42 results about "Nanocages" patented technology

The invention discloses a nickel-based noble metal multi-shell nanocage material and a preparation method and application thereof, and relates to the technical field of nano functional materials.According to the nickel-based noble metal multi-shell nanocage material and the preparation method thereof, nickel nanoparticles serve as a core material, and the complexing and growth rate of noble metal is regulated and controlled by controlling the using amount of ligands; the technology of precious metal multi-step precise feeding, step-by-step programmed heating and system residual ligand reuse is combined, and precise epitaxial growth of multiple precious metals on the surfaces of the nickel nanoparticles is achieved. And carrying out carbon carrier loading and inorganic acid selective etching to accurately remove a part of nickel matrix and reserve a complete noble metal shell layer, thereby finally preparing the nickel-based noble metal multi-shell nanocage material with a hollow structure.

The invention discloses a photo-thermal regenerative carbon nanocage confinement lithium chloride low-temperature energy storage composite material, and preparation and application thereof, and belongs to the technical field of energy storage materials. The composite material takes a carbon nanocage with a micropore-mesopore-macropore hierarchical structure as a carrier, lithium chloride is loaded in a nano cavity and a pore channel of the carbon nanocage in a limited range to form a stable composite structure, and the problems of leakage and agglomeration of lithium chloride can be effectively inhibited; during preparation, the carbon nanocage is prepared through a chemical vapor deposition method, and the carbon nanocage can be obtained through drying, vacuum impregnation, suction filtration and freeze-drying shaping, the process is simple and controllable, and the graded pore mass transfer advantage of the carbon nanocage can be reserved; the composite material can stably work under the environment with the temperature of 20-40 DEG C and the relative humidity of 30%-60%, and the fit lt is achieved; the device can capture, store and release 100 DEG C low-grade heat energy, can be directly driven by solar energy to dehydrate and regenerate, has the advantages of high cycle stability and green regeneration, is suitable for adsorption type heat storage, solar photo-thermal energy storage and industrial waste heat recovery devices, and has remarkable industrial application value.

The invention relates to the technical field of battery materials, in particular to a multi-metal sulfide hollow nanocage composite material preparation method which comprises the following steps: S1, precursor preparation, S2, vulcanizing agent preparation and S3, composite preparation. According to the invention, the graphene oxide in the additive component is used as a conductive base material, can provide a macro-scale electron high-speed transmission channel, forms a three-dimensional cross-linked polymer conductive network, effectively fills gaps between graphene sheet layers, and physically prevents re-stacking caused by Van der Waals' force; the conductivity of a polyaniline molecular chain can be improved by doping phytic acid through rich phosphate groups, phytic acid molecules can also be intercalated between graphene sheets to prevent interlayer accumulation, the high specific surface area and a smooth ion transmission channel of the composite material are cooperatively maintained, and the conductivity of the composite material is improved. Therefore, the conductivity of the composite material is comprehensively improved.

The invention provides a lysosome endogenous zinc ion detection probe, a preparation method thereof and application in zinc level detection in an Alzheimer's disease biological model, the preparation method comprises the following steps: 1) modifying a hydrophobic group with a DNA nano structure to prepare a DNA nano cage which has cell lysosome targeting ability and contains a specific hydrophobic cavity; 2) providing a hydrophobic fluorescent dye with zinc ion responsiveness; and 3) mixing the DNA nanocage and the hydrophobic zinc ion responsive dye through oscillation or ultrasonic mixing, so that the hydrophobic dye enters a hydrophobic cavity of the DNA nanocage and is packaged in the hydrophobic cavity, thereby obtaining the lysosome endogenous zinc ion detection probe. The lysosome endogenous zinc ion detection probe prepared according to the method disclosed by the invention has higher sensitivity, better stability and good biological safety, can be used for carrying out imaging monitoring on endogenous lysosome zinc ions in an AD (Alzheimer's disease) biological model, and has a good medical application prospect.

The present application is directed to a nanocage of Formula (I): wherein A and R are as described herein. The present application is also directed to a process for preparation of a nanocage of Formula (I). Methods of utilizing the nanocage for detecting an analyte in a fluid and for functionalizing a polymer are also described.

A fusion protein comprising: a first nanocage monomer subunit of a nanocage monomer; and a bioactive moiety attached to the first nanocage monomeric subunit; wherein the fusion protein is self-assembled with a protein comprising a second nanocage monomer subunit to form a nanocage monomer.

This invention discloses an ultrasonic-responsive modular acoustic printing ink, a printing platform, and their applications, relating to the fields of biomedical engineering and biomanufacturing. The ultrasonic-responsive element of this invention is a hollow nanocage composed of fluorinated silk fibroin, and the critical response sound pressure can be set by adjusting the degree of fluorination. The modular acoustic printing ink includes this ultrasonic-responsive element, a biopolymer prepolymer matrix, and optional functional additives. The printing platform integrates a focused ultrasonic transducer, an ink application device, an ultrasonic imaging module, and a control system. This invention uses an ultrasonic triggering method, breaking through the depth limitations of traditional photopolymer printing, to achieve minimally invasive in-situ printing of subcutaneous tissues several centimeters deep. It also features high spatiotemporal resolution, good biocompatibility, and mechanical adaptability, and can flexibly realize functions such as conductivity and drug loading. It is suitable for scenarios such as bioelectrode preparation, visceral wound closure, and controlled drug release, providing a new tool for precision medicine.

The invention relates to a polypyrrole conductive material with a hollow nanocage structure and a preparation method and application thereof, and belongs to the technical field of preparation of nano conductive materials, the method comprises the steps that pyrrole is polymerized on the surface of nano zinc oxide in situ, the mass ratio of pyrrole to nano zinc oxide is (0.5-1.5): 1, and a PPy / ZnO composite material with a core-shell structure is obtained; and dispersing the PPy / ZnO composite material with the core-shell structure in an acid solution, and etching the nano zinc oxide through double decomposition reaction to obtain the polypyrrole conductive material with the hollow nano-cage structure. The process controllability is high, the prepared polypyrrole nanocage has an ultrathin shell layer and a clear hollow cavity, a large specific surface area and rich internal and external reaction interfaces are provided, rapid diffusion of electrolyte ions and charge storage are facilitated, and excellent electrochemical performance is shown when the polypyrrole nanocage serves as an electrode material.

This invention discloses a miR-141 / near-infrared light dual-response synergistic drug delivery system, relating to the fields of biomedicine and nanomedicine. The system uses DNA-modified gold nanocages as carriers, loading doxorubicin (a chemotherapy drug) and methylene blue (a photosensitizer). H-type DNA nanolocks formed by thiol-modified A and B chains achieve specific recognition of miR-141 and dual response to near-infrared light. miR-141 binding triggers initial unwinding of the nanolocks, followed by complete unwinding and drug release via 808nm near-infrared light irradiation (photothermal effect). A 650nm laser excites methylene blue to generate reactive oxygen species, simultaneously completing quantitative detection of miR-141 (fluorescence / SERS signal complementarity) and synergistic treatment in three modes: chemotherapy + photothermal + photodynamic therapy. In vitro experiments show a miR-141 detection sensitivity of 5.0 × 10⁻⁶. ‑12 M, with a dual-response drug release rate exceeding 60%; in vivo experiments have demonstrated a tumor inhibition rate exceeding 70% and good biocompatibility. This system solves the problems of single-response and separation of diagnosis and treatment in existing delivery systems, and is suitable for precision treatment of miR-141 positive solid tumors such as MCF-7.

The invention relates to the technical field of supercapacitor electrode materials, in particular to a preparation method of a NiCo2O4 / C / MnO2 ternary electrode material with a nanocage structure. The preparation method comprises the following steps: by taking nickel chloride hexahydrate, sodium citrate dehydrate, potassium hexacyanocobaltate and the like as raw materials, ultrasonically dissolving the raw materials, stirring, standing, aging and the like to obtain a NiCo-PBA nanocube, etching with an ammonia water solution, carbonizing with glucose, soaking with a KMnO4 solution and the like, and finally successfully synthesizing the ternary electrode material with a NiCo2O4 / C / MnO2 hollow nanocage structure. The method is mild in condition and relatively simple and convenient to operate, and the composite electrode material prepared by the preparation method has excellent super-capacitance performance and cycling stability when being used for a supercapacitor electrode; and the capacitance of the electrode material is far higher than that of a common electrode material of a conventional supercapacitor.

The invention discloses ultrasonic response type modular acoustic printing ink, a printing platform and application of the printing platform, and relates to the technical field of biomedical engineering and biological manufacturing. The ultrasonic response element is a hollow nanocage formed by fluoridized silk fibroin, and the critical response sound pressure can be set by regulating and controlling the fluorination degree; the modular acoustic printing ink comprises the ultrasonic response element, a biopolymer prepolymer matrix and an optional functional additive. The printing platform integrates a focused ultrasonic transducer, an ink applying device, an ultrasonic imaging module and a control system. An ultrasonic triggering mode is adopted, the depth limitation of traditional photocuring printing is broken through, minimally invasive in-situ printing of subcutaneous deep tissue of several centimeters is achieved, high temporal-spatial resolution, good biocompatibility and mechanical adaptability are achieved, the functions of electric conduction, medicine carrying and the like can be flexibly achieved, the method is suitable for biological electrode preparation, visceral wound plugging, medicine controlled release and other scenes, and the application prospect is wide. And a novel tool is provided for precision medical treatment.

Porous compositions and methods of making and using same. The compositions may be one or more layer(s) of mesoporous inorganic materials. The mesoporous inorganic material(s) may be a plurality of inorganic nanocages, which may be microporous. A composition may include homostacks of layers of the same inorganic mesoporous materials. A composition may include heterostacks of layers of inorganic mesoporous materials, where at least two of the layers are different. The compositions may be surface functionalized. The compositions may be formed in a reaction mixture including one or more precursor(s), one or more surfactant(s), water, and one or more organic solvent(s). The compositions may be formed at the liquid-liquid interface between the water and the one or more organic solvent(s). A composition may be used as a catalyst, in a catalytic method, as a separation medium, in a separation method, in nanomedicine applications, or the like.

According to the CuO (at) Pd hollow porous nanocage and the preparation method and application thereof, a Cu2O nanocube serves as an etching template, the hollow porous CuO (at) Pd nanocage is obtained through the redox electrode potential relation of palladium and copper, a unique three-dimensional open frame of the hollow porous CuO (at) Pd nanocage provides high-density active site exposure and a three-dimensional confinement effect for oxygen deficiency engineering, and the hollow porous CuO (at) Pd nanocage can be applied to oxygen deficiency engineering. The multi-enzyme activity of peroxidase, oxidase and laccase is remarkable, a three-channel sensor array is constructed aiming at high toxicity, difficult degradability and reducibility of phenolic pollutants and differential response of phenolic antioxidants to the activities of the three enzymes, the multi-enzyme activity can be dynamically adjusted through pH and temperature, and the detection sensitivity is high. The sensor array has the advantages that the pH limit neglected by the existing sensor array is solved, phenolic isomers with different concentrations and under the same concentration are distinguished at the same time, the linear range is wide, the sensitivity is high, the specificity and the anti-interference capability are excellent, and efficient oxidative degradation and accurate recognition of six phenolic substances are realized.

The invention discloses a tunable and high-sensitivity'yolk-shell-satellite 'multistage SERS (Surface Enhanced Raman Scattering) nanometer material as well as a preparation method and application thereof. According to the unique nanometer material provided by the invention, anisotropic gold nanorods are used as'yolk', cubic nanocages are used as'shell ', and gold nanoparticles are decorated on the outermost side through chemical in-situ growth to form a'satellite' structure. The yolk-shell-satellite Rod (at) Cavity (at) AuNPs multistage material prepared by the method provided by the invention contains rich nano tips and edges, forms dense SERS hot spots, provides ultrahigh sensitivity and can detect Raman signals of Raman active molecules 4-MBA molecules with the concentration of 10-12M; according to the egg yolk-shell-satellite Rod (at) Cavity (at) AuNPs plasma structure prepared by the preparation method disclosed by the invention, the morphology and SERS activity of the egg yolk-shell-satellite Rod (at) Cavity (at) AuNPs plasma structure are highly controllable, and extremely high signal reproducibility and environmental stability are achieved.

The application discloses a coordination gradient optimized nanocage Fe monatomic-sulfur positive electrode and a preparation method thereof, which comprises a carbon-based nanocage confined Fe monatomic material with a coordination shell gradient optimized and elemental sulfur. The coordination structure of metal Fe monatomic and nitrogen in the carbon-based ZIF-8 derived nanocage is precisely controlled, and the gradient optimization design of the Fe monatomic coordination shell is realized in combination with sulfur atoms, thereby breaking the limitation of the catalytic activity of the traditional M-N4 configuration. Meanwhile, the effective regulation of the size and shell thickness of the carbon nanocage is achieved by using the dopamine coating method coupled with high-temperature pyrolysis. The material utilizes the synergistic mechanism of physical confinement and chemical anchoring, significantly enhances the adsorption and catalytic conversion capacity of polysulfides, effectively suppresses the shuttle effect, and relieves the volume expansion problem in the charging and discharging process, thereby greatly improving the oxidation-reduction reaction kinetics, cycle stability and comprehensive electrochemical performance of lithium-sulfur batteries.

The disclosure relates to particle-based assays for the detection of analytes. Using various combinations of particular technologies, including gold nanorods, silver nanoparticles, gold / silver nanoshells, gold / silver nanocages and nanobubble detection, enhanced detection limits can be achieved across a large range of analytes.

The invention discloses a fluorescence visualization-photoelectrochemical dual-mode PFOS sensor based on a molecular nanocage as well as a preparation method and application thereof, and belongs to the technical field of environmental pollutant detection. Comprising a substrate, a titanium dioxide TiO2 layer and a lead coordination beta-cyclodextrin molecular nanocage MNCs layer which are sequentially arranged from bottom to top, and the titanium dioxide TiO2 layer and the lead coordination beta-cyclodextrin molecular nanocage MNCs layer form a TiO2 / MNCs heterostructure. Electron transfer of a TiO2 / MNCs interface is hindered through host-guest combination of PFOS and MNCs, so that the photocurrent concentration dependency is reduced; meanwhile, the PFOS limits intramolecular movement of the MNCs, inhibits non-radiative decay and enhances fluorescence emission. The sensor disclosed by the invention has the advantages of ultrahigh sensitivity, wide linear range, excellent selectivity and visual fluorescence response capability, and can be applied to dual-mode detection of PFOS in a complex water body.

The invention discloses a ZIF-67-based derivative hollow nano cage-shaped H-NiCoFe-LDH, which is characterized in that cobalt nitrate hexahydrate, dimethylimidazole, nickel nitrate hexahydrate and ferrous chloride tetrahydrate are used as raw materials, firstly ZIF-67 is obtained through a standing method, then ZIF-67 / NiCo-LDH with a core-shell structure is obtained through first-step ion exchange, and finally, ZIF-67 / NiCo-LDH with a core-shell structure is obtained through second-step ion exchange. Carrying out ion exchange in the second step to obtain ZIF-67 derived hollow nano cage-shaped H-NiCoFe-LDH; the basic microstructure of the H-NiCoFe-LDH is a polyhedral structure, the surface of the polyhedral structure is coated with a sheet structure, the H-NiCoFe-LDH is in a hollow nanocage shape, and the size of the H-NiCoFe-LDH is 400 The preparation method comprises the following steps: 1, preparing the polyhedral ZIF-67; 2, preparation of the ZIF-67 / NiCo-LDH with the core-shell structure; 3, preparation of the hollow nano cage-shaped H-NiCoFe-LDH derived on the basis of the ZIF-67 is carried out; all the steps are carried out at room temperature. When the H-NiCoFe-LDH composite material is used as a supercapacitor electrode material, the charge and discharge voltage range is 0-0.45 V, and when the discharge current density is 1A g <-1 >, the specific capacitance of H-NiCoFe-LDH is 1800-1900F g <-1 >.

The invention relates to the technical field of chemical synthesis and dye-sensitized photoelectrochemical cells, and discloses a metal-organic coordination nanocage as well as a preparation method and application thereof. The metal-organic coordination nanocage provided by the invention has good light absorption and catalytic hydrogen production performance, can be loaded on the surface of a semiconductor functional layer to form a photocathode, is applied to a dye-sensitized photoelectrochemical cell, and has the advantages of simple structure and low cost compared with a mode of separating a dye from a catalyst in a traditional system. According to the metal-organic coordination nanocage, the charge transfer efficiency and the structural stability are remarkably improved through the molecular integration design, efficient photocurrent response can be achieved in a neutral PBS buffer solution and under low bias voltage, the problem that a substrate is corroded by an acid environment is avoided, in addition, the metal-organic coordination nanocage can respond in a wide spectral range, and the performance of the metal-organic coordination nanocage is improved. The electron injection efficiency is optimized through energy level matching with the semiconductor function layer, and the problems that a traditional photocathode interface is serious in charge recombination, low in charge transfer efficiency and the like are solved.

The application relates to a bridged Fe-Cu bimetal carbon nanocage oxygen reduction reaction electrocatalyst as well as a preparation method and application thereof. The bridged Fe-Cu bimetal carbon nanocage oxygen reduction reaction electrocatalyst has a connected multi-level hole nanocage formed by a zeolitic imidazole metal covalent organic framework and Fe / Cu bimetal atoms bridged in the connected multi-level hole nanocage structure; wherein the Fe / Cu bimetal atoms have a bridged diatomic configuration, and are preferably N4Fe-CuN4 structures; wherein the electronic state of the Cu atom is Cu + , and the electronic state of the Fe atom is Fe 3+ .

The invention discloses a hollow nanocage hydrogen evolution catalyst with an ordered three-dimensional structure of ultrathin nanosheets rich in metal / oxide interfaces and a preparation method of the hollow nanocage hydrogen evolution catalyst. The preparation method comprises the following steps: directly preparing a metal hydroxide-organic ligand compound with nanorod morphology through an aqueous solution; carrying out secondary hydrothermal preparation to obtain a hollow metal oxysalt hollow nanocage compound; and finally, carrying out controllable reduction to obtain the electrolytic water hydrogen evolution catalyst rich in the metal / oxide interface. The water electrolysis hydrogen evolution catalyst prepared by the method has a nanocage structure formed by vertically and orderly stacking ultrathin nanosheets, is large in specific surface area, high in electrocatalytic activity and good in stability, and has very high industrial application value.

The application is suitable for the field of gas sensor detection, and provides a potential type hydrogen sensor and a preparation method thereof; the potential type hydrogen sensor comprises a zinc oxide nanocage sensitive electrode, a reference electrode, a solid electrolyte and a ceramic plate with a heating element, the heating element is used for heating the solid electrolyte, the sensitive electrode and the reference electrode; the solid electrolyte is installed on the ceramic plate, the zinc oxide nanocage sensitive electrode and the reference electrode are located on the surface of the solid electrolyte; the zinc oxide nanocage sensitive electrode is made of nanocage-shaped zinc oxide electrode material; the application takes the zinc oxide nanocage as the sensitive electrode, significantly improves the response value to hydrogen, and the response value to 20ppm hydrogen is increased by 11.6 times; compared with the existing most advanced potential type hydrogen sensor, the application also has obviously higher response, and has more advantages in low concentration hydrogen detection.

The application relates to the technical field of battery materials, in particular to a preparation method of a multi-metal sulfide hollow nanocage composite material, which comprises the following steps: S1, precursor preparation; S2, sulfidation agent preparation; and S3, composite preparation.In the application, the graphene oxide in the additive component is used as a conductive base material, can provide a macroscopic scale high-speed electron transmission channel, forms a three-dimensional cross-linked polymer conductive network, effectively fills the gaps between the graphene sheet layers, physically prevents the re-stacking of the graphene sheet layers due to the van der Waals force, and significantly enhances the toughness of the overall structure, the doping of the phytic acid can improve the conductivity of the polyaniline molecular chain by using the rich phosphoric acid groups of the phytic acid, and the phytic acid molecules can also be intercalated between the graphene sheet layers to prevent the layer accumulation, cooperatively maintain the high specific surface area and the unblocked ion transmission channel of the composite material, so that the conductivity of the composite material is comprehensively improved.

The present application relates to a kind of injectable temperature-sensitive hydrogel of near-infrared light response and its preparation method and application.The injectable temperature-sensitive hydrogel of near-infrared light response is: by chitosan, puerarin and near-infrared light response material jointly self-assembled to form the hydrogel with nanofiber network structure;Wherein chitosan and puerarin self-assemble to form nanofiber, and near-infrared light response material is embedded in nanofiber inside and is adsorbed on nanofiber surface;The concentration of solid component in the injectable temperature-sensitive hydrogel of near-infrared light response is 1.5-100 mg / mL, preferably 10-30 mg / mL;The concentration of near-infrared light response material in the injectable temperature-sensitive hydrogel of near-infrared light response does not exceed 1 mg / mL;The near-infrared light response material is selected from at least one of gold nanorod, gold nanoparticle, gold nanocluster and gold nanocage.

The application relates to a preparation method and application of a ternary prussian blue derivative nanocage core-shell electrode material, and relates to a preparation method and application of an electrode material. The application aims to solve the problems of poor electrochemical performance and low cycle life of existing supercapacitors. The method comprises the following steps: I, preparing nickel-cobalt-iron prussian blue; II, preparing a core-shell electrode material; and the ternary prussian blue derivative nanocage core-shell electrode material is used as a supercapacitor. The electrochemical performance of the obtained ternary prussian blue derivative nanocage core-shell electrode material is tested, and experiments show that the electrode material has high capacitive performance; when the current density is 1 A / g, the specific capacity of the material in 1 mol / L KOH solution reaches 1644.4 F / g; after 6000 single electrode cycles, there is still 97.27% of the initial capacitance value, which indicates that the supercapacitor core-shell electrode material provided by the application has high service life.

The application discloses a kind of functional ferritin nanoparticles and preparation method thereof, including the nanocage structure formed by self-assembly of multiple human heavy chain ferritin subunits, therapeutic agent wrapped in the nanocage structure, and functional polypeptide fused with human heavy chain ferritin subunit.The nanoparticles of the application can efficiently load chemotherapeutic drugs, can actively target and efficiently enter cancer cells, and have good biocompatibility.The application also discloses the use of the functional ferritin nanoparticles in the preparation of a medicament for treating cancer.

The invention provides a core-shell cobalt and nitrogen doped graphene oxygen reduction electrocatalyst and a preparation method thereof. The preparation method comprises the following steps: preparing a Zn doped ZIF-67 precursor; preparing a hollow porous nanocage; the ZIF-8 is synthesized; the preparation method comprises the following steps: constructing a core-shell composite precursor: ultrasonically dispersing a hollow porous nanocage in ethanol, slowly injecting into an ethanol dispersion liquid containing ZIF-8, stirring, centrifuging, washing and drying to obtain the core-shell composite precursor; and carrying out second-stage heat treatment on the core-shell composite precursor in an inert atmosphere, and carrying out pyrolysis to obtain the core-shell cobalt and nitrogen doped graphene oxygen reduction electrocatalyst, which is recorded as NG / Co-X. According to the core-shell structure with the ZIF-8 as the shell layer and the different Zn-doped ZIF-67 as the core layer, the active site distribution and mass transfer path of the catalyst are optimized, the conductivity and stability are improved, the synergistic effect of Co ions and a nitrogen-doped carbon matrix is enhanced, and the ORR activity is improved.

Nanocage multimers, including ROOL IncRNA monomers, for delivering a cargo into a target cell are described.