69 results about "Polymeric micelles" patented technology

The invention discloses a cosmetic composition and a preparation method thereof, and belongs to the technical field of cosmetics. The invention discloses a chamomile essential oil toner which is mainly prepared from the following raw material components in parts by mass: 10 to 20 parts of modified toner, 50 to 60 parts of water, 4 to 6 parts of glycerol, 2 to 4 parts of propylene glycol, 0.8 to 1.2 parts of sodium chloride, 6.5625 to 7.875 parts of chamomile essential oil polymer micelle, 2.1875 to 2.625 parts of adhesive, 10.5 to 11.5 parts of capric triglyceride and 0.8 to 1.2 parts of cetyl polyethylene glycol. Through the synergistic effect of the modified toner and chamomile essential oil polymer micelles in a specific ratio, the dispersion stability of the toner is improved, meanwhile, the slow release effect of active ingredients is enhanced, and the chamomile essential oil toner has the advantages that the makeup holding property, the storage stability and the mildness are improved, meanwhile, the toner dispersity is improved, and the sensitive skin stimulation risk is reduced.

The present invention provides a polymeric complex comprising a cytokine and a block copolymer represented by the following formula (1).

The invention discloses a method for preparing mesoporous Bi2O3 through block polymer micelle induced self-assembly and application, and relates to the field of supercapacitor electrode materials. The method comprises the following steps: dissolving P123 in a solvent, adding an acidic reagent, then adding Bi (NO3) 3.5 H2O or BiCl3, and uniformly stirring to form a mixed solution; preparing KOH into a KOH solution, adding the KOH solution into the mixed solution, stirring, and standing to obtain the mesoporous Bi2O3. Mesoporous Bi2O3 is synthesized by adopting a micelle-induced self-assembly method, the microtopography and particle size of the mesoporous Bi2O3 can be regulated and controlled, the mesoporous structure enables the Bi2O3 material to have higher specific surface area and porosity, more active sites are exposed, the stability and electrochemical performance of the Bi2O3 electrode material are improved, and the preparation method is suitable for industrial production. The problems of poor conductivity and poor cycling stability are solved.

Micellar compositions comprising hedgehog pathway inhibitors and their use in the treatment of skin diseases, skin conditions or skin disorders such as skin cancer, including basal cell cancer, are disclosed.

The invention discloses a dual stimuli-responsive polymer micelle as well as a preparation method and application thereof. The micelle is jointly formed by a phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer and a catechol modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer, wherein the phenylboronic acid modified polyethylene glycol monomethyl ether-(alpha-propargyl-delta-valerolactone-lactide) copolymer is used for modifying the phenylboronic acid; when the micelle is formed, pH and ROS can be formed in a hydrophobic core to stimulate corresponding boric acid ester bonds; the micelle is used for loading hydrophobic antitumor drugs. The polymer micelle prepared by the invention can be stable in an in-vivo circulating physiological environment, and makes stimulation response to a tumor microenvironment to cause structure loosening or dissociation, so that effective delivery of hydrophobic antitumor drugs is realized, the problems of instability of the micelle in vivo and drug pre-leakage are effectively solved, and the drug delivery efficiency is improved. Theoretical and practical basis is provided for promoting cancer treatment of a polymer micelle drug delivery system.

The invention provides a polymer micelle composition. The polymer micelle composition is prepared from ampelopsis grossedentata extract or dihydromyricetin, an amphiphilic polymer capable of forming a polymer micelle; and an antioxidant. The invention also provides a method for preparing the polymer micelle composition. The invention also relates to application of the polymer micelle composition in preparation of medicines or cosmetics. The invention further relates to medicines or cosmetics containing the polymer micelle composition.

A living cell drug delivery system, a preparation method therefor, and use thereof. The living cell drug delivery system comprises carrier cells, polymer micelles, and a metal polyphenol network coating. The polymer micelles are loaded on the surface of the carrier cells, and the metal polyphenol network coating covers the surface of the polymer micelles. The raw materials of the metal polyphenol network coating comprise a first metal salt, a second metal salt and a polyphenol.

The invention relates to the technical field of nano-micelles, in particular to rifapentine-loaded bone targeting nano-micelles as well as a preparation method and application thereof.The rifapentine-loaded bone targeting nano-micelles are prepared by accurately controlling a synthesis process (shading, catalyst ratio, temperature and feed ratio) of a bone targeting nano-micelle carrier (ALN-PLGA-mPEG) modified by alendronate sodium (ALN). The bone targeting ability of alendronate sodium (ALN) is combined with the drug loading and long circulation advantages of polymer mPEG-PLGA micelles to construct a bone targeting nano-micelle carrier (ALN-PLGA-mPEG), so that the obtained rifapentine-loaded bone targeting nano-micelle (ALN-PLGA-mPEG (at) RPT) can significantly improve the bone targeting and slow release performance, and provides a new strategy with high efficiency and low toxicity for precise treatment of bone tuberculosis.

The invention discloses a polymer with pH responsiveness and active targeting as well as a preparation method and application of the polymer. The polymer has the following chemical structural formula: # imgabs0 #, in the formula, the value of n is 37, and the value range of m is 20-43. The polymer not only can realize pH responsiveness and active targeting at the same time, but also has good biocompatibility and biodegradability, can be self-assembled in an aqueous medium to form a polymer micelle with a core-shell structure to be used as a targeting carrier of an antitumor drug, and has excellent drug loading performance. Therefore, the active targeting release of the anti-tumor drug is realized, so that the drug toxicity is reduced, and the targeting treatment effect is improved.

According to the invention, a polymer prodrug is designed and prepared, and a dasatinib (DAS) and triphenylphosphine-adriamycin (TPP-DOX, TD) co-loaded nano-micelle is constructed; the preparation method has the advantages that 1) the optimal preparation process of the polymer micelle is determined by a single factor investigation method, namely the optimal nano-micelle is prepared by using a dialysis method and taking DMF (Dimethyl Formamide) as a solvent according to the mass ratio of a prodrug material to a carried drug being 15: 1, and the preparation method is simple and clear and is easy to industrialize; 2) the particle size is small and uniform, so that the nanoparticles can be enriched at a tumor part through an EPR effect; 3) the amphiphilic micromolecule prodrug improves the water solubility of DAS, improves the drug stability, has high drug loading capacity, and avoids adverse reactions possibly caused by carriers and auxiliary materials; and 4) the polymer nano-micelle co-loaded with the DAS and the TPP-DOX has good MMP-2 sensitive responsiveness, enhances the drug targeting delivery capability, has good blood compatibility and safety, improves the drug curative effect, reduces the toxic and side effects, and has a good tumor MDR reversing effect.

The present disclosure provides a composition in which a radical reaction-imparting substance and a polymer micelle that encapsulates a hydrophobic substance are uniformly mixed.

The invention discloses a docetaxel-loaded retinoic acid derivative polymer micelle and a preparation method thereof, and belongs to the technical field of biological medicines. The polymer micelle is prepared from docetaxel and a retinoic acid derivative polymer mPR. The preparation method comprises the following steps: mixing and dispersing the polymer mPR and docetaxel into a drug film, and hydrating with a proper medium to prepare the polymer micelle. The docetaxel polymer micelle disclosed by the invention is high in encapsulation efficiency, high in drug loading capacity, high in stability and relatively good in curative effect and safety.

The invention relates to the technical field of biological medicines, and particularly discloses an application composition of stem cell exosomes in promoting tissue repair, which comprises the stem cell exosomes selected from induced pluripotent stem cells, mesenchymal stem cells, embryonic stem cells, hematopoietic stem cells or neural stem cells and used for promoting tissue repair and cell regeneration, and the stem cell exosomes selected from the induced pluripotent stem cells, the mesenchymal stem cells, the embryonic stem cells, the hematopoietic stem cells and the neural stem cells. The tissue repair promoting factor is selected from an epidermal growth factor, a transforming growth factor beta, a platelet-derived growth factor or a combination thereof, and is used for optimizing cell proliferation, differentiation and wound healing; the biodegradable carrier is selected from hydrogel, lipidosome, polymer micelle, nano particles or natural plant extract; by optimizing the transmission relation between the biodegradable carrier and the stem cell exosome and combining with the cell proliferation model, different doses and delivery modes can be flexibly regulated and controlled, the treatment scheme is further optimized, and the effect of the treatment scheme is accurately predicted. Due to the design, the common problems of unstable effect, long treatment period and the like in the traditional stem cell application are solved.

The invention discloses a preparation method and application of a targeting small molecule (ACUPA) coupled nano drug delivery system (AMC) specifically combined with prostate specific membrane antigen (PSMA), and belongs to the technical field of biological medicine. The targeting micromolecule (ACUPA) coupled nano drug-loaded delivery system (AMC) is a targeting micromolecule coupled nano drug-loaded polymer micelle which can be specifically combined with prostate specific membrane antigen (PSMA). The micelle is formed by self-assembly through a film hydration method. The targeting micromolecule (ACUPA) specifically bound with the prostate specific membrane antigen (PSMA) is coupled with the polymer micelle through a chemical bond. The targeting micromolecule (ACUPA) can be specifically combined with prostate cancer cells expressing PSMA, a nano drug-loaded preparation is delivered to the prostate cancer cells, the active targeting property of combination with a specific antigen, the endothelial action of the antigen cells and the high-permeability long-retention effect of the nano preparation are fully exerted, multiple effects are synergistic, and the drug-loaded nano drug-loaded preparation is prepared. The toxicity of the medicine on prostate cancer cells is remarkably increased, and then the targeted therapy of prostate cancer is enhanced.

Micelle compositions comprising a hedgehog pathway inhibitor and their use in treating skin diseases, conditions, or disorders, such as skin cancers, including basal cell carcinoma, are disclosed.

The application discloses a kind of dual targeting / drug-loaded reduction-sensitive nano-carrier, and the micelle is formed by the micelle of block polymer by solvent evaporation method, and the multi-block polymer is Tel-PEG-ss-PCL, the hydrophilic end of which is PEG with targeting group Tel, and the hydrophobic end is PCL, which is a core-shell structure, the core is the hydrophobic end PCL, and the shell is the hydrophilic block with targeting group Tel.The nano-carrier selects the polymer micelle with hydrophilic end polyethylene glycol and hydrophobic end polycaprolactone as drug carrier to improve the problem of poor water solubility of drug;Tel, an angiotensin II type receptor (AT1R) ligand, is used to simultaneously target CAFs and tumor cells overexpressing AT1R, kill tumor cells and CAFs, and double drug loading to overcome drug resistance;Meanwhile, disulfide bond is used to respond to high concentration glutathione (GSH) in tumor cells to achieve precise control release of drug in cells.The nano-carrier realizes the treatment effect of solubilization of poorly soluble drug, tumor and CAFs dual targeting and reversal of drug resistance.

The invention relates to a micelle dispersion liquid and a preparation method thereof, the dispersion liquid comprises a polymer micelle composed of an amphiphilic high-molecular polymer, an ionic salt, and one or more of sodium hyaluronate, sodium carboxymethyl cellulose and collagen, and the dispersion liquid can be used in the field of medical beauty, such as a filler or a hydro-optical needle.

The application relates to the technical field of polymer micelles, in particular to a pH response star polymer micelle and a preparation method and application thereof. The pH response star polymer micelle takes pentaerythritol as a core, and other block structures include polyethylene glycol monomethyl ether, a dynamic imine bond, gamma-amino-epsilon-caprolactone and epsilon-caprolactone. After loading an anticancer drug doxorubicin, the polymer micelle can stably exist in a neutral environment of human normal tissues, and can control the release of the drug in a slightly acidic environment of tumor cells.

The invention discloses a folate receptor mediated reduction-released dual-targeting curcumin polymer micelle and a preparation method thereof. A tumor target molecule folic acid is modified on a biodegradable hydrophilic polyethylene glycol skeleton, and is coupled with curcumin through a disulfide bond to construct an amphiphilic polymer monomer with a high grafting rate, and the molecular formula of the amphiphilic polymer monomer is FA-PEG2K-SS-CUR; the curcumin micelle is prepared by self-assembly through a dialysis method, so that a traditional encapsulation drug loading mode is simplified, the drug is a part of a carrier, and drug leakage is avoided. The polymer micelle obtained by the method has high drug loading rate, stability and biocompatibility, improves the solubility of curcumin in water, enhances the targeted release of tumor cells, reduces the toxic and side effects, and has a higher antitumor effect than the bulk drug.

Pharmaceutical compositions of polymeric micelle cinacalcet suitable for intravenous or intraperitoneal administration, and methods of making and use thereof in the treatment of various diseases and disorders, such as hyperparathyroidism and hypercalcemia, are provided.

The present application relates to a ginsenoside Rg3 drug delivery system, and a preparation method and application thereof. White yam polysaccharides (BSPs) are extracted from white yam by water extraction and alcohol precipitation, and then subjected to defatting, decolorization, deproteinization and chromatographic purification. A small hydrophobic molecule SA is introduced to modify the structure of BSPs, and a dialysis method is used to prepare BSPs-SA polymer micelles, and an amphiphilic copolymer BSPs-SA is obtained as a carrier material. An emulsion solvent evaporation method is used to prepare G-Rg3@BSPs-SA polymer micelles, and the freeze-dried powder is loaded into a colon-soluble capsule shell to prepare a G-Rg3@BSPs-SA colon-soluble capsule with double targeting. The in vitro drug release behavior and preliminary stability of the capsule are evaluated. After oral administration of the delivery system, no drug is released in the upper gastrointestinal tract, and after entering the colon, the capsule shell is degraded in the specific pH environment of the colon to release G-Rg3@BSPs-SA polymer micelles. Through the dual targeting function on tumor cells and M2-TAMs, the delivery system can achieve multi-link regulation of "inhibiting tumor cell growth and regulating immune microenvironment" of colon cancer, and effectively inhibit the occurrence and development of colon cancer.

This invention discloses a method for preparing mesoporous amorphous alloy thin films, relating to the field of metal thin film technology. The method includes: mixing a diblock polymer, an organic solvent, water, and a metal salt precursor to obtain a mixed solution containing polymer micelles; adding a boron-containing reducing agent to the mixed solution to obtain an electrolyte; using a conductive substrate as the working electrode, performing linear voltammetry scanning in the electrolyte using a three-electrode system to obtain an initial deposition layer; placing the initial deposition layer in the electrolyte and allowing it to stand, then performing autocatalytic chemical deposition under a protective gas to obtain an initial alloy thin film; and immersing the initial alloy thin film in an organic solvent to obtain a mesoporous amorphous alloy thin film. This invention utilizes the high efficiency of electroreduction and the controllability of chemical reduction through an electrodeposition-induced autocatalytic process, achieving controllable synthesis of mesoporous amorphous alloy thin films with uniform pore size and consistent three-dimensional porosity.

The invention discloses a micelle nano-drug as well as a preparation method and application thereof. The micelle nano-drug is a polymer micelle co-loaded photosensitizer and inhibitor nano-drug. Recurrence and metastasis of cancer are closely related to tumor stem cells (CSCs), and great challenges are brought to treatment. The micelle provided by the invention can stably load two drugs, and simultaneous ablation of tumor cells and CSCs can be realized through combination of photothermal therapy (PTT) and stem cell inhibition, so that the proportion of CSCs in cancer cells can be significantly reduced, and formation of tumor spheres can be inhibited. Targeted micelles are obtained by modifying ligands, and the curative effect is further enhanced. Experiments prove that the medicine disclosed by the invention shows obvious survival benefits in a tumor model and a postoperative model, and the expression of CSC related biomarkers is obviously reduced. The micelles are combined with NIR irradiation, a promising strategy is provided for simultaneously ablating cancer cells and inhibiting CSCs, and rapid tumor elimination and recurrence prevention can be realized.

The invention belongs to the field of nano-drug delivery systems, and particularly relates to a double-sensitive type co-loaded emodin and chlorambucil micelle as well as a preparation method and application thereof. The structural formula of the polymer is as follows: polyethylene glycol monomethyl ether, p-hydroxymethyl phenylboronic acid pinacol ester and emodin grafted dendritic polymer p (mPEG-co-HPBE-co-EMD) are designed and synthesized by taking polymethacrylate as a connecting unit, and the dendritic polymer p (mPEG-co-HPBE-co-EMD) is used for entrapment of chlorambucil. The co-drug-loaded polymeric micelle can be used for co-delivery of the emodin and the chlorambucil, improves the water solubility of drugs, has proper particle size and ROS / pH dual sensitivity, can realize targeted release of the emodin and the chlorambucil at tumor sites, and realizes collaborative treatment of chemotherapy and oxidation therapy. In the # imgabs0 # formula, n = 30-85, and x: y: z = 1: (2-5): (1-3).

The invention discloses an active oxygen response type polymer prodrug micelle, and further discloses a polymer prodrug micelle loaded with oridonin or dihydroartemisinin and a polymer prodrug micelle loaded with the oridonin and the dihydroartemisinin at the same time. The invention further provides a preparation method of the polymer prodrug micelle. The ORI and DHA co-loaded active oxygen responsive polymer prodrug micelle provided by the invention can significantly improve the water solubility and biocompatibility of ORI and DHA, can effectively eliminate reduced glutathione in gastric cancer cells AGS cells and amplify active oxygen, and finally causes the generation of a large amount of lipid peroxides, thereby killing tumor cells and inducing cell ferroptosis, and has a good application prospect. And finally, tumor proliferation is inhibited.

The present invention relates to a preparation method for synthesizing small-sized silica nanoparticles based on a copolymer template, comprising the following steps: dissolving a binary random copolymer or a block-random copolymer in a good solvent to obtain a copolymer solution; adding a poor solvent to the copolymer solution to obtain a polymer micelle seed solution; adding an alkaline reagent to the polymer micelle seed solution for mixing, and adding a silicon precursor for mixing and dispersion, generating a sol-gel reaction to obtain symmetrical or asymmetrical small-sized silica nanoparticles; adding a silane coupling agent containing a long carbon chain or a long fluorocarbon chain to the asymmetrical small-sized silica nanoparticles for modification to obtain small-sized silica nanoparticles with amphiphilicity. Compared with the prior art, the present invention can realize the synthesis of small-sized silica nanoparticles in high-concentration polymers or silicon precursors.

The invention discloses a photoresponse drug delivery system and a preparation method and application thereof. The photoresponse drug delivery carrier comprises a photosensitive liposome and a metal polyphenol coordination polymer micelle, the metal polyphenol coordination polymer micelle comprises a metal polyphenol network coating and a polymer micelle, the surface of the polymer micelle is coated with the metal polyphenol network coating, and the metal polyphenol network coating is coated with the polymer micelle. The metal polyphenol coordination polymer micelle is loaded on the surface of the photosensitive liposome; the photosensitive lipidosome comprises a lipidosome membrane and an inner water phase located in the lipidosome membrane, the inner water phase comprises EDTA and ammonium salt, and the lipidosome membrane comprises a lipid material and a photosensitizer. The photoresponse drug delivery system has an efficient photoresponse drug release rate, sequential release of drugs can be achieved, and multi-mode combined anti-tumor is achieved through combination of photodynamic and chemotherapeutic drugs.

The present invention discloses a fluorinated zinc phthalocyanine derivative and its preparation method and application. The fluorinated zinc phthalocyanine derivative is obtained by chemically covalently linking trithiocarbonate to the four amino groups of tetraaminoperfluorophthalocyanine zinc. The fluorinated zinc phthalocyanine derivative can be used as a star-shaped RAFT chain transfer agent to induce hydrophobic methacrylate monomers and / or hydrophilic acrylate monomers to prepare four-arm star-shaped random copolymers through near-infrared light-controlled reversible addition-fragmentation chain transfer polymerization. The star-shaped polymer prepared by the above method has a narrow molecular weight distribution and can form polymer micelles with uniform hydrodynamic diameter in an aqueous solution below its critical aggregation concentration. In addition, the above polymer micelles have a high singlet state yield and good oxygen carrying capacity, and can be used for two-photon photodynamic therapy of hypoxic tumors.

The invention belongs to the technical field of polymer self-assembly, and particularly relates to an amphiphilic polymer with reduction response and a preparation method and application of a micelle of the amphiphilic polymer. The preparation method of the amphiphilic polymer comprises the following steps: taking 3, 3 '-dithiodipropionic anhydride (DTDPA) as an intermediate, connecting amino polyethylene glycol monomethyl ether to one end of the 3, 3'-dithiodipropionic anhydride through ring opening polymerization, and connecting racemic polylactic acid to carboxyl at the other end of the 3, 3 '-dithiodipropionic anhydride through esterification reaction. The amphiphilic polymer has a novel structure, and has unique design in structural composition and formula. The particle size of the polymer micelle prepared from the amphiphilic polymer is in a micron level, the size is uniform, the dispersity is good, and the polymer micelle has certain drug loading capacity.

This application discloses a method and apparatus for preparing formaldehyde-free decorative paper impregnated with aqueous polyacrylate, belonging to the field of decorative paper production technology. The method includes: providing continuously running formaldehyde-free decorative paper; establishing an asymmetric pulsed electric field within a reactor impregnated with an aqueous polyacrylate emulsion along the path of the formaldehyde-free decorative paper; and controlling the formaldehyde-free decorative paper to pass through the reactor, so that negatively charged polymer micelles in the aqueous polyacrylate emulsion, under the action of the asymmetric pulsed electric field, overcome electrostatic repulsion and surface tension, and are forcibly and rapidly penetrate and fill the internal fiber network of the formaldehyde-free decorative paper. This application fundamentally solves the technical problem of the difficulty in deeply and uniformly impregnating the base paper with environmentally friendly aqueous resin under high-speed production conditions by introducing an electrodynamic forced penetration mechanism.