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A noninvasive method for measuring histamine from skin as an objective measurment of itch

一种组胺、上皮的技术，应用在测量作为瘙痒的客观量度的皮肤中的组胺的非侵入性领域

Active Publication Date: 2012-07-04
PROCTER & GAMBLE CO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Although histamine levels in dandruff and seborrheic dermatitis have not been previously studied, there may be a strong association between pruritus severity and histamine levels

Method used

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  • A noninvasive method for measuring histamine from skin as an objective measurment of itch
  • A noninvasive method for measuring histamine from skin as an objective measurment of itch
  • A noninvasive method for measuring histamine from skin as an objective measurment of itch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0063] Basic procedure for histamine work in Study #1 and Study #2

[0064] Dandruff subjects were identified by quantitative screening machine in two separate clinical studies; Study #1 and Study #2. Study #2 also included dandruff-free subjects, who were also assessed at baseline to establish normalized histamine levels (n=121).

[0065] Subjects washed with a regular, conditioner-free, non-dandruff shampoo for two weeks prior to treatment with the anti-dandruff shampoo. After three weeks of treatment with an anti-dandruff shampoo (shampoo composition containing zinc pyrithione), from among the highest exfoliation octads measured by the quantitative screening machine at the baseline follow-up Collect tape peel samples. Scalp tape strips were taken as baseline after three weeks of product treatment. The tape was stored at -80°C until extraction. Sampling of sites involved in dandruff by parting the hair by applying Tape (CuDerm Corporation) and rub the tape as needed....

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Abstract

A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.

Description

field of invention [0001] The present invention relates to methods of measuring the amount of histamine in a skin sample and objectively correlating and correlating the amount of histamine as it is directly related to the itching sensation in mammals. Background of the invention [0002] The severity of pruritus symptoms in scalp dermatitis has been assessed in the past. The most frequently described symptom associated with an unhealthy scalp is itching. It is also the most bothersome symptom with the greatest negative impact on the patient's quality of life. [0003] With regard to the general physiology of itch, the itch sensation represents the termination of complex physiological pathways initiated at the skin surface. Many stimuli can initiate a cascade of events that ultimately leads to the itching sensation. The stimulation triggers the release of histamine together with specific receptor cells in the dermis. The histamine then binds to the nerve endings, initiati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N1/28
CPCG01N33/6881G01N2001/4061G01N2001/2833A61P17/04
Inventor J.R.施瓦兹K.M.科尔P.W.多伊尔K.R.韦迈耶T.M.伯特A.M.菲诺R.L.威玛拉塞纳G.M.法达耶尔
Owner PROCTER & GAMBLE CO
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