39 results about "Pimple" patented technology

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with an acne removing effect, a preparation method of the sialic acid composition and cosmetics. The composition is prepared from 8%-20% of sialic acid, 10%-25% of ectoine, 5%-15% of a humectant, 0.1%-1% of a thickening agent, 0.05%-0.5% of a pH regulator and the balance of water. Cubilose acid can promote collagen synthesis, repair damaged skin barrier and reduce inflammatory response caused by external stimulation, and acne generation is inhibited from acne inducement; meanwhile, the sialic acid can inhibit release of proinflammatory factors such as TNF-alpha and IL-6 by adjusting a TLR receptor signal channel, red and swollen pox is relieved, and the generated pox is inhibited from the aspect of inhibiting inflammation; the sialic acid is non-irritant, and can slightly promote cutin renewal under high concentration, so that the problems of skin desquamation, sensitivity and the like caused by barrier injury can be effectively avoided. Ectoin is compounded, so that the Ectoin and sialic acid can generate a synergistic interaction effect.

Compositions and methods for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on skin. A preferred benzimidazole compound comprises mebendazole. A treatment composition preferably comprises 0.05-0.075 weight percent mebendazole, and may comprise up to 20.0% mebendazole, in an aqueous carrier or vehicle comprising a cream, gel, lotion, liquid, emulsion, aerosol spray, non-aerosol spray,, suspension, or ointment and is applied at least once daily over a treatment period of at least two weeks to result in a reduction of cutaneous cytotoxic CD+8 T-cells, papules, pustules, swelling, appearance of redness or inflammation, and / or reduction in itchiness, and hot or burning sensation in the affected area compared to pre-treatment levels.

The invention belongs to the technical field of pharmacy, and mainly relates to a traditional Chinese medicine composition ointment for treating bacterial fungal infection and dermatitis and a preparation method thereof. The traditional Chinese medicinal materials such as the sophora flavescens, the blackberry lily, the cortex dictamni, the gallnut, the fructus cnidii, the aloe, the cortex pseudolaricis, the fructus kochiae, the cortex phellodendri, the typhonium giganteum, the radix stemonae, the hedyotis diffusa, the spina gleditsiae and the rhizoma smilacis glabrae which are subjected to biological fermentation can inhibit the growth of fungi and also can relieve itching and relieve swelling; the traditional Chinese medicine has small side effects; ti / ZIF-8 is also added, so that the antibacterial effect is more obvious; the traditional Chinese medicine composition can be used for treating acute and chronic dermatitis, eczema, dermatophytosis, tinea manuum, foot sweat, fungal infection, skin itch, papule, plaque papule, erythroderma and intractable skin stubborn dermatitis caused by various bacteria and fungi, red swelling and itching caused by mosquito bite, and inhibiting candida albicans, staphylococcus aureus and the like. In general, the method has a very wide application prospect in the field.

The invention relates to the technical field of treatment of eczema-like skin symptoms, in particular to an essential oil composition for treating eczema-like skin symptoms and application thereof, and the essential oil composition comprises the following components in parts by weight: 10-20 parts of lavender essential oil, 5-10 parts of tea tree essential oil, 30-40 parts of olive oil, 5-10 parts of squalane, 0.5-1 part of vitamin E and 1-5 parts of plant extract. The lavender essential oil and the tea tree essential oil are compounded, and the olive oil, the squalane, the vitamin E and the plant extract are supplemented, so that symptoms such as skin erythema, papule and pruritus caused by eczema can be effectively relieved, and good anti-inflammatory, antibacterial, moisturizing and repairing effects are achieved. The composition has the advantages of simple components, simplified preparation process, low production cost and wide application range, and can better meet clinical requirements.

Compositions and methods for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on skin. A preferred benzimidazole compound comprises mebendazole. A treatment composition preferably comprises 0.05-0.075 weight percent mebendazole, and may comprise up to 20.0% mebendazole, in an aqueous carrier or vehicle comprising a cream, gel, lotion, liquid, emulsion, aerosol spray, non-aerosol spray,, suspension, or ointment and is applied at least once daily over a treatment period of at least two weeks to result in a reduction of cutaneous cytotoxic CD+8 T-cells, papules, pustules, swelling, appearance of redness or inflammation, and / or reduction in itchiness, and hot or burning sensation in the affected area compared to pre-treatment levels.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

1. The name of this design product: acne needle. 2. Purpose of this product: used for picking blackheads and clearing pimples. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

1. Name of the product in this design: Multifunctional Acne Clip (Cell). 2. Purpose of this design: For use as a beauty tool to remove blackheads, pimples, and acne. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides oil-control skin-care colloidal sulfur powder cream and a preparation method thereof. The oil-control skin-care colloidal sulfur powder cream comprises the following components in percentage by mass: 5-10% of sulfur, 15-25% of kaolin, 10-20% of silicon dioxide, 3-8% of acacia gum, 10-25% of a wetting agent, 2-7% of an active component, 1-4% of an auxiliary agent and the balance of a solvent. According to the invention, colloidal sulfur with relatively small particle size is used, so that effective delivery is provided, visibility and odor of components are reduced to the greatest extent, and acne and comedo are prevented by a milder method, so that the composition becomes an ideal choice for people with sensitive skin. Besides, silicon dioxide, kaolin, colloidal sulfur and other components are compounded, specific powder-to-cream treatment is carried out, the powder-to-emulsion texture is unique, use is easier, when pressure is applied in the smearing process, the powder is subjected to phase change, light emulsion is formed, and therefore the powder acts on the skin, and the requirements of the market and consumers are met.

The invention relates to application of cembratrienediol in preparation of a medicine for preventing and treating rosacea, and belongs to the technical field of biological medicine. The invention provides an application of cembratrienediol in preparation of a medicine for preventing / or treating rosacea. The cembratrienediol can obviously improve erythema and inflammation of an injection area of a rosacea mouse model for a long time and a short time; the skin tissue pathological inflammation of the rosacea mouse model can be obviously relieved (including the thickening of the skin epidermis of the rosacea mouse model, the inflammatory cell infiltration of the skin tissue of the rosacea mouse model and the capillary hyperplasia of the skin tissue of the rosacea mouse model); skin inflammation of a rosacea patient can be remarkably relieved (including relieving pain of the skin of the rosacea patient and relieving the red and swollen degree of the skin of the rosacea patient), and skin injuries of the rosacea patient can be remarkably improved (including improving papules and pustules of the skin of the rosacea patient).

The invention discloses a dehumidifying and detoxifying medicine for treating eczema and a preparation method thereof. The medicine is prepared from radix sophorae flavescentis, herba portulacae, cortex phellodendri, fructus cnidii, radix sanguisorbae, cortex dictamni, radix salviae miltiorrhizae, nidus vespae and Sinkiang lithospermum erythrorhizon. The traditional Chinese medicine has the effects of clearing heat, drying dampness, astringing liquid, cooling blood, removing toxicity, diminishing swelling, dispelling wind, arresting itching and astringing sores, can be used for treating symptoms such as skin redness and swelling, scorching hot, papule, blister, erosion and exudation caused by eczema, and is suitable for patients with eczema caused by damp-heat accumulation in skin and exuberance of blood heat and toxin.

【Solution】A composition and method for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on the skin. Preferred benzimidazole compounds include mebendazole. The therapeutic composition preferably contains 0.05 to 0.20% by weight of mebendazole in an aqueous or non-aqueous carrier or vehicle including creams, gels, lotions, liquids, emulsions, microemulsions, aerosol sprays, non-aerosol sprays, serums, solutions, suspensions, or ointments, may contain up to 20.0% of mebendazole, and is applied at least once a day over a treatment period of at least two weeks, resulting in a reduction in the appearance of skin cytotoxic CD+8 T cells, papules, pustules, swelling, redness or inflammation, and / or itching at the affected site compared to pre-treatment levels.

1. Name of the product in this design: Acne Tweezers (Straight Head + Angled Head + Bent Head). 2. Purpose of this design: For puncturing and removing pimples or acne. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Design 1 is designated as the basic design.

1. The name of the design product: vertical lines of cream bottle (400 g). 2. The use of the design product: bottle for containing cosmetic products. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

1. The name of this design product: acne needle. 2. Purpose of this product design: used to remove acne, blackheads and pimples, etc. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1. 5. The left view has been shown in the stereogram 1, so the left view is omitted; the right view has been shown in the stereogram 2, so the right view is omitted.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

The invention discloses an acne-removing and soothing cosmetic composition and application of the acne-removing and soothing cosmetic composition, wherein the acne-removing and soothing cosmetic composition contains a medicago sativa seed extract, an Artemisia princeps leaf extract and an onis spinosa root extract, and the acne-removing and soothing cosmetic composition is prepared from the following raw materials in parts by weight: 1 part of an extract of the seeds of the medicago sativa, 1 part of an extract of the leaves of the Artemisia princeps and 1 part of an extract of the roots of the onis spinosa. According to the composition, flavone and polysaccharide components in the alfalfa seeds and natural active substances in the artemisia kuichi leaves and the red formononeus roots are utilized to synergistically exert antibacterial and soothing effects. The composition disclosed by the invention has an inhibition effect on acne pathogenic bacteria. Experimental results show that the composition can inhibit the activity of hyaluronidase and has a soothing effect. The external preparation containing the extract is tested by 12 patients with mild and moderate acnes, the number of inflammatory papules and the skin redness and swelling degree are remarkably reduced, and the safety is good. The composition is derived from natural plants, is free of hormone and antibiotic components, is suitable for daily skin care products, and is used for treating acne and soothing skin.

This invention provides a topical traditional Chinese medicine preparation for treating fungal skin infections and its preparation method, belonging to the field of biomedical technology. The topical traditional Chinese medicine preparation is based on traditional Chinese medicine theory and scientifically formulated, using *Ling Shou Ci*, *Da Cha Gen*, *Fu Fang Teng*, *Mesona chinensis*, *Bai La Jiao*, *Bai Niu Wei Qi*, *Nai Zhi Shu*, *Di Yu*, and *Er Cao* as raw materials. The extracts prepared from the above-mentioned medicinal materials exhibit strong antibacterial and bactericidal effects against *Trichophyton rubrum*, *Trichophyton mentagrophytes*, and *Microsporum gypseum*, inhibiting the development of pathogens at the source. The topical traditional Chinese medicine preparation can significantly inhibit the body's inflammatory response, effectively improving and alleviating skin lesions such as erythema, papules, desquamation, alopecia, and inflammatory infiltration caused by fungal infections. It has a significant therapeutic effect on fungal skin diseases, and the topical traditional Chinese medicine preparation provided by this invention has great potential for application in the treatment of fungal skin diseases.

The invention belongs to the technical field of cosmetics, and particularly relates to an acne-removing herbal composition and application thereof. The acne-removing herbal composition provided by the invention comprises the lotus corniculatus seed extract, the hairyvein agrimony extract, the lagopsis supine extract and the alchemilla japonica extract which are compounded to achieve a synergistic effect, so that the prepared composition can effectively reduce the biofilm formation rate of propionibacterium acnes and has an excellent propionibacterium acnes inhibiting effect. The acne-removing herbal composition provided by the invention can be applied to skin care products such as emulsion and the like, is wide in applicable object range, is simple and easy to operate in preparation method, and is suitable for actual production; the emulsion can significantly improve the acne improvement rate and the papule improvement rate, has an excellent acne improvement effect, and is mild and non-irritating.

This invention discloses the application of dermal ethylsin in the preparation of antibacterial and repairing cosmetics or pharmaceuticals, and compositions containing it. Dermal ethylsin can inhibit Propionibacterium acnes, Staphylococcus aureus, and / or Staphylococcus epidermidis, and can promote keratinocyte migration and / or upregulate the expression of repair-related genes. Cytotoxicity tests show that dermal ethylsin has good safety. Human efficacy evaluation shows that serums containing dermal ethylsin can significantly reduce inflammatory papules, improve skin redness, and improve barrier function. Therefore, dermal ethylsin can be used as a dual-action antibacterial and repairing active agent in cosmetics or pharmaceuticals for acne skin care, sensitive skin repair, and / or post-medical aesthetic repair. Dermal ethylsin is derived from *Gnaphalium affine*, has good safety, and is non-irritating to the skin.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for treating rosacea, its preparation method, and its application. This invention provides a traditional Chinese medicine composition for treating rosacea, comprising dandelion, purslane, sophora flavescens, sophora japonica flower, and rhubarb. The traditional Chinese medicine composition of this invention has the effects of clearing heat and detoxifying, reducing inflammation and antibacterial properties, cooling blood and promoting blood circulation, and repairing the skin barrier. It can be used to treat erythematous rosacea, relieving erythema, telangiectasia, papules, itching, and burning sensation on the skin, and reducing the risk of recurrence.

The application discloses a kind of acarid-removing and acne-removing compositions and its preparation method and application, the acarid-removing and acne-removing composition includes the following components: turmeric extract 5~20%, bai xianpi extract 2~22%, saffron extract 1~10%, menthol 5%, propylene glycol 7~15% and solubilizer 5~20%, the rest is water;And the extraction mode of the turmeric extract includes ultrasonic-assisted solvent extraction, the extraction mode of the bai xianpi extract includes supercritical extraction and polyhydric alcohol-assisted water extraction;The components in acarid-removing and acne-removing composition are simple and mild, the extract prepared by special process and the combination between composition components are good in compatibility, can play the synergistic acarid-removing effect, inhibit mite activity, reduce mite reproduction speed, inhibit inflammation and long pimple, help skin quickly restore to balanced state;Effective extract has no significant odor, can be widely adapted to different system products.

The invention relates to an externally applied blood-cooling acne-eliminating traditional Chinese medicine composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The composition is prepared from the following raw materials in parts by weight: 15 to 20 parts of cortex phellodendri, 15 to 30 parts of herba taraxaci, 15 to 30 parts of folium isatidis, 9 to 15 parts of herba violae, 9 to 15 parts of radix sophorae flavescentis, 15 to 30 parts of radix et rhizoma rhei, 9 to 15 parts of radix angelicae sinensis and 20 to 30 parts of radix trichosanthis. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition focuses on the mechanism that depression is dispersed to eliminate heat and toxin is decomposed to dissipate blood stasis, the depression-heat-toxin-blood stasis pathogenesis chain of acne is synchronously cut off in a multi-node manner through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims of treating blood stasis and toxin simultaneously and clearing and removing blood stasis and toxin simultaneously are met, and 60 patients verify that the total effective rate reaches 92.5%, the acne symptom can be effectively improved, inflammatory papules and pustules can be relieved, and cyst nodules can be reduced; scar repair is promoted, and pigmentation is reduced.

The invention belongs to the technical field of pharmacy, and mainly relates to an ointment for treating dermatitis fungal infection based on a traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicinal materials such as the sophora flavescens, the blackberry lily, the cortex dictamni, the gallnut, the fructus cnidii, the aloe, the cortex pseudolaricis, the fructus kochiae, the cortex phellodendri, the typhonium giganteum, the radix stemonae, the hedyotis diffusa, the spina gleditsiae and the rhizoma smilacis glabrae which are subjected to biological fermentation can inhibit the growth of fungi and also can relieve itching and relieve swelling; the traditional Chinese medicine has small side effects; ti / ZIF-8 is also added, so that the antibacterial effect is more obvious; the traditional Chinese medicine composition can be used for treating acute and chronic dermatitis, eczema, dermatophytosis, tinea manuum, foot sweat, fungal infection, skin itch, papule, plaque papule, erythroderma and intractable skin stubborn dermatitis caused by various bacteria and fungi, red swelling and itching caused by mosquito bite, and inhibiting candida albicans, staphylococcus aureus and the like. In general, the method has a very wide application prospect in the field.

The invention relates to an external ointment for treating eczema and a preparation method thereof. Sinkiang lithospermum erythrorhizon, radix sophorae flavescentis and cortex phellodendri are used as monarch drugs. Sinkiang lithospermum erythrorhizon clears heat, cools blood, detoxifies and promotes eruption, radix sophorae flavescentis and cortex phellodendri clear heat, eliminate dampness, dispel wind and arrest itching, and directly act on the root of eczema damp-heat toxin. Salvia miltiorrhiza, radix rehmanniae, radix paeoniae rubra, cortex moutan and purslane are used as ministerial drugs. The radix rehmanniae, the radix paeoniae rubra and the cortex moutan are used for cooling blood and clearing heat, and the purslane is used for clearing away heat and toxic materials and assisting the monarch drug to enhance the effects of clearing heat and cooling blood, and dispersing blood stasis and relieving itching. Cynanchum paniculatum, radix saposhnikoviae, radix angelicae, platycodon grandiflorum, sanguisorba officinalis and cortex dictamni are used as adjuvant drugs. Radix cynanchi paniculati and divaricate saposhnikovia root dispel wind and arrest itching, radix angelicae dahuricae eliminates dampness and arrest itching, platycodon grandiflorum carries medicine and is transdermal, sanguisorba officinalis is used for cooling blood and astringing, cortex dictamni is used for clearing heat and eliminating dampness, and monarch and ministerial medicines are jointly assisted in A trace amount of dexamethasone is used for assisting rapid anti-inflammation, uncomfortable symptoms such as skin itch, papule and scabbing caused by eczema can be relieved, and instant pain of a patient can be rapidly relieved; skin barrier damage caused by eczema is improved, and normal physiological function recovery of skin is promoted.

1. The name of this design product: Acne Clip (Anti-slip Twill 1). 2. Purpose of this product design: used to remove blackheads, pimples, etc. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1. 5. The top view has been expressed in the stereogram, so the top view is omitted; the bottom view has been expressed in the stereogram, so the bottom view is omitted.

1. Name of the product in this design: Blackhead Shovel. 2. Purpose of this design: A tool for removing blackheads, pimples, dead skin, and dirt during beauty care. 3. The key design feature of this product is its shape. 4. Images or photos that best illustrate the design key points: composite state diagrams.

1. Name of the design product: Packaging bag (acne patch). 2. Use of the design product: For the outer packaging of acne patches. 3. Design key points of the design product: The combination of shape and pattern. 4. Picture or photograph that best shows the design key points: Front view. 5. This design product is a thin product, and the left view, right view, top view, and bottom view are omitted.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.