28results about How to "Easy to swallow" patented technology

The preparation method comprises the following steps: mixing polysaccharide gum with water, carrying out wet ultrafine grinding to obtain an ultrafine polysaccharide gum aqueous solution, and uniformly infiltrating the polysaccharide gum into cellulose or derivatives thereof by adopting high-shear mixing to form micelles; and promoting the micelles to form a honeycomb structure through microwave vacuum drying, and finally spraying ultrapure water atomized by high pressure to the honeycomb micelles and drying to obtain the hydrogel for absorbing grease. The water absorption capacity of the prepared hydrogel reaches 100 times or above, the storage modulus is 1350 Pa or above, grease can be efficiently absorbed, and the hydrogel has wide development prospects in the field of weight-reducing medicine or food.

The invention relates to the technical field of freshwater fish culture, and discloses a culture box for freshwater fish culture, which comprises a culture box and a feeding tank, the top of the feeding tank is fixedly connected with a feeding hopper, and a feeding mechanism is arranged in the feeding tank; the feeding mechanism comprises a motor, a vertical shaft, a disc, movable teeth and fixed teeth; the motor is fixedly connected to the outer wall of the top of the feeding tank, the output end of the bottom of the motor penetrates into the feeding tank, animal livers in the smashing chamber are smashed into small blocks through friction and collision of movable teeth and fixed teeth, swallowing of the mandarin fish fries is facilitated, growth and development of the mandarin fish fries are facilitated, a bent pipe is driven by a disc to rotate, and the feeding efficiency is improved. The feeding range is expanded through the rotating bent pipe, and the gear and the rack are arranged to move back and forth in the rotating process of the bent pipe, so that the feeding range of the bent pipe is further expanded, mandarin fish fries are prevented from being grabbed by adult fishes during concentrated feeding, mandarin fish ingestion is more uniform, and the overall mandarin fish growth efficiency is improved.

The invention discloses a pharmaceutical composition, a preparation containing the pharmaceutical composition, a kit containing the pharmaceutical composition, and a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises the following components: an active pharmaceutical ingredient and a hot melt adhesive, wherein the mass percent of the active pharmaceutical ingredients is 0.3%-50%; the hot melt adhesive is poloxamer P188 and / or poloxamer P407; the mass percent of the hot melt adhesive in the pharmaceutical composition is 5%-30%. According to the pharmaceutical composition, the preparation containing the pharmaceutical composition and the kit containing the pharmaceutical composition, the stability of the active pharmaceutical ingredients can be improved while the active pharmaceutical ingredients are rapidly released to achieve rapid effect, swallowing of a patient can be further improved, and the medication compliance of the patient in actual taking can be improved.

The utility model provides a spherical tablet, and belongs to the field of pharmaceutical preparations. The spherical tablet comprises an upper hemisphere, a lower hemisphere and a middle belt, and the middle belt is located in the middle of the spherical tablet and is in a belt shape with the same thickness. The upper hemisphere and the lower hemisphere are located on the two end faces of the middle belt, and the two hemispheres are the same in size and shape. The diameter of the middle zone is larger than the diameter of the hemisphere, the diameter of the hemisphere of an upper stamping die and the diameter of the hemisphere of a lower stamping die of a tablet pressing die adopted when the spherical tablet is pressed ranges from 6.5 mm to 10 mm, and the ratio of the arc depth to the diameter of the hemisphere is (0.2-0.4): 1. The spherical tablet is small in size, easy to swallow, high in drug loading capacity and less in taking quantity; and the tablet has the advantages of good compressibility, good hardness, strong shock resistance and wear resistance, small tablet weight difference, facilitation of later coating and other operations, and good uniformity and reproducibility.

The invention discloses a furosemide micro-tablet preparation and a method for preparing the furosemide micro-tablet, furosemide, an adhesive, a diluent and other raw materials are subjected to top spray fluidized bed granulation and other preparation methods to prepare the furosemide micro-tablet with good compressibility, the furosemide micro-tablet can be dosed for multiple times in a small dosage, and the furosemide micro-tablet preparation can be used for preparing the furosemide micro-tablet. Especially for people with large individual metabolism difference, such as old people and infants, the medicine can be taken in a counting manner and is accurately administered, for people with difficulty in taking conventional preparations, the medicine taking compliance can be improved, and the method and the raw materials used by the invention are convenient for industrial production.

The invention discloses a novel hydrochlorothiazide dosage form and a method for preparing the novel hydrochlorothiazide dosage form, the novel hydrochlorothiazide dosage form with good compressibility is prepared from hydrochlorothiazide, an adhesive, a filling agent and other raw materials through top spray fluidized bed granulation and other preparation methods, and the novel hydrochlorothiazide dosage form has the advantages that the novel hydrochlorothiazide dosage form has obvious curative effect on patients suffering from edema, hypertension and diabetes insipidus; according to the present invention, the pharmaceutical composition can be subjected to multiple administration at a small dose, can be subjected to counting administration especially for people with large individual metabolism difference, such as old people and children, can achieve accurate administration, can improve the medication compliance for people with difficulty in taking conventional preparations, and has characteristics of simple method, easily available raw materials, and easy industrial production.

The invention relates to tamarind polysaccharide yellow wine jellies suitable for people with dysphagia and a preparation method thereof. The tamarind polysaccharide yellow wine jellies comprise the following raw materials: tamarind polysaccharide, cane sugar, citric acid and yellow wine. Wherein the solid-liquid ratio of the tamarind polysaccharide to the yellow wine is 0.2-2.5 wt%; the solid-liquid ratio of the cane sugar to the yellow wine is 6-18wt%; the solid-liquid ratio of the citric acid to the yellow wine is 0.02 wt%-0.14 wt%. The preparation process comprises the following steps: mixing the tamarind polysaccharide, the cane sugar and the citric acid in the yellow wine, heating and stirring for a period of time, and then cooling in a mold at low temperature to form the tamarind polysaccharide yellow wine jelly. Compared with the prior art, the tamarind polysaccharide wine has the advantages that the tamarind polysaccharide and the high-quality yellow rice wine are used as the basis for the first time, a unique wine jelly form is formed through special freezing process treatment, the tamarind polysaccharide wine can be used as a beverage and a low-calorie dessert, a novel healthy diet choice is provided, and the tamarind polysaccharide wine is suitable for large-scale popularization and application. The traditional flavor and nutritional ingredients of the yellow rice wine are reserved, and meanwhile, patients with dysphagia can take and eat the yellow rice wine more easily and conveniently.

The present application relates to a kind of tetrahydroxy bile acid pharmaceutical composition and its preparation method and application.The present application provides a kind of pharmaceutical composition, it includes 100 weight parts of compound shown in formula I and 300~900 weight parts of saccharide.The present application also provides the use of the pharmaceutical composition in the preparation of drug for treating PFIC.The pharmaceutical composition of the present application can improve dose accuracy, solve the problem of poor taste of bile acid compound, easy to swallow, can improve the compliance of children drug.The pharmaceutical composition of the present application has good stability, easy to transport and store.In addition, the pharmaceutical composition of the present application realizes the stability of treatment effect under different doses, easy to accurately dose children according to body weight, while having good bioavailability, can realize good absorption and utilization in vivo.

The papaya, radix puerariae and fructus lycii soft capsule with the health-care function of enhancing immunity is provided, the product is processed by taking the radix puerariae extract, the fructus lycii extract and the papaya extract as main raw materials and adopting a scientific and reasonable production process, and the papaya, radix puerariae and fructus lycii soft capsule not only is convenient to take and high in safety, but also has a unique effect in the aspect of enhancing immunity.

The invention belongs to the field of pharmaceutical preparations, and discloses high-stability acetylcysteine direct granules based on pH response and a preparation process of the high-stability acetylcysteine direct granules. The preparation process comprises the following steps: (1) pretreatment: adding acetylcysteine and docusate sodium into a fluidized bed to prepare an inclusion compound; (2) preparation of a granulation solution: dissolving hydroxypropyl methyl cellulose in deoxygenated water, adding Eudragit L100-55, mixing, and adjusting the pH value to 7 or completely dissolving white particles; (3) preparing a soft material: mixing the inclusion compound with cane sugar, adjusting the rotating speed, and adding the granulation solution; (4) wet granulation; (5) drying; (6) total mixing; and (7) packaging. The docusate sodium-coated acetylcysteine clathrate compound is adopted to protect API, Eudragit L100-55 is adopted as a pH response mixture to endow the particles with the ability of selectively releasing acetylcysteine in the particles under different pH conditions, meanwhile, the pungent smell of API in the drug-containing particles can be blocked, swallowing by a patient is more convenient, and caking is not prone to occurring during storage.

The invention discloses a hydrochlorothiazide micro-tablet preparation and a method for preparing hydrochlorothiazide micro-tablets, the hydrochlorothiazide micro-tablets with good compressibility are prepared from hydrochlorothiazide, an adhesive, a filling agent and other raw materials through top-spraying fluidized bed granulation and other preparation methods, and the hydrochlorothiazide micro-tablets have the advantages that the hydrochlorothiazide micro-tablets have no toxic or side effects on patients suffering from edema, hypertension and diabetes insipidus; according to the present invention, the pharmaceutical composition can be subjected to multiple administration at a small dose, can be subjected to counting administration especially for people with large individual metabolism difference, such as old people and children, can achieve accurate administration, can improve the medication compliance for people with difficulty in taking conventional preparations, and has characteristics of simple method, easily available raw materials, and easy industrial production.

Provided herein are solid amorphous dispersions, compositions and solid oral dosage forms comprising a compound of Formula (I). In some embodiments, the composition comprises a polymeric excipient, and optionally a crystallization inhibiting polymer. In some embodiments, the compositions may be used to treat fibrosis, cancer, and / or inflammatory diseases / disorders.

The invention relates to a feed processing method and processing device.The feed processing method comprises the steps that raw materials are smashed and mixed with a first additive to generate a first mixed material, the first mixed material is subjected to superfine smashing treatment, the first mixed material obtained after superfine smashing is mixed with a second additive to generate a second mixed material, and the second mixed material is mixed with a third additive to generate a feed. Performing crushing treatment on the second mixture, performing expansion granulation on the crushed second mixture to generate pellet feed, and performing crushing treatment on the pellet feed to obtain feed with different particle sizes; according to the feed processing method and processing equipment disclosed by the invention, the mixing effect of the ingredients during feed production and the quality of the finally prepared finished product can be effectively ensured through multiple times of crushing and batch mixing, so that macromolecular substances such as protein and starch in the feed are convenient to digest and absorb; meanwhile, the pellet feed generated through puffing is crushed into feed with different particle sizes, so that animals in different growth stages can eat the feed, and the utilization efficiency of the feed is indirectly improved.

The utility model discloses a double-component tablet structure which comprises a tablet outer coating, tablet medicine cores are arranged on the inner side of the tablet outer coating, the tablet medicine cores are connected through tablet connecting ends, and tablet outer fractures are formed in the tablet outer coating and the tablet medicine cores. An external segment is arranged outside the tablet outer coating and the tablet medicine core, the interior of the tablet medicine core is connected with an isolating layer, and a tablet inner fracture is formed in the isolating layer. According to the double-component tablet structure, the tablet is composed of the tablet medicine core and the tablet outer coating, the swallowing bitter taste of the tablet is improved, the smooth arc-shaped outer segment is utilized, so that the whole tablet is smooth and free of edges and corners, the whole tablet is convenient to swallow, the throat is prevented from being scratched, the transverse plane of the tablet is convenient to break through the outer fracture of the tablet, and the tablet is convenient to swallow. The size of the tablet is reduced, vertical plane breaking of the tablet is facilitated through the inner fracture of the tablet, the size of the tablet is further reduced, and the fracture of the tablet is prevented from being broken into foam through the breaking mode.

The invention discloses a crystal form A of acetyl L-carnitine hydrochloride, a preparation method of the crystal form A, and a bulk drug, a food additive, a feed additive and a composition containing the crystal form A. The crystal form A of the acetyl L-carnitine hydrochloride is good in solubility, high in stability, high in purity, regular in shape and suitable for being applied to bulk drugs, food additives and feed additives. The preparation method is simple in process, the crystal form A can be obtained at high yield through in-situ crystallization of a reaction solution and dispersion of ethanol, and the preparation method is suitable for large-scale industrial production.

The utility model discloses a bite force measuring instrument with a T-shaped chew stick, which relates to the technical field of medical appliances, and comprises a shell, an air pressure sensor is arranged in the shell, a digital display screen is arranged on the shell, the air pressure sensor is electrically connected with the digital display screen, and the digital display screen is electrically connected with the T-shaped chew stick. A T-shaped chewing stick is arranged on one side of the shell, the surface of the T-shaped chewing stick is fixedly connected with an adapter pipe communicated with the interior of the T-shaped chewing stick, the surface of the adapter pipe is fixedly connected with a handheld pipe communicated with the interior of the adapter pipe, and the end, away from the adapter pipe, of the handheld pipe is fixedly connected with a communicating pipe; the end, away from the handheld pipe, of the communicating pipe is fixedly connected with the surface of the shell. According to the bite force measuring instrument and device with the T-shaped chew stick, the bite force of a user can be measured through the change of air pressure, so that a patient can clearly know the bite force of the patient, the strength of chewing gutta-percha can be adjusted by the patient, and invalid chewing actions are reduced.

The application relates to a capsule endoscope device, which comprises a capsule endoscope and a connecting assembly connected to the capsule endoscope. The capsule endoscope comprises a shell, and a sampling port is arranged on the shell and communicates between the inside and outside of the shell; the connecting assembly comprises a connecting piece arranged on the outer wall of the shell and having a hollow inner cavity, a pump arranged in the hollow inner cavity, and a connecting pipe arranged on the side of the connecting piece away from the shell; wherein the pump comprises a pump inlet in fluid communication with the sampling port, a pump outlet in fluid communication with the connecting pipe, and the connecting pipe comprises a liquid outlet channel communicating between the pump outlet and the outside of the connecting pipe. The capsule endoscope device provided by the application can realize the purpose of directly collecting liquid in the body and conveying the collected liquid to the outside of the body through the connecting assembly, and has the advantages of small product size, convenience in swallowing, high sampling efficiency and high sampling success rate.

The invention relates to the technical field of traditional Chinese medicines, in particular to a Chinese herbal medicine combined prescription for treating human calculi. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-3 parts of medulla tetrapanacis, 1-3 parts of medulla stachyuri, 2-4 parts of folium eriobotryae, 2-4 parts of radix pachysandrae, 1-3 parts of radix abri, 2-4 parts of herba violae, 2-4 parts of mottled bamboo, 1-3 parts of tropaeolum majus, 1-3 parts of radix tinosporae, 2-4 parts of flos paulowniae, 2-4 parts of black peach blossom, 1-3 parts of herba physalis alkekengi, 1-3 parts of folium dichotomae, 2-4 parts of yeast for making hard liquor, 1-3 parts of koji flower, 2-4 parts of youngia japonica and 1-3 parts of , 2-4 parts of hollow grass and 1-3 parts of lysimachia christinae hance. The formula has the advantages that various herbal medicines in the formula have a synergistic effect, for example, the medulla tetrapanacis, the medulla stachyuri and the like assist in removing urinary calculus, and the folium eriobotryae and the like improve inflammation and blood circulation. The raw materials are natural, small in side effect and suitable for long-term or weak patients. The powder is simple to prepare and convenient to go out; the tablet is scientific in process, accurate in dosage and easy to swallow; the pill takes honey as an adhesive, has a lasting drug effect, is suitable for long-term conditioning, and has a good treatment effect on human calculi.

This invention belongs to the field of pharmaceutical formulations, specifically relating to a levocarnitine oral gel and its preparation method. This invention discloses a stable levocarnitine oral gel composition comprising levocarnitine, a gel matrix, an alkali metal salt, and sodium polyacrylate. The stable levocarnitine oral gel disclosed in this invention is easy to swallow, has good medication adherence, does not undergo dehydration and shrinkage during the observation period, has stable product quality, good safety, and is convenient to carry and use; the process is simpler, with high production efficiency and lower risk, making it suitable for large-scale industrial production.

The invention belongs to the technical field of application of veterinary chemical drugs, and provides application of ursodesoxycholic acid in preparation of drugs for treating biliary tract diseases of pets. The medicine for treating the biliary tract diseases of the pets is a medicinal preparation consisting of an active ingredient ursodesoxycholic acid and one or more medicinal carriers. The invention also provides an ursodesoxycholic acid self-microemulsion preparation. The ursodesoxycholic acid self-microemulsion preparation comprises the following components: ursodesoxycholic acid, a surfactant, a cosurfactant, an oil phase and a flavoring agent. After being orally taken, the self-microemulsion preparation is in contact with gastrointestinal fluid and spontaneously emulsified into O / W microemulsion with the particle size smaller than 50 nm, bitter fat-soluble medicine is wrapped in emulsion droplets, contact with taste buds is reduced, and palatability is improved. The self-microemulsion preparation can also cause secretion of bile and lipase of the pets, so that distribution of ursodesoxycholic acid in the bile is promoted, and the curative effect of ursodesoxycholic acid on the aspect of treating biliary tract diseases of the pets is improved.

The invention discloses empagliflozin and metformin compound sustained-release granules and a preparation method thereof.The empagliflozin and metformin compound sustained-release granules comprise empagliflozin quick-release granules and metformin sustained-release coating granules, each metformin sustained-release coating granule comprises a core layer and a coating layer, the core layer is a mixture of metformin hydrochloride, an adhesive and sodium polystyrene sulfonate, and the coating layer is a mixture of metformin hydrochloride, an adhesive and sodium polystyrene sulfonate. The sodium polystyrenesulfonate accounts for 10%-30% of the total weight of the metformin sustained-release coated granules; the coating layer is a mixed material of polyvinyl acetate, triacetin and Tween 80, and the mass ratio of polyvinyl acetate to triacetin to Tween 80 is (75-85): (10-15): (5-10). Sodium polystyrenesulfonate and metformin hydrochloride are mixed and then coated with the coating layer, so that the bitter taste of metformin hydrochloride can be completely covered.

The invention discloses a composition for reducing oral sweetness of artificially synthesized disaccharide and improving taste and application of the composition. The composition in the form of oral gel at least comprises the following components in percentage by mass: 30%-70% of lactulose, 0.05%-2% of a gel matrix material and the balance of water. The composition in the form of oral gel can be used for preparing lactulose oral gel. The lactulose oral gel which is fresh and smooth in taste, easy to swallow, free of adhesion to oral mucosa, free of stickiness and low in bleeding rate is obtained by researching the variety and dosage of the gel matrix material.

The invention discloses a full-nutrient formula mousse product special for tumor patients and a preparation method, and relates to the technical field of full-nutrient mousse, and the preparation method comprises the following steps: preparing lipidosome coated with nutrients, preparing nanoparticles coated with trace elements, modifying the surfaces of the lipidosome and the nanoparticles with a targeting substance, and preparing the full-nutrient formula mousse product. All the raw materials are mixed to prepare the full-nutrient mousse, and the full-nutrient mousse has the advantages that some nutrients which have an auxiliary effect on tumor treatment but are poor in stability or difficult to absorb in gastrointestinal tracts are wrapped in nano-particles through a nanotechnology; the surface of the nano-particles is modified with a targeting substance which can be specifically recognized and taken by tumor tissues or immune cells, so that the concentration of the nutrients in a tumor microenvironment or an immune regulation site is improved, the action effect of the nutrients is enhanced, vitamin C is prepared into a nano-liposome wrapped form and is added into mousse, and the mousse has the effect of improving the tumor microenvironment or immune regulation site. Liposome can protect vitamin C from being damaged by gastric acid and enable the vitamin C to be more effectively absorbed by intestinal tracts.

This invention belongs to the field of pharmaceutical formulation technology, and specifically relates to a sulfonamide derivative sustained-release granule and its preparation method. The sulfonamide derivative sustained-release granule includes a drug-loaded layer, a sustained-release layer I, and a sustained-release layer II. The drug-loaded layer includes a blank pellet core and an active ingredient layer, wherein the active ingredient is a compound of formula I. This invention prepares the drug into sustained-release granules with uniform particle size, precisely controls the particle size distribution of the blank pellet core and the sustained-release granules, and sequentially performs two sustained-release layer coatings on the drug-loaded layer, adjusting the type and amount of excipients in each layer to obtain sustained-release granules that are gritty, palatable, and easy to swallow. These sustained-release granules can be flexibly dosed according to clinical needs; by measuring different volumes, the dosage requirements of patients of different weights or ages can be met. Only one dose is required daily, achieving precise and convenient oral administration for children, while obtaining suitable sustained-release characteristics with a stable release rate and no burst release.

The present invention relates to a method for treating autism spectrum disorders and a multilayer dripping pill containing intestinal flora. On the one hand, the multilayer dripping pills involved include a multilayer (e.g., 2 to 5 layers) structure of inner layer, middle layer, and outer layer in a concentric circle shape, wherein: the inner layer is a homogeneous mixture of live microorganisms such as probiotics or bacterial powder of intestinal flora and oily substances; the middle layer is an oily substance; the outer layer is a rubber shell formed by dripping and drying a colloid formed by a polymer material, a plasticizer, and water. The multilayer dripping pills of the present invention are used to encapsulate biologically active substances, especially for encapsulating live probiotics or fecal bacteria powder, which can be delivered to the intestines by oral administration, which can greatly reduce the impact of the digestive tract on the flora, and can significantly increase the rate of live bacteria to the intestines compared to encapsulation with acid-resistant capsules. Compared with other drug delivery technologies, sustained-release dripping pills can greatly improve the convenience of taking and improve patient compliance.

The utility model relates to the technical field of feed mixing devices, the feed mixing device comprises a mixing cylinder, a fixing table is fixed to the outside of the mixing cylinder in a penetrating manner, supporting legs are fixedly mounted at the lower end of the fixing table, a distribution assembly is fixedly mounted at the upper end of the fixing table, and the distribution assembly comprises a supporting table; the supporting table and the fixing table are fixedly connected through guide columns, three component cylinders are arranged at the upper end of the supporting table, scale marks are carved outside the component cylinders, discharging pipes are connected to the lower ends of the component cylinders, control valves are arranged outside the discharging pipes, and the lower ends of the discharging pipes penetrate through the interior of the mixing cylinder; a stirring motor is fixedly mounted at the top of the mixing barrel, an output shaft of the stirring motor penetrates through the interior of the mixing barrel, and a rotating column is fixedly mounted at the lower end of the output shaft; the feed mixing device for the chicken farm is good in mixing effect, and feed with different components can be conveniently and quantitatively mixed.

This invention discloses a method for preparing soft-particle starter feed based on low-temperature curing and microencapsulation, belonging to the field of livestock and poultry feed preparation technology. The method includes basic raw material pretreatment, low-temperature curing, mixing and blending, soft-particle molding, drying and cooling, and screening and packaging steps. The core lies in employing a process of "low-temperature curing + double-layer microencapsulation + soft-particle molding," combined with an excipient system composed of modified chitosan, sodium alginate, and attapulgite solution. Low-temperature curing preserves heat-sensitive nutrients and kills harmful microorganisms; double-layer microencapsulation enables targeted release of core functional components, ensuring their activity; soft-particle molding balances palatability and intestinal protection; and the various components of the excipients synergistically improve feed stability, probiotic colonization rate, and digestibility.

The present application discloses a kind of protein jelly, including the following components by mass percentage, 20~35% whey protein, 2~10% gelatin, 59~78% ultrapure water.The protein jelly of the present application is only composed of two proteins and water, and the ingredients are transparent and safe.The first protein (whey protein) is a nutritional supplement protein, and the second protein (gelatin) also serves as a gel excipient, without the need for additional excipients, humectants, sweeteners, fillers, emulsifiers or pigments.The protein content of the jelly of the present application is extremely high, with a maximum of 35g per 100g, and the protein potency is ≥1, all derived from natural proteins, with zero added sugar and zero artificial additives.The texture is soft and elastic, does not need to be chewed, and is easy to swallow.The formula of the present application is extremely simple, and the process is simple.