36 results about "Upper gastrointestinal" patented technology

The present disclosure provides methods of treating inflammation of the upper gastrointestinal tract, especially the esophagus, by administering an oral corticosteroid. In some cases, the methods include treating eosinophilic esophagitis (EoE) by administering an oral corticosteroid in an induction phase and a maintenance phase to improve peak eosinophilic counts and symptoms. In embodiments, the methods include treating EoE by administering the oral corticosteroid at nighttime and / or while the patient is lying down.

Provided are a medical image device and an automated control technique, particularly, an endoscopic device for capturing an image of an upper gastrointestinal tract using an endoscope and a method of controlling the endoscopic device. The method of controlling an endoscopic device includes acquiring an image of an upper gastrointestinal tract from an image sensor, detecting at least one first body part from the image, based on a pre-trained model, calculating relative position information between the detected at least one first body part and a front-end portion of the endoscopic device, generating, based on the relative position information, a first control signal for steering the front-end portion to correspond to the at least one first body part, and transmitting the first control signal to a driver.

The invention relates to the technical field of computer vision and medical image processing, and discloses a digestive endoscopy report generation method and device based on a multi-modal large language model. The method specifically comprises the following steps: for a plurality of upper gastrointestinal endoscopy images, extracting a first image feature through a visual encoder to perform anatomical part identification; extracting a second image feature from the first image feature by using a self-attention mechanism to perform background gastric mucosa classification; generating description about digestive tract diseases through a large language model, and under the guidance of the description, extracting third image features from the first image features to perform digestive tract disease classification; the constructed text instruction about report generation and the third image feature are combined and then input into a multi-mode decoder, and a digestive endoscopy report is generated. According to the method, a plurality of upper gastrointestinal endoscopy image analysis tasks can be processed at the same time, and a digestive endoscopy report which does not depend on a fixed template and has rich context content can be generated with high efficiency and high accuracy.

The invention discloses a tracheal catheter special for upper gastrointestinal endoscopic surgery, which comprises an inner tube, an outer tube capable of sliding up and down with the inner tube is sleeved outside the inner tube, the top end of the outer tube is fixedly connected with the inner tube through a fixing knob, a respirator joint is arranged at the top end of the inner tube, an inner tube water bag is arranged at the bottom of the inner tube, and an outer tube water bag is arranged at the bottom of the inner tube. An inner tube suction hole is formed in one side of the inner tube water bag, and a Murphy hole is formed in the position, located below the inner tube water bag, of the bottom of the inner tube. The problems that in an upper gastrointestinal endoscopic surgery in the prior art, the exposed part of the tracheal catheter affects surgical operation, the cuff of the tracheal catheter compresses a surgical site or affects taking out of a specimen, the tracheal catheter rubs with an endoscope and is prone to disengagement to damage tracheal mucosa, and blood and secretions in the trachea are not sucked thoroughly are solved.

The forceps channel pipe assembly comprises a main pipe body, a front connector and a rear connector, a second annular groove is formed in the peripheral side face of the left end of the front connector, a third annular groove is formed in the peripheral side face of the right end of the front connector, a fourth annular groove is formed in the peripheral side face of the right end of the rear connector, and a threaded structure is arranged on the peripheral side face of the left end of the rear connector. Pipe head pressing assemblies are arranged at the left end and the right end of the main pipe body respectively, the left end of the front connector is fixedly arranged at the right end of the main pipe body in an inserted and glued mode through the pipe head pressing assemblies, and the right end of the rear connector is fixedly arranged at the left end of the main pipe body in an inserted and glued mode through the pipe head pressing assemblies. The connection firmness of the clamp channel pipe assembly, the camera seat and the clamp channel socket three-way part of the upper digestive tract endoscope handle operation part and the connection firmness of the front joint and the rear joint at the end part of the main pipe body are obviously improved; the probability of cracking of adhesive layers at the joint positions between the main tube body and the camera seat and between the main tube body and the upper digestive tract endoscope handle operation part pincer channel insertion opening three-way part when the main tube body falls accidentally or is impacted by external force is effectively avoided or reduced.

Systems, methods and devices for endoluminal surgical procedures include a robotic surgical systems adapted and configured to perform lower and upper gastrointestinal endoluminal submucosal dissection (ESD), endoluminal ‎sleeve gastroplasty (ESG), trans-oral endoluminal fundoplication, bariatric endoluminal antral myotomy (BEAM), peroral endoluminal myotomy (POEM), gastroplasty with endoscopic myotomy (GEM), trans-vaginal hysterectomy, trans-vaginal oophorectomy, and trans-vaginal oophoro-salpingectomy. The systems include a physician console, a patient cart and a system controller. The system controller is adapted and configured to receive a plurality of control inputs from ‎each of a plurality of hand control input devices, to process the plurality of control inputs and to ‎transmit a plurality of control outputs to an axial translation actuator, a roll actuator, ‎a steerable overtube controller, a plurality of instrument controllers and a videoscope ‎controller.

Enfumafungin derivative triterpenoid antifungal compounds are used to treat or prevent fungal infections occurring in or under acidic conditions where the pH is lower than about 7, due to their unexpected, enhanced efficacy under such conditions. The enfumafungin derivative triterpenoids (or pharmaceutically acceptable salts or hydrates thereof) are inhibitors of (1,3)-β-D-glucan synthesis and are useful in the treatment or prevention of yeast or mold infections that occur in anatomic areas having a low pH, such as the vaginal cavity, or under acidic local environment conditions such of those seen in fungal abscesses, empyema, or upper gastrointestinal tract infections.

Orally administered pharmaceutical compositions comprising incretin or its analogues or derivatives are presented, which allow for prolonged glycemic control. The formulations presented herein incorporate a self-emulsifying drug delivery system (SEDDS). Advantageously, such formulations provide protection in the upper gastrointestinal tract from proteolytic conditions while allowing for efficient drug release and absorption in the lower gastrointestinal tract.

[Problem] The purpose of the present invention is to provide a medical simulator for performing a procedure practice of cannulation in ERCP, the medical simulator making it possible to perform a procedure practice that is similar to an actual practice. [Solution] This medical simulator 10 uses an upper gastrointestinal tract model 30 comprising an esophagus model 31, a stomach model 32, and a duodenum model 33 provided with a detachable papilla-of-vater model 60, the upper gastrointestinal tract model 30 being housed in an opaque casing 40.

The invention relates to oral probiotic hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing inulin-modified thiolated polysaccharide with a probiotic liquid, and quickly crosslinking to form probiotic hydrogel, so as to construct a colon-targeted probiotic delivery system; the system can effectively protect the probiotics from passing through the upper digestive tract, and realizes targeted release of the probiotics at the colon part by using a dual mechanism that the inulin is specifically ingested by the probiotics in the colon and the disulfide bond is easily reduced and disassembled by reduced glutathione (GSH) in the colon. The oral probiotic hydrogel disclosed by the invention is applied to preparation of medicines for preventing and treating irritable bowel syndrome, diarrhea, constipation, dyspepsia, inflammatory bowel disease, colon cancer, diabetes mellitus, obesity and hypercholesteremia.

1. Name of the product in this design: Packaging box and its main body. 2. Purpose of this design: The entire product and parts thereof are used to house electronic upper gastrointestinal endoscopes and electronic lower gastrointestinal endoscopes. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Design 2 is a partial design, and the dashed lines in the figure indicate the parts that do not require protection.

An upper gastrointestinal tract ultrasound image processing method and apparatus, a device, and a medium. The method comprises: positioning, from an upper gastrointestinal tract ultrasound image, a position of a starting contour line corresponding to an ultrasonic probe (S11); acquiring a position of a lesion image region contained in the upper gastrointestinal tract ultrasound image (S12); expanding outward on the basis of the position of the starting contour line, and positioning, from the upper gastrointestinal tract ultrasound image, a position of each layer of anatomical structure boundary contour line of an upper gastrointestinal tract wall (S13); and outputting a positional relationship between the lesion image region and each layer of anatomical structure boundary contour line (S14).

Overt hepatic encephalopathy is a serious complication of cirrhosis and affects lipid and lipoprotein metabolism. The present invention relates to a biomarker for the prognosis of hepatic encephalopathy. The biomarker includes one or more of high-density lipoprotein cholesterol, model for end-stage liver disease score, age, gender, upper gastrointestinal bleeding, spontaneous bacterial peritonitis, overt hepatic encephalopathy grade, ascites, aspartate aminotransferase, alanine aminotransferase, total bilirubin, serum albumin, total cholesterol, low-density lipoprotein cholesterol, serum creatinine, neutrophil-lymphocyte ratio, prothrombin time, and prothrombin activity level. Compared with patients with alcoholic hepatitis, liver disease, liver failure, etc. proposed in the prior art, due to the specificity of the target population, the biomarker proposed in this application can significantly improve the accuracy of the assessment of the prognosis of overt hepatic encephalopathy.

The present application relates to a ginsenoside Rg3 drug delivery system, and a preparation method and application thereof. White yam polysaccharides (BSPs) are extracted from white yam by water extraction and alcohol precipitation, and then subjected to defatting, decolorization, deproteinization and chromatographic purification. A small hydrophobic molecule SA is introduced to modify the structure of BSPs, and a dialysis method is used to prepare BSPs-SA polymer micelles, and an amphiphilic copolymer BSPs-SA is obtained as a carrier material. An emulsion solvent evaporation method is used to prepare G-Rg3@BSPs-SA polymer micelles, and the freeze-dried powder is loaded into a colon-soluble capsule shell to prepare a G-Rg3@BSPs-SA colon-soluble capsule with double targeting. The in vitro drug release behavior and preliminary stability of the capsule are evaluated. After oral administration of the delivery system, no drug is released in the upper gastrointestinal tract, and after entering the colon, the capsule shell is degraded in the specific pH environment of the colon to release G-Rg3@BSPs-SA polymer micelles. Through the dual targeting function on tumor cells and M2-TAMs, the delivery system can achieve multi-link regulation of "inhibiting tumor cell growth and regulating immune microenvironment" of colon cancer, and effectively inhibit the occurrence and development of colon cancer.

1. The name of this design product: Endoscope image processor all-in-one machine. 2. Purpose of this design product: Used for image processing in endoscopic diagnosis and treatment with electronic bronchoscopes, electronic nasopharyngeal endoscopes, electronic upper gastrointestinal endoscopes, electronic lower gastrointestinal endoscopes, etc. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The upper gastrointestinal hemorrhage nursing device comprises a nursing bed board, a bolster assembly used for limiting the head of a patient is fixedly installed at the top of the nursing bed board, two head guardrails are symmetrically and fixedly installed at the top of the nursing bed board, and two tail guardrails are symmetrically and fixedly installed at the top of the nursing bed board; after the arranged driving steering engine is started, the rotating rod can be driven to rotate by forty degrees in the positive direction and forty degrees in the negative direction, so that the headrest frame rotates by forty degrees in the positive direction and forty degrees in the negative direction, automatic lateral deviation adjustment of the head of a patient can be achieved, the patient is helped to flexibly adjust the posture of the head in the lying state, and comfort in the sleeping process is guaranteed; meanwhile, the driving steering engine can be connected to a timing control module, timing reciprocating rotation of the rotating rod is achieved through a preset program, the lateral deviation direction of the head of the patient can be periodically adjusted, the situation that the head of the patient faces the same side for a long time is effectively avoided, and the skin compression time of the head, the face and the neck is shortened.

The utility model discloses an anti-condensation precise drug release pipeline device for an upper digestive tract, which comprises a triple-combination drug delivery pipe used for maintaining drug particles atomized by drug atomization equipment in a micron-sized state all the time and delivering the drug particles to a target focus area, the three-layer structure of the triple-combination medicine feeding pipe sequentially comprises a hydrophobic structure layer, a supporting structure layer and a heat insulation structure layer from inside to outside, and the polytetrafluoroethylene layer serves as the hydrophobic structure layer, has extremely high hydrophobicity and prevents medicine particles from being condensed or deposited in the pipe; the glass fiber layer serves as a supporting structure layer and wraps the polytetrafluoroethylene layer, and it is guaranteed that the pipeline is kept stable; the polyurethane foam layer is used as a heat insulation structure layer, wraps the glass fiber layer, has excellent biocompatibility and heat insulation effect, and avoids the influence of temperature fluctuation on the drug stability; according to the triple-combination medicine delivery tube, medicine can be efficiently and accurately delivered to a target focus area, and therefore the treatment effect is improved.

To provide an endoscope device for acquiring upper gastrointestinal tract images and a method of controlling the same.SOLUTION: The invention belongs to the field of medical imaging equipment and automation control technology, and particularly relates to an endoscope device associated with imaging of the upper gastrointestinal tract using an endoscope, and to a method of controlling the endoscope device. The method includes the steps of: acquiring an image of the upper gastrointestinal tract from an image sensor; sensing at least one first body part from the image based on a pre-trained model; calculating relative position information between the sensed first body part and a distal end portion; generating a first control signal related to the position of the first body part based on the relative position information; and transmitting the first control signal to a drive unit.SELECTED DRAWING: Figure 2

The utility model relates to the technical field of medical equipment, in particular to an upper gastrointestinal hemorrhage nursing device which comprises a helmet worn on the head of a patient and further comprises an air bag, the air bag is embedded in the helmet, the peripheral side of the air bag is fixedly connected with the inner wall of the helmet, and an inflation structure used for inflating the air bag is installed on the helmet. One end of the transmission device is fixed to the top end of the helmet, the other end of the transmission device is fixedly provided with a gear, and the outer surface of the gear is sleeved with a rectangular frame; when a user rotates the head, the helmet can be driven to rotate, the gear fixed to the end of the transmission shaft is used for driving the tooth groove plates to slide in the rectangular frame, the tooth groove plates can pull the spring to deform in the sliding process, and after muscles at the neck of a patient are relaxed, the spring reversely pulls the two tooth groove plates to reset under the action of the restoring force of the spring. The head of the patient is corrected to a posture deviating to one side of the sickbed, so that the problem that the patient suffocation is easily caused because the patient is in a face-up posture when haematemesis occurs and blood cannot be discharged in time is solved as far as possible.

The invention provides an endoscope device for obtaining an upper gastrointestinal tract image and a control method. The invention belongs to the technical field of medical imaging equipment and automatic control, and particularly relates to an endoscope device for shooting an image of an upper gastrointestinal tract by using an endoscope. A control method of an endoscope device according to an embodiment of the present specification may include: acquiring an image of an upper gastrointestinal tract from an image sensor; sensing at least one first body part from the image according to a pre-trained model; calculating relative position information between the sensed first body part and the front end part; generating a first control signal related to the position of the first body part according to the relative position information; and transmitting the first control signal to a driving unit.

To provide an endoscope device for acquiring upper gastrointestinal tract images and a method of controlling the same.SOLUTION: The invention belongs to the field of medical imaging equipment and automation control technology, and particularly relates to an endoscope device associated with imaging of the upper gastrointestinal tract using an endoscope, and to a method of controlling the endoscope device. The method includes the steps of: acquiring an image of the upper gastrointestinal tract from an image sensor; sensing at least one first body part from the image based on a pre-trained model; calculating relative position information between the sensed first body part and a distal end portion; generating a first control signal related to the position of the first body part based on the relative position information; and transmitting the first control signal to a drive unit.SELECTED DRAWING: Figure 2

The application is a colon-targeting lipid nanoparticle based on ginsenoside Rg3, a calcium alginate microsphere thereof and application thereof in treating ulcerative colitis, and belongs to the technical field of new excipients and new dosage forms of pharmaceutical preparations, and particularly relates to an oral colon-targeting delivery system for treating ulcerative colitis. The system replaces cholesterol in traditional lipid nanoparticles with ginsenoside Rg3, constructs lipid nanoparticles capable of efficiently loading TNF-alpha siRNA, and effectively improves the targeting property and lysosome escape ability of the lipid nanoparticles on inflammatory macrophages. In order to further realize colon-specific delivery, the above-mentioned lipid nanoparticles are loaded in a pH-responsive calcium alginate microsphere, so that the drug is kept stable in the upper gastrointestinal tract and is released in a responsive manner in the colon. Pharmacodynamic studies show that the drug delivery system can significantly relieve the symptoms of colitis, effectively silence the expression of TNF-alpha, repair the intestinal barrier, and regulate the intestinal microbiota. The application provides a safe and efficient new strategy for solving the problems of poor gastrointestinal stability and low targeting efficiency of oral delivery of nucleic acid drugs.

The application discloses a solution method and device for direction perception disorder caused by rotating a mirror, and solves the problem that it is difficult to determine the adjacent tissue structure outside the part after endoscopic examination is rotated in similar upper gastrointestinal tract wall lesions. The application comprises the following steps: acquiring the pose information of an endoscope in an electromagnetic navigation system of a lumen target position and corresponding lumen image as a reference pose; acquiring the trajectory pose of the endoscope after adjusting the field of view in the electromagnetic navigation system and corresponding lumen image, and determining the Euler angle of each trajectory point according to the trajectory pose; acquiring the trajectory pose of the endoscope after adjusting the field of view in the electromagnetic navigation system and corresponding lumen image, and determining the Euler angle of each trajectory point according to the trajectory pose; and reconstructing the lumen and the adjacent tissue according to the lumen image three-dimensionally, and obtaining the rotated lumen and the adjacent tissue according to the rotating angle and the corresponding lumen image. Through the application, the adjacent tissue outside the endoscope can be clearly known after the endoscope is rotated to the best field of view.

The application provides an upper gastrointestinal tract transport function detection device, which is provided with a functional device on a flexible core body; the functional device comprises an embeddable sensor, an impedance electrode, a microprocessor and a wireless module; the flexible core body can be swallowed through the oral cavity or inserted into the gastrointestinal tract for transport function detection, transport characteristic parameter collection is completed, and detection of different aspects of gastrointestinal function is realized; the embeddable sensor collects data through a storage chip or a matched external wireless receiver. The application adopts a bionic structure design, has the characteristics of being easy to swallow and inserted into the esophagus, can detect key parameters including axial pressure, acceleration and orientation, and further calculates various transport indexes and pressures at specific times and positions through the key parameters, solves the problems of function detection of esophageal tortuosity, transport acceleration, speed and trajectory, and meets the functional requirements of organic lesion and sensory function diagnosis by obtaining the information and the esophageal pressure and symptom related characteristics.

Orally administrable pharmaceutical compositions comprising an incretin or analog or derivative thereof are presented that allow for extended control of blood glucose. Formulations presented herein comprise a self-emulsifying drug delivery system (SEDDS). Advantageously such formulations afford protection from the proteolytic conditions in the upper gastrointestinal tract while allowing for effective drug release and absorption in the lower gastrointestinal tract.

The invention belongs to the technical field of health-care foods, and particularly relates to a health-care food for assisting in regulating blood fat, blood pressure and blood sugar and a preparation method of the health-care food. A multistage pellet system is constructed by utilizing a phytosterol solid dispersion system, a nitrate-citrulline slow release system and a propionate-fermented fiber colon targeting system. Phytosterol is rapidly dissolved out of the pellet A at the upper section of the stomach and intestine, cholesterol absorption is competed, and the intestinal mucosa environment is optimized; the pellet B slowly releases beet nitrate and L-citrulline in the small intestine, and NO is stably supplied to improve vasodilation; the pellet C releases propionate and fermented fiber in a targeted manner through the colon, regulates blood sugar through short-chain fatty acid and reversely enhances an NO pathway, so that bidirectional synergy is realized; besides, the conflict of hydrophilic and hydrophobic components is eliminated through the HPMC-PVP co-loaded solid dispersion, the crosslinking degree of alginate gel beads and the loading proportion of propionate are controlled to avoid acidic interference, the bioavailability of active components is remarkably improved, and dynamic synergistic regulation of blood fat, blood pressure and blood sugar is achieved.

The invention relates to the technical field of medical equipment, and discloses a digestive system department upper gastrointestinal hemorrhage nursing device which comprises a main body structure and a nursing trolley, a collecting groove is formed in the top of the nursing trolley, a collecting frame is arranged at the bottom of the collecting groove, and a push-pull rod is fixedly connected to one side of the nursing trolley. A box door is formed in the other side of the nursing trolley, and a folding part is arranged on the side, away from the box door, of the nursing trolley; the opening and closing assembly comprises blocking plates arranged on the two sides of the bottom of the collecting tank, linkage pieces are arranged at the bottoms of the blocking plates, handrail plates are fixedly connected to the tops of the linkage pieces, and guide pieces are fixedly connected to the surfaces of the handrail plates; opening and closing of the collecting groove are automatically controlled by pressing the armrest plate, the collecting groove can be closed in time after the patient vomits, the blood smell is effectively prevented from diffusing to the surrounding environment, the possibility of inducing the patient to vomit again is greatly reduced, and the nursing experience of the patient is improved.

[Problem] The purpose of the present invention is to provide a medical simulator using an upper gastrointestinal tract model, the medical simulator being capable of enabling practice of a procedure closer to actual clinical practice. [Solution] Provided is a medical simulator 10 using an upper gastrointestinal tract model 30 including an esophagus model 31, a stomach model 32, and a duodenum model 33, the medical simulator 10 comprising a shape changing unit configured to change a shape of the upper gastrointestinal tract model 30 due to rotation of a mounting table 461 on which the stomach model 32 is placed.

The invention relates to the technical field of upper digestive tract hemostasis, and discloses an upper digestive tract bleeding hemostasis device which comprises an outer sleeve, a sleeve is fixedly connected to one end of the outer sleeve, and a first clamping piece, a second clamping piece, a first sliding pipe, a second sliding pipe, a sealing plug and a first spring are arranged in the sleeve. Expansion sleeves are fixedly installed on the inner surfaces of the first clamping piece and the second clamping piece, expansion copper sheets are fixedly installed on the outer surface of the sealing plug, reserved grooves are formed in the inner sides of the first clamping piece and the second clamping piece, and a stretching steel wire is fixedly connected to one end face of the sealing plug. Through cooperation of the sleeve, the first clamping piece, the second clamping piece, the first sliding pipe, the second sliding pipe, the sealing plug and the first spring, the two hemostatic clips can be clamped on a wound at a time, and compared with an existing hemostatic clip, the number of times of drawing out and feeding back and forth from a biopsy hole channel in an endoscope can be reduced; therefore, the operation time can be shortened, and time and labor are saved.

The invention relates to the technical field of medical data processing based on an intelligent chip, in particular to an upper gastrointestinal hemorrhage prediction method combined with past medical history analysis of a patient. According to the method, the previous medical history similarity of a to-be-analyzed patient and a historical patient is determined according to the correlation degree of medical history characteristics between the to-be-analyzed patient and the historical patient and upper gastrointestinal hemorrhage; analyzing deviation conditions of different upper digestive tract condition characteristics of the to-be-analyzed patient and the historical patient, and determining the similarity of the upper digestive tract condition of the to-be-analyzed patient and the historical patient; and determining the disease condition matching degree of the to-be-analyzed patient and the historical patient in combination with the past medical history similarity, the upper digestive tract disease condition similarity and the disease condition repetition frequency of the to-be-analyzed patient and the historical patient, screening out a feature convergence patient corresponding to the to-be-analyzed patient, and taking the upper digestive tract disease condition features of the feature convergence patient as prediction data of the to-be-analyzed patient. According to the method, the accuracy of data prediction is improved by analyzing factor characteristics in different aspects.