44 results about "Seborrheic dermatitis" patented technology

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention relates to the technical field of antibacterial peptides, in particular to an antibacterial peptide for maintaining scalp flora health and a preparation method and application thereof. The antibacterial peptide for maintaining scalp flora health comprises a polypeptide of which the amino acid sequence comprises an amino acid sequence as shown in SEQ ID NO.1, and a polypeptide of which the amino acid sequence comprises an amino acid sequence as shown in SEQ ID NO.2; or a polypeptide of which the amino acid sequence is composed of amino acid residues as shown in SEQ ID NO.1; or a polypeptide having 99% or more, 95% or more, 90% or more, 85% or more or 80% or more homology with the defined amino acid sequence. The antibacterial peptide for maintaining scalp flora health is good in safety and can be used for treating scalp problems such as dandruff, seborrheic dermatitis, scalp itching and alopecia caused by scalp flora imbalance.

The invention relates to the technical field of daily chemical products, in particular to hair-growing and hair-developing Chinese herbal paste shampoo and a preparation method thereof.The hair-growing and hair-developing Chinese herbal paste shampoo is prepared from 8-15 parts of polygonum multiflorum extract, 6-12 parts of cacumen biotae extract, 5-10 parts of ginger extract, 0.5-2 parts of ginsenoside, 0.2-0.8 part of dipotassium glycyrrhizinate, 1-3 parts of sodium hyaluronate and the balance deionized water; the traditional Chinese medicine composition has multiple effects of hair follicle activation, melanin regeneration and seborrheic dermatitis prevention and treatment. The paste shampoo comprises a Chinese herbal medicine extract, a natural thickening agent and functional auxiliary materials, and through gradient extraction, a targeted drug loading technology and a pH response type slow release system, the transdermal efficiency and the acting time of active ingredients are remarkably improved. The preparation process is simple and controllable, and the product has the functions of preventing alopecia, growing hair, smoothing and brightening and repairing scalp barrier, is suitable for people with alopecia, dry hair, white hair and seborrheic dermatitis, and has the characteristics of high safety and low irritation.

To provide a sebum secretion-inhibiting composition containing, as an effective ingredient, 3, 4, 5-trimethoxycinnamate thymol ester, or a stereoisomer, pharmaceutically acceptable salt, hydrate or solvate thereof.SOLUTION: The disclosed compositions can inhibit sebum secretion of skin or scalp exerting useful effects such as prevention or amelioration of seborrheic dermatitis, seborrheic scalp inflammation, prevention or amelioration of acne, or pore-shrinking.SELECTED DRAWING: Figure 1

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to Chinese herbal medicine emulsifiable paste for dermatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: radix sophorae flavescentis, cortex phellodendri, cortex dictamni, fructus cnidii, fructus kochiae, radix scutellariae, radix paeoniae rubra, radix salviae miltiorrhizae, herba schizonepetae, radix saposhnikoviae Systematic design is carried out aiming at complex pathogenesis of seborrheic dermatitis, medicinal materials such as radix sophorae flavescentis and cortex phellodendri are used for synergistically clearing heat and drying dampness, malassezia is inhibited, and lipid control and bacteriostasis are carried out from the source; radix scutellariae, radix salviae miltiorrhizae and the like are combined to cool and activate blood and control inflammation for a long time; the herba schizonepetae, the radix saposhnikoviae and the like are added for targeted itching relieving and secondary injury reduction; in the dosage form, a low-oil-burden matrix composed of light grease such as jojoba oil and squalane is adopted, the texture is light and thin, hair follicles are not blocked, and phytosterol is introduced to synchronously repair the skin barrier; according to the system, the use comfort and compliance are remarkably improved while permeation of active ingredients is guaranteed.

The invention relates to a traditional Chinese medicine external preparation for treating scalp inflammation. The traditional Chinese medicine external preparation is prepared from honeysuckle, radix sophorae flavescentis, fructus kochiae, cortex dictamni, dandelion, radix salviae miltiorrhizae, menthol, borneol and a transdermal enhancer. The preparation plays anti-inflammatory, bacteriostatic and barrier repairing roles through a multi-target synergistic mechanism, and is suitable for scalp inflammatory diseases such as seborrheic dermatitis and contact dermatitis. The preparation maximally retains active ingredients by adopting a specific extraction process, and the transdermal efficiency is improved by combining a triple permeation enhancing technology. The active ingredients reach the treatment concentration in the deep hair follicle. The pH value (5.5-6.0) of the preparation is matched with the weak acid environment of scalp, malassezia is selectively inhibited without damaging effective microbial communities, and the recurrence risk is reduced from the source. A spray, a lotion and a gel are proved to be capable of remarkably relieving erythema pruritus, inhibiting pathogenic bacteria colonization and accelerating cuticle repair, and have no skin irritation.

The invention provides a traditional Chinese medicine composition for regulating scalp micro-ecology, an external preparation containing the traditional Chinese medicine composition and application of the external preparation, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition for regulating and controlling scalp micro-ecology is prepared from cacumen biotae, rhizoma cyperi, fructus cnidii, cortex dictamni, radix sanguisorbae, herba ecliptae and herba menthae. Based on the compatibility principle of monarch, minister, assistant and guide, the composition takes fructus cnidii for eliminating dampness and killing parasites as monarch, cortex dictamni and cacumen biotae for removing heat to cool blood as minister, garden burnet, eclipta and rhizoma cyperi for astringing, detoxifying, nourishing yin and regulating qi as assistant, and mint for guiding the medicine to move upwards and transdermal permeation as guide, so that multiple effects of inhibiting bacteria, resisting inflammation, repairing a barrier, regulating sebum secretion and the like are synergistically realized. Modern pharmacological studies show that the active ingredients can inhibit malassezia proliferation, regulate and control inflammatory pathways of NF-kB, TLR4 and the like, reduce expression of proinflammatory factors of IL-6, TNF-alpha and the like, and promote skin barrier repair. Clinical observation shows that the composition can significantly improve the scalp seborrheic dermatitis symptom.

The present disclosure is related to a topical formulation comprising clascoterone in a mixture of aqueous and oily gel phases. The present disclosure further relates to a method of treating or preventing skin conditions such acne vulgaris, acne conglobata, acne fulminans, androgenetic alopecia, hidradenitis suppurativa (also known as acne inversa), hirsutism, cancer-therapy-induced rash, eczema, rosacea, atopic dermatitis, psoriasis, inverse psoriasis, seborrheic dermatitis, acanthosis nigricans, wound, and female pattern hair loss, comprising topically administering to a subject in need thereof an effective amount of the formulation.

The present invention belongs to the technical field of cosmetics, and particularly relates to a scalp care composition with oil control and anti-dandruff effects and its application. The scalp care composition with oil control and anti-dandruff effects comprises the following components in percentage by mass: 1-5% of capryloyl glycine; 80-94% of green tea fermentation broth; and 5-15% of solubilizer. The scalp care composition prepared by the present invention has certain effects such as oil control and antioxidant. When used on hair, it can preferably reduce the secretion of scalp oil, thereby reducing seborrheic dermatitis and dandruff, and achieving the effects of oil control and anti-dandruff. At the same time, compared with traditional hair products, the scalp care composition of the present invention can effectively solve the problems that excessive use of surfactants will bring a tight feeling to the scalp, cause hair dryness, frizz and other problems.

The present invention relates to the technical field of microorganisms. Disclosed in the present invention are Lacticaseibacillus casei VB179 for inhibiting Malassezia, and a culture device and the use thereof. Specifically, disclosed in the present invention is Lacticaseibacillus casei VB179, wherein the Lacticaseibacillus casei VB179 is deposited in the China General Microbiological Culture Collection Center with a deposit number of CGMCC No. 28623 and a deposit date of 12 October 2023. The Lacticaseibacillus casei VB179 of the present invention can significantly inhibit the growth of Malassezia, and can further be used for treating skin diseases caused by the excessive reproduction of Malassezia, such as tinea versicolor, Malassezia folliculitis, seborrheic dermatitis and atopic dermatitis.

The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and / or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, Tinea versicolor, Pityriasis versicolor, Tinea circinata, Tinea pedis, Tinea unguium, Tinea manus, Tinea cruris, Tinea corporis, Tinea faciei, Tinea capitis, and / or Tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

The present discovery pertains generally to the field of therapeutic compounds. More specifically the present discovery pertains to certain di-isopropyl-phosphinoyl-alkanes as described herein, DIPA-1-7, DIPA-1-8, and DIPA-1-9, collectively referred to herein as “DIPA compounds”, that are useful, for example, in the treatment of the discomforts of dermatological disorders (e.g., diseases) The treatment is for the dysesthesia (e.g., caused by irritation, itch, or pain) due to dermatitis, urticaria; scalp itch; vulvar itch; lichen sclerosus; cholestatic itch; psoriasis; sebhorrheic dermatitis; allergic conjunctivitis; blepharitis; and pruritus of the elderly. The applicant has found that topical delivery of DIPA compounds to the skin alleviates the dysesthesia of these conditions in human subjects. The present discovery pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in the treatment of the dysesthesia of these dermatological disorders.

The invention relates to a composition for treating scytitis, and belongs to the technical field of medicines for treating scytitis. The present application provides a composition containing one or more of human milk oligosaccharides. Preferably, the composition contains the lactose-N-trisaccharide. The mass percentage content of the lactose-N-trisaccharide in the composition is 0.5 to 2 percent. The invention provides the HMO (s)-containing composition for treating the scytitis, and the composition has the advantages of safety and effectiveness, and can well improve the scytitis and relieve the pain of a patient. The composition has the advantages of being comfortable to use, high in bioavailability, good in stability, few in adverse reaction, free of pollution to clothes and the like. The skin inflammation comprises but is not limited to dermatitis, atopic dermatitis, contact dermatitis, allergic dermatitis, seborrheic dermatitis, infectious dermatitis, acne, burn or surgical incision and the like.

The invention discloses a natural plant hair dye, and relates to the technical field of cosmetics. The agent II comprises myrrh; the invention also discloses a preparation method of the plant hair dye, which comprises the following steps of: preparing the agent I, decocting the catechu and the deionized water according to the material-liquid ratio of 1: 6-1: 8 until the catechu and the deionized water are completely dissolved, adding the reducing agent, the alkaline agent and the penetrating agent when the catechu is cold, stirring and dissolving, regulating the pH value to 7-9 by using the alkaline agent, and adding the thickening agent, the essence and the balance of the deionized water; in the preparation of the agent II, the material-liquid ratio of myrrh to deionized water is 1: 6-1: 8. The hair dye disclosed by the invention has the effects of relieving and treating head dermatitis, including symptoms of hair dyeing contact dermatitis and seborrheic dermatitis. For the hair with head dermatitis and afraid of further aggravation of inflammation due to hair dyeing, the hair dye can be used for protecting scalp and treating inflammation during hair dyeing.

The invention provides application of breast milk oligosaccharide or fucose in inhibition of malassezia, and relates to the technical field of cosmetics. The invention provides an effective pharmaceutical ingredient for treating malassezia disease, tinea versicolor, pityrosporum reef, seborrheic dermatitis, atopic dermatitis or psoriasis and other diseases related to malassezia, and also provides a new effective ingredient for washing care products for preventing and / or reducing dandruff.

This disclosure relates to an embodiment of the use of tocotrienols in pharmaceutical, veterinary, or cosmetic applications, particularly in cosmetic formulations, whereby stabilizing tocotrienols does not impair their function in the skin. Specifically, this disclosure relates to the modification, molecular stabilization, and penetration properties of tocotrienols in human skin using nicotinic acid. The compounds and compositions of this subject matter are useful in the medical, veterinary, or cosmetic industries as a preventative, therapeutic, or treatment of dermatological diseases or skin disorders, as a treatment or treatment of acne or seborrheic dermatitis, or as anti-aging agents.

This disclosure provides fast acting itch relief and cooling sprays containing hydrocortisone, a cooling agent, such as sensate molecule (e.g. menthyl lactate), and a soothing agent (such as e.g., Aloe vera). The sprays of the disclosure can be used to relieve itching associated with minor skin irritations, inflammation, and rashes due to eczema, psoriasis, poison ivy, oak, sumac, insect bites, detergents, jewelry, cosmetics, soaps, seborrheic dermatitis. The disclosure also provides for methods of treating skin with cooling sprays as well as containers containing the spray.

This application provides the use of an antimicrobial peptide in the preparation of skin care products. The antimicrobial peptide of this application can effectively inhibit *Propionibacterium acnes* and *Malassezia*, thereby preventing skin problems such as acne, skin inflammation, and dandruff caused by the overgrowth of these two bacteria. Therefore, the antimicrobial peptide of this application has skin care uses in inhibiting acne, relieving skin inflammation such as folliculitis, pityriasis versicolor, and seborrheic dermatitis, and in inhibiting dandruff, and has significant practical value.

The invention discloses superoxide dismutase for controlling skin grease secretion abnormity and application thereof, belongs to the field of biological medicines, and relates to application of superoxide dismutase in medicines or medical instruments for treating diseases such as seborrheic dermatitis, seborrheic alopecia and the like by controlling skin grease secretion. The invention also discloses application of the composition in cosmetics with an oil control effect. At present, most medicines for treating abnormal skin grease secretion are human hormone disruptors, are poor in safety and strong in side effect and cannot be used for a long time; oil control components in cosmetics are generally multi-component mixtures, and the safety and the batch stability of the oil control components need to be optimized. The invention provides a biomedical material which is high in safety, good in stability and single in composition, and can be used for developing medicines, medical instruments or cosmetics for controlling abnormal skin grease secretion. The invention provides therapeutic activity of superoxide dismutase in skin oil control and application of the superoxide dismutase.

The present invention concerns a method for qualitative and quantitative detection of monounsaturated fatty acids (MUFAs) in a human or animal lipid biological sample, preferably in a sebum sample. In particular, the method of the present invention can be advantageously used for the qualitative and quantitative detection of MUFAs in a human lipid biological sample, such as, human sebum, for the diagnosis of excessive secretion of MUFAs occurring in Parkinson's disease (PD), acne or seborrheic dermatitis.

The present application relates to the technical field of antibacterial peptides, and particularly relates to an antibacterial peptide for maintaining scalp microbial flora health, a preparation method and application thereof.The antibacterial peptide for maintaining scalp microbial flora health comprises the following: a polypeptide with an amino acid sequence comprising SEQ ID NO.1 or SEQ ID NO.2; or a polypeptide with an amino acid sequence consisting of the amino acid residues shown in SEQ ID NO.1 or SEQ ID NO.2; or a polypeptide with 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology with the amino acid sequence defined above.The antibacterial peptide for maintaining scalp microbial flora health has good safety and can be used for treating scalp problems such as dandruff, seborrheic dermatitis, scalp itching and hair loss caused by scalp microbial flora imbalance.

The present disclosure relates to the field of personal care and more particularly to a method for preventing or treating inflammatory skin conditions including atopic dermatitis and seborrheic dermatitis which comprises applying to the skin a composition comprising an active agent selected among sclareol, sclareol-like, sclareolide or sclareolide-like and a physiologically acceptable carrier.Another object of the present invention is a method for improving the aspect of inflammatory prone skin, which comprises applying to the skin a composition comprising an active agent selected among sclareol, sclareol-like, sclareolide or sclareolide-like and a physiologically acceptable carrier.

The present application relates to the technical field of antibacterial peptides, in particular to an antibacterial peptide for inhibiting Malassezia, a preparation method and application thereof. The antibacterial peptide for inhibiting Malassezia comprises any one of the following (a)-(d) polypeptides: (a) a polypeptide comprising an amino acid sequence shown in SEQ ID NO. 1, or a polypeptide consisting of amino acid residues shown in SEQ ID NO. 1; (b) a polypeptide formed by substitution, deletion and / or addition of one or more amino acid residues in the amino acid sequence defined in (a); (c) a polypeptide obtained by modifying the N-terminal and / or C-terminal of the polypeptide defined in (a); and (d) a polypeptide having 99% or more, 95% or more, 90% or more, 85% or more, or 80% or more homology with the amino acid sequence defined in (a). The antibacterial peptide for inhibiting Malassezia has good safety to the skin, and can be used for treating dandruff, seborrheic dermatitis, tinea versicolor and Malassezia folliculitis caused by Malassezia fungal infection, and can be applied to cosmetics or external-use drugs for treating dandruff, seborrheic dermatitis, tinea versicolor and Malassezia folliculitis. The antibacterial peptide has significant antibacterial effect on Malassezia restricta and Malassezia furfur, and has great application value.

The invention discloses emulsifiable paste for treating eczema and dermatitis (seborrheic dermatitis) and a preparation method thereof, and belongs to the technical field of eczema and dermatitis (seborrheic dermatitis) medicines, the emulsifiable paste is prepared from the following raw materials in parts by weight: 6-10 parts of rhinacanthus nasutus, 6-10 parts of jatropha curcas, 6-10 parts of catechu, 6-10 parts of breynia fruticosa, 15-20 parts of coal tar, 40-80 parts of water, 40-50 parts of an emulsifier and 0.05-0.1 part of a preservative. The preparation method comprises the following steps: decocting the rhinacanthus nasutus, the jatropha curcas, the catechu and the breynia fruticosa with water, and then fishing out the medicinal materials to obtain medicine slurry; and mixing the medicine slurry, coal tar, an emulsifier and a preservative, adding into an emulsifying machine, and emulsifying to obtain the product. The external emulsifiable paste for eczema and dermatitis (seborrheic dermatitis) has the effects of astringing ulcers, astringing wounds and stopping bleeding, resisting viruses, dissipating blood stasis and diminishing swelling, relieving pain and itching, controlling pathogenic organisms on skin, promoting skin repair, inhibiting reproduction of viruses and fungi and the like.

The present invention is directed to a method of treating a fungal infection comprising administering topically, to a subject in need thereof, an anti-fungal effective amount of roflumilast. Preferably, topically administered roflumilast is used to treat fungal infections, fungal growth of and / or hypersensitivity to the fungi Malassezia spp. Patients may also be suffering from seborrheic dermatitis, dandruff, dupilumab facial redness, tinea versicolor, pityriasis versicolor, tinea circinata, tinea pedis, tinea unguium, tinea manus, tinea cruris, tinea corporis, tinea faciei, tinea capitis, and / or tinea incognito. Topically administered roflumilast is a quick and effective antifungal agent and presents a viable alternative to current antifungal treatments.

The invention belongs to the technical field of biological medicines, and particularly discloses a polypeptide with malassezia resisting activity and application of the polypeptide in improvement of seborrheic dermatitis. The polypeptide provided by the invention comprises an amino acid sequence as shown in SEQ ID NO: 1. The polypeptide has a remarkable inhibiting effect on the key pathogenic bacterium-malassezia causing seborrheic dermatitis, experimental data shows that the polypeptide can remarkably inhibit the growth and constant value of the malassezia at a low concentration, and the effect of the polypeptide can be close to that of a positive control ketoconazole. The polypeptide shows an excellent dermatophyte removing effect in a malassezia induced mouse seborrheic dermatitis model, experimental data proves that the fungal load of the skin tissue of the affected part of a mouse is remarkably reduced after administration, and the polypeptide still can keep high biological activity and stability in a complex skin physiological microenvironment, and has a good application prospect. The malassezia can effectively penetrate through a sebum layer to act on thalli, so that the decomposition effect of the malassezia on sebum is effectively restrained.

The present specification relates to a composition for inhibiting sebum secretion, which comprises, as an active ingredient, thymol 3, 4, 5-trimethoxycinnamate (3, 4, 5-Trimethoxyl cinnamate Thymol Ester), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The composition according to the present disclosure can inhibit sebum secretion of skin or scalp, and further has useful effects of preventing or ameliorating seborrheic dermatitis, seborrheic head dermatitis, acne, minimizing pores, and the like.

A composition for inhibiting sebum secretion is disclosed. The composition contains 3,4,5-trimethoxycinnamate thymol ester, a stereoisomer, pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient. The composition can inhibit sebum secretion in the skin or scalp, and further has useful effects such as the prevention or improvement of seborrheic dermatitis, seborrheic scalp dermatitis, or acne, or the tightening of pores. Methods for inhibiting sebum secretion employing 3,4,5-trimethoxycinnamate thymol ester, a stereoisomer, pharmaceutically acceptable salt, hydrate, or solvate are disclosed.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating seborrheic dermatitis and alopecia and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: Sophora flavescens 9-11 parts, Phellodendron chinense 9-11 parts, Paris polyphylla 4-6 parts, Lotus leaf 9-11 parts, Fructus Kochiae 14-16 parts, Dictamnus dasycarpus 14-16 parts, Mentha haplocalyx 9-11 parts, and Salvia miltiorrhiza 19-21 parts. The traditional Chinese medicine composition has a good therapeutic effect on treating seborrheic dermatitis and alopecia, can improve the pathological state of skin, improve hair growth, and has a good application prospect.