2results about How to "Reduce atrophy" patented technology

The invention relates to hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological hydrogel materials. The hydrogel comprises a prednisolone sodium phosphate hydrogel P-Gel skeleton and gold nanoparticles PCAu, wherein the gold nanoparticles PCAu are uniformly loaded on the P-Gel skeleton and are coated by procyanidine. According to the preparation method, a three-dimensional cross-linked network skeleton of PSP hydrogel P-Gel is self-assembled and constructed by utilizing ion coordination and hydrogen-bond interaction of prednisolone sodium phosphate PSP under the action of Ca < 2 + >, and the hydrogel PCAu-coated P-Gel is formed by uniformly loading gold nanoparticles PCAu which are green synthesized from procyanidine PC and have stable surfaces. The hydrogel can promote rapid repair of spinal cord injury and relieve far-end muscle atrophy and fibrosis; and meanwhile, the injectable self-healing hydrogel has the engineering advantages of injectability, self-healing and the like, and shows good clinical transformation potential.

The invention relates to the technical field of biological materials, in particular to a bionic nerve conduit and a preparation method and application thereof. Through layered functional design, the multifunctional nerve conduit which sequentially comprises an inner layer, a middle layer and an outer layer from inside to outside is prepared. Wherein the inner layer is used for constructing parallel oriented nanofibers through an electrostatic spinning technology, and is connected with divalent metal ions after being modified by connecting molecules, so as to regulate and control the behaviors of endothelial cells and blood vigor cells; the middle layer adopts a melt spinning technology to form micron fibers which are arranged in a crossed manner, so that sufficient radial and circumferential mechanical support is provided to enhance the deformation resistance; the outer layer utilizes an electrostatic spinning technology to construct compact and randomly arranged nanofibers, so that on one hand, fibrosis infiltration can be prevented; on the other hand, the structural integrity can be effectively ensured. The bionic nerve conduit provides a new material and a new strategy with clinical transformation potential for peripheral nerve defect repair in a complex environment.