23 results about "Soft gelatin capsule" patented technology

The present application belongs to the field of pharmaceutical analysis, and particularly relates to a dissolution determination method for soft capsule preparation, which installs a screen on the upper side of the stirring paddle of a dissolution device, so that when the soft capsule shell has a large crack and large oil drops appear, the large oil drops can be dispersed into small droplets through the screen, thereby ensuring that the drug dispersion measurement result in the dissolution cup is scientific and reasonable.

The application discloses a gelatin soft capsule continuous production process. The process uses a vacuum stirring defoaming device to actively defoam the glue solution, and adds a monitoring point after defoaming. According to the real-time situation, the process parameters are adjusted, so that the defoamed gelatin can reach the production standard without standing, thereby further completing the continuous production of the gelatin soft capsule. The application has important significance for improving the yield and quality of the soft capsule.

The invention relates to the field of soft capsule preparation materials, and discloses a double-layer soft glue film, a preparation method and application thereof and a large-capacity capsule. The double-layer soft glue film comprises a gelatin-based glue layer and an inner barrier layer, the gelatin-based glue layer comprises gelatin, a composite plasticizing system, a shading system and soluble calcium salt; and the inner barrier layer comprises hydroxypropyl methyl cellulose. According to the invention, the compactness and adhesive force of a film body are obviously improved, the peel strength can reach 0.85 N / cm, the oil penetration rate is lower than 1%, and the retention rate of fat-soluble contents reaches 96% or above. The adhesive film is suitable for preparing large-loading high-content fat-soluble soft capsules, and has the advantages of high strength, low migration and excellent damp-heat stability.

The disclosure generally relates to soft gelatin oral dosage form. In particular the disclosure relates to an oral dosage form comprising a soft gelatin capsule and a liquid fill, where the liquid fill is a suspension of an H2 receptor antagonist in a hydrophobic / lipophilic excipient. The disclosure also relates to a method of treating a gastric disease or disorder by using said oral dosage form.

The disclosure generally relates to soft gelatin oral dosage form. In particular the disclosure relates to an oral dosage form comprising a soft gelatin capsule and a liquid fill, where the liquid fill is a suspension of an H2 receptor antagonist in a hydrophobic / lipophilic excipient. The disclosure also relates to a method of treating a gastric disease or disorder by using said oral dosage form.

The invention relates to a soft gelatin capsule. The soft gelatin capsule comprises a capsule shell and filler wrapped by the capsule shell. The capsule shell comprises a low viscosity gelatin having a viscosity of from about 1.5 to about 2.4 mPas and a gel strength of from about 150 to about 280 g Bloom, preferably from about 180 to about 250 g Bloom, in each case as measured in 6.67% gelatin solution at 60 DEG C according to GME-proprietary Standard Test Method for Edible Gelatin.

The invention discloses a soft capsule, a vegetable gum composition and a detection method of the soft capsule. The vegetable gum composition comprises the following components in percentage by weight: 4-20% of carrageenan; 60-85% of a starch film-forming agent containing cassava oxidized hydroxypropyl; wherein the final viscosity MVU of the cassava oxidized hydroxypropyl is 100 to 300 WF, the carboxyl content is 0.025 to 0.4 g / 100 g, and the hydroxypropyl content is 3.0 to 5.0 g / 100 g; 8-15% of a plasticizer; and 0-6% of a coagulant aid.

The present invention relates to the field of gelatin capsules and in particular to the provision of a gelatin composition for use in the manufacture of gelatin capsules, in particular soft gelatin capsules. The composition of the present invention is particularly useful to reduce cross linking over time in capsules, improving capsule stability.

The present invention relates to a soft gelatin capsule comprising a capsule shell and a filling encased by the capsule shell. The capsule shell comprises a low-viscosity gelatin having a viscosity of about 1.5 to about 2.4 mPa·s and a gel strength of about 150 to about 280 g Bloom, preferably of about 180 to about 250 g Bloom, in each case measured in a 6.67% gelatin solution at 60° C. according to the GME monograph “Standardised Methods for the Testing of Edible Gelatin.”

Provided are a coating composition and application thereof in soft capsules or gummy candies. The coating composition comprises iota carrageenan at 4-12 wt%, pretreated starch at 12-30 wt%, plasticizer at 15-50 wt%, and water at 25-55 wt%, wherein the potassium ion content of the iota carrageenan is 4.0-8.0 wt%, the weight ratio of the pretreated starch to the iota carrageenan is 1:1-7.5:1, and the pH value of the coating composition when formulated into a 5 wt% aqueous solution is 5.0-8.5, and the pretreated starch is prepared by a method comprising adding starch into water to prepare a 20 wt% starch slurry, adding an acidity regulator to control the pH value of the starch slurry to 2.0-6.5, and then drying. The coating composition can be applied in the field of food or pharmaceutical products.

The present invention relates to pharmaceutical compositions comprising one or more cannabinoids and optionally one or more pharmaceutically acceptable carriers, diluents, adjuvants, excipients, or any combination thereof. In particular, the compositions of the present invention comprise a mixture of THC and CBD in varying proportions and are preferably in the form of sublingual tablets, sublingual drops, or soft gelatin capsules.

The invention relates to a fish oil soft capsule and a preparation method thereof, and belongs to the technical field of health care products. The problems that an existing fish oil soft capsule wall material is insufficient in compactness and poor in stability are solved. The soft capsule consists of a content and a wall material in a mass ratio of 1: (0.8-1.2), the content contains fish oil, vitamin E and phospholipid, and the wall material contains gelatin, glycerol, a kelp-radix polygonati officinalis mixed extract and purified water. The kelp-polygonatum odoratum mixed extract is prepared by grinding, ultrasonic extraction, filtration and concentration, and the kelp-polygonatum odoratum mixed extract and gelatin are synergistically cross-linked to form a compact wall material structure. The preparation method comprises the steps of constant-temperature stirring, dissolving, pelleting forming, shaping, drying and the like. According to the scheme, by utilizing the synergistic effect of mucopolysaccharide in kelp and radix polygonati officinalis, the illumination stability and oxidation stability of the soft capsule are improved, the content exudation rate is reduced, proper physicochemical properties are considered, the shelf life is prolonged, and the preparation method is simple, low in cost and good in application prospect.

The application discloses application of a gel composition in preparation of a medical pressed plant source soft capsule, and the gel composition is composed of a gelling agent and a gelling accelerator, wherein the gelling agent is composed of agar and carrageenan, the carrageenan is kappa-carrageenan and / or iota-carrageenan, and the gelling accelerator is composed of a soluble potassium salt and a soluble sodium salt. The medical pressed plant source soft capsule prepared by the application can avoid problems of a gelatin soft capsule, avoid safety hazards of the gelatin, and improve stability and safety of the plant soft capsule, and therefore has good application value in the medical industry and the health product industry.

The invention provides a skin membrane composition and application thereof in soft capsules or gel candies. The skin film composition comprises 4-12 wt% of iota-carrageenan, 12-30 wt% of pretreated starch, 15-50 wt% of a plasticizer and 25-55 wt% of water, the potassium ion content in the iota-carrageenan is 4.0-8.0 wt%, the weight ratio of the pretreated starch to the iota-carrageenan is 1: 1-7.5: 1, the pH value of the skin film composition is 5.0-8.5 when the skin film composition is prepared into a 5 wt% aqueous solution, and the pretreated starch is prepared by a method comprising the following steps: mixing the pretreated starch and the iota-carrageenan with the plasticizer; the method comprises the following steps: adding starch into water to prepare 20wt% starch slurry, adding an acidity regulator to regulate the pH value of the starch slurry to 2.0-6.5, and then drying. The skin membrane composition can be applied to the field of food or medicine.

The soft capsule cleaning device comprises a pump body, a flow dividing pipe, a cleaning table and an installation plate, a set of supporting frames used for supporting and installing the pump body are arranged at the lower end of the pump body, the front view cross section of each supporting frame is of an inverted concave structure, a set of bases are arranged at the lower end of each supporting frame, and the bases are connected with the pump body. The lower ends of the left side and the right side of the supporting frame are fixedly connected with the base, and the front side of the supporting frame is provided with a set of water guide pipes used for guiding external cleaning liquid into the pump flow column. And external cleaning water is guided into the inner water storage cavity in the base disc through the pump flow column, then the cleaning water is divided through multiple channels in the inner water storage cavity, and the cleaning water is transmitted through the multiple sets of water guide pipes, so that the cleaning area of the soft capsules is increased.

The invention relates to the technical field of low-temperature forming soft capsule preparation, and particularly discloses a low-temperature forming soft capsule and a preparation method thereof. The low-temperature forming soft capsule comprises a capsule shell and a content, the capsule shell is composed of gelatin, sodium gluconate modified carrageenan, sodium carboxymethyl cellulose, glycerin, propylene glycol, a condensation coalescing agent and water, and the content is composed of vegetable fat, a temperature-sensitive active component and an antioxidant. The low-temperature forming soft capsule provided by the invention can be formed under a low-temperature condition, thermo-sensitive active ingredients are prevented from being inactivated due to a traditional high-temperature process, and meanwhile, the low-temperature forming soft capsule rubber provided by the invention has good compactness and toughness. The preparation method of the low-temperature forming soft capsule does not need special complex equipment, and is suitable for large-scale production.

The utility model belongs to the technical field of soft capsule molds, and particularly relates to an anti-adhesion soft capsule mold which comprises a mold body, a plurality of forming grooves are formed in the outer surface of the mold body, extrusion grooves are formed in the inner walls of the forming grooves, and a plurality of mounting blocks are fixedly connected to the inner surface of the mold body. A moving groove is formed in the mounting block, an extrusion rod is arranged in the moving groove, a connecting column is fixedly connected to the side wall of the extrusion rod, a limiting disc is fixedly connected to the end, away from the extrusion rod, of the connecting column, and a spring groove is formed in the mounting block. Demolding of soft capsules at corresponding positions can be controlled through movement of the extrusion rod, demolding is more convenient, and cracks are prevented from occurring on the surfaces of the capsules.

The present application relates to soft capsule preparation material field, disclose a kind of double-layer soft gelatin film and its preparation method and application and big loading capsule.The double-layer soft gelatin film includes gelatin-based glue layer and inner barrier layer;The gelatin-based glue layer includes gelatin, composite plasticizing system, shading system, soluble calcium salt;The inner barrier layer composition includes hydroxypropyl methyl cellulose.The present application significantly improves the compactness of film body and adhesion, peel strength can reach 0.85 N / cm, oil permeation rate is less than 1%, the retention rate of fat-soluble content reaches more than 96%.The glue film is suitable for preparing big loading high content fat-soluble soft capsule, with high strength, low migration and excellent humidity and heat stability.

The present invention relates to the field of gelatin capsules, and more particularly to providing gelatin compositions for use in the manufacture of gelatin capsules, especially soft gelatin capsules. The compositions of the present invention are particularly useful in reducing crosslinking in capsules over time and improving the stability of the capsules.

Soft gelatin capsules comprising a suspension composition of nintedanib or a pharmaceutically acceptable salt thereof in medium chain triglycerides and carrier system, wherein the carrier system comprises solubilizers, phospholipids, thickeners and mixtures thereof.

The present invention provides compositions and methods for the treatment or prevention of pulmonary hypertension comprising administering an ascomycin, or a pharmaceutically acceptable salt, solvate, analog, or prodrug thereof to the patient with pulmonary hypertension. Described herein are liquid formulations which deliver an ascomycin. The liquid formulation can be placed in a soft gelatin capsule.