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681results about How to "Anti aging" patented technology

Application of cycloastragenol in delaying cell senescence and increasing passage times of cell senescence

PendingCN119082004Aanti agingReduce the number of passagesAntinoxious agentsSkeletal/connective tissue cellsTelomeraseDecreased telomerase activity
The invention relates to the technical field of biology, in particular to application of cycloastragenol in delaying cell senescence and increasing passage times of the cell senescence, and the cycloastragenol can delay the cell senescence and increase the passage times of the cell senescence by improving the relative telomerase activity of the cell. Cell experiments prove that the natural telomerase activator cycloastragenol used in the invention has no toxic or side effect on cells under the conditions of low-concentration (25-100 [mu] M) and short-time (12-24 h) incubation. Finally, a culture scheme of cycloastragenol is determined through drug toxicity and anti-aging tests: P3 and P6 generation cells are cultured for 24 hours by using 100 [mu] M cycloastragenol, P9 generation cells are cultured for 12 hours by using 100 [mu] M cycloastragenol, and under the culture condition, the relative telomerase activity of the cells can be remarkably improved, the aging level of the cells can be delayed, and the passage frequency of the cells can be remarkably prolonged.
Owner:CHONGQING ACAD OF ANIMAL SCI

Recombinant IV type collagen as well as preparation method and application thereof

The invention provides recombinant IV-type collagen as well as a preparation method and application thereof, and relates to the technical field of biochemical engineering. The preparation method of the recombinant IV-type collagen comprises the following steps: obtaining a codon from amino acid of the recombinant IV-type collagen, further obtaining a target gene, and synthesizing the target gene onto an expression vector to obtain a plasmid; transferring the plasmid into an expression host, and screening a positive transformant to obtain an expression strain; and culturing the expression strain, and expressing the target protein to obtain the crude recombinant IV-type collagen. The high-purity recombinant IV-type collagen is prepared through a genetic engineering technology, and the recombinant IV-type collagen can significantly down-regulate inflammatory factors and reduce inflammation; heat injury can be reduced by up-regulating heat shock protein; after heat injury, the recombinant IV-type collagen can obviously lower metal matrix protease of heat injury cells, and also can obviously promote gene expression of type I collagen and type III collagen, improve skin elasticity and moisture content and delay skin aging.
Owner:XIAN GIANT BIOGENE TECH CO LTD +1

Eutectic microcapsule wrapping technology and application thereof in cosmetics

ActiveCN119112677AAntioxidant is goodGood soothing and anti-allergicCosmetic preparationsToilet preparationsPolymer scienceEthyl palmitate
The invention relates to a eutectic microcapsule wrapping technology and application thereof in cosmetics, and belongs to the technical field of cosmetic production. The wall material of the eutectic microcapsule inclusion comprises at least one of hydrogenated lecithin, caprylic / capric triglyceride, sucrose stearate, PEG-8 caprylic / capric glycerides, PEG-40 hydrogenated castor oil, soya bean lecithin, cyclodextrin, ethyl palmitate and troxerutin. The core material is prepared from at least one of salicylic acid, 4-butylresorcinol, glabridin, a kava extract, cortex magnoliae officinalis total phenols, ginseng oil, ganoderma lucidum spore oil, astaxanthin, coenzyme Q-10, a rosemary extract, ceramide and vitamin E. According to the invention, multiple eutectic coating can be formed, the consumption of the wall material can be reduced, the cost is saved, the wall material and the core material are matched for use, so that the excellent effects of permeation, oxidation resistance, soothing, allergy resistance and skin repair can be achieved, and the utilization rate of active substances is increased.
Owner:GUANGZHOU GAOTAI BIOTECHNOLOGY CO LTD

Oyster peptide enzyme oral liquid capable of enhancing immunity and preparation method of oyster peptide enzyme oral liquid

The invention relates to the technical field of health care product preparation, and particularly discloses an oyster peptide enzyme oral liquid capable of enhancing immunity and a preparation method thereof, the oyster peptide enzyme oral liquid comprises the following components: 20 parts of oyster peptide, 50 parts of plant enzyme liquid, 5 parts of honey, 2 parts of fructo-oligosaccharide, 2 parts of lemon juice and 100 parts of purified water; the oyster peptide enzyme oral liquid contains rich natural antioxidant ingredients including oyster peptide and plant enzyme liquid, the oyster peptide contains a large amount of sulfur-containing amino acid, and the ingredients can be used as antioxidants to reduce generation of free radicals and protect cells from oxidative damage; the plant enzyme is rich in natural antioxidant enzyme, can promote synthesis of antioxidant enzyme in vivo and remove free radicals in vivo so as to slow down senescence and diseases, the oyster peptide and the enzyme act together to improve the activity of catalase in vivo, and oxidative stress is reduced by removing superoxide anion free radicals.
Owner:GUANGDONG MEDICAL UNIV

Anti-saccharification and anti-aging aronia melanocarpa fruit composition and preparation method thereof

The invention belongs to the technical field of functional foods and health foods, and particularly relates to an anti-saccharification and anti-aging aronia melanocarpa fruit composition and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 150 to 400 parts of aronia melanocarpa fruit fermentation liquor, 10 to 80 parts of lycium ruthenicum, 10 to 80 parts of ginseng, 0.5 to 2.5 parts of grape seed extract, 10 to 70 parts of collagen peptide, 0.5 to 4 parts of sodium hyaluronate, 0.1 to 0.8 part of resveratrol and 0.03 to 0.3 part of yeast extract. The content of type I collagen peptide in the skin is increased, the generation of in-vitro anti-glycation end products is inhibited, and the anti-glycation and anti-aging effects are achieved.
Owner:LIAONING LINGXIUSHAN MINERAL SPRING DRINK CO LTD

Use method for spraying traditional Chinese medicine preparation on surface of porous inner wall to achieve traditional Chinese medicine health care function

The invention discloses a method for using a traditional Chinese medicine preparation to spray the traditional Chinese medicine preparation on the inner wall surfaces with air permeability, humidity regulation, diatom ooze, large white putty walls, inorganic coatings and other adsorption and porous walls, so that the inner wall surface layer has a traditional Chinese medicine health care function. Comprising the following steps: preparing a slow-release traditional Chinese medicine preparation with a health-care function according to health-care and treatment requirements; drying the microporous material which is smeared on the surface of the inner wall and has an adsorption function; the traditional Chinese medicine preparation is uniformly sprayed on a microporous wall, and after being absorbed, the traditional Chinese medicine preparation can be slowly released into a room within an effective time according to treatment and health care requirements, and functional traditional Chinese medicine gas is released into air so as to achieve the effects of improving immunity, delaying senescence, sterilizing, inhibiting diseases and improving air quality. And through mutual compatibility of the medicines, the effects of purifying indoor air and improving living comfort are achieved.
Owner:SHENZHEN PUHUA ECOLOGICAL TECHNOLOGY CO LTD

Gene modified mesenchymal stem cell as well as preparation method and application thereof

The invention belongs to the technical field of biology, and particularly relates to a genetically modified mesenchymal stem cell as well as a preparation method and application thereof. The invention relates to a gene modified mesenchymal stem cell, the gene modified mesenchymal stem cell is a mesenchymal stem cell of an over-expression SIRT6 gene, and the acquisition number of the SIRT6 on NCBI (National Center of Biotechnology Information) is NM001193285. The invention finds that SIRT6 is helpful for delaying the cell senescence process and obviously improving the anti-senescence capability of cells by regulating senescence-related genes and proteins.
Owner:BAIOPAI (TIANJIN) BIOTECHNOLOGY CO LTD +1

Composition with function of stabilizing skin enzyme activity as well as preparation method and application of composition

The invention provides a composition with a function of stabilizing skin enzyme activity as well as a preparation method and application of the composition, and the composition is prepared from the following components in parts by mass: 0.001 to 0.01 part of superoxide dismutase, 0.001 to 0.05 part of nicotinamide adenine dinucleotide, 0.11 to 12 parts of a polypeptide compound a and 0.005 to 0.5 part of a polypeptide compound b. The invention also provides a preparation method of the composition and application of the composition in preparation of skin care products for improving skin enzyme activity, repairing skin and resisting aging. The composition can be prepared into emulsion, solution, paste, gel or spray. The composition can effectively improve the enzyme activity of skin, improve the texture and appearance of the skin and repair the skin, and is beneficial to delaying the aging of the skin at the same time.
Owner:WANWANSHENG BIOTECHNOLOGY (SHENZHEN) CO LTD

Cosmetic applying dalbergia odorifera branch and leaf extract and preparation method thereof

The invention relates to the technical field of cosmetics, and particularly discloses a cosmetic applying a dalbergia odorifera branch and leaf extract and a preparation method of the cosmetic. The invention discloses a dalbergia odorifera flower and leaf shampoo which is prepared from the following raw materials: a dalbergia odorifera branch and leaf extract, butanediol, glyceryl polyether-26, rosa damascena flower water, propylene glycol, betaine, a lactobacillus fermentation product, p-hydroxyacetophenone, a saussurea involucrata extract and deionized water. The dalbergia odorifera branch and leaf extract, butanediol, glyceryl polyether-26, rosa damascena flower water, propylene glycol, betaine, the lactobacillus fermentation product, p-hydroxyacetophenone, the saussurea involucrata extract and deionized water are poured into a mixing container according to the proportion and stirred to be uniform, and the skin lotion is prepared. The dalbergia odorifera extract has the beneficial effects that the juice extracted from fresh branches and leaves of dalbergia odorifera is used and applied to skin care cosmetics, and has good effects of moisturizing, moistening skin, whitening, repairing, resisting wrinkles, resisting oxidation and delaying senescence together with other extracts, and the dalbergia odorifera extract is simple in preparation process, relatively low in production cost, easy for large-scale production and high in economic value.
Owner:HAINAN ZHENRUN BIOTECHNOLOGY CO LTD

Gynecological gel for tightening and repairing and preparation method thereof

The invention provides a tightening and repairing gynecological gel. Preparation raw materials comprise carbomer, sodium hyaluronate, an animal umbilical cord extract, madecassoside, carnosine, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a tea leaf extract, a chamomile flower extract, elastic collagen, arginine, pentanediol, butanediol, glycerin, p-hydroxyacetophenone, capryloyl hydroximic acid and purified water. The gynecological gel can maintain balanced strains, so that the microenvironment of the vagina is kept normal; vaginal atrophy is improved, the tight state of the vagina is recovered, and vaginal dryness is relieved; damaged mucosa can be repaired, the natural defense function of women is enhanced, and gynecological infection is prevented. The gynecological gel has good biocompatibility, cell affinity and mechanical properties, and can supplement collagen to female private parts, repair damaged vaginal mucosa and promote wound healing; the vagina can be moisturized and moistened, the looseness and dryness of the vagina are improved, the micro-ecological balance of the vagina is adjusted, and the immunity of a female reproductive system is improved.
Owner:济南磐升生物技术有限公司

Nanometer liquid spraying film-forming agent for fruit planting disease and insect pest resistance and preparation method of nanometer liquid spraying film-forming agent

The invention relates to the technical field of agriculture, and discloses a nano liquid spray film-forming agent for fruit planting and disease and insect pest resistance and a preparation method thereof. The nano liquid spray film-forming agent has good disease-resistant and insect-resistant effects, has good film-forming property after being sprayed on the surfaces of plant leaves or fruits and air-dried, can well attach the pesticide to the leaves, can improve the utilization rate of the pesticide, and can be used as a long-acting slow-release disease-resistant and insect-resistant agent. The material is simple in preparation method and low in raw material cost, can be stored for 1-3 months after long-term application, can also solve the problem of pesticide residues, and can be used for producing green organic food. The nano liquid spray film-forming agent disclosed by the invention can jointly realize safety, environmental friendliness and functionality, is harmless to a human body and the environment while ensuring a fruit preservation effect, and is suitable for environments such as orchards and comprehensive fruit and vegetable gardens in wet areas.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY +1

Citric acid-based biological material as well as preparation method and application thereof

The invention relates to a citric acid-based particle injection material as well as a preparation method and application thereof. The preparation method comprises the following steps: melting and heating citric acid and 1, 8-octylene glycol to form a POC prepolymer, dissolving the POC prepolymer with an organic solvent to obtain a dissolved solution, and slowly pouring the dissolved solution into ultrapure water for multiple times for purification to obtain a purified POC degradable prepolymer; and dissolving the POC degradable prepolymer with a solvent, adding inorganic salt particles, and carrying out a cross-linking reaction to obtain the POC injectable particle material. Medicines, active molecules, various metal ions and the like are loaded on POC in a physical compounding or chemical crosslinking mode, and the citric acid-based particle injection material is obtained. The citric acid-based biological material provided by the invention, as a novel medical beauty raw material and a related particle injection filler thereof, can effectively promote regeneration, proliferation, migration and chemotaxis of skin cells, promote the production of collagen and achieve a medical beauty effect. Meanwhile, the immune response of the organism can be activated, inflammation is reduced, the product after degradation is citric acid which can be metabolized randomly, and obvious immunogenicity and toxic and side effects are avoided.
Owner:WESTLAKE UNIV

Tightening and anti-wrinkle composition and tightening and anti-wrinkle skin care product

The invention discloses a firming and anti-wrinkle composition and a firming and anti-wrinkle skin care product. The firming and anti-wrinkle composition comprises the following components in parts by weight: 25-30 parts of water; 35 to 40 parts of glycerol; 10 to 15 parts of butanediol; 10 to 15 parts of maltodextrin; 5 to 10 parts of leontopodium alpinum extract; 0.1 to 0.5 part of kangaroo claw extract; 0.1 to 0.5 part of a geranium wilfordii extract; 0.1 to 0.5 part of swertia indica extract; and 0.01 to 0.1 part of a thyme extract. The active ingredients of the firming and anti-wrinkle composition and the skin care product are mainly plant extracts, so that the firming and anti-wrinkle composition and the skin care product not only have the effects of firming and anti-wrinkle, resisting and diminishing inflammation, whitening skin and the like, but also have no side effect on the skin.
Owner:FUZHOU YOUYAN BIOCHEMICAL PROD TECH R&D CO LTD

Anti-aging composition containing PQQ and preparation method thereof

The invention discloses an anti-aging composition containing PQQ and a preparation method of the anti-aging composition, and belongs to the field of medicines or health food, the anti-aging composition comprises PQQ, an antioxidant, collagen, hyaluronic acid and a plant extract, and the content of PQQ is 0.1-5%; 1%-10% of collagen; 0.05%-2% of hyaluronic acid; the antioxidant comprises the following components in percentage by weight: 0.5%-5% of vitamin C, 0.1%-3% of alpha-tocopherol and 0.05%-2% of beta-carotene; the composition contains PQQ and various antioxidants such as vitamin C, alpha-tocopherol, beta-carotene, coenzyme Q10 and glutathione, and the components have a synergistic effect, so that free radicals can be effectively removed, oxidative damage can be reduced, and cell aging can be delayed; most of the components in the composition are natural substances or are widely applied to the fields of food and health care products, the safety is high, and the quality and safety of the product can be ensured through the steps of strict preparation process control, accurate component dissolving method, pH value adjustment, filtration and the like.
Owner:NANJING DIANCHUANG BIOTECHNOLOGY CO LTD

An anti-aging functional peptide composition and preparation method thereof

The present invention discloses an anti-aging functional peptide composition and a preparation method thereof, and relates to the technical field of food health care. The anti-aging functional peptide composition comprises the following components by weight: 1-10 parts of ascorbic acid polypeptide, 10-30 parts of calcium peptide chelate, 1-10 parts of medicinal fasciculus polysaccharide, 10-20 parts of plant extract, 1-10 parts of bird's nest extract, 1-5 parts of sea cucumber peptide, 1-5 parts of chlorella active peptide, 1-10 parts of auxiliary materials and 15-45 parts of water. The present invention adopts the above-mentioned anti-aging functional peptide composition and a preparation method thereof, in which the calcium peptide chelate and the medicinal fasciculus polysaccharide in the anti-aging functional peptide composition cooperate with each other, and are supplemented with other extracts, and multiple components cooperate with each other to effectively remove free radicals, thereby delaying aging.
Owner:HAINAN HUAYAN BIOTECH

Costrum peptide composition and application thereof

The invention mainly provides a novel colostrum peptide composition (composite peptide composition) and application thereof, the colostrum peptide composition takes colostrum hydrolyzed peptide, collagen peptide and casein peptide as necessary components, the three components have synergistic effect to achieve the effects of assisting in resisting fatigue, assisting in resisting oxidation (delaying senescence) and improving immunity, and in addition, the colostrum peptide composition has the effects of resisting fatigue and resisting oxidation (delaying senescence) and improving immunity. The synergistic effect can be embodied in the form of synergistic reduction and synergism.
Owner:HEILONGJIANG FEIHE DAIRY CO LTD

Low-temperature storage and preservation method for litchis

The invention discloses a low-temperature storage and preservation method for litchis. The method comprises the following steps of: removing branches and leaves of fresh litchis which are 80-90% mature, and reserving bare litchis; the fruits pass through a sorting line, and defective fruits are picked out; and soaking the lychee in an ergothioneine and mannitol solution, draining water, packaging the lychee with a moisture-permeable and air-permeable functional fresh-keeping bag, and storing the lychee at the temperature of-1 DEG C to 5 DEG C. According to the fresh-keeping method combining ergothioneine, mannitol and a moisture-permeable and air-permeable functional fresh-keeping bag, the fresh-keeping period of the litchis can be effectively prolonged through natural oxidation resistance and hydration and by matching with humidity adjustment and gas exchange, and the flavor, texture and nutritional ingredients of the litchis are kept. The method not only meets green and environment-friendly requirements, but also can remarkably reduce loss of litchis in transportation and storage, reduce food waste and improve food safety, and is an advanced and efficient fruit fresh-keeping technology.
Owner:SOUTH CHINA BOTANICAL GARDEN CHINESE ACADEMY OF SCI

Application of MAVS as mitochondrial stabilizer in delaying senescence

The invention discloses application of MAVS as a mitochondrial stabilizer in delaying senescence. Experiments prove that the deletion of the MAVS protein accelerates the aging of the human mesenchymal stem cells; the MAVS can interact with the OPA1 to maintain the mitochondrial function, so that the aging of the human mesenchymal stem cells is delayed. The invention discloses an important role of the MAVS-OPA1-mitochondrial axis in regulating and controlling the aging process of the human mesenchymal stem cells. The method has an important application value.
Owner:INST OF ZOOLOGY CHINESE ACAD OF SCI +1

Ceramide liposome for skin care products and preparation method of ceramide liposome

The invention relates to the field of skin care products, and discloses a ceramide liposome for skin care products and a preparation method thereof, the ceramide liposome comprises the following components by weight: 5-10 parts of hydrogenated lecithin, 0.5-2 parts of modified cholesterol, 0.5-2 parts of ceramide, 0.1-2.5 parts of sucrose stearate, 0.1-1 part of polyglycerol-10 stearate, and 15-30 parts of an organic solvent; the modified cholesterol is prepared by grafting glycine cholesteryl ester and carboxymethyl chitosan through a chemical reaction, the glycine cholesteryl ester is prepared from cholesterol, N-t-butyloxycarboryl glycine and trifluoroacetic acid as raw materials, and the carboxymethyl chitosan is prepared by grafting chloroacetic acid and chitosan. According to the invention, hydrogenated lecithin, modified cholesterol, ceramide, sucrose stearate and polyglycerol-10 stearate are used as raw materials to prepare the ceramide liposome with good stability, good skin barrier repairing property and good moisturizing and water locking effects.
Owner:GUANGZHOU HUALIANG BIOTECHNOLOGY CO LTD

CircRNA (Ribonucleic Acid) as cell senescence marker and regulation and control target and application of circRNA

The invention discloses an application of a circRNA molecule as a diagnostic marker in a cell senescence diagnostic kit and an application of the circRNA molecule as a cell senescence treatment target. According to the application disclosed by the invention, the circHERC1 is found to be low in expression in natural aging and aging-inducing cell models, and the circHERC1 is over-expressed in endothelial cells, so that the multiplication capacity of the endothelial cells can be improved, the telomere length of the cells can be effectively prolonged, telomerase can be activated, the positive rate of beta-galactosidase of the cells can be reduced, and the expression quantity of aging-related proteins can be reduced.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

Green-protecting preservative as well as preparation method and application thereof

The invention provides a green-protecting preservative as well as a preparation method and application thereof, and relates to the technical field of fruit preservation. The green-protecting preservative disclosed by the invention is prepared from the following components in parts by weight: 20 to 40 parts of chitosan, 1 to 5 parts of 6-benayl aminopurine, 1 to 5 parts of gibberellic acid, 10 to 20 parts of citric acid and 3 to 10 parts of cortex cinnamomi extract. The green-protecting preservative disclosed by the invention is safe and simple to use, and can well maintain the color of the green lemons, delay the degradation of chlorophyll in the peel of the green lemons, maintain the fragrance of the green lemons and reduce the morbidity of diseases and insect pests such as black spots of the green lemons during storage, the color of the green lemon fruits changes slowly during storage, and the quality of the fruits is well maintained.
Owner:GUANGXI SUBTROPICAL CROPS RESEARCH INSTITUTE(GUANGXI SUBTROPICAL AGRICULTURAL PRODUCTS PROCESSING RESEARCH INSTITUTE)

Intervertebral disc repair material based on intervertebral disc degeneration staged treatment strategy as well as preparation method and application of intervertebral disc repair material

The invention belongs to the technical field of biomedical materials, and discloses an intervertebral disc repair material based on an intervertebral disc degeneration staged treatment strategy as well as a preparation method and application of the intervertebral disc repair material. The intervertebral disc repair material comprises a sandwich-structure dual-electroactive stent and composite hydrogel attached to the dual-electroactive stent, the double-electroactive stent with the sandwich structure comprises a conductive porous stent with a conductive through pore channel structure and piezoelectric fiber films positioned on the upper side and the lower side of the conductive porous stent; the composite hydrogel comprises hydrogel and antioxidant nano enzyme uniformly dispersed in the hydrogel; the antioxidant nano-enzyme is a core-shell structure nano-particle with Co-Ni bimetallic oxide as a core and polydopamine as a shell. The degeneration early intervertebral disc is repaired through the antioxidant and anti-inflammatory nano-enzyme, the defective intervertebral disc after resection is repaired through the double electroactive scaffolds, and the electroactive scaffold enhanced composite hydrogel can replace the degeneration later intervertebral disc, so that corresponding treatment is achieved for different stages of intervertebral disc degeneration.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Multifunctional beauty microneedle for improving skin photoaging and preparation method and application thereof

The invention belongs to the technical field of biological materials, and particularly relates to a multifunctional beauty microneedle for improving skin photoaging and a preparation method and application thereof. According to the invention, water-soluble hyaluronic acid and chitosan / beta-sodium glycerophosphate temperature-sensitive hydrogel are used as a polymer of a microneedle substrate layer, and the polymer comprises exosome of human adipose-derived mesenchymal stem cells and epigallocatechin gallate. When the microneedle is inserted into the skin, hyaluronic acid is quickly dissolved after contacting with tissue fluid, the needle tip is implanted into the skin, and the CS / beta-GP temperature-sensitive hydrogel is in a solid-gel-like state and can slowly release two cosmetic active ingredients in a long-acting manner under the influence of environment temperature and humidity; the facial mask has the effects of promoting tissue regeneration, reducing hyperpigmentation, replenishing water, preserving moisture, resisting oxidation, delaying skin aging and the like, so as to achieve the medical beauty effects of reducing wrinkles, whitening, preserving moisture, rejuvenating the face and the like. The microneedle provided by the invention can be further prepared into a patch, and is beneficial to treatment of wrinkles and stains at specific parts.
Owner:SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE)

Fermented caffeine eye cream composition and eye cream containing same

The invention discloses a fermented caffeine eye cream composition. Comprising the following components in parts by weight: 30 to 80 parts of a fermentation composition, 1 to 5 parts of caffeine, 0.1 to 0.3 part of hydroxypropyl tetrahydropyrantriol, 0.5 to 2 parts of nicotinamide, 0.1 to 1 part of squalane, 0.01 to 0.5 part of a ceramide composition, 0.005 to 0.05 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.005 to 0.05 part of a polypeptide composition, 0.01 to 0.5 part of carnosine, 0.01 to 0.5 part of tetrahydromethylpyrimidine carboxylic acid and 3 to 12 parts of a plant extract. The invention also discloses an eye cream containing the eye cream composition. The fermented caffeine eye cream composition provided by the invention can effectively smooth the skin surface, and is beneficial to preventing and comforting aging, improving skin elasticity, improving dark circles, relieving edema and removing under-eye puffiness.
Owner:GUANGDONG BAILICHEN BIOTECHNOLOGY CO LTD

Red ginseng extract special care essence and preparation method thereof

The invention provides a red ginseng extract special care essence and a preparation method thereof, and a red ginseng extract composition. The red ginseng extract composition comprises a red ginseng extract, deer bone collagen peptide, a red camellia extract, beta-nicotinamide mononucleotide, a rose extract, a moutan bark extract and a ligusticum wallichii extract. According to the invention, the red ginseng extract, the deer bone collagen peptide, the red camellia flower extract, the beta-nicotinamide mononucleotide, the rose flower extract, the moutan bark extract and the ligusticum wallichii extract are adopted, so that the prepared special care essence with the red ginseng extract has better oxidation resistance and aging resistance.
Owner:YANBIAN TANJUN BIOTECH

Composition for improving osteothione as well as preparation method and application of composition

PendingCN119303061AIncrease the effect of relaxing muscles and activates the collateralsanti agingHydrolysed protein ingredientsSkeletal disorderBone densityOsteoclast maturation
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for improving osteothione as well as a preparation method and application thereof. The invention provides a composition for improving osteothione, which is prepared from the following components in parts by mass: 500 to 600 parts of folium cortex eucommiae, 300 to 350 parts of male flower of cortex eucommiae, 300 to 350 parts of wine-processed rhizoma polygonati, 300 to 350 parts of radix fici simplicissimae, 200 to 250 parts of maca, 90 to 120 parts of natto, 60 to 80 parts of calcined oyster shell and 0.5 to 1 part of ossein. The composition can increase the number of bone trabecula, increase bone density, bone volume fraction, the number of bone trabecula, bone trabecula thickness and bone surface area-to-tissue volume ratio, lower bone surface area-to-bone volume ratio and bone trabecula separation degree, enhance osteoblast activity, inhibit osteoclast maturation and differentiation and relieve inflammation, and is high in safety performance. In conclusion, the composition provided by the invention has a certain improvement effect on osteoporosis.
Owner:HUNAN ACAD OF CHINESE MEDICINE

Lactobacillus reuteri and application thereof

The invention discloses a strain of lactobacillus reuteri YSLR01 and application of the strain of lactobacillus reuteri YSLR01 in preparation of anti-inflammatory, anti-oxidation, fat-reducing and anti-aging products. According to the invention, a YSLR01 strain with anti-inflammatory, anti-oxidation, fat-reducing and anti-aging effects is separated from excrement of healthy human beings, the strain is preserved in China General Microbiological Culture Collection Center on September 2, 2024, and the preservation number is CGMCC NO.31800. The invention further discloses a preparation method of the YSLR01 strain. Researches show that the YSLR01 strain can significantly reduce secretion of inflammatory factors in a lipopolysaccharide (LPS)-induced RAW264.7 cell inflammation model, improve the oxidation resistance of caenorhabditis elegans, enhance the body length, action ability and reproductive capacity of the caenorhabditis elegans, reduce fat deposition in the body and delay aging of the body.
Owner:ZHEJIANG INST OF TIANJIN UNIV (SHAOXING)

Aggregate of matrix-enabled mesenchymal stem cells and application thereof

The invention relates to the technical field of biology, in particular to a matrix-enabled mesenchymal stem cell aggregate and application, and the matrix-enabled mesenchymal stem cell aggregate is obtained by subculturing matrix-enabled mesenchymal stem cells in a 3D cell culture system. The matrix-enabled mesenchymal stem cells are obtained by subculture of mesenchymal stem cells in a cell culture matrix, and the cell culture matrix is prepared from 1-3 parts of hE-cad-Fc and 1-3 parts of hN-cad-Fc. Endogenous epithelium cadherin and nerve cadherin are highly expressed in cell aggregation cells, so that transcription factors are promoted to enter nuclei, the expression levels of anti-inflammatory immune regulation related factors and matrix degradation and cell migration related factors are up-regulated, and activated macrophages are promoted to be polarized to M2 type macrophages; the effects of anti-inflammation, immune regulation, tissue damage repair and the like of intravenous implantation of the matrix-enabled mesenchymal stem cell aggregate for treating diseases such as hepatic fibrosis, diabetes mellitus, nerve injury and the like are remarkably improved.
Owner:NANKAI UNIV

Eyedrop for treating photochemical injury of eyes and preparation method of eyedrop

The invention relates to the technical field of traditional Chinese medicines, and discloses eye drops for treating photochemically damaged eyes and a preparation method thereof. The eyedrops are prepared from the following raw materials: rhizoma polygonati, musk, flos chrysanthemi indici, semen cassiae, honeysuckle flowers, cortex phellodendri, herba houttuyniae, pearl powder, cortex fraxini, flatstem milkvetch seeds, rhizoma seu radix notopterygii and carthamin yellow. The traditional Chinese medicine composition is reasonable in component compatibility and synergistic in interaction, conforms to the traditional Chinese medicine theory, has the effects of clearing heat and purging fire, clearing liver and improving vision, clearing away heat and toxic materials and inducing diuresis to alleviate edema, can treat various eye diseases and discomfort caused by electronic equipment, and can also remarkably recover the activity of SOD and inhibit generation of MDA, so that retina lipid peroxidation caused by illumination is relieved, and the retina lipid peroxidation effect is improved. The composition has a good protection effect on the retina damaged by photochemistry, and the curative effect is remarkable.
Owner:CHEN JINJI BIOMEDICAL TECH (GUANGZHOU) CO LTD

Application of thyroid hormone T3 in preparation of medicine for delaying or treating intervertebral disc degeneration

The invention relates to application of thyroid hormone T3 in preparation of a medicine for delaying or treating intervertebral disc degeneration, and the thyroid hormone T3 can inhibit glycolysis capability of degeneration nucleus pulposus cells and reduce intervertebral disc lactic acid accumulation, so that nucleus pulposus cell senescence and apoptosis are relieved, and intervertebral disc degeneration is delayed or treated. Compared with the prior art, the technology for delaying or treating intervertebral disc degeneration by applying the thyroid hormone T3 provides new application of the thyroid hormone T3, the application value of the thyroid hormone T3 is greatly improved, the application range of the thyroid hormone T3 is expanded, the new field of application of the thyroid hormone T3 is expanded, and the thyroid hormone T3 has wide application prospects and commercial value.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV