38 results about "Polymeric micelles" patented technology

The invention discloses a method for preparing mesoporous Bi2O3 through block polymer micelle induced self-assembly and application, and relates to the field of supercapacitor electrode materials. The method comprises the following steps: dissolving P123 in a solvent, adding an acidic reagent, then adding Bi (NO3) 3.5 H2O or BiCl3, and uniformly stirring to form a mixed solution; preparing KOH into a KOH solution, adding the KOH solution into the mixed solution, stirring, and standing to obtain the mesoporous Bi2O3. Mesoporous Bi2O3 is synthesized by adopting a micelle-induced self-assembly method, the microtopography and particle size of the mesoporous Bi2O3 can be regulated and controlled, the mesoporous structure enables the Bi2O3 material to have higher specific surface area and porosity, more active sites are exposed, the stability and electrochemical performance of the Bi2O3 electrode material are improved, and the preparation method is suitable for industrial production. The problems of poor conductivity and poor cycling stability are solved.

The invention relates to the technical field of nano-micelles, in particular to rifapentine-loaded bone targeting nano-micelles as well as a preparation method and application thereof.The rifapentine-loaded bone targeting nano-micelles are prepared by accurately controlling a synthesis process (shading, catalyst ratio, temperature and feed ratio) of a bone targeting nano-micelle carrier (ALN-PLGA-mPEG) modified by alendronate sodium (ALN). The bone targeting ability of alendronate sodium (ALN) is combined with the drug loading and long circulation advantages of polymer mPEG-PLGA micelles to construct a bone targeting nano-micelle carrier (ALN-PLGA-mPEG), so that the obtained rifapentine-loaded bone targeting nano-micelle (ALN-PLGA-mPEG (at) RPT) can significantly improve the bone targeting and slow release performance, and provides a new strategy with high efficiency and low toxicity for precise treatment of bone tuberculosis.

The present disclosure provides a composition in which a radical reaction-imparting substance and a polymer micelle that encapsulates a hydrophobic substance are uniformly mixed.

The invention discloses a docetaxel-loaded retinoic acid derivative polymer micelle and a preparation method thereof, and belongs to the technical field of biological medicines. The polymer micelle is prepared from docetaxel and a retinoic acid derivative polymer mPR. The preparation method comprises the following steps: mixing and dispersing the polymer mPR and docetaxel into a drug film, and hydrating with a proper medium to prepare the polymer micelle. The docetaxel polymer micelle disclosed by the invention is high in encapsulation efficiency, high in drug loading capacity, high in stability and relatively good in curative effect and safety.

Micelle compositions comprising a hedgehog pathway inhibitor and their use in treating skin diseases, conditions, or disorders, such as skin cancers, including basal cell carcinoma, are disclosed.

The application discloses a kind of dual targeting / drug-loaded reduction-sensitive nano-carrier, and the micelle is formed by the micelle of block polymer by solvent evaporation method, and the multi-block polymer is Tel-PEG-ss-PCL, the hydrophilic end of which is PEG with targeting group Tel, and the hydrophobic end is PCL, which is a core-shell structure, the core is the hydrophobic end PCL, and the shell is the hydrophilic block with targeting group Tel.The nano-carrier selects the polymer micelle with hydrophilic end polyethylene glycol and hydrophobic end polycaprolactone as drug carrier to improve the problem of poor water solubility of drug;Tel, an angiotensin II type receptor (AT1R) ligand, is used to simultaneously target CAFs and tumor cells overexpressing AT1R, kill tumor cells and CAFs, and double drug loading to overcome drug resistance;Meanwhile, disulfide bond is used to respond to high concentration glutathione (GSH) in tumor cells to achieve precise control release of drug in cells.The nano-carrier realizes the treatment effect of solubilization of poorly soluble drug, tumor and CAFs dual targeting and reversal of drug resistance.

The invention relates to a micelle dispersion liquid and a preparation method thereof, the dispersion liquid comprises a polymer micelle composed of an amphiphilic high-molecular polymer, an ionic salt, and one or more of sodium hyaluronate, sodium carboxymethyl cellulose and collagen, and the dispersion liquid can be used in the field of medical beauty, such as a filler or a hydro-optical needle.

The application relates to the technical field of polymer micelles, in particular to a pH response star polymer micelle and a preparation method and application thereof. The pH response star polymer micelle takes pentaerythritol as a core, and other block structures include polyethylene glycol monomethyl ether, a dynamic imine bond, gamma-amino-epsilon-caprolactone and epsilon-caprolactone. After loading an anticancer drug doxorubicin, the polymer micelle can stably exist in a neutral environment of human normal tissues, and can control the release of the drug in a slightly acidic environment of tumor cells.

Pharmaceutical compositions of polymeric micelle cinacalcet suitable for intravenous or intraperitoneal administration, and methods of making and use thereof in the treatment of various diseases and disorders, such as hyperparathyroidism and hypercalcemia, are provided.

The present application relates to a ginsenoside Rg3 drug delivery system, and a preparation method and application thereof. White yam polysaccharides (BSPs) are extracted from white yam by water extraction and alcohol precipitation, and then subjected to defatting, decolorization, deproteinization and chromatographic purification. A small hydrophobic molecule SA is introduced to modify the structure of BSPs, and a dialysis method is used to prepare BSPs-SA polymer micelles, and an amphiphilic copolymer BSPs-SA is obtained as a carrier material. An emulsion solvent evaporation method is used to prepare G-Rg3@BSPs-SA polymer micelles, and the freeze-dried powder is loaded into a colon-soluble capsule shell to prepare a G-Rg3@BSPs-SA colon-soluble capsule with double targeting. The in vitro drug release behavior and preliminary stability of the capsule are evaluated. After oral administration of the delivery system, no drug is released in the upper gastrointestinal tract, and after entering the colon, the capsule shell is degraded in the specific pH environment of the colon to release G-Rg3@BSPs-SA polymer micelles. Through the dual targeting function on tumor cells and M2-TAMs, the delivery system can achieve multi-link regulation of "inhibiting tumor cell growth and regulating immune microenvironment" of colon cancer, and effectively inhibit the occurrence and development of colon cancer.

This invention discloses a method for preparing mesoporous amorphous alloy thin films, relating to the field of metal thin film technology. The method includes: mixing a diblock polymer, an organic solvent, water, and a metal salt precursor to obtain a mixed solution containing polymer micelles; adding a boron-containing reducing agent to the mixed solution to obtain an electrolyte; using a conductive substrate as the working electrode, performing linear voltammetry scanning in the electrolyte using a three-electrode system to obtain an initial deposition layer; placing the initial deposition layer in the electrolyte and allowing it to stand, then performing autocatalytic chemical deposition under a protective gas to obtain an initial alloy thin film; and immersing the initial alloy thin film in an organic solvent to obtain a mesoporous amorphous alloy thin film. This invention utilizes the high efficiency of electroreduction and the controllability of chemical reduction through an electrodeposition-induced autocatalytic process, achieving controllable synthesis of mesoporous amorphous alloy thin films with uniform pore size and consistent three-dimensional porosity.

The invention discloses a photoresponse drug delivery system and a preparation method and application thereof. The photoresponse drug delivery carrier comprises a photosensitive liposome and a metal polyphenol coordination polymer micelle, the metal polyphenol coordination polymer micelle comprises a metal polyphenol network coating and a polymer micelle, the surface of the polymer micelle is coated with the metal polyphenol network coating, and the metal polyphenol network coating is coated with the polymer micelle. The metal polyphenol coordination polymer micelle is loaded on the surface of the photosensitive liposome; the photosensitive lipidosome comprises a lipidosome membrane and an inner water phase located in the lipidosome membrane, the inner water phase comprises EDTA and ammonium salt, and the lipidosome membrane comprises a lipid material and a photosensitizer. The photoresponse drug delivery system has an efficient photoresponse drug release rate, sequential release of drugs can be achieved, and multi-mode combined anti-tumor is achieved through combination of photodynamic and chemotherapeutic drugs.

The invention belongs to the technical field of polymer self-assembly, and particularly relates to an amphiphilic polymer with reduction response and a preparation method and application of a micelle of the amphiphilic polymer. The preparation method of the amphiphilic polymer comprises the following steps: taking 3, 3 '-dithiodipropionic anhydride (DTDPA) as an intermediate, connecting amino polyethylene glycol monomethyl ether to one end of the 3, 3'-dithiodipropionic anhydride through ring opening polymerization, and connecting racemic polylactic acid to carboxyl at the other end of the 3, 3 '-dithiodipropionic anhydride through esterification reaction. The amphiphilic polymer has a novel structure, and has unique design in structural composition and formula. The particle size of the polymer micelle prepared from the amphiphilic polymer is in a micron level, the size is uniform, the dispersity is good, and the polymer micelle has certain drug loading capacity.

This application discloses a method and apparatus for preparing formaldehyde-free decorative paper impregnated with aqueous polyacrylate, belonging to the field of decorative paper production technology. The method includes: providing continuously running formaldehyde-free decorative paper; establishing an asymmetric pulsed electric field within a reactor impregnated with an aqueous polyacrylate emulsion along the path of the formaldehyde-free decorative paper; and controlling the formaldehyde-free decorative paper to pass through the reactor, so that negatively charged polymer micelles in the aqueous polyacrylate emulsion, under the action of the asymmetric pulsed electric field, overcome electrostatic repulsion and surface tension, and are forcibly and rapidly penetrate and fill the internal fiber network of the formaldehyde-free decorative paper. This application fundamentally solves the technical problem of the difficulty in deeply and uniformly impregnating the base paper with environmentally friendly aqueous resin under high-speed production conditions by introducing an electrodynamic forced penetration mechanism.

This invention belongs to the field of nanomedicine delivery systems, specifically relating to a dual-sensitivity co-loaded emodin and chlorambucil micelles, their preparation method, and applications. The polymer structure is as follows: Using polymethacrylate as the linking unit, this invention designs and synthesizes a dendritic polymer p(mPEG-co-HPBE-co-EMD) grafted with polyethylene glycol monomethyl ether, p-hydroxymethylphenylboronic acid pinacol ester, and emodin, and uses it for encapsulating chlorambucil. This co-loaded polymer micelle can be used for the co-delivery of emodin and chlorambucil. This co-loaded micelle improves the water solubility of the drug, has a suitable particle size, and dual ROS / pH sensitivity, enabling targeted release of emodin and chlorambucil at tumor sites, achieving synergistic treatment with chemotherapy and oxidative therapy. In the formula, n = 30-85, x:y:z = 1:2-5:1-3.

The application provides a kind of construction and application of multi-stage targeted carrier of viral antigen and adjuvant.It is a kind of nanometer loading SARS-CoV-2 and other viral recombinant protein antigens and vaccine adjuvant Toll-like receptor agonists by using liposome, solid lipid nanoparticle, nanoemulsion, polymer micelle and nanocapsule, etc., the surface of the nanocarrier is modified by using mannose and cationic peptide Par, and the nanocarrier is endowed with multi-stage targeting of dendritic cells and endoplasmic reticulum.By adjusting the ratio of Man and Par, the processing of SARS-CoV-2 and other viral recombinant protein antigens in the endoplasmic reticulum and lysosome of DC cells can be effectively regulated, the presentation of exogenous antigens by DC cells is enhanced, and the initiation of CD8+ and CD4+ T cells in the body is promoted; meanwhile, the nanocarrier can also deliver very low dose of CpG-OND adjuvant directly to the endoplasmic reticulum of DC cells to play a role, and the potential immunotoxicity induced by the adjuvant is reduced.

The invention provides a preparation method and application of a ZnIn2S4 / polymer micelle nano composite photocatalyst, and belongs to the field of advanced material design and photocatalysis. According to the preparation method, a photo-induced polymerization induced self-assembly method is adopted, a polyacrylic acid macromolecular chain transfer agent and a styrene monomer are co-assembled with a ZnIn2S4 photocatalyst in the process of forming polymer micelles through in-situ polymerization under ultraviolet irradiation, and therefore the novel ZnIn2S4 / polymer micelle nano-composite photocatalyst is prepared. The preparation method disclosed by the invention is simple, and the compounding of ZnIn2S4 and the polymer micelle is realized in situ through a photo-induced polymerization induced self-assembly method. Besides, the inorganic / organic nano-composite photocatalyst prepared by the method has remarkable photocatalytic performance, can quickly degrade dye wastewater, and has a better application prospect in the technical field of environmental pollution treatment.

The invention relates to the technical field of oil and gas drilling and completion, in particular to a leaking stoppage material and a preparation method and application thereof, and the leaking stoppage material comprises 1-3 wt% of calcium carbonate, 1-2 wt% of white asphalt and 1-2 wt% of modified polylactic acid. Through the synergistic effect of white asphalt and calcium carbonate, the structural stability of the plugging layer is enhanced; under the action of modified polylactic acid, polymer micelles can be pressed and attached to the surface of well wall rock and are associated to form a plugging layer, so that the permeability of the plugging layer is effectively reduced, and the damage to a reservoir is reduced; under the combined action of calcium carbonate, white asphalt and modified polylactic acid, the plugging material is endowed with better plugging strength, has better degradability, does not need a complicated plugging removal procedure, and does not generate new chemical or mechanical plugging, so that secondary damage to a reservoir is avoided. The problems that in the prior art, a leakage-proof and leakage-stopping material is poor in leakage-proof and leakage-stopping capacity, the later-period plug removal process is complex, and a reservoir is prone to being damaged are solved.

This utility model discloses a polymer micelle detection sampler, belonging to the field of sampler technology. This polymer micelle detection sampler includes a sampling mechanism and a storage mechanism. The sampling mechanism includes a sampling cylinder with a piston slidably mounted inside. A push-pull rod is fixedly mounted at the center of one side of the piston, and a handle is fixedly mounted on the bottom side of the sampling cylinder. The storage mechanism includes a connecting seat and a sample bottle. The bottom end of the connecting seat is connected to one side of the upper end of the sampling cylinder. A stirring rod is rotatably connected to one end of the connecting seat. An inlet tube is mounted on one side of the stirring rod at one end of the connecting seat. The sample bottle is sleeved on the outside of the stirring rod, and one end of the sample bottle is threadedly connected to the outside of one end of the connecting seat. A first one-way valve is embedded in one end of the sample bottle. This utility model can effectively improve the practicality of the polymer micelle detection sampler and has high practical value.

This invention discloses a rod-shaped polycyclic polymer, its synthesis method, and its applications. The rod-shaped polymer can be used as a lysosomal destructive drug by forming petal-shaped polymer micelles. Currently, there are no reported methods for preparing polycyclic polymers with rod-shaped molecular chains. This invention reports a method for preparing a polycyclic polymer with rod-shaped molecular chains approximately 100 nm in length. Furthermore, there are no reported methods for preparing petal-shaped polymer micelles. This invention reports a method for preparing petal-shaped polymer micelles from a rod-shaped polymer, and this petal-shaped polymer can be used as a lysosomal destructive drug.

The application discloses a high-efficiency mucus-penetrating amphiphilic polymer micelle, and a preparation method thereof, which comprises the following steps: (1) CB-tBu synthesis; (2) synthesis of an NHS-ATRP initiator; (3) synthesis of NHS-PCB-tBu; (4) synthesis of PHABA; (5) synthesis of NHS-Azo; (6) synthesis of NHS-Azo-PCB-tBu; (7) synthesis of DSPE-Azo-PCB; and (8) preparation of the high-efficiency mucus-penetrating amphiphilic polymer micelle. The high-efficiency mucus-penetrating amphiphilic polymer micelle DSPE-Azo-PCB prepared by the application has a stronger mucus-penetrating effect and can efficiently cross the lung mucosal barrier; the micelle has a lower critical micelle concentration, and can effectively improve the structure dissociation problem of micelles caused by a large amount of blood dilution at present, and has huge social and economic benefits.

The present invention relates to a polymeric nanoparticle for oral administration of physiologically active substances and a preparation method therefor and, more specifically, to a carrier or polymeric hydrogel for delivery of a physiologically active substance and a preparation method therefor, wherein the carrier or polymeric hydrogel comprises: polymeric micelles including a PEG-based block copolymer prepared by a reversible addition–fragmentation chain transfer (RAFT) radical polymerization method using a polymer that has a specific functional group at the chain end thereof and a boronic acid group introduced into the backbone thereof; and a physiologically active substance that can be encapsulated in the polymeric micelles, including a type 2 diabetes drug, insulin, an anti-obesity agent, a DPP-4 inhibitor, or an anticancer agent.

Provided herein are therapeutic peptides. In some aspects, therapeutic peptides are provided that can alter EphB4 / EFNB2 signaling and can be used to treat a cancer. In some embodiments, the peptides are comprised in nanoparticles, such as core-cross-linked polymeric micelles (CCPM).

The invention provides a reduction-sensitive drug-loaded polymer micelle as well as a preparation method and application thereof. Wherein the polymer micelle comprises a micelle skeleton formed by an amphiphilic polymer, a docetaxel conjugate entrapped in the micelle skeleton, and miR-600 and hyaluronic acid adsorbed on the micelle skeleton. The polymer micelle disclosed by the invention can be used for loading hydrophilic or hydrophobic drugs by utilizing the amphipathy, and can also be used for efficiently loading drugs such as mRNA and the like by utilizing the charge property of the polymer micelle. Besides, the polymer micelle can protect the loaded medicine from external interference by utilizing a unique space structure, and can release mitochondrial targeting conjugates in tumor cells, so that cascade targeting is realized, and the medicine effect is improved.

Disclosed are POEGMA copolymer conjugates that have phase transition behavior and a reduced or eliminated host-immune response. An example conjugate includes a biologically active agent and a copolymer of POEGMA conjugated to the biologically active agent where the conjugate has a transition temperature. The POEGMA copolymer conjugates can form drug releasing depots, which can be useful in methods of treating diseases.

The invention provides a drug-loaded polymer nanocapsule and a preparation method thereof. The preparation method comprises the following steps: loading an indissolvable drug in a polymer micelle in a supramolecular self-assembly manner under hydrophilic and hydrophobic effects, enriching charged monomers on the surface of the drug-loaded micelle under supramolecular electrostatic attraction, hydrogen bonds and other non-covalent acting forces, and adding a cross-linking agent and an initiator to initiate an in-situ free radical polymerization reaction on the surface of the micelle to prepare the drug-loaded micelle. A polymer shell layer can be formed on the surface under the precondition that the structure of the internal micelle is not changed, so that the protection of an internal hydrophobic drug is realized. The modified drug-loaded micelle shows good properties in the aspects of stability and cellular uptake, and meanwhile, the polymer shell can controllably release drugs, that is, the shell can swell, degrade and release the internally loaded drugs under specific conditions, shows a good effect in an experiment, and has good application prospects. The invention solves the problems of stable delivery and controllable release of insoluble drugs.

The present specification discloses a poly (ethylene glycol)-b-poly ([R, S]-beta-hydroxybutyric acid) (PEG-b-PBHB) copolymer (the omega-terminal is modified), and nano-sized polymeric micelles or nanoparticles formed from the copolymer that can continuously release or slowly release low molecular beta-hydroxybutyric acid in vivo, the invention also relates to a preparation or preparation method of the nano particles or medical application of the nano particles. The nanoparticles can continuously release or slowly release the beta-hydroxybutyric acid in a living body, so that the original physiological activity of the beta-hydroxybutyric acid can be exerted in the living body.

To provide a micelle capable of increasing retentivity in blood and efficiently releasing a protein in an acidic condition for increasing a therapeutic effect by a therapeutic protein.SOLUTION: A polymer composite containing a protein and a block copolymer represented by the following formula (1) is provided.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of polymer nano-drugs, and particularly relates to a drug-co-loaded polymer micelle, a gel drug system, a preparation method and application. The polymer micelle double-drug nano preparation is obtained by self-assembly and self-crosslinking of the amphiphilic block polymer and co-loading of an anti-tumor drug at the same time. The polymer micelle co-loaded with the medicine has the advantages that the preparation is simple and controllable, the medicine proportion is adjustable, the size is small, the storage is easy, the stability is high, the biocompatibility is excellent, the medicine in cells can be quickly and proportionally released, the synergistic anti-tumor effect is strong, the in-vivo safety is high, the tumor can be completely eradicated, and the like. In general, the polymer micelle carrying the two anti-tumor drugs has the multiple advantages of being easy to prepare, safe, efficient and synergistic and the like, postoperative recurrence of malignant tumors can be effectively restrained, and the postoperative survival rate is greatly improved.

This invention provides a tumor-targeting Bletilla striata polysaccharide polymer nanomicelle, its preparation method, and its application. The invention involves the self-assembly of Bletilla striata polysaccharide and vitamin E succinate in water to form polymer nanomicelles—a tumor-targeting and biodegradable drug delivery system. Bletilla striata polysaccharide is the main active ingredient of the traditional Chinese medicine Bletilla striata, a natural biodegradable polymer material with antitumor activity, enabling a "drug-adjuvant" effect. Simultaneously, the biodegradability of the raw material addresses the safety issue of long-term retention of "ineffective" carriers in vivo. The vitamin E succinate is used as a hydrophobic modification of Bletilla striata polysaccharide, forming the polymer micelles, and also possesses antitumor activity, resulting in a synergistic effect.