59results about How to "Anti aging" patented technology

The application belongs to the technical field of functional polypeptides, and particularly relates to an active peptide for senescent cells and a preparation method thereof, wherein the active peptide is obtained by molecular docking simulation screening and optimization with a helical structure segment in an IL-6R protein combined with a gp130 protein as a polypeptide template; the active peptide after functional optimization contains an FF unit driving nano self-assembly, a GFLG unit capable of being specifically cut by a lysosome protease highly expressed in a microenvironment of senescent cells, and an RYFQKWEKLRNQ unit generating high affinity with an IL-6 / IL-6R / gp130 complex; the designed active peptide itself has anti-aging activity and can also be used for synergistic delivery of drugs, and has a broad application prospect.

The invention relates to the technical field of building waterproof composite materials, in particular to an organic silicon modified resin building waterproof composite material and a preparation method thereof. Comprising a waterproof roll and a waterproof coating arranged on the surface of the waterproof roll, the waterproof coating is prepared from the following components in parts by weight: 20 to 32 parts of silane modified polyether, 15 to 30 parts of organic silicon modified resin, 5 to 10 parts of polysaccharide-based composite polylactic acid, 8 to 12 parts of plasticizer, 1 to 3 parts of curing agent, 0.5 to 2 parts of titanium dioxide and 0.5 to 3 parts of water removal agent. An organic silicon structure in the prepared waterproof composite material has the characteristic of low surface energy, so that the surface of a coating presents strong hydrophobicity, and liquid water permeation is effectively blocked; the waterproof coating can be matched with a compact cross-linked network structure to form a continuous and seamless waterproof film, realizes high hydrostatic pressure resistance and low water absorption, and is suitable for key waterproof parts such as roofs, basements and toilets.

The present application belongs to the field of edible fungi, and particularly relates to a new species of Russula and application thereof. Pseudolagarobasidium acaciicola The taxonomic name of the new species of Russula is Pseudoguignardia sp., which has been registered and preserved in the Guangdong Microbial Culture Collection Center on April 24, 2022, and the preservation number is GDMCC No. 62414. The new species of Russula GDMCC No. 62414 provided in the present application can be artificially cultivated, and has the characteristics of large number of fruiting bodies, high yield, good mushroom shape and the like, and is a new species of Russula with great development potential.

This invention belongs to the field of daily chemical products technology, specifically relating to an antibacterial care liquid and its preparation method. It is processed from main ingredients and auxiliary ingredients. The auxiliary ingredients include the following components by weight percentage: purified water 89.30%, silver ions 3%, honeysuckle extract 1.2%, wild chrysanthemum extract 1.2%, purslane extract 1.2%, clover extract 1.0%, gentian root extract 1.0%, hyaluronic acid 0.5%, carbomer 0.8%, and triethanolamine 0.8%. The main ingredient is American cockroach extract, and the weight ratio of the main ingredient to the auxiliary ingredients is 3:100. The product of this invention has the effects of repairing skin cells and slowing down skin aging. It can solve the problems of dry and loose skin, and at the same time, it can resist acne and pimples, remove acne marks, lighten scars, and make the skin moist, shiny, and elastic. It also has a good repairing effect on various wounds such as ultraviolet rays and radiation burns, as well as bedsores and frostbite.

The invention discloses application of triflorin or pharmaceutically acceptable salt or solvate thereof in preparation of a medicine for preventing, delaying and / or treating heart aging and / or myocardial injury. The invention provides a new strategy and a candidate substance for developing medicines, health-care products or functional foods for preventing, delaying and / or treating heart aging and / or myocardial injury, maintaining heart health and reducing the risk of aging-related cardiovascular diseases.

A water tank of a water pick and the water pick, the water tank comprising a tank body and a water suction pipe, the tank body having a liquid storage cavity for storing liquid; the water suction pipe is integrally formed with the tank body and extends to the bottom of the liquid storage cavity, the water suction pipe has a liquid inlet and a liquid outlet that are in communication with each other, the liquid outlet is used to communicate with the main machine of the water pick, the liquid inlet is close to the bottom of the liquid storage cavity and communicates with the liquid storage cavity, and the liquid outlet is farther away from the bottom of the liquid storage cavity than the liquid inlet. The water suction pipe is designed to be integrated with the water tank, a hose does not need to be independently arranged, the assembly steps of the water suction pipe are reduced, the risk of water leakage is reduced, the water tank can be made of the same material as the tank body, corrosion resistance and aging resistance can be achieved, and even the structural strength and production efficiency can be improved.

This invention discloses an active peptide, a cosmetic containing the active peptide, and its applications, belonging to the field of cosmetic technology. The amino acid sequence of the active peptide is MQWNCPLGSAVITLHYRGDK. This invention has experimentally demonstrated the use of this active peptide in the preparation of anti-skin aging cosmetics. The polypeptide of this application has antioxidant, cell proliferation enhancement, anti-aging, and skin aging delaying effects, and can be used to develop and prepare anti-skin aging cosmetics.

The utility model discloses an anti-vibration and anti-deposition residue collecting device which comprises a box body, and the box body is provided with a residue stirring device. An inclined filter plate is arranged at the bottom in the box body, and a water hammer absorbing device is mounted at the top in the box body; a water hammer absorbing device is arranged at the top of the box body, the water hammer absorbing device comprises an air cylinder, the bottom of the air cylinder is communicated with the box body, a piston is arranged in the air cylinder, and a sealing ring is arranged on the outer side of the piston; the sediment collecting device has the advantages that the sediment can be effectively prevented from being deposited at the bottom, meanwhile, the shock-proof function of the sediment collecting device can effectively reduce the impact force of surge on the sediment groove, the service life of the sediment collecting device is prolonged to the maximum extent, and the cost for treating membrane concentrated liquid is reduced to a certain extent.

This invention discloses a cyclic nonapeptide with both anti-photoaging and antioxidant effects. The amino acid sequence of the cyclic nonapeptide is: cyclic (arginine-glycine-aspartic acid-serine-asparagine-lysine-valine-lysine-phenylalanine). The cyclic nonapeptide of this invention can effectively reduce deep photoaging caused by UVA and surface oxidative damage induced by UVB, thereby achieving comprehensive skin protection.

This invention belongs to the field of microbial application technology, specifically relating to a method for preparing fermented *Lactobacillus limnoxicamis* extracellular vesicles, the product, and its applications, particularly the application of these fermented *Lactobacillus limnoxicamis* extracellular vesicles and their lyophilized formulations in the preparation of products with antioxidant or anti-aging effects. In this invention, *Lactobacillus limnoxicamis* is inoculated into a modified extracellular vesicle induction medium for fermentation. After culture, a two-stage solid-liquid separation is performed, and the supernatant is collected to obtain the extracellular vesicle processing solution. This solution is purified using a capillary electrophoresis system, and the positive extreme liquid is collected and filtered to obtain the purified product of fermented *Lactobacillus limnoxicamis* extracellular vesicles. The extracellular vesicles derived from fermented *Lactobacillus limnoxicamis* prepared by this invention can effectively scavenge free radicals. Somatic cell experiments have demonstrated its excellent anti-aging properties, and the transformation and application research of *Lactobacillus* extracellular vesicles has explored its development potential in the field of anti-aging products.

The invention discloses a muscle anti-aging composition with spermidine combined with a wolfberry aqueous extract and application of the muscle anti-aging composition, and belongs to the technical field of application of bioactive substances. The composition is prepared by compounding spermidine and a Chinese wolfberry aqueous extract according to a specific ratio, and the Chinese wolfberry aqueous extract is prepared by an optimized aqueous extraction process, so that core active ingredients are reserved to a greater extent. The optimal mass ratio of spermidine to the wolfberry aqueous extract is 1: 2. Through a synergistic effect mechanism, the antioxidant capacity of senescent muscle cells is remarkably improved, and the muscle cell oxidative stress and senescence process induced by D-galactose is effectively inhibited. The composition is simple in preparation process and safe in components, can be widely applied to the fields of food, health care products and medicines, and provides a new solution for developing efficient and natural muscle anti-aging products.

The invention provides a method for preventing and controlling tomato bemisia tabaci by using nesidiocoris tenuis, and relates to the technical field of pest prevention and control. The method comprises the following steps: S1, raising seedlings of tomatoes, and transplanting 20-25 days after raising the seedlings; s2, according to an intercropping mode that two rows of kidney bean planting belts are arranged every 3-4 rows of tomatoes, the kidney beans are arranged in a staggered mode and planted in different periods; s3, after tomato seedlings are planted, the density of the nesidiocoris tenuis in the kidney bean planting zone and the density of bemisia tabaci on tomato plants are monitored in real time, and the nesidiocoris tenuis is supplemented according to the monitored value; s4, performing field management. According to the method, the kidney beans and the tomatoes are intercropped, the kidney beans are used for providing a good survival and inhabitation environment for the nesidiocoris tenuis, good disease and pest prevention and control can be achieved in the whole growth period of the tomatoes, meanwhile, the yield of the tomatoes and the kidney beans can be improved, and economic benefits are increased.

The invention relates to the technical field of analysis of intestinal flora structures, and discloses a method for analyzing an adjusting effect of intestinal flora in a longevity / aging process, which comprises the following steps: step 1, selecting research objects: randomly selecting 30 old people of more than 100 years old, and selecting 30 old people of 60-70 years old as a control group; 2, basic condition investigation and physical examination of a research object; and 3, detecting technical indexes of a research object. According to the invention, the change of intestinal micro-ecology of the 100-year old people is preliminarily discussed, and the dominant flora with longevity characteristics and the biomarkers are determined. The influence of aging on intestinal microecology is obvious, so that the diversity of intestinal flora is obviously reduced, and the structural proportion of the intestinal flora is also changed; the intestinal flora spectrums of the same age group are relatively similar, that is, the core flora exists; the'core flora 'of different age groups has difference. By combining genetic backgrounds, lifestyles and environmental factors of different samples, the influence of different lifestyles and environmental factors on the structure and longevity of intestinal bacteria is determined.

The invention discloses a method for preparing low-sensitization protein peptide through microwave combined enzymolysis composite modification and application, and relates to the technical field of food processing. The treatment method comprises the following steps: preparing protein powder into a solution, adding tea polyphenol into the solution, and uniformly mixing to prepare a protein solution; carrying out microwave modification treatment on the protein solution; adding compound protease into the protein solution subjected to microwave treatment for enzymolysis and enzyme deactivation; and filtering the enzymolysis product, and drying the filtrate to obtain the low-sensitization protein peptide. According to the method, microwave and enzymolysis combined composite modification is adopted, so that the sensitization of protein can be reduced, the reaction time is shortened, and the method is simple in process, free of pollution and high in safety. In the enzymolysis process, active peptide substances which are easy to digest and absorb, can enhance immunity and delay senescence are synchronously generated, and tea polyphenol added in the formula can synergistically relieve anaphylactic reaction and play an anti-oxidation role, so that multi-element synergy of desensitization, function enhancement and flavor optimization is realized, and the added value and market application potential of the product are improved.

This invention relates to the field of polymer compound technology, specifically to an antibacterial food-grade plastic product for sealing and preservation and its preparation method, comprising an outer support layer and an inner antibacterial layer. The outer support layer is prepared by melt blending raw materials such as PBAT, PLA, and modified nano-calcium carbonate, wherein the mass ratio of PBAT to PLA is 90-100:10-20. The inner antibacterial layer is composed of nano-chitosan, tea polyphenols, essential oil microcapsules, glycerol, and agarose, composited on the surface of the outer support layer. The essential oil microcapsules have a core-shell structure, loading plant essential oils onto mesoporous silica as a carrier, and are coated with calcium alginate on the outer layer. The antibacterial food-grade plastic product prepared by this invention possesses long-lasting antibacterial properties, excellent mechanical properties, and heat-sealing strength, and has broad application prospects in the food packaging field.

The invention discloses mushroom and lucid ganoderma wine and a brewing method thereof.The mushroom and lucid ganoderma wine is prepared from 260-300 kg of rice wine, 430-470 kg of distilled liquor, 6-12 kg of mushrooms, 1-5 kg of lucid ganoderma, 2-7 kg of milkvetch roots, 2-7 kg of Chinese wolfberry fruits, 1-5 kg of mulberries, 6-12 kg of cistanche deserticola and 250-300 kg of cold boiled water according to 1000 kg of finished products. The lentinus edodes and lucid ganoderma wine brewed by the method integrates the effects of various medicinal and edible food materials such as the sticky rice, the lentinus edodes, the lucid ganoderma and the astragalus membranaceus, and has relatively high nutritional and medicinal values; the effects of resisting cancer, enhancing human immunity, tonifying qi, soothing the nerves, relieving cough and asthma, supporting healthy energy, protecting the liver, resisting fatigue, delaying senescence, reducing blood sugar, promoting circulation, expanding blood vessels, reducing blood cholesterol and triglyceride and the like can be achieved.

The application discloses a kind of substance for detecting tsRNA marker, including one or more of the following applications: A1) in the application in preparing diagnostic blood vessel senile product;A2) in the application in preparing screening blood vessel senile product;A3) in the application in preparing treatment blood vessel senile product;A4) in the application in preparing blood vessel senile prognosis evaluation product;A5) in the application in preparing product for distinguishing blood vessel senile and other diseases;tsRNA marker is tsRNA-3031b, nucleotide sequence is as shown in SEQ ID No.1.The tsRNA-3031b marker provided in the application is significantly increased in the expression amount in the plasma of blood vessel senile patient compared with healthy control, indicating that tsRNA-3031b is a potential blood vessel senile biomarker.The ROC curve of the efficiency in diagnosing blood vessel senile patient shows that tsRNA-3031b has good diagnostic efficiency.

This invention belongs to the field of fiber material technology, and relates to a composite fiber containing nano-natural tea fiber, its preparation method, and its application. The raw materials for preparing the composite fiber include nano-natural tea fiber and basic fiber pulp, wherein the nano-natural tea fiber is a yerba mate nanofiber microemulsion. This invention integrates nanotechnology into the preparation of natural tea fiber. The microemulsion method allows for the simultaneous and uniform dispersion of multiple effective components from tea leaves in the yerba mate nanofiber microemulsion, effectively showcasing the multifunctionality of the fabric. The microemulsion system exhibits high uniformity and long-term stability, eliminating the need for additional surfactants during spinning to achieve high dispersion of the nano-tea fiber in the spinning solution, ensuring the long-lasting effectiveness of the resulting functional fabric. Furthermore, yerba mate contains abundant tea polyphenols and unique yerba mate alkaloids, which further enhance the overall performance of the composite fiber.

This invention provides exosomes derived from rice, their preparation method, and applications. The exosomes have a bilayered membrane spherical structure with a particle size ranging from 20 to 1000 nm. These exosomes are obtained from rice callus tissue and possess high biocompatibility, stability, and sustainable mass production characteristics. Furthermore, experiments have demonstrated that these exosomes have anti-aging, cell regeneration and tissue repair promotion, and protective functions, and can also significantly improve cell absorption efficiency and the delivery efficiency of active ingredients such as peptides.

This invention discloses a pharmaceutical composition, its formulation, and its application for treating rheumatic arthralgia. The pharmaceutical composition comprises the following components in parts by weight: 20-40 parts of Salvia miltiorrhiza, 10-20 parts of Paeonia lactiflora, 20-40 parts of Panax notoginseng rootlets, 10-20 parts of Ligusticum chuanxiong, 9-20 parts of Angelica sinensis, 9-20 parts of Clematis chinensis, 9-20 parts of Angelica pubescens, 9-20 parts of Chaenomeles speciosa, 9-20 parts of Saposhnikovia divaricata, 9-20 parts of Achyranthes bidentata (processed with wine), and 9-20 parts of Carthamus tinctorius. Pharmaceutically acceptable excipients may be added to the pharmaceutical composition to prepare a formulation. The pharmaceutical composition and its formulation can be used to treat rheumatic arthralgia.

This invention provides a functional fascia gun head, belonging to the field of massage devices and physical therapy technology. This functional fascia gun head consists of a power-generating layer and a regular fascia gun head; the power-generating layer can be placed outside or inside the regular fascia gun head. Another design of the functional fascia gun head is entirely composed of a power-generating layer. When the fascia gun is in operation, the power-generating layer generates a Maxwell pulse electric field and a pulse displacement field current under force, forming a pulse wave. This pulse wave can effectively penetrate multiple layers of skin structure, promoting blood circulation and cell activation, achieving various health benefits such as warming the meridians and activating collaterals, relaxing muscles, relieving pain, preventing injury, dispelling cold and dampness, harmonizing yin and yang, promoting homeostasis, and delaying aging. The power-generating layer is made of various materials and has various structural forms; the manufacturing process is simple, significantly improving the product's multifunctionality and ease of use, providing more diversified and efficient options for the medical and beauty fields.

The application belongs to the technical field of building construction, and particularly relates to a prefabricated elevator shaft inner wall anti-falling noise reduction plate and a mounting method, which comprises a noise reduction plate, cast-in-place concrete and an anti-falling connecting piece, the anti-falling connecting piece is horizontally arranged and embedded in the cast-in-place concrete, the noise reduction plate and the cast-in-place concrete are integrally formed through the anti-falling connecting piece, the noise reduction plate comprises a convex block plate and a concave groove plate, a plurality of convex block portions are arranged on the side surface of the convex block plate close to the concave groove plate, a plurality of concave groove portions corresponding to the convex block portions are arranged on the side surface of the concave groove plate, and the side surface of the concave groove plate away from the convex block plate is fixedly connected with the cast-in-place concrete through the anti-falling connecting piece; compared with the prior art, the application has the advantages and positive effects that the cost is low, the wall cost is reduced, the building wall noise reduction and structure integration can be realized, the building wall heat preservation and structure have the same service life, and the problems of high maintenance cost and high maintenance frequency of the traditional sound absorption and noise reduction system are solved.

The application discloses a kind of detection piRNA marker material, including one or more of the following applications: A1) in the application in the preparation of diagnostic blood vessel senile product;A2) in the application in the preparation of screening blood vessel senile product;A3) in the application in the preparation of evaluating blood vessel senile risk product;A4) in the application in the preparation of blood vessel senile prognosis evaluation product;A5) in the application in the preparation of distinguishing blood vessel senile and other diseases product;PiRNA marker is hsa_piR_017724, nucleotide sequence is as shown in SEQ ID No.1.The hsa_piR_017724 marker provided by the application is significantly increased in the expression amount in the plasma of blood vessel senile patient compared with healthy control, indicating that hsa_piR_017724 is a potential blood vessel senile biomarker.The ROC curve of the efficiency in diagnosing blood vessel senile patient shows that hsa_piR_017724 has good diagnostic efficiency.

This invention discloses a facial mask containing natural agarwood extract and its preparation method. The mask comprises the following raw materials in parts by weight: 5-10 parts agarwood extract, 1-5 parts wheat germ extract, 2-5 parts tremella extract, 1-4 parts superoxide dismutase, and 0.5-4.5 parts Bacillus fermentation product. This facial mask possesses the ability to synergistically scavenge ABTS free radicals and synergistically promote the production of type III collagen. On the one hand, it reduces oxidative damage at the source, slowing down the aging process; on the other hand, the production of type III collagen repairs and regenerates the skin, making it firmer and more elastic. The facial mask of this invention synergistically enhances the skin barrier from different aspects, achieving a better synergistic beauty effect. Furthermore, the facial mask of this invention also has good brightening, soothing, and calming effects, and is safe, effective, natural, and low-irritant.

The application relates to the technical field of flow control, in particular to an organic waste gas desorption condensation treatment method and system, which comprises the following steps: acquiring internal temperature sequences and external temperature sequences of condensation equipment in a condensation state and condensation equipment in a condensation regeneration state at each moment, respectively; acquiring a condensation completion moment after each condensation is completed and a regeneration completion moment after each condensation regeneration is completed; determining relative condensation efficiencies, relative internal-external temperature differences and temperature gradient characteristics at each moment; determining condensation progress at any historical condensation moment and regeneration progress at any historical regeneration moment; determining real-time regeneration progress, real-time condensation progress and condensation progress errors at the current moment; and controlling the heat medium flow in combination with a PID algorithm. The application realizes real-time regulation and control of the heat medium flow, so that the condensation process and the condensation capacity regeneration process are synchronously performed, thereby reducing the overall energy consumption of the condensation equipment and being beneficial to delaying equipment aging.

The utility model belongs to the technical field of protection engineering, specifically is a kind of steel structure corrugated board shed hole with passive protective net, including protective sheet;The protective sheet is arc-shaped arrangement;Multiple cavities are equipped in the middle part of the protective sheet;Multiple reinforcing bars are fixedly connected in the middle part of the protective sheet;First connecting groove is set in the sidewall of the protective sheet;The sidewall of the protective sheet is fixedly connected with connecting plate;The first connecting groove and connecting plate are oppositely arranged;Multiple sleeve connectors are fixedly connected in the end of the protective sheet;Buffering assembly is installed in the middle part of the protective sheet;The above-mentioned structure protective sheet can reduce structural deadweight, reduce transportation and hoisting difficulty, macromolecular polymer material can effectively resist aging, ensure the service life of product, and the protective sheet has good insulation, so that it can adapt to discharge environment, and the protective sheet can be quickly connected during installation.

The present application belongs to the field of microbial technology, and more specifically, the present application relates to an inactivated culture of plant lactobacillus BGI-N6, its use and products containing the inactivated culture. The present application provides an inactivated culture product of probiotics, which can break through the condition limitation of application of active probiotics, effectively eliminate free radicals, inhibit collagenase and elastase, inhibit skin pathogenic bacteria, so as to achieve better effect of slowing down skin aging.

This application discloses a method for directly cultivating seedlings from the germination of *Cymbidium goeringii* seeds in Yunnan. The method includes the following steps: sowing *Cymbidium goeringii* seeds on a modified culture medium, followed by 6 months of constant temperature cultivation at 25℃ to obtain small pseudobulbs suitable for direct transplanting. This method is simple to operate; seeds begin to germinate and turn green 20 days after sowing, begin to grow leaves after 45 days, begin to root after 60 days, and show significant root growth after 90 days. The pseudobulbs also enlarge synchronously. After 6 months, the plants naturally shed their leaves in the tissue culture bottle, and the pseudobulbs can be transplanted to the field for acclimatization and cultivation. This method eliminates the need to change the culture medium, removes the manual transfer step in the tissue culture process, and solves the problems of yellowing, difficult rooting, and high contamination rates after transfer of tissue culture seedlings. Furthermore, the plants naturally shed their leaves in the tissue culture bottle, directly obtaining small pseudobulbs without hardening off, and improving the transplant survival rate, which is beneficial for the large-scale cultivation of *Cymbidium goeringii*.

The application discloses application of LRP1 high-expression mesenchymal stem cells in treatment of osteoarthritis, wherein the LRP1 high-expression mesenchymal stem cells are cells with LRP1 expression levels of 25.00% to 25.99% obtained through flow sorting.The LRP1 high-expression mesenchymal stem cells have a good intervention effect on knee osteoarthritis, can not only inhibit knee osteoarthritis cartilage matrix degradation, delay chondrocyte aging, improve Col II and ACAN expression in chondrocytes and maintain chondrocyte function.Compared with a traditional UCMSCs therapy, the UCMSC-LRP1h can solve the problem of dilution of ineffective subpopulations in a mixed cell population, and has a better intervention effect.This has a broad prospect in the market of clinical transformation and precision treatment.

The application discloses a milk-derived active peptide IPLQPNFQADQFQGK with strong antioxidation and immunoregulation, and a preparation method and application thereof, and relates to the active peptide field. An active peptide is screened from a product obtained by subjecting lactoferrin to protease hydrolysis and fermentation of paracasei, and it is verified that the active peptide has excellent antioxidation and immunoregulation effects, can enhance the immunity of the body, effectively resist oxidative stress, and delay aging. The active peptide is natural milk-derived, free of chemical addition, has high biocompatibility, and can be widely used for preparing antioxidation and / or immunoregulation products.