therapy. In vitro experiments show a miR-141 detection sensitivity of 5.0 × 10⁻⁶. ‑12 M, with a dual-response drug release rate exceeding 60%; in vivo experiments have demonstrated a tumor inhibition rate exceeding 70% and good biocompatibility. This system solves the problems of single-response and separation of diagnosis and treatment in existing delivery systems, and is suitable for precision treatment of miR-141 positive solid tumors such as MCF-7.

The invention discloses a Zn / Fe co-doped SnO2 ultrathin hollow edge nanocage superstructure composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a zinc-iron Prussian blue nano cubic precursor, and dispersing the zinc-iron Prussian blue nano cubic precursor in deionized water for standing and precipitation to obtain a zinc-iron Prussian blue nano cage; the preparation method comprises the following steps: preparing a tin-coated zinc-iron prussian blue nanocage, dispersing the tin-coated zinc-iron prussian blue nanocage in deionized water to form a suspension A, dissolving stannous salt in concentrated hydrochloric acid to form a solution B, pouring the solution B into the suspension A under stirring, uniformly stirring, and standing at 30-180 DEG C to react for 3-24 hours to obtain a tin-coated zinc-iron prussian blue nanocage ultrathin hollow-edge nanocage material; annealing is conducted for 1-5 h at the temperature of 280-550 DEG C; the material has unique hollow edges and a completely open cage-shaped cavity structure, and when the material is used as a gas sensitive material of a gas sensor, the material has very high sensitive response to hydrogen sulfide gas and is good in stability.