11results about How to "Reduce atrophy" patented technology

The invention provides a pharmaceutical composition for preventing and treating gingival atrophy and a preparation method and application thereof, and belongs to the technical field of biological medicine. The composition contains finless eel peptide, skipjack elastin peptide, quinoa rice extract, gleditsia sinensis rice extract, calendula extract, chamomile extract, chitosan, peach gum, hydroxyapatite and the like, and the finless eel peptide, the skipjack elastin peptide, the quinoa rice extract and the gleditsia sinensis rice extract are specific enzymatic hydrolysates. The monopterus albus peptide, the skipjack elastin peptide, the quinoa rice extract and the gleditsia sinensis rice extract jointly promote repair and regeneration of gingival tissues. The calendula extract, the chamomile extract and the chitosan have anti-inflammatory and antibacterial effects, so that gingival inflammation is relieved, and bacterial infection is prevented. And the chitosan and the calendula extract can accelerate the repair of damaged gingival tissues. The monopterus albus peptide, the skipjack elastin peptide and the hydroxyapatite are matched for use to jointly maintain the normal structure and function of gingiva. All the components have a synergistic effect, so that gingival atrophy can be effectively prevented and improved.

The invention particularly relates to the technical field of wheelchairs, and discloses a rehabilitation walking-assisting wheelchair which comprises a frame, the rear portion of the upper end of the frame is fixedly connected with a chair back, the inner surface of the chair back is rotatably connected with a cushion, and the inner surface of the chair back, the rear end of the chair back and the left end and the right end of the frame are jointly provided with active and passive assemblies. The inner cavity and the lower end of the cushion are jointly provided with a ventilation massage assembly. According to the rehabilitation walking-assisting wheelchair, by arranging the driving mechanism, the fixing mechanism and the hand exercising mechanism, when a user uses the wheelchair, the corresponding exercising mode can be performed according to the self condition of the user according to the two exercising modes of hand active exercising and leg passive exercising or hand passive exercising and leg active exercising of the user; the health-care pillow can effectively enhance muscle strength, improve joint flexibility, promote blood circulation, prevent muscle atrophy and joint stiffness, and is beneficial to improving physical strength, improving cardio-pulmonary functions, promoting self-movement ability and reducing bedsore risks.

The invention belongs to the technical field of biology, and particularly relates to a mesenchymal stem cell aggregate jointly energized by matrix and cell factors and application of the mesenchymal stem cell aggregate. The aggregate is prepared by culturing mesenchymal stem cells in a culture medium added with a cell culture matrix and IGF-1 (Insulin-like Growth Factor-1) to obtain pretreated mesenchymal stem cells; and continuing subculture in a 3D cell culture system to obtain the cadherin cell culture medium, wherein the cadherin cell culture medium is prepared from 1-3 parts of hE-cad-Fc and 1-3 parts of hN-cad-Fc. The obtained aggregate is complete in structure and clear in boundary, cell endogenous cadherin and phosphorylated IGF-1 receptors are highly expressed, and the curative effect of treating refractory and repeated immune disorder diseases, such as systemic sclerosis, xerosis and systemic lupus erythematosus, with complex etiology is remarkably improved.

The invention relates to a pharmaceutical composition for treating chronic atrophic gastritis and precancerous lesions and application thereof, the pharmaceutical composition is a Xiansheng stomach tonifying formula and comprises herba epimedii, codonopsis pilosula, fructus alpiniae oxyphyllae, poria cocos, roasted rhizoma atractylodis macrocephalae, caulis perllae, vinegar-processed rhizoma cyperi, galangal, rhizoma nardostachyos, vinegar-processed rhizoma sparganii, vinegar-processed curcuma zedoary, dark plum and honey-fried licorice root. The formula is scientific and reasonable, clinical research proves that the Xiansheng stomach tonifying formula has a good curative effect on clinical symptoms of patients suffering from chronic atrophic gastritis and precancerous lesions, has the effect of preventing the precancerous lesions of gastric cancer from being converted into gastric cancer, and has the effects of recovering and improving the gastric mucosa state under a gastroscope, improving the gastric mucosa quality and improving the gastric mucosa quality. The curative effect of reversing pathological changes such as atrophy, intestinal metaplasia and atypical hyperplasia and precancerous lesions is achieved; animal experiments prove that the traditional Chinese medicine composition can improve the pathological state of glandular gastric mucosa of a CAG mouse model, delay glandular gastric mucosa tissue cell senescence of the CAG mouse model and prevent gastric precancerous lesions from being converted into gastric cancer, and also has the effect of resisting gastric senescence.

The invention relates to the technical field of plasticizers, in particular to an environment-friendly biological plasticizer for biological specimen preservation and a preparation method of the environment-friendly biological plasticizer. The environment-friendly biological plasticizer for preserving the biological specimen is prepared from the following raw materials in parts by weight: 10 to 20 parts of natural resin, 10 to 20 parts of carnauba wax, 20 to 30 parts of vegetable oil and 2 to 5 parts of functional additive, the environment-friendly biological plasticizer for preserving the biological specimens, prepared by the invention, not only has a better effect in the aspect of keeping the cellular morphology of the biological specimens and can effectively reduce the deformation and atrophy of the cells, but also has excellent environment-friendly performance and effectively ensures the quality of the biological specimens.

The invention relates to hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological hydrogel materials. The hydrogel comprises a prednisolone sodium phosphate hydrogel P-Gel skeleton and gold nanoparticles PCAu, wherein the gold nanoparticles PCAu are uniformly loaded on the P-Gel skeleton and are coated by procyanidine. According to the preparation method, a three-dimensional cross-linked network skeleton of PSP hydrogel P-Gel is self-assembled and constructed by utilizing ion coordination and hydrogen-bond interaction of prednisolone sodium phosphate PSP under the action of Ca < 2 + >, and the hydrogel PCAu-coated P-Gel is formed by uniformly loading gold nanoparticles PCAu which are green synthesized from procyanidine PC and have stable surfaces. The hydrogel can promote rapid repair of spinal cord injury and relieve far-end muscle atrophy and fibrosis; and meanwhile, the injectable self-healing hydrogel has the engineering advantages of injectability, self-healing and the like, and shows good clinical transformation potential.

The present invention belongs to the technical field of biological medicines, and relates to a new application of adenosylcobalamin, specifically, the application of adenosylcobalamin in the preparation of a drug for treating or preventing chronic pancreatitis. Adenosylcobalamin can inhibit macrophage M2 polarization, reduce pancreatic fibrosis caused by chronic pancreatitis, and reduce pancreatic tissue changes caused by chronic pancreatitis. The present invention provides a basis for drug screening for chronic pancreatitis.

The invention relates to the technical field of biological materials, in particular to a bionic nerve conduit and a preparation method and application thereof. Through layered functional design, the multifunctional nerve conduit which sequentially comprises an inner layer, a middle layer and an outer layer from inside to outside is prepared. Wherein the inner layer is used for constructing parallel oriented nanofibers through an electrostatic spinning technology, and is connected with divalent metal ions after being modified by connecting molecules, so as to regulate and control the behaviors of endothelial cells and blood vigor cells; the middle layer adopts a melt spinning technology to form micron fibers which are arranged in a crossed manner, so that sufficient radial and circumferential mechanical support is provided to enhance the deformation resistance; the outer layer utilizes an electrostatic spinning technology to construct compact and randomly arranged nanofibers, so that on one hand, fibrosis infiltration can be prevented; on the other hand, the structural integrity can be effectively ensured. The bionic nerve conduit provides a new material and a new strategy with clinical transformation potential for peripheral nerve defect repair in a complex environment.

The invention relates to the technical field of biology, in particular to application of matrix-enabled mesenchymal stem cells, the matrix-enabled mesenchymal stem cells are obtained by culturing and enabling mesenchymal stem cells on a cell culture medium hENFc, and the cell culture medium hENFc is prepared from 1-3 parts of hE-cad-Fc and 1-3 parts of hN-cad-Fc; matrix-enabled mesenchymal stem cells can promote cell nucleus transfer of beta-catenin, enhance multiplication capacity and stemness maintenance capacity of in-vitro amplification and delay cell senescence and apoptosis, and hMSCs subjected to long-term enabled culture (fifteenth generation and above) of hENFc do not have tumorigenicity, do not have any adverse effect on animals and meet the clinical application standard of hMSCs; the traditional Chinese medicine composition can be used for treating immune disorder diseases, such as systemic lupus erythematosus, diabetic nephropathy, systemic sclerosis and xerosis, and has a wide application prospect.

The invention discloses a wearable balance bandage assembly for a single-arm handicapped, and relates to the technical field of special garments. The elastic bandage is in an elliptical ring shape, one end of the elastic bandage is sleeved on the arm and the same shoulder of the handicapped, and the other end of the elastic bandage is wound on the armpit of the other arm; the part, sleeving the arm of the handicapped, of the elastic bandage is a sleeve bandage part; a counterweight module is mounted at the lower end of the sleeve binding belt part. According to the wearable balance bandage assembly for the single-arm handicapped, various problems caused by limb imbalance of the single-arm handicapped in daily life are solved. The assembly provides necessary counter weight to balance the body, the problems of muscle sagging and atrophy are reduced through the design of the elastic bandage, and inconvenience and wearing and taking-off difficulty of a traditional cosmetic artificial limb are avoided. Due to the design of the air bag layer, the wearing adaptability is improved, the single-arm disabled person can participate in social contact and occupational activities more confidently, the social isolation feeling brought by the disabled person is reduced, and an important role is played in promoting mental health.

The present invention relates to a method for dynamically regulating the charge of a liquid and its application. The method for dynamically regulating the charge of a liquid first contacts a liquid layer with a first solid layer to form a double electric layer structure at the solid-liquid contact interface, then applies a quantitative unipolar charge on the surface of the first solid layer or on the surface of a second solid layer spaced apart from it in a contact electrification manner to construct a passive electric field, and dynamically regulates the charge composition of a dense layer in the double electric layer through the passive electric field, thereby controlling the ratio of the number of free heterogeneous charges in the diffusion layer of the double electric layer, regulating the charge of the liquid layer, thereby realizing passive dynamic regulation of the charge distribution in the double electric layer generated when a dielectric solid and a liquid contact each other, thereby further realizing passive dynamic regulation of the charge of the liquid. Through the regulation method, ion-containing droplets can be transported through the interior of a non-ion-containing liquid, and ion-containing liquid and non-ion-containing liquid in a mixed liquid can also be separated.