15 results about "Vaginal atrophy" patented technology

The invention relates to the technical field of gynecological medical instruments, and discloses an intelligent vagina support system, which comprises a shape memory alloy support skeleton, which comprises a memory alloy skeleton and a connecting ring, the phase change temperature of the shape memory alloy support skeleton is set to be in a human body vagina temperature range, and the shape memory alloy support skeleton is subjected to phase change under temperature triggering and dynamically adapts to pelvic floor muscle stress change; the detachable double-channel medicine bin comprises a detachable antibiotic medicine bin and a detachable estrogen medicine bin which are respectively and correspondingly used for treating infection and vaginal atrophy; and the sensing module comprises an outer insulating layer, an inner electrode and a main body, integrates a pressure sensor and a pH detection electrode, and is used for monitoring environmental parameters in the vagina in real time. The system adopts shape memory alloy as a supporting framework, austenite phase change occurs under triggering of body temperature, and the system is dynamically attached to the anatomical structure of the vagina. Stable radial supporting force is provided during resting and is lower than a mucous membrane ischemia threshold value; when the abdominal pressure suddenly rises during cough or movement, dynamic supporting force compensation is provided through hyperelastic deformation, and instrument displacement or compression injury is effectively prevented.

Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).

The invention relates to an apparatus and a method, termed the "Capsul eProbe", adapted from the capsule endoscopy technology for cervical and / or vaginal examinations. The CapsuleProbe features a capsule endoscope enclosed in a cylindrical housing designed for easy insertion into the vaginal canal. This device provides a minimally invasive and user-friendly option for patients as well as enhanced visualization of the cervix for healthcare providers. With its substantially minimized dimensions comparing to existing medical devices for cervical and / or vaginal examinations, this device improves feasibility, accessibility, and patient comfort significantly, particularly for postmenopausal women and those suffering from vaginal atrophy, by reducing or eliminating procedure-related pain and / or bleeding from the tearing of vaginal walls caused by existing invasive medical devices used for cervical and / or vaginal examinations.

According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

The invention belongs to the technical field of dressings, and particularly relates to a gel dressing containing recombinant collagen as well as a preparation method and application of the gel dressing. The gel dressing containing the recombinant collagen is prepared from the following raw materials in percentage by weight: 0.1 to 1 percent of the recombinant collagen, 0.5 to 1 percent of sodium hyaluronate, 0.08 to 0.15 percent of radices stellariae dichotomae cyclopeptide, 0.5 to 1 percent of carbomer, 0.03 to 0.06 percent of cryptomeria fortunei bud extract, 15 to 20 percent of poloxamer, 0.1 to 0.5 percent of xanthan gum, 3 to 8 percent of glycerol, 0.04 to 0.08 percent of edetate disodium, 0.1 to 0.3 percent of triethanolamine, 0.08 to 0.12 percent of preservative and the balance of deionized water. The gel dressing has excellent biocompatibility, good hemostasis, cell growth promotion and tissue repair performance, and can be used for repairing vaginal mucous membrane chap and hemostasis of diffuse superficial bleeding, and improving the symptoms of elasticity reduction and the like caused by vaginal atrophy.

The application relates to a shrinking and lubricating gel, which comprises the following raw materials in percentage by weight: xanthan gum 0.1-2%, trehalose 0.1-2%, carbomer 0.1-3%, glycerol 1-20%, gelatin alginate complex 1-10%, humectant 0.2-4%, disodium edetate 0.01-0.1%, polyethylene glycol 0.1-2%, pH regulator 0.1-3%, royal jelly extract 0-2%, schisandra extract 0-2%, and the balance is water. The application forms a protective biological gel layer on the vaginal wall through the lubricating gel, so as to prevent pathogenic microorganisms from planting, and is suitable for improving itching, erosion, burning, vaginal atrophy, sexual intercourse pain, senile vaginitis, abnormal leucorrhea, urinary urgency, dysuria and other menopausal reproductive urological syndromes.

Device (1, 20, 100, 200) for the treatment of vaginal atrophy, the device comprising a treatment module (2, 21, 101, 201) configured for insertion into the vagina and having a microtrauma module. The microtrauma module is configured to deliver a negative pressure mechanical microtrauma treatment to the vaginal wall upon insertion. The microtrauma module comprises a plurality of pores (6, 106, 206) in fluid connection with a vacuum pump, the device being arranged to generate a negative pressure at the pores (6, 106).

The invention relates to a method and an apparatus, termed the “CapsuleProbe”, adapted from the capsule endoscopy technology for cervical and / or vaginal examinations. The CapsuleProbe features a capsule endoscope enclosed in an elongated cylindrical housing designed for easy insertion into the vaginal canal. This device provides a minimally invasive and user-friendly option for patients as well as enhanced visualization of the cervix for healthcare providers. With its substantially minimized dimensions comparing to existing medical devices for cervical and / or vaginal examinations, this device improves feasibility, accessibility, and patient comfort significantly, particularly for postmenopausal women and those suffering from vaginal atrophy, by reducing or eliminating procedure-related pain and / or bleeding from the tearing of vaginal walls caused by existing medical devices used for cervical and / or vaginal examinations.

According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

A method of treating vaginal tissue atrophy in a female subject, the method including the steps of engaging an energy delivery element with tissue in or around the subject's vagina; applying energy to the tissue from the energy delivery element; and increasing blood flow to internal vaginal tissue to an increased level above a baseline level of blood flow to the internal vaginal tissue, the increased level of blood flow to the internal vaginal tissue persisting after the applying step ceases. The invention also provides devices for performing this therapy.

The invention is suitable for the technical field of biological medicines and gynecological external preparations, and provides a temperature-sensitive gynecological gel for preventing vaginal mucosa atrophy and a preparation method thereof. The gynecological gel is prepared from the following raw materials in parts by weight: 70 to 95 parts of temperature-sensitive gel matrix, 1 to 5 parts of prebiotics, 0.01 to 0.1 part of superoxide dismutase, 1 to 3 parts of modified glycyrrhizic acid and 2 to 4 parts of sustained release microspheres of which the internal effective component is tanshinone IIA (at) collagen-sodium hyaluronate, the anti-inflammatory and anti-oxidation effects of the modified glycyrrhizic acid, the safe microcirculation improvement effect of the tanshinone IIA and the moisturizing, mucous membrane tissue repair promotion and anti-inflammatory effects of the collagen and the sodium hyaluronate have a synergistic effect, so that the vaginal atrophic mucous membrane is efficiently repaired; the invention also discloses a preparation method of the temperature-sensitive gel. The gel preparation is stable in preparation process and high in safety, is suitable for preventing and treating vaginal mucosa atrophy caused by postmenopausal or hormone level fluctuation, and has a good clinical application prospect.

The invention discloses an SOD (superoxide dismutase) oil mixture for improving vaginal atrophy and dryness and increasing vaginal elasticity, and relates to the technical field of laser cladding. The invention discloses a skin-care essence, which is prepared from the following ingredients in percentage by mass: 0.1 to 1 percent of superoxide dismutase, 10 to 20 percent of deep sea fish oil, 5 to 10 percent of vitamin E, 3 to 8 percent of squalane, 1 to 3 percent of sodium hyaluronate, 0.5 to 2 percent of chitosan quaternary ammonium salt, 1 to 3 percent of phytosterol, 0.1 to 0.5 percent of lavender essential oil, 0.1 to 0.5 percent of tea tree essential oil and the balance of purified water. According to the SOD oil mixture for improving the vaginal atrophy and dryness and increasing the vaginal elasticity, various components cooperate with one another, the SOD oil mixture plays a role in the aspects of oxidation resistance, inflammation resistance, moisturizing, repairing and the like, the symptoms of the vaginal atrophy and dryness can be effectively improved, the vaginal elasticity is increased, the treatment effect is improved, the components are natural, harmful chemical substances are not contained, and the SOD oil mixture does not irritate vaginal mucosa; no obvious side effect exists. Through detection of skin irritation index (PII) determination, biocompatibility experiment and the like, it is proved that the composition is good in safety and suitable for long-term use.

The invention relates to an apparatus and a method, termed the “CapsuleProbe”, adapted from the capsule endoscopy technology for cervical and / or vaginal examinations. The CapsuleProbe features a capsule endoscope enclosed in a cylindrical housing designed for easy insertion into the vaginal canal. This device provides a minimally invasive and user-friendly option for patients as well as enhanced visualization of the cervix for healthcare providers. With its substantially minimized dimensions comparing to existing medical devices for cervical and / or vaginal examinations, this device improves feasibility, accessibility, and patient comfort significantly, particularly for postmenopausal women and those suffering from vaginal atrophy, by reducing or eliminating procedure-related pain and / or bleeding from the tearing of vaginal walls caused by existing invasive medical devices used for cervical and / or vaginal examinations.

According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

The present invention relates to a pharmaceutical or nutraceutical composition, in the form of a unit dosage for oral administration, comprising collagen peptides, astragalus powder, centella asiatica extract, mononucleotides, hyaluronic acid, for use in the prevention and / or treatment of uro-gynaecological disorders selected from: genitourinary syndrome, vulvovaginal atrophy, scleroatrophic lichen, vulvovaginal itching, vulvovaginal dryness.