Short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis

Abstract

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

Description

Technical Field

[0001] This invention relates to the field of topical preparations and scalp care technology, specifically a short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp. Background Technology

[0002] Seborrheic dermatitis is a common, chronic, relapsing inflammatory skin disease that frequently occurs in areas rich in sebaceous glands, such as the scalp and face. Its clinical manifestations mainly include erythema, oily scaling, and itching, and may be accompanied by folliculitis, papules, or pustules. The pathogenesis of this disease is related to multiple factors, including excessive sebum secretion, Malassezia colonization, impaired skin barrier function, and individual immune responses. Recurrent flare-ups and scratching can further damage hair follicles, becoming an important factor in inducing or aggravating hair loss.

[0003] Currently, there are three main types of topical shampoos for this type of scalp problem: (1) Traditional Chinese medicine shampoos mainly composed of water extracts or crude extracts of Chinese medicinal herbs such as Sophora flavescens and Phellodendron chinense. However, the content of active ingredients is unstable and the batch consistency is poor, which affects the stability of the therapeutic effect; (2) Antifungal shampoos mainly composed of single chemical components such as ketoconazole and piroctone olamine. Although they are effective in inhibiting Malassezia, they have limited comprehensive improvement effects on complex inflammation, excessive sebum secretion and hair loss; (3) Conventional liquid shampoos have a short stay time on the scalp, and the active ingredients are rinsed off before they can fully exert their effects, resulting in low utilization.

[0004] To address the aforementioned issues, a compound topical formulation was designed that achieves synergistic effects across multiple targets (anti-inflammatory, antibacterial, and oil-controlling) and possesses excellent scalp retention properties, thereby resolving the technical problems mentioned above. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp, thus solving the technical problems mentioned in the background section.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp, comprising the following components by weight percentage: active ingredient combination: halcinonide 0.01–0.05 wt%; piroctone olamine 0.5–1.0 wt%; total alkaloids of Sophora flavescens 0.1–0.3 wt%; berberine 0.05–0.1 wt%; baicalin 0.03–0.1 wt%; osthol 0.02–0.05 wt%; total phenolic acids of Tanshinone 0.01–0.05 wt%; indirubin 0.005–0.02 wt%; monoammonium glycyrrhizate 0.02– 0.1 wt%; Total flavonoids from Smilax glabra 0.01–0.05 wt%; Surfactant matrix: a compound system of amphoteric surfactants, glycoside surfactants and sodium olefin sulfonate, totaling 12.0–20.0 wt%; Rheology modifier: cross-linked acrylic polymer 0.2–0.4 wt%, neutralized to pH 4.8–5.8 by alkali; Pearlizing thickener: ethylene glycol distearate 0.5–1.0 wt%; Humectant: propylene glycol and glycerin, totaling 5.0–8.0 wt%; Preservative system: phenoxyethanol 0.6–1.0 wt% and ethylhexylglycerin 0.3–0.5 wt%; Balance: purified water.

[0007] Preferably, the surfactant matrix is ​​composed of the following components: cocamidopropyl betaine 5.0–8.0 wt%; decyl glucoside or lauryl glucoside 2.0–4.0 wt%; sodium olefin sulfonate (AOS) 4.0–6.0 wt%.

[0008] Preferably, the acrylic crosslinking polymer in the rheology control system is Acrylates / C10-30AlkylAcrylateCrosspolymer.

[0009] Preferably, the rinsing agent further comprises a chelating agent EDTA-2Na 0.05–0.15 wt%.

[0010] Preferably, the rinsing agent is a semi-solid colloid with a pearlescent appearance and a viscosity of 2500–6500 mPa·s at 25°C.

[0011] Preferably, the method includes the following steps: a) dissolving the surfactant matrix in a portion of purified water at 45–50°C and stirring until homogeneous to form a surfactant phase; b) cooling the system to below 35°C, adding a humectant, chelating agent, and preservative system, and mixing until homogeneous; c) dispersing an acrylic crosslinking polymer in a small amount of water, slowly adding it to the system obtained in step b), and neutralizing it with alkali to bring the pH of the system to 4.8–5.8 and initially increase the viscosity; d) sequentially adding all the active ingredients combination described in claim 1, and shearing and stirring at 800–1200 rpm for 7–10 minutes to ensure thorough and uniform dispersion; e) adding the pearlescent thickener ethylene glycol distearate, and homogenizing at low speed until a uniform and stable pearlescent appearance and final consistency are formed; f) degassing and sieving the obtained product, and filling it into a light-proof container.

[0012] Preferably, the alkali used in step c) is a sodium hydroxide solution, and the sieve used for sieving in step f) is 80–100 mesh.

[0013] A non-pharmaceutical shampoo for daily care, improving scalp oil secretion, relieving itching, and assisting in preventing hair loss, comprises the following ingredients by weight percentage: Active ingredient combination: piroctone olamine 0.5–1.0 wt%; salicylic acid 0.2–1.0 wt%; ZincPCA 0.1–0.5 wt%; nicotinamide 1.0–3.0 wt%; caffeine 0.1–0.5 wt%; total alkaloids of Sophora flavescens 0.1–0.3 wt%; berberine 0.05– 0.1 wt%; baicalin 0.03–0.1 wt%; osthol 0.02–0.05 wt%; total phenolic acids of tanshinone 0.01–0.05 wt%; indirubin 0.005–0.02 wt%; monoammonium glycyrrhizate 0.02–0.1 wt%; total flavonoids of Smilax glabra 0.01–0.05 wt%; surfactant matrix, rheology regulation system, pearlescent thickener, humectant, preservative system, and balance as defined in any one of claims 1 to 5.

[0014] Preferably, the active ingredient combination contains 0.4–0.6 wt% salicylic acid, 0.2–0.4 wt% ZincPCA, and 1.5–2.5 wt% nicotinamide.

[0015] Beneficial effects This invention provides a short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp. By combining standardized extracts of effective components from traditional Chinese medicine with modern active ingredients, this invention addresses the issue of significant batch-to-batch quality variations in traditional Chinese medicine shampoos. The combination of multiple active ingredients aims to synergistically target multiple areas, including anti-inflammatory, antibacterial, and oil-controlling effects, to comprehensively improve scalp condition. Furthermore, the specific semi-solid colloidal formulation enhances the product's retention on the scalp, ensuring effective cleansing while improving the post-use refreshing feeling. This shampoo is available in both hormone-containing and hormone-free versions, providing options for different severity levels and stages of use. Attached Figure Description

[0016] Figure 1 This is a flowchart illustrating the structure of a short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp, as described in this invention. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Please see Figure 1 This invention provides a technical solution: a short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp, comprising the following ingredients by weight percentage: active ingredient combination: halcinonide 0.01–0.05 wt%; piroctone olamine 0.5–1.0 wt%; total alkaloids of Sophora flavescens 0.1–0.3 wt%; berberine 0.05–0.1 wt%; baicalin 0.03–0.1 wt%; osthol 0.02–0.05 wt%; total phenolic acids of Tanshinone 0.01–0.05 wt%; indirubin 0.005–0.02 wt%; monoammonium glycyrrhizate 0.02–0.1 wt%. Total flavonoids from Smilax glabra 0.01–0.05 wt%; Surfactant matrix: a compound system of amphoteric surfactants, glycoside surfactants and sodium olefin sulfonate, totaling 12.0–20.0 wt%; Rheology modifier: cross-linked acrylic polymer 0.2–0.4 wt%, neutralized to pH 4.8–5.8 by alkali; Pearl thickener: ethylene glycol distearate 0.5–1.0 wt%; Humectant: propylene glycol and glycerin, totaling 5.0–8.0 wt%; Preservative system: phenoxyethanol 0.6–1.0 wt% and ethylhexylglycerin 0.3–0.5 wt%; Balance: purified water.

[0019] In this embodiment, the surfactant matrix is ​​further configured to consist of the following components: cocamidopropyl betaine 5.0–8.0 wt%; decyl glucoside or lauryl glucoside 2.0–4.0 wt%; sodium olefin sulfonate (AOS) 4.0–6.0 wt%.

[0020] In this embodiment, the acrylic crosslinking polymer in the rheology control system is Acrylates / C10-30AlkylAcrylateCrosspolymer.

[0021] In this embodiment, the rinsing agent is further configured to contain 0.05–0.15 wt% chelating agent EDTA-2Na.

[0022] In this embodiment, the rinsing agent is further configured as a semi-solid colloid with a pearlescent appearance and a viscosity of 2500–6500 mPa·s at 25°C.

[0023] This embodiment is further configured to include the following steps: a) at 45–50°C, dissolve the surfactant matrix in a portion of purified water and stir until homogeneous to form a surfactant phase; b) cool the system to below 35°C, add a humectant, chelating agent, and preservative system, and mix until homogeneous; c) disperse the acrylic crosslinked polymer in a small amount of water, slowly add it to the system obtained in step b), and neutralize it with alkali to bring the pH of the system to 4.8–5.8, and initially increase the viscosity; d) add all the active ingredients combination described in claim 1 in sequence, and shear and stir at 800–1200 rpm for 7–10 minutes to ensure that it is fully dispersed and homogeneous; e) add the pearlescent thickener ethylene glycol distearate, and homogenize at low speed until a uniform and stable pearlescent appearance and final consistency are formed; f) degas and sieve the obtained product, and fill it into a light-proof container.

[0024] In this embodiment, the alkali used in step c) is a sodium hydroxide solution, and the sieve used for sieving in step f) is 80–100 mesh.

[0025] A non-pharmaceutical shampoo for daily care, improving scalp oil secretion, relieving itching, and assisting in preventing hair loss, comprises the following ingredients by weight percentage: Active ingredient combination: piroctone olamine 0.5–1.0 wt%; salicylic acid 0.2–1.0 wt%; ZincPCA 0.1–0.5 wt%; nicotinamide 1.0–3.0 wt%; caffeine 0.1–0.5 wt%; total alkaloids of Sophora flavescens 0.1–0.3 wt%; berberine 0.05– 0.1 wt%; baicalin 0.03–0.1 wt%; osthol 0.02–0.05 wt%; total phenolic acids of tanshinone 0.01–0.05 wt%; indirubin 0.005–0.02 wt%; monoammonium glycyrrhizate 0.02–0.1 wt%; total flavonoids of Smilax glabra 0.01–0.05 wt%; surfactant matrix, rheology regulation system, pearlescent thickener, humectant, preservative system, and balance as defined in any one of claims 1 to 5.

[0026] In this embodiment, the active ingredient combination is further configured to contain 0.4–0.6 wt% salicylic acid, 0.2–0.4 wt% ZincPCA, and 1.5–2.5 wt% nicotinamide.

[0027] Its detailed connection method is a well-known technology in this field. The following mainly introduces the working principle and process, and the specific work is as follows.

[0028] Example: Preparation of a pharmaceutical-grade compound lotion 1. Formulation (weight percentage, w / w%) Active ingredients: Halcimonide: 0.025% Piroctone olamine: 0.80% Total alkaloids in Sophora flavescens (calculated as matrine): 0.15% Berberine: 0.05% Baicalin: 0.08% Osthole: 0.03% Total Salvianolic acids in Tanshinone: 0.02% Indirubin: 0.01% Monoammonium glycyrrhizinate: 0.08% Total flavonoids from Smilax glabra: 0.02% Matrix components: Cocamidopropyl Betaine: 6.00% Decyl Glucoside: 3.00% Sodium Alpha-Olefin Sulfonate: 5.00% Acrylates / C10-30 Alkyl Acrylate Crosspolymer:0.30% Glycol distearate: 0.80% Propylene Glycol: 4.00% Glycerin: 3.00% Phenoxyethanol: 0.80% Ethylhexylglycerin: 0.40% EDTA disodium: 0.10% Citric acid / Sodium hydroxide: as needed (for pH adjustment) Purified water: Add to 100 The preparation method describes the preparation of the detergent by the following steps: (1) Weigh approximately 60% of the formulated amount of purified water into the main preparation pot and heat it to 48±2℃. While stirring, add sodium olefin sulfonate, cocamidopropyl betaine and decyl glucoside in sequence, and maintain the temperature while stirring for about 15 minutes until all surfactants are completely dissolved, resulting in a clear or slightly turbid solution. (2) Cool the system obtained in step (1) to below 35℃. Add propylene glycol, glycerol, disodium EDTA, phenoxyethanol and ethylhexylglycerol, and stir until evenly mixed. (3) In another container, slowly sprinkle the acrylic crosspolymer (Acrylates / C10-30 AlkylAcrylate Crosspolymer) into approximately 10 times its weight of room temperature purified water and let it stand to allow it to swell fully. Then add the pre-dispersion to the main pot while stirring slowly. (4) At a moderate shear rate, slowly add 10% sodium hydroxide solution to adjust the pH of the system to 5.5±0.3. At this point, the viscosity of the system increases significantly, forming a uniform matrix. (5) Maintain the system temperature below 35℃, and add the total alkaloids of Sophora flavescens, berberine, baicalin, osthol, total phenolic acids of Tanshinone, indirubin, monoammonium glycyrrhizate, and total flavonoids of Smilax glabra in sequence. Stir after each addition to ensure uniform dispersion. Then add piroctone ketone ethanolamine and halcinonide, increase the stirring speed to about 1000 rpm, and continue shearing and stirring for 8 minutes to ensure uniform dispersion of all active ingredients. (6) Add ethylene glycol distearate and use low-speed homogenization stirring until the system exhibits a uniform pearlescent appearance. (7) After vacuum degassing, filter the obtained product through a 100-mesh nylon sieve, and finally fill the light-proof pressure pump bottle with the product.

[0029] 3. Product Properties: The obtained detergent is a white to off-white, pearlescent semi-solid colloid. Its pH value is 5.5, and its viscosity, measured using a Brookfield DV2T viscometer (RV spindle #6, 10 rpm, 25℃), is 4500 mPa·s. After 3 months of accelerated stability testing at 40℃ and 75% relative humidity, the content of its main active ingredient (determined by HPLC) remained above 95% of the initial content, indicating good formulation stability.

[0030] Example 2: Preparation of a non-pharmaceutical version of the compound lotion 1. Formulation (by weight, w / w %) Active ingredients: Piroctone olamine: 0.75% Salicylic acid: 0.50% ZincPCA: 0.30% Niacinamide: 2.00% Caffeine: 0.30% Total alkaloids in Sophora flavescens: 0.15% Berberine: 0.05% Baicalin: 0.05% Osthol: 0.03% Total phenolic acids in tanshinone: 0.05% Indigo red: 0.01% Glycyrrhizic acid monoammonium salt: 0.05% Total flavonoids from Smilax glabra: 0.02% Matrix components: Cocamidopropyl betaine: 7.00% Lauryl Glucoside: 3.00% Sodium olefin sulfonate: 4.00% Acrylates / C10-30 Alkyl Acrylate Crosspolymer:0.25% Ethylene glycol distearate: 0.70% Propylene glycol: 4.00% Glycerin: 3.00% Phenoxyethanol: 0.80% Ethylhexylglycerin: 0.40% Menthol: 0.03% Disodium EDTA: 0.10% Citric acid / sodium hydroxide: Appropriate amount (for pH adjustment) Purified water: Add to 100% Preparation method: The preparation method of the lotion is carried out according to the steps of Example 1. Salicylic acid is first partially neutralized with a small amount of sodium hydroxide solution before being added. All active ingredients are added and dispersed sequentially at a temperature below 35°C. Menthol is pre-dissolved in a small amount of propylene glycol and added in the final stage of step (5). The viscosity of the system is finally fine-tuned using sodium chloride (0.5%).

[0031] It should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

Claims

1. A short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp, characterized in that, It consists of the following components by weight percentage: Active ingredient combination: Halcinonide 0.01–0.05 wt%; Piroctone olamine 0.5–1.0 wt%; Total alkaloids of Sophora flavescens 0.1–0.3 wt%; Berberine 0.05–0.1 wt%; Baicalin 0.03–0.1 wt%; Osthol 0.02–0.05 wt%; Total phenolic acids of Tanshinone 0.01–0.05 wt%; Indirubin 0.005–0.02 wt%; Monoammonium glycyrrhizate 0.02–0.1 wt%; Total flavonoids of Smilax glabra 0.01–0.05 wt%; Surfactant matrix: A compound system consisting of 12.0–20.0 wt% amphoteric surfactants, glycoside surfactants and sodium olefin sulfonate; Rheology control system: 0.2–0.4 wt% acrylic crosslinked polymer, neutralized with alkali to a system pH of 4.8–5.8; Pearl thickener: 0.5–1.0 wt% ethylene glycol distearate; Moisturizers: propylene glycol and glycerin, total amount 5.0–8.0 wt%; Preservative system: phenoxyethanol 0.6–1.0 wt% and ethylhexylglycerin 0.3–0.5 wt%; The remainder is purified water.

2. The short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp according to claim 1, characterized in that, The surfactant matrix is ​​composed of the following components: Cocamidopropyl betaine 5.0–8.0 wt%; Decyl glucoside or lauryl glucoside 2.0–4.0 wt%; Sodium olefin sulfonate (AOS) 4.0–6.0 wt.

3. A short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp according to claim 1, characterized in that, The acrylic crosslinking polymer in the rheology control system is Acrylates / C10-30AlkylAcrylateCrosspolymer.

4. A short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp according to claim 1, characterized in that, The rinsing agent also contains 0.05–0.15 wt% chelating agent EDTA-2Na.

5. A short-contact rinse for treating seborrheic dermatitis and bacterial folliculitis of the scalp according to claim 1, characterized in that, The rinsing agent is a semi-solid colloid with a pearlescent appearance and a viscosity of 2500–6500 mPa·s at 25°C.

6. A method for preparing the short-contact flushing agent according to any one of claims 1 to 5, characterized in that, Includes the following steps: a) At 45–50°C, the surfactant matrix is ​​dissolved in a portion of purified water and stirred until homogeneous to form the surfactant phase; b) Cool the system to below 35°C, add the humectant, chelating agent and preservative system, and mix thoroughly. c) Disperse the acrylic crosslinking polymer in a small amount of water, slowly add it to the system obtained in step b), and neutralize it with alkali to bring the pH of the system to 4.8–5.8, and the viscosity initially increases; d) Add all the active ingredients as described in claim 1 in sequence, and shear and stir at 800–1200 rpm for 7–10 minutes to ensure that they are fully dispersed and uniform; e) Add the pearlescent thickener ethylene glycol distearate and homogenize at low speed until a uniform and stable pearlescent appearance and final consistency are formed; f) Degas and sieve the obtained product, and fill it into a light-proof container.

7. The preparation method according to claim 6, characterized in that, The alkali used in step c) is a sodium hydroxide solution, and the sieve used in step f) is 80–100 mesh.

8. A non-pharmaceutical shampoo for daily care, improving scalp oil secretion, relieving itching, and assisting in preventing hair loss, characterized in that... It consists of the following components by weight percentage: Combination of active ingredients: Piroctone olamine 0.5–1.0 wt%; Salicylic acid 0.2–1.0 wt%; ZincPCA 0.1–0.5 wt%; Nicotinamide 1.0–3.0 wt%; Caffeine 0.1–0.5 wt%; Total alkaloids of Sophora flavescens 0.1–0.3 wt%; Berberine 0.05–0.1 wt%; Baicalin 0.03–0.1 wt%; Osthol 0.02–0.05 wt%; Total phenolic acids of Tanshinone 0.01–0.05 wt%; Indirubin 0.005–0.02 wt%; Monoammonium glycyrrhizate 0.02–0.1 wt%; Total flavonoids of Smilax glabra 0.01–0.05 wt%; The surfactant matrix, rheology modifier, pearlescent thickener, humectant, preservative system, and balance are as defined in any one of claims 1 to 5.

9. The non-pharmaceutical version of the lotion according to claim 8, characterized in that, The active ingredient combination contains 0.4–0.6 wt% salicylic acid, 0.2–0.4 wt% ZincPCA, and 1.5–2.5 wt% nicotinamide.

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