79 results about "Baseline level" patented technology

A stimulation device is provided that stimulates breathing to manipulate blood gas concentrations such as SaO2 or PCO2 and thereby treat underlying causes of breathing disorders and heart failure progression. A programmable device is provided for setting diaphragm stimulation waveforms that adjust minute ventilation about a predetermined baseline value. Normal breathing of the subject is observed to establish a baseline reference minute ventilation, and the device is programmed to produce stimulation waveforms that may provide either a decrease or an increase in the patients minute ventilation. The minute ventilation of the subject may be decreased or increased from the baseline level by decreasing or increasing a parameter that changes minute ventilators.

A medical device identifies a hemodynamically unstable arrhythmia based upon optical hemodynamic sensor signals. The optical hemodynamic sensor includes a light source for transmitting light corresponding to first and second wavelengths through a blood perfused tissue of a patient and a light detector for generating optical signals corresponding to an intensity of the detected light at the first and second wavelengths. At a low motion period for the patient, optical signals are obtained from the optical hemodynamic sensor and are analyzed to determine a baseline motion level for the patient. Subsequent signals obtained from the optical hemodynamic sensor are compared to the baseline motion levels, with only those signals corresponding to periods where motion does not exceed the baseline level of motion being further analyzed to determine if they are consistent with a hemodynamically unstable arrhythmia.

The subject invention discloses a method for determining the prognosis and probable clinical course of a subject diagnosed with B-CLL. Specifically, the invention involves comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein an elevated level of CD38 expression in relation to the baseline level of CD38 expression may indicate poor prognosis or aggressive course of disease in the subject. Also disclosed is a method for determining whether the Ig V genes of the B-CLL cells of a B-CLL patient are mutated, comprising comparing CD38 expression in a biological sample from the subject containing B-CLL cells to a baseline level of CD38 expression, wherein a lower level of CD38 expression in relation to the baseline level indicates IG V gene mutation.

A method for monitoring an environment for threat conditions potentially related to a catastrophic event is disclosed herein. The method includes determining baseline levels of one or more environmental agents in an area based upon first measurement data received from a sensor network. The method further includes establishing one or more threshold levels relative to the baseline levels. Second measurement data received from the sensor network is then processed with respect to the one or more baseline levels. The method also includes identifying at least one threat based upon the processing of the second sensor measurement data. The identified threat is then assesses and prioritized.

Method and apparatus for predicting future failure of a disc drive head from degradation in a head readback response characteristic, such as electrical resistance, readback signal amplitude, asymmetry or nonlinearity. During manufacturing, the disc drive determines and store a baseline level for a selected readback response characteristic of the head indicative of head performance as data are read back from a disc. During subsequent data processing use, the disc drive subsequently periodically determines a subsequent level for the readback response characteristic of the head. The possibility of a future failure of the drive is next predicted in relation to a difference between the baseline level and the subsequent level for the readback response characteristic of the head. An indication of the possibility of the future failure is provided to allow a host device to reallocate data stored on the disc before the failure of the head.

Some method examples may include pacing a heart with cardiac paces, sensing a physiological signal for use in detecting pace-induced phrenic nerve stimulation, performing a baseline level determination process to identify a baseline level for the sensed physiological signal, and detecting pace-induced phrenic nerve stimulation using the sensed physiological signal and the calculated baseline level. Detecting pace-induced phrenic nerve stimulation may include sampling the sensed physiological signal during each of a plurality of cardiac cycles to provide sampled signals and calculating the baseline level for the physiological signal using the sampled signals. Sampling the sensed physiological signal may include sampling the signal during a time window defined using a pace time with each of the cardiac cycles to avoid cardiac components and phrenic nerve stimulation components in the sampled signal.

Methods and apparatuses for touch sensing are disclosed. In one example, both an inactive state baseline level and an active state baseline level are utilized.

A system and method of detecting a loss of electrical contact between a pair of electrodes that are electrically coupled to skin of a subject. The method includes monitoring parameters of a transthoracic impedance between the pair of electrodes in at least one of a low frequency regime and a high frequency regime, detecting an occurrence of chest compressions based on a signal indicative of chest compressions, establishing baseline levels of the parameters in at least one of the low and high frequency regimes, detecting whether changes in at least one parameter exceeds the baseline level by a threshold, determining that at least one electrode of the pair of electrodes is losing electrical contact with the skin responsive to the at least one parameter exceeding the baseline level by the threshold, and issuing an alert in response to a determination that the at least one electrode is losing electrical contact.

The invention provides tools for management of patients diagnosed with ankylosing spondylitis and prior to the initiation of therapy with an anti-TNFalpha agent. The tools are specific markers and algorithms of predicting response to therapy based on standard clinical primary and secondary end-points using serum marker concentrations. In one embodiment the baseline level of leptin or osteocalcin is used to predict the response at Week 14 after the initiation of therapy. In another embodiment, the change in a serum protein biomarker after 4 weeks of therapy is used such as complement component 3.

Apparatus and methods are provided to control a device, such as a light emitting dermatologic or cosmetic treatment device, and ensure that the device is in contact with skin while also determining the pigmentation level of skin. One or more light sources contact the skin and one or more detectors measure spectral remission from the skin. The obtained remission measurements are compared with known skin spectral remission values, and calibration allows measurements of absolute remission to be converted to fractional remission values. Skin pigmentation levels are compared to known base-line levels to determine and control appropriate treatment parameters. A temperature sensor allows correction for temperature variations. The apparatus may or may not be incorporated into the treatment device.

A system and method for metering usage of a data processing system and scaling system performance is disclosed. In one embodiment, an authorization key is purchased that specifies both a baseline performance level and a ceiling performance level. The cost of the baseline and ceiling performance levels is included in the price of the key. After the key is installed on the data processing system, the system performance level is monitored and averaged over predetermined time periods. The customer is charged on a “pay-as-you-go” basis for any time periods during which the average performance level exceeds the baseline performance level. Performance of the data processing system is not allowed to exceed the ceiling level obtained with the authorization key. In one embodiment, the baseline level may be set to zero so that all performance consumption is purchased by the customer as it is utilized.

A read servo mechanism that uses levels of read data signal quality to maintain track centerline is presented. In a seek operation mode, a baseline signal quality value is sampled at a current tracking position and, once the baseline signal quality value is established, the head is stepped to change its position and the signal quality value sampled after each position change to determine change in signal quality until the change in signal quality is found to be insignificant. After a predetermined interval, the signal quality value is again sampled. If the signal quality value has changed significantly or the time that has expired since the seek operation mode ended is greater than some larger interval, the seek operation is repeated in an effort to search for a new baseline level of signal quality (and, therefore, the new track center).

A system and method for metering usage of a data processing system and scaling system performance is disclosed. In one embodiment, an authorization key is purchased that specifies both a baseline performance level and a ceiling performance level. After the key is installed on the data processing system, the system performance level is monitored and averaged over predetermined time periods. The customer is charged on a “pay-as-you-go” basis for any time periods during which the average performance level exceeds the baseline performance level. Performance of the data processing system is not allowed to exceed the ceiling level obtained with the authorization key. In one embodiment, the baseline level may be set to zero so that all performance consumption is purchased by the customer as it is utilized. A report may be generated that includes data upon which analysis of the measured processor utilization data may be performed.

The invention relates to the field of treatment of biological and medical signals, in particular to a device for automatically identifying a fetal heart rate baseline and a method for realizing the device. The method provided by the invention comprises the steps of: collecting fetal heart rate data within a preset time length to obtain a fetal heart rate data series h'(n); preprocessing the collected fetal heart rate data series h'(n) to obtain respective fetal heart rate data series corresponding to the preprocessing process; selecting a main dominant peak value according to the frequency distribution of the respective fetal heart rate data series corresponding to the preprocessing process; and performing dynamic baseline identification according to the respective fetal heart rate data series corresponding to the preprocessing process and the main dominant peak value to obtain, display and print a dynamic baseline. According to the technical scheme of the device provided by the invention, the influence of regular changes of fetal heart rate on baseline solutions can be effectively avoided, and the baseline level and the changes thereof of a fetus under different conditions can beaccurately reflected.

The present invention relates to a detection device (6) for detecting photons emitted by a radiation source (2). The detection device (6) is configured to detect the photons during a first time period. The detection device (6) comprises a sensor (10) having an intermediate direct conversion material for converting photons into electrons and holes, a shaping element (20), and a compensation unit (450, INT, 950). The compensation unit (450, INT, 950) is adapted to provide a compensation signal based on the electrical pulse and on a photoconductive gain of said sensor (10). The core of the invention is to provide circuits to reduce artifacts due to inherent errors with direct conversion detectors in spectral computed tomography by determining a compensation current, by detecting or monitoring a baseline restorer feedback signal, or by ignoring signals above the baseline level.

A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.

The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or structures 1-45 and imaging the patient. After said imaging, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is imaged again. Finally, baseline levels of amyloid deposition in the patient before treatment with the anti-amyloid agent are compared with levels of amyloid deposition in the patient following treatment with the anti-amyloid agent.

The present invention controls reagent flow levels in a selective non-catalytic reduction (SNCR) system by more accurately predicting Nitrogen Oxides (NOx) production with a municipal waste combustor. In one embodiment, the reagent levels correspond with measured furnace temperatures. The reagent levels may have a baseline level from prior measured NOx that is then modified according to temperatures measurements. A slow controller may use NOx measurements over an extended period to define a base regent level, and a fast controller may use additional information such as the furnace temperature to modify the base regent level. The fast controller may further receive two additional signals that are added individually or together to maximize NOx control while minimizing ammonia slip from the reagent. The two signals are a feed-forward signal from the combustion controller and a feedback signal from an ammonia analyzer downstream of the combustion zone.

A system and method provide fail-safe operation of a lighting system. A lighting level detector is used to obtain a baseline lighting level for a low-intensity light. If the detector measures less than the baseline level when an occupancy sensor determines the space is unoccupied, a high-intensity light is energized and an indication is provided to a user that the low-intensity light has failed. A method provides daylighting operation of a lighting system. An occupancy sensor can have Wi-Fi functionality to enable remote configuration of the sensor. A line voltage occupancy sensor can include an interface with low voltage devices. An occupancy sensor can include an integral interface to enable an external control system to override the sensor's normal logic under emergency conditions. An occupancy sensor can include an active temperature compensation feature. An occupancy sensor can also incorporate an automatically adjustable coverage area.

A ballast system and method use a situational adaptive approach to measure, control and monitor the level of liquid in an onboard ballast tank. A baseline level of liquid in the tank, established while the watercraft is static, is stored in memory associated with a controller. While the watercraft is moving, the controller monitors pump conditions, e.g., run time, flow, vacuum, etc., and extrapolates the amount of water added to or drained from the tank. The baseline level and extrapolated added / drained amount are added to accurately determine the true liquid level in the tank. That information is displayed to the watercraft operator. The system can automatically adjust watercraft attitude by adding / draining water from the ballast tank based on preset values to provide a desired wake. The system can display ballast levels in volume, percentage of full, and weight; and can provide estimated times to achieve preset levels, empty or full.

The invention discloses an obese patient functional image analysis method based on mutual sample entropy. The method is characterized by comprising the following steps of collecting resting-state functional magnetic resonance data of a brain; selecting interest areas; extracting a time sequence of voxels in each interest area, up-sampling the time sequence of each voxel, and calculating the mutual sample entropy value of any two interest areas; comparing the mutual sample entropy value of any two interested area of the obese patient with the mutual sample entropy value of corresponding two interested areas of a normal testee, and determining the reason for obesity or worsening of the obesity. The method has the beneficial effects that starting with the physiological line of the obese patient through the resting-state imaging way, the changing of physiological activity of the brain of the patient can be accurately reflected; the EEG signal brain network establishing method is applied to fMRI, and the problem that the fMRI time resolution is not high can be overcome by utilizing the up-sampling method; the mutual sample entropy overcomes the matching problem of the mutual approximate entropy.

The present invention provides for the removal of mercury utilizing Mer proteins. After the Mer proteins have been expressed and isolated, or alternatively using the native Mer protein complex, either can be used as a chelating agent to remove mercury from any aqueous mercury containing environment. The Mer protein may be used in a solution to bind mercury where the solution contains a Mer proteins may be reversibly attached to a removal apparatus as a Mer ligand. The Mer complex may also be used within a bioreactor to bind and reduce Hg(2+). The bioreactor may have any competent bacteria capable of producing a Mer complex attached within the bioreactor also containing an inlet and an outlet. In addition, the Mer complex may be enhanced within Mer competent bacteria by a method of enhancement that comprises the creation of a baseline of Mer competent bacterial growth, creating a stock of Mer competent bacteria growing at the baseline level and then adding baseline bacteria to successively higher levels of Hg until the bacteria can grow in 1 mM Hg. The advantage of the Mer proteins is that the mercury binding is exclusive in regards to other metals.

An apparatus, system, and method are disclosed for detecting the formation of a short between a magnetoresistive (“MR”) head and a head substrate. The apparatus is presented with a logic unit containing a plurality of modules configured to functionally execute the necessary steps of generating a baseline electric potential level between a head substrate and ground, monitoring the level of the electric potential between the head substrate and ground, and detecting the formation of a short circuit between the MR head and the head substrate by detecting a change in the electric potential level monitored by the monitoring module from the baseline level to a predetermined threshold level. Beneficially, such an apparatus, system, and method would reduce read errors on the magnetic tape storage system, the time and resources required to recover from such errors, and allow for preventative measures to obviate contamination short related failures of tape drive systems.

The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and change of the biochemical marker, in particular molecules related to alpha 1-antitrypsin, and comparing with a predetermined baseline level of the biochemical marker contained in serum. Statistical analysis can be performed to evaluate the baseline level indicating the occurrence of endometriosis. Therefore, the present invention can provide an auxiliary guideline for the diagnosis of endometriosis. The present invention also relates to usage of the biochemical marker.

The present invention provides a chromatograph / mass spectrometer capable of producing a composite chromatogram from plural chromatogram signals without causing the baseline level to rise or the intensity of the chromatogram peak to decrease. The chromatograph / mass spectrometer includes a chromatograph unit for separating a sample into components in the order of time, a mass spectrometer unit for analyzing the components of the sample, and a signal generator for producing a signal carrying a chromatogram obtained by the analysis. It also includes a chromatogram composer for receiving signals of plural chromatograms simultaneously measured under different conditions, for choosing the largest value of the plural signals for each point in time, and for integrating the chosen values to produce a composite chromatogram.

An apparatus, system, and method are disclosed for detecting the formation of a short between a magnetoresistive (“MR”) head and a head substrate. The apparatus is presented with a logic unit containing a plurality of modules configured to functionally execute the necessary steps of generating a baseline electric potential level between a head substrate and ground, monitoring the level of the electric potential between the head substrate and ground, and detecting the formation of a short circuit between the MR head and the head substrate by detecting a change in the electric potential level monitored by the monitoring module from the baseline level to a predetermined threshold level. Beneficially, such an apparatus, system, and method would reduce read errors on the magnetic tape storage system, the time and resources required to recover from such errors, and allow for preventative measures to obviate contamination short related failures of tape drive systems.

The present invention controls reagent flow levels in a selective non-catalytic reduction (SNCR) system by more accurately predicting Nitrogen Oxides (NOx) production with a municipal waste combustor. In one embodiment, the reagent levels correspond with measured furnace temperatures. The reagent levels may have a baseline level from prior measured NOx that is then modified according to temperatures measurements. A slow controller may use NOx measurements over an extended period to define a base regent level, and a fast controller may use additional information such as the furnace temperature to modify the base regent level. The fast controller may further receive two additional signals that are added individually or together to maximize NOx control while minimizing ammonia slip from the reagent. The two signals are a feed-forward signal from the combustion controller and a feedback signal from an ammonia analyzer downstream of the combustion zone.

Methods and systems are provided for indicating water at an oxygen sensor based on power consumption of a heating element of the oxygen sensor. In one example, water may be indicated at an oxygen sensor positioned in an intake of an engine responsive to power consumption of the heating element of the oxygen sensor increasing above a baseline level. Engine operating parameters may then be adjusted based on the water indication and the power consumption.