111 results about "Soft gelatin capsule" patented technology

The present invention relates to a reduced form of Coenzyme Q also known as ubiquinol in oral dosage form such as a gelatin capsule, preferably a soft gelatin capsule. Compositions according to the present invention include storage stable compositions comprising effective amounts of ubiquinol in combination with an amount of a reducing agent effective to maintain ubiquinol in its reduced state when formulated in capsules, tablets and other orally administrable form. Methods of use are also disclosed.

An improved controlled release composition for non-parenteral administration of active agents and other therapeutics, particularly for oral or topical administration, has been developed. The composition is made by dispersing a complex formed of an active agent bound to an ion-exchange resin or to another form of resin or carrier, in a non-ionic non-aqueous (“NINA”) vehicle. The complexes are optionally coated with one or more layers of coating material to provide a controlled pattern of release of active agent from the carrier. Replacing the usual aqueous vehicle with a NINA vehicle, such as an oil or an ointment, allows the active agent-carrier complexes, with or without coatings, to be both orally and topically administered. The compositions can be formulated as powders, liquids, liquid suspensions, gels, capsules, soft gelatin capsules, tablets, chewable tablets, topical ointments, lotions, pourable or pumpable fluids, semisolid, crushable tablets, and unit-of-use sachets or capsules for reconstitution or direct application. The combination of multiple active agents is possible with this system, in which one or more active agents are bound to particles and one or more active agents are dissolved or dispersed in the NINA vehicle. This allows the combination of two or more active agents, which are otherwise incompatible, into a single dosage form.

A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.

The present invention is directed to compositions and methods of delivery of fill materials containing active agents, optionally dissolved or suspended in a suitable carrier, encapsulated in a chewable soft gelatin capsule.

The present invention describes an improved commercial process for the production of carotenoid-cyclodextrin complexes and formulation of the complex for human ingestion. Complexation with cyclodextrins (e.g., α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, or HP-β-cyclodextrin) significantly improves the uptake of carotenoids (e.g., lycopene, lutein, or zeaxanthin) and their mixtures in vitro. The method for making such complexes includes forming a carotenoid/cyclodextrin complex; freezing drying said carotenoid/cyclodextrin complex; and blending said freeze-dried carotenoid/cyclodextrin complex with a mixture of lecithin and a vegetable oil or a vegetable oil suitable for soft gelatin capsules. The cyclodextrin/carotenoid complex can be formed in a molar ratio of between about 0.5:1.0 and 10:1. In vivo, in a human study, the lutein/γ-cyclodextrin complex formulated in lecithin-oil or oil showed a better absorption of lutein, as compared to the free lutein-oil formulation.

The invention provides a novel soft gelatin capsule comprising a fill material consisting essentially of S-adenosylmethionine (SAMe) salt disposed within an enteric coated soft gelatin film.

Pharmaceutical compositions comprising a fatty acid salt, a dicarboxylic acid salt, an alkyl sulfate salt, an aryl sulfate salt or an alkyl aryl sulfonate salt of methylene blue or a derivative of methylene blue are described herein. The compositions are preferably administered orally and can be administered as tablets, soft or hard shell capsules (e.g. soft gelatin capsules), suspensions or solutions. The composition can also be formulated as a suppository or enema or rectal administration. The compositions further comprise a pharmaceutically acceptable carrier and optionally one or more pharmaceutically acceptable excipients. Suitable excipients include diluents, binders, plasticizers, lubricants, disintegrants, colorants, stabilizers, surfactants, and combinations thereof. The fatty acid salts, alkyl sulate salts, aryl sulfate salts or alkyl aryl sulfonate salts can be co-mixed or co-melted with one or more fatty acids to make more hydrophobic compositions, which may result in less staining formulations. The compositions can be formulated for immediate release, controlled release such as extended release, delayed release, and pulsatile release, or combinations thereof. In one embodiment, the derivative of methylene blue is methylene dodecylsulfate.

The invention relates to a method for preparing alginate soft capsule. By adopting a mode of emulsifying/de-emulsifying and emulsion dropping, oil-in-water emulsion containing polyvalent metal ions with high oil-water ratio is dropped into univalent soluble alginate solution, and then the polyvalent metal ions react with the univalent alginate solution to form insoluble alginate gel so as to obtain a primary soft capsule form of which outer layer is wrapped with the alginate gel; then, the primary soft capsule form is subjected to steps of drying and dehydrating so that the emulsion inside the soft capsule is de-emulsified; and finally, a circular soft capsule is obtained, wherein the interior of the circular soft capsule has oily liquid substances, the exterior of the circular soft capsule has an alginate gel wrapping layer, the radial size of the circular soft capsule is in millimeter scale, and the circular soft capsule can be directly taken orally. The soft capsule obtained by the method has the advantages of good mechanical property, even and round appearance, non-eccentric oil drops and high oil content; and the preparation method is simple and has low cost. Under the condition that the internal oily liquid substances are the same, the soft capsule which is prepared by the method and can be directly taken orally can be used for replacing gelatin soft capsules which are directly taken orally.

The present invention relates to a stable pharmaceutical composition comprising soft gelatin capsules containing at least one sparingly soluble active drug (singly or in combination with sparingly soluble and/or soluble drugs) and a solvent system, wherein the solvent system comprises of solvent, co-solvent, solubilizer(s), surfactant, aqueous solution of alkali and crystal growth inhibitor. The present invention further relates to process for preparing a stable pharmaceutical composition of sparingly soluble active drug(s) in soft gelatin capsules.

In one aspect, pharmaceutical compositions and methods for the treatment of vulvovaginal atrophy (VVA) are provided. In one embodiment, the method comprises digitally inserting into the lower third of the vagina of a subject having VVA a soft gelatin capsule containing a liquid pharmaceutical composition.

A method and composition are presented for enhancing the dissolution and bioavailable properties of CoQ10 nutritional supplements and/or therapeutic agents for a human being and other mammals. The method includes preparing an anhydrous self-microemulsifying base composition by combining: CoQ10, a water-immiscible, and a non-ionic surfactant, containing polyethylene glycol. For an orally administered CoQ10 nutritional supplement in a capsule formulation, a unit dosage from the composition is added to a dissolvable capsule, preferably a soft gelatin capsule, in order to form the nutritional supplement. When a capsule containing the self-microemulsifying composition enters the digestive tract, the temperature of the body's digestive juices warms the composition, causing any of the CoQ10 that may have re-crystallized out of the composition to become re-dissolved into the composition before the capsule dissolves. The re-dissolution of CoQ10 is bioavailable when the capsule dissolves. Upon dissolution of the capsule, the self-microemulsifying composition comes into contact with the digestive juices and naturally forms micellar-type bioavaible microemulsions, consisting of micelles containing CoQ10. In addition to the capsule formulation, the invention includes parenteral, liquid, topical and ophthalmic formulations.

A preparation method of a soft capsule without gelatin belongs to the technical filed of processing of soft capsules. The preparation method is that pullulan taken as major ingredient is respectively mixed with xanthan gum, carrageenan or gellan gum and other microbial polysaccharide gum or seaweed polysaccharide gum, the mixture is subjected to such procedures as sol, degassing, drooling and drying to form a gum skin film, and the gum skin film is pressed through a soft capsule pressing machine via a film rotating method to form the soft capsule. According to the invention, the soft capsule only adopts the pullulan, xanthan gum or carrageenan and other microbial polysaccharide gum or seaweed polysaccharide gum as the raw materials, and does not use the gelatin, adopts two processes of drooling to form the film and soft capsule pressing through the film rotating method; and meanwhile, during pressing, any oil-soluble drugs or health care food can be installed, so that the soft capsule without gelatin can be made.

The present invention is directed to compositions, methods of delivery and packaged nutraceuticals of a stabilized Feverfew Extract. More specifically, the stabilized Feverfew extract contains at least about 4% parthenolide. In a particular embodiment, the stabilized Feverfew extract is provided in a soft gelatin capsule, at a concentration effective to provide relief of the identified affliction, such as a migraine headache.

Orally administrable softgels or soft gelatin capsules and fill compositions therefore for use in treating various dermatological conditions. These compositions are also particularly useful for treating children or patients of at least 55 years of age.

The invention discloses a formula of a non-gelatin soft capsule shell. The soft capsule shell is prepared from the following components in percentage by weight: 25-75 percent of modified starch, 10-30 percent of carrageenan, 10-25 percent of a plasticizer, 40-50 percent of water, 2-12 percent of a thickening agent and the balance of pigment which can be added according to the required color of the soft capsule pill. According to the formula, the main component gelatin of a traditional capsule shell material is replaced by modified starch and carrageenan, so that multiple defects of gelatin can be overcome, the modified starch has the characteristics of film performance, air resistance, adhesion and the like, has high safety performance and good elasticity, and has the dissolving speed superior to that of gelatin; the soft capsule prepared from modified starch and carrageenan has stable property, and cannot easily perform a crosslinking phenomenon; and the soft capsule prepared by using gelatin replacing materials does not have the problem of oxidation crosslinking, and an antioxidant does not need to be added.

The present invention relates to pharmaceutical formulations for oral administration through a soft gelatin capsule, wherein the pharmaceutical dosage form has pseudoephedrine hydrochloride as the active pharmaceutical ingredient. The active pharmaceutical ingredient, pseudoephedrine hydrochloride as an active is embedded in a suitable matrix, wherein said matrix composition is characterized by reducing the extractability of the pseudoephedrine hydrochloride.

The invention discloses a multi-panax healthcare food and a preparation method thereof. A brain-invigorating and intelligence-developing healthcare food is made from two or more varieties of the main raw materials such as panax ginseng, panax quinquefolius, radix pseudostellariae and root of pilose asiabell, effective ingredients generated from separation and extraction of the main raw materials, and effective parts made through emendation of the main raw materials or chemical monomers as the main ingredients; the preparation method of the multi-panax healthcare food disclosed by the invention comprises the steps of separation, extraction, emendation and refinement of the main raw materials, namely panax ginseng, panax quinquefolius, radix pseudostellariae and root of pilose asiabell; and dosage forms of the product include but are not limited to pulvis, granules, tablet, hard gelatin capsule, soft gelatin capsule, drop pill, micro-pill, injection medicine, spray medicine, oral liquid and infusion solution. The product can also be researched and developed into a medicament with brain invigoration, intelligence development and memory improving functions according to the relevant regulations of China.

A vegetative soft capsule instead of gelatin capsule is prepared from hydrophilic gel, adhesive and water, and features no pollution caused by animal protein. Its preparing process is also disclosed.