20 results about "Seborrheic dermatitis" patented technology

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to Chinese herbal medicine emulsifiable paste for dermatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: radix sophorae flavescentis, cortex phellodendri, cortex dictamni, fructus cnidii, fructus kochiae, radix scutellariae, radix paeoniae rubra, radix salviae miltiorrhizae, herba schizonepetae, radix saposhnikoviae Systematic design is carried out aiming at complex pathogenesis of seborrheic dermatitis, medicinal materials such as radix sophorae flavescentis and cortex phellodendri are used for synergistically clearing heat and drying dampness, malassezia is inhibited, and lipid control and bacteriostasis are carried out from the source; radix scutellariae, radix salviae miltiorrhizae and the like are combined to cool and activate blood and control inflammation for a long time; the herba schizonepetae, the radix saposhnikoviae and the like are added for targeted itching relieving and secondary injury reduction; in the dosage form, a low-oil-burden matrix composed of light grease such as jojoba oil and squalane is adopted, the texture is light and thin, hair follicles are not blocked, and phytosterol is introduced to synchronously repair the skin barrier; according to the system, the use comfort and compliance are remarkably improved while permeation of active ingredients is guaranteed.

The invention provides a traditional Chinese medicine composition for regulating scalp micro-ecology, an external preparation containing the traditional Chinese medicine composition and application of the external preparation, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition for regulating and controlling scalp micro-ecology is prepared from cacumen biotae, rhizoma cyperi, fructus cnidii, cortex dictamni, radix sanguisorbae, herba ecliptae and herba menthae. Based on the compatibility principle of monarch, minister, assistant and guide, the composition takes fructus cnidii for eliminating dampness and killing parasites as monarch, cortex dictamni and cacumen biotae for removing heat to cool blood as minister, garden burnet, eclipta and rhizoma cyperi for astringing, detoxifying, nourishing yin and regulating qi as assistant, and mint for guiding the medicine to move upwards and transdermal permeation as guide, so that multiple effects of inhibiting bacteria, resisting inflammation, repairing a barrier, regulating sebum secretion and the like are synergistically realized. Modern pharmacological studies show that the active ingredients can inhibit malassezia proliferation, regulate and control inflammatory pathways of NF-kB, TLR4 and the like, reduce expression of proinflammatory factors of IL-6, TNF-alpha and the like, and promote skin barrier repair. Clinical observation shows that the composition can significantly improve the scalp seborrheic dermatitis symptom.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-isopropyl-phosphinoyl-alkanes as described herein, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”, that are useful, for example, in the treatment of the discomforts of dermatological disorders (e.g., diseases) The treatment is for the dysesthesia (e.g., caused by irritation, itch, or pain) due to dermatitis, urticaria; scalp itch; vulvar itch; lichen sclerosus; cholestatic itch; psoriasis; sebhorrheic dermatitis; allergic conjunctivitis; blepharitis; and pruritus of the elderly. The applicant has found that topical delivery of DIPA compounds to the skin alleviates the dysesthesia of these conditions in human subjects. The present discovery pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in the treatment of the dysesthesia of these dermatological disorders.

This disclosure relates to an embodiment of the use of tocotrienols in pharmaceutical, veterinary, or cosmetic applications, particularly in cosmetic formulations, whereby stabilizing tocotrienols does not impair their function in the skin. Specifically, this disclosure relates to the modification, molecular stabilization, and penetration properties of tocotrienols in human skin using nicotinic acid. The compounds and compositions of this subject matter are useful in the medical, veterinary, or cosmetic industries as a preventative, therapeutic, or treatment of dermatological diseases or skin disorders, as a treatment or treatment of acne or seborrheic dermatitis, or as anti-aging agents.

This application provides the use of an antimicrobial peptide in the preparation of skin care products. The antimicrobial peptide of this application can effectively inhibit *Propionibacterium acnes* and *Malassezia*, thereby preventing skin problems such as acne, skin inflammation, and dandruff caused by the overgrowth of these two bacteria. Therefore, the antimicrobial peptide of this application has skin care uses in inhibiting acne, relieving skin inflammation such as folliculitis, pityriasis versicolor, and seborrheic dermatitis, and in inhibiting dandruff, and has significant practical value.

The present invention concerns a method for qualitative and quantitative detection of monounsaturated fatty acids (MUFAs) in a human or animal lipid biological sample, preferably in a sebum sample. In particular, the method of the present invention can be advantageously used for the qualitative and quantitative detection of MUFAs in a human lipid biological sample, such as, human sebum, for the diagnosis of excessive secretion of MUFAs occurring in Parkinson's disease (PD), acne or seborrheic dermatitis.

The present application relates to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide for maintaining scalp microbial flora health, a preparation method and application thereof.The antibacterial peptide for maintaining scalp microbial flora health comprises the following: a polypeptide with an amino acid sequence comprising SEQ ID NO.1 or SEQ ID NO.2; or a polypeptide with an amino acid sequence consisting of the amino acid residues shown in SEQ ID NO.1 or SEQ ID NO.2; or a polypeptide with 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology with the amino acid sequence defined above.The antibacterial peptide for maintaining scalp microbial flora health has good safety and can be used for treating scalp problems such as dandruff, seborrheic dermatitis, scalp itching and hair loss caused by scalp microbial flora imbalance.

The present application relates to the technical field of antibacterial peptides, in particular to an antibacterial peptide for inhibiting Malassezia, a preparation method and application thereof. The antibacterial peptide for inhibiting Malassezia comprises any one of the following (a)-(d) polypeptides: (a) a polypeptide comprising an amino acid sequence shown in SEQ ID NO. 1, or a polypeptide consisting of amino acid residues shown in SEQ ID NO. 1; (b) a polypeptide formed by substitution, deletion and / or addition of one or more amino acid residues in the amino acid sequence defined in (a); (c) a polypeptide obtained by modifying the N-terminal and / or C-terminal of the polypeptide defined in (a); and (d) a polypeptide having 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology with the amino acid sequence defined in (a). The antibacterial peptide for inhibiting Malassezia has good safety to the skin, and can be used for treating dandruff, seborrheic dermatitis, tinea versicolor and Malassezia folliculitis caused by Malassezia fungal infection, and can be applied to cosmetics or external-use drugs for treating dandruff, seborrheic dermatitis, tinea versicolor and Malassezia folliculitis. The antibacterial peptide has significant antibacterial effect on Malassezia restricta and Malassezia furfur, and has great application value.

The invention discloses emulsifiable paste for treating eczema and dermatitis (seborrheic dermatitis) and a preparation method thereof, and belongs to the technical field of eczema and dermatitis (seborrheic dermatitis) medicines, the emulsifiable paste is prepared from the following raw materials in parts by weight: 6-10 parts of rhinacanthus nasutus, 6-10 parts of jatropha curcas, 6-10 parts of catechu, 6-10 parts of breynia fruticosa, 15-20 parts of coal tar, 40-80 parts of water, 40-50 parts of an emulsifier and 0.05-0.1 part of a preservative. The preparation method comprises the following steps: decocting the rhinacanthus nasutus, the jatropha curcas, the catechu and the breynia fruticosa with water, and then fishing out the medicinal materials to obtain medicine slurry; and mixing the medicine slurry, coal tar, an emulsifier and a preservative, adding into an emulsifying machine, and emulsifying to obtain the product. The external emulsifiable paste for eczema and dermatitis (seborrheic dermatitis) has the effects of astringing ulcers, astringing wounds and stopping bleeding, resisting viruses, dissipating blood stasis and diminishing swelling, relieving pain and itching, controlling pathogenic organisms on skin, promoting skin repair, inhibiting reproduction of viruses and fungi and the like.

The invention belongs to the technical field of biological medicines, and particularly discloses a polypeptide with malassezia resisting activity and application of the polypeptide in improvement of seborrheic dermatitis. The polypeptide provided by the invention comprises an amino acid sequence as shown in SEQ ID NO: 1. The polypeptide has a remarkable inhibiting effect on the key pathogenic bacterium-malassezia causing seborrheic dermatitis, experimental data shows that the polypeptide can remarkably inhibit the growth and constant value of the malassezia at a low concentration, and the effect of the polypeptide can be close to that of a positive control ketoconazole. The polypeptide shows an excellent dermatophyte removing effect in a malassezia induced mouse seborrheic dermatitis model, experimental data proves that the fungal load of the skin tissue of the affected part of a mouse is remarkably reduced after administration, and the polypeptide still can keep high biological activity and stability in a complex skin physiological microenvironment, and has a good application prospect. The malassezia can effectively penetrate through a sebum layer to act on thalli, so that the decomposition effect of the malassezia on sebum is effectively restrained.

A composition for inhibiting sebum secretion is disclosed. The composition contains 3,4,5-trimethoxycinnamate thymol ester, a stereoisomer, pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient. The composition can inhibit sebum secretion in the skin or scalp, and further has useful effects such as the prevention or improvement of seborrheic dermatitis, seborrheic scalp dermatitis, or acne, or the tightening of pores. Methods for inhibiting sebum secretion employing 3,4,5-trimethoxycinnamate thymol ester, a stereoisomer, pharmaceutically acceptable salt, hydrate, or solvate are disclosed.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating seborrheic dermatitis and alopecia and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: Sophora flavescens 9-11 parts, Phellodendron chinense 9-11 parts, Paris polyphylla 4-6 parts, Lotus leaf 9-11 parts, Fructus Kochiae 14-16 parts, Dictamnus dasycarpus 14-16 parts, Mentha haplocalyx 9-11 parts, and Salvia miltiorrhiza 19-21 parts. The traditional Chinese medicine composition has a good therapeutic effect on treating seborrheic dermatitis and alopecia, can improve the pathological state of skin, improve hair growth, and has a good application prospect.

The present specification relates to a composition comprising camellia saponin, which is capable of coping with global warming and inhibiting sebum production caused by heat. According to the composition disclosed by the invention, sebum secretion of skin or scalp can be inhibited, and further, the composition has the beneficial effects of preventing or improving seborrheic dermatitis and head seborrheic dermatitis or shrinking pores and the like.

The invention belongs to the technical field of medicines, and discloses a hydroxime compound derived from an aqueous extract of heads of angelica sinensis, a dehydrated furazan compound of the hydroxime compound, and preparation and application of the hydroxime compound and the dehydrated furazan compound. In particular discloses a hydroxime compound, a dehydrated furazan compound thereof, pharmaceutically acceptable salts of the dehydrated furazan compound and a pharmaceutical composition of the dehydrated furazan compound. The invention also discloses application of the compound in preparation of medicines for treating arthritis, asthma, chronic obstructive pneumonia, pneumonia, cystic fibrosis, diabetes, obesity, hypercholesterolemia, contact dermatitis, psoriasis, atopic dermatitis, stasis dermatitis, seborrheic dermatitis, neurodermatitis and the like, inflammatory enteritis, multiple sclerosis, Parkinson's disease, cardiovascular disease, autoimmune disease, gout and the like. The invention also relates to applications in medicines or health-care products for treating hyperuricemia and cancers. Activity evaluation of a cell model for starting reporter gene expression by using an NF-kappa B reaction element proves that the compound can significantly inhibit NF-kappa B induced transcriptional regulation and is expected to become a therapeutic drug for treating the various diseases.

The present application belongs to the technical field of laser, and particularly relates to a multi-wavelength pulsed fiber laser for seborrheic dermatitis treatment, comprising: a data acquisition module for acquiring the skin horny layer thickness and sebum excretion rate of a patient and calculating the current impedance scattering ratio; a treatment planning module for triggering a wavelength reorganization instruction to recalculate the weight coefficient when the current impedance scattering ratio exceeds a first threshold; a wavelength optimization module for generating the weight coefficient containing the target wavelength through a multi-objective optimization algorithm; a pulse modulation module for calculating the pulse duration corresponding to each wavelength according to the weight coefficient; an energy control module for calculating the total output energy; a skin feedback module for generating a temperature gradient matrix; and a laser emission module for generating a driving current according to the total output energy and the temperature gradient matrix to emit the multi-wavelength pulsed fiber laser for seborrheic dermatitis treatment. The present application realizes the precise treatment of seborrheic dermatitis and significantly improves the treatment effect.

The invention discloses a medicinal moxa composition for preventing and treating seborrheic dermatitis and myasthenia. The medicinal moxa composition comprises notopterygium root, eucommia ulmoides, teasel root, semen plantaginis and moxa. Based on the theory of'the bladder dominates the exterior and the liver and kidney dominates the tendons', the medicinal moxa composition disclosed by the invention starts from the bladder meridian, and simultaneously improves the symptoms of seborrheic dermatitis and myasthenia through the effects of dispelling wind and eliminating dampness, nourishing the liver and the kidney, strengthening the muscles and bones, clearing heat and promoting diuresis and the like. The eucommia ulmoides can tonify liver and kidney and strengthen muscles and bones; radix dipsaci tonifies liver and kidney and strengthens muscles Semen plantaginis clears heat and promotes diuresis; the moxa has the effects of warming channels and expelling cold, promoting blood circulation to remove meridian obstruction, clearing damp and relieving itching, and killing parasites and stopping bleeding, and the five medicines are compatible to form a balanced system for dispelling wind and eliminating dampness, tonifying liver and kidney, strengthening muscles and bones, and clearing heat and promoting diuresis. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for remarkably improving the skin symptoms of patients with seborrheic dermatitis and enhancing the muscle strength of the patients with myasthenia at the same time.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention discloses an application of an agilawood leaf alcohol extract in preparation of a healthy product for inhibiting sebum secretion. The invention verifies that the agilawood leaf alcohol extract has the activity of reducing sebaceous gland and inhibiting sebum secretion, and particularly, the agilawood leaf alcohol extract can effectively reduce the content of free fatty acid in skin tissues of a sebum excessive secretion model mouse and can effectively recover sebaceous gland expansion caused by a modeling reagent of the sebum excessive secretion model. The invention shows that the phoebe davidii leaf alcohol extract and the effective components thereof possibly have wide application prospects in treatment of skin diseases related to excessive sebum secretion, such as seborrheic dermatitis, acne and psoriasis, and a new application direction and a product development idea are provided for resource utilization of non-edgeworthia chrysantha part of the phoebe davidii; and a foundation is laid for exploring new drugs and new action targets for treating related skin diseases.