360results about How to "Good immune regulation" patented technology

The invention discloses a high-efficiency multifunctional foliage fertilizer and a production method thereof. The foliage fertilizer is prepared by chelating shrimp processing leftovers, which serve as the main raw material, with medium and minor elements. The foliage fertilizer is prepared from 10-30% of amino acids, 2-8% of medium and minor elements, 10-30% of organic nitrogen, 3-20% of phosphorus, 3-20% of potassium, and 10-30% of shrimp peptide protein, chitosan, chitosan oligosaccharide, chitin, glucosamine hydrochloride, astacin and shrimp cephalin. The foliage fertilizer disclosed by the invention enhances the low-temperature tolerance, drought tolerance, salt damage tolerance, chemical damage tolerance and other stress tolerances of crops on the premise of comprehensively and efficiently supplementing necessary nutrients for crops, and has the functions of restoring the wound in the root system, enhancing the disease resistance of the crops, inhibiting disease and pest and the like. The production technique can reduce the acidolysis consumption, avoids introducing abundant inorganic salts and chloride ions to destroy soil ecological equilibrium and influence plant growth, lowers the energy consumption and requirements for equipment strength, and can implement the clean production of complete utilization and zero pollution discharge.

The present invention relates to a preparation process for producing feed additive bioactive small-peptide. It is characterized by that said preparation process includes the following steps: using oceanic small misullaneous fishes and offals obtained by processing aquatic products as raw material, cleaning said raw material, using mincing machine to mince said raw material to obtain fish pulp material; placing the fish pulp material into an enzymolysis equipment, and adding trypsinase, controlling temperature at 45-55deg.C, regulating pH value to 6-7 and making enzymolysis for 3-5hr; making enzyme inactivation treatment, filtering and removing impurity, concentrating so as obtain the invented paste-like bioactive small-peptide.

The invention relates to dioscorea opposita peptide polysaccharide composite nutrient solution prepared by comprehensive development and utilization of dioscorea opposita through biological enzyme engineering. The optimal process conditions of step enzymolysis of composite enzyme comprises the following steps of: 1)first step of enzymolysis technology condition, namely, the rate of solid to liquid is 1: (10-15), the enzyme addition quantity accounts for 0.1 to 0.2 percent of total amount, the enzymolysis temperature is between 65 and 75 DEG C, a pH value is 6.0 to 7.0, and time is 1 to 2 hours; 2) second step of enzymolysis technology, the enzyme addition quantity accounts for 0.1 to 0.5 percent of total pulp quantity, the enzymolysis temperature is between 50 and 60 DEG C, the pH value is 6.0 to 7.0, and the time is 3 to 4 hours. The dioscorea opposita is comprehensively developed and utilized by a biological enzyme engineering technology to prepare dioscorea opposita peptide polysaccharide composite nutrient solution, and the comprehensive utilization rate of the dioscorea opposita and active ingredient extraction are greatly improved; the developed dioscorea opposita peptide composite nutrient solution is rich in nutritive ingredients such as peptide, polysaccharide, amino acid and the like, and is comprehensive and rich in nutrition; by the process to prepare the dioscorea opposita peptide polysaccharide composite nutrient solution, the process has the characteristics of reasonable and simple production technology and easiness in industrial production; and the prepared dioscorea opposita peptide polysaccharide composite nutrient solution can be widely applied to various health-care food and health-care medicine.

The invention relates to the field of feed additives, in particular to a functional milk cow feed additive capable of resisting heat stress and improving milk quality. The functional milk cow feed additive capable of resisting heat stress and improving milk quality contains the following raw materials by mass percent: 91-94 percent of yeast cultures, 5-8 percent of organic selenium, 0.5-1 percent of organic chromium and 0.1-0.3 percent of vitamin E. Since organic trace elements such as selenium AF and biological chromium which are produced through an amino acid chelation technique and the like are added into the feed additive, the problem of low absorbing and utilization ratio of the organic trace elements which are absorbed and utilized by milk cows is effectively solved. The problem of low immunity caused by heat stress is relieved, the occurrence probability of susceptible diseases such as mammitis is reduced, the digestion and utilization ratio of a feed is enhanced, the production performance is ensured to be fully exerted, and since several additives take a synergistic effect to the milk cows which are at the period of summer heat stress, the heat stress is effectively relieved by improving the body immunity and adjusting the gastrointestinal tract function.

The invention relates to gene segments for coding alpha, beta or gamma interferons of pigs and an application thereof. According to the preference of codons of a Pichia stipitis expression system, high-expression codons are selected to renewedly design and synthesize new mature peptide nucleotide sequences of the alpha, beta and gamma interferon of the pigs, and recombinant yeast expression plasmids of pPICZalphaC-IFN-alpha, pPICZalphaC-IFN-beta and pPICZaplhaC-IFN-gamma are successfully constructed, which not only correctly expresses the alpha, beta and gamma interferons of the pigs in Pichia stipitis, but also enables the alpha, beta and gamma interferons of the pigs to be easier to express in the Pichia stipitis with higher expression level, and lays a foundation for the large-scale production and fermentation of the gene engineering.

The invention belongs to the technical field of biomedicines, and in particular relates to application of seaweed polysaccharides. The seaweed polysaccharides can be taken as preparations for preparing anti-viral or immune medicines. Cell models and in-vivo animal experiments show that the seaweed polysaccharides can be used for significantly enhancing the animal immunity, and can also be used for promoting the generation of cell factors, the typing of T lymphocytes and the proliferation of mouse spleen cells so as to ensure that cellular immune reaction can be activated. The functional seaweed polysaccharides disclosed by the invention are natural polysaccharides which are extracted from seaweeds such as large seaweeds and kelps, gulfweeds, grateloupia sparsa, eucheuma muricatum, ulva pertusa kjellm, enteromorpha, gracilaria, ascophyllum nodosum and scytosiphon lomentaria, and can also be low-molecular-weight seaweed polysaccharides or seaweed oligosaccharides which are prepared by degrading the seaweed polysaccharides by virtue of different preparation methods. According to the application disclosed by the invention, a polysaccharide extract of single seaweed or a polysaccharide extract mixture of a variety of seaweeds can be taken as a novel anti-viral and immune enhancing agent to be applied to feeds of livestock, poultry, fish, shrimps and shellfish, and has wide application prospects.

The invention discloses an artificial culture method of Zn-enriched cordyceps militaris mycelia and a culture medium thereof; according to weight percentage, the formulation components of the culture medium comprise: 1.0 to 3.0 percent of glucose, 0.5 to 1.0 percent of peptone, 0.1 to 1.0 percent of yeast extract, 1.0 to 2.0 percent of agar powder and the rest of water, and the pH value of the culture medium is 5.0 to 7.5. The artificial culture method comprises the steps of test tube slant surface strain culture (activation), test tube liquid strain culture, triangular flask liquid seed culture, seeding tank culture, fermenter culture, plate-frame filtration, crashing, drying in vacuum, crashing and leading the mycelia into powder. The operation is simple, the culture period is short, the yield of mycelia is high, no pollution and waste are produced, and the method has the function of supplementing zinc, thus being capable of carrying out industrial production.

The invention relates to a method for preparing a biological polysaccharide self-assembly modificatory chitosan antibacterial biological material, which is characterized by comprising the following steps: (1) preparing a lentinan derivant, i.e. lentinan sulfate; (2) preparing a chitosan membrane base material; (3) preparing a lentinan sulfate solution and a chitosan solution; and (4) carrying outlayer-by-layer self-assembly of the lentinan sulfate and the chitosan on the surface of the base material: respectively carrying out alternative self-assembly on the chitosan membrane base material in the lentinan sulfate solution and the chitosan solution for 5 times to obtain a surface layer-by-layer self-assembly modificatory chitosan mebrane containing 5 bilayers with the outermost layer of the lentinan sulfate, washing and drying to obtain the biological polysaccharide self-assembly modificatory chitosan antibacterial biological material. The chitosan antibacterial biological material prepared by the method has excellent antibacterial activity; and the method has simple preparation process, easy control, mild preparation conditions and low cost.

Belonging to the field of microbial agents and fertilizers, the invention specifically relates to an Enteromorpha microbial agent suitable for the demands of planting, livestock and poultry, aquaculture, sewage treatment and other fields, and further discloses a preparation method of the microbial agent. The Enteromorpha microbial agent provided by the invention employs Enteromorpha to prepare a slurry, and is compounded with Streptomyces microflavus, Lactobacillus casei, bacillus subtilis, rhodopseudomonas palustris, Pichia membranaefaciens and other main beneficial microbial floras, and has the multiple functions of effectively improving agricultural product quality, effectively lowering the cost of animal and plant growth period, increasing agricultural product output and the like. The microbial agent also has the functions of purifying water, removing hydrogen sulfide and other odors from sewage, garbage and livestock raising housings, and improving the environment, etc.

The invention relates to special complete formula feed for sows in the perinatal period. The feed comprises components including corn, fermented soybean meal, fermented peanut meal, oat, super steamed fish meal, egg powder, glucose, brown sugar, an emulsified fish oil-lard compound, seaweed meal, multivitamins, composite organic trace elements, a compound enzyme for pigs, choline chloride, lysine, ethoxyquinoline, phytase, salt, stone powder, calcium hydrophosphate, chitosan oligosaccharide, linseed meal, a cucubalus root-ricepaperplant pith-motherwort herb extract and mushroom powder. The feed effectively solves several common problems such as constipation, prolonged labor, postpartum lactation disorder and inadequate milk in the perinatal period of the sows, provides great help for pig farms for increase of the sow health level, the subsequent litter size and the utilization years as well as reduction of the labor intensity of workers for nursing of the sows in the perinatal period, and has very high economic significance and usage value.

The invention provides quinoa food and a preparing method thereof. The quinoa food is mainly prepared from, by mass, 50-60 parts of quinoa flour, 40-50 parts of wheat flour, 20-25 parts of shortening, 15-20 parts of sweetening agent, 10-15 parts of eggs, and 0.8-1.2 parts of sodium bicarbonate. The preparing method comprises the steps of pretreating and grinding quinoa to obtain quinoa flour, mixing other materials with water evenly, adding the quinoa flour to the mixture, conducting rolling, compression molding and baking, and then conducting cooling. By making crispy cookies with quinoa flour as the raw material, the quinoa food tastes unique and sweet, is purely natural, and contains various nutritional ingredients, amino acids and microelements.

The invention belongs to the technical field of biological medicines, and particularly relates to drug-carrying liposome modified by antimicrobial peptide and a preparation method and application thereof. The liposome modified by the antimicrobial peptide is provided, the antimicrobial peptide is modified by a hydrophobic segment, the hydrophobic modified antimicrobial peptide is prepared by coupling the hydrophobic segment (or named as nitrogen tail end coupling a hydrophobic compound) at the nitrogen tail end, the amino acid sequence of the antimicrobial peptide is VQWRIRVAVIRK-NH2 beginning from the nitrogen tail end. The drug-carrying liposome is further provided, the drug-carrying liposome is obtained by loading antibiotics on the liposome. According to the liposome which are loaded with antibiotics, the antimicrobial peptide and the antibiotics are loaded into the liposome simultaneously, and good antibacterial activity in vivo, the immune regulation effect and good safety are achieved; and the liposome which are loaded with antibiotics is an ideal candidate drug for treating MRSA, and relieving of antibiotic resistance is facilitated, and new thoughts and strategies are provided for treating bacterial infection.

A nutritive cordyceps additive of forage for promoting growth of fowls and animals, and improving the taste of egg and meat is prepared from Paecilomyces Guni, through slant culture, liquid seed culture, liquid fermenting, culturing in solid medium, etc.

The invention discloses walnut meal composite nutrition powder and a preparation technology of the walnut meal composite nutrition powder. The preparation technology of the walnut meal composite nutrition powder comprises the steps that (1) pearl barley powder and walnut meal powder serve as main raw materials, extrusion processing is carried out on the raw materials through a bulking machine under the conditions that the extrusion temperature is 150DEG C-170DEG C, and the screw speed is 540-580r / min, and pearl barley and walnut powder extruded materials are obtained; (2) the extruded materials are smashed to form powdery materials with the specification of being larger than 100 meshes, the powdery materials are placed into a homogenizer, sucrose and water are added, high-pressure homogeneity processing is carried out under the conditions that the pressure is 20-25MPa, and the temperature is 70-80DEG C, then, composite probiotics inoculated fermentation processing is carried out on the materials to form walnut meal composite fermentation liquid, and spray drying processing is carried out on the walnut meal composite fermentation liquid to obtain the walnut meal composite nutrition powder. The walnut meal composite nutrition powder and the preparation technology of the walnut meal composite nutrition powder have the advantages of being simple in processing technology, low in manufacturing cost, capable of making full use of the nutrition complementary advantage of the raw materials, capable of achieving all nutritional functions of the walnut meal raw materials, good in quality of products, good in taste of the products, rich in nutrient of the products, stable in quality and performance of the products and the like.

The invention discloses compound nutritional noodles and a preparation method thereof. The compound nutritional noodles are prepared by taking perilla frutescens, se-enriched mushrooms and buckwheat as main raw materials, wherein the organic selenium content of the compound nutritional noodles reaches 200 mu g / kg, and the alpha linolenic acid content of the compound nutritional noodles reaches 2%. The preparation method comprises the steps of: (1) preparation of se-enriched mushroom powder or se-enriched malt powder; (2) preparation of perilla frutescens pulp; (3) preparation of buckwheat powder; (4) determination of a formula of the nutritional noodles; and (5) preparation of the noodles. Research proves that due to the reasonable collocation of the perilla frutescens pulp, the se-enriched mushroom powder or the se-enriched malt powder and the buckwheat powder, strong nutrition and health care functions can be brought into play in the aspects of regulating the fat metabolism, enhancing the immunoregulation, reducing the high blood fat and low-density lipoprotein cholesterol, eliminating lead and detoxifying, protecting the liver and heart and blood vessels, and the like. Therefore, the compound nutritional noodles disclosed by the invention have the function of compound nutrition, increase the diet varieties, and can promote the health of people. The compound nutritional noodles are suitable for adults and children to eat.

The invention discloses an ecological health care type carp complete expanded compound feed, which is prepared from the following components in parts by weight: 12%-15% of fish meal, 17%-20% of flour, 11%-14% of green bran, 0-3% of DDGS (dried distiller grains with soluble), 10%-13% of soybean meal, 28%-31% of rapeseed meal, 12.6%-15.6% of cottonseed meal, 2.2%-4% of soybean oil, 0.8%-1% of lecithin oil, 0.2% of common salt, 2.0%-2.4% of calcium dihydrogen phosphate, 0.15% of choline, 0.03%-2.5% of zeolite powder, 1% of premix, 0.01% of bacillus licheniformis and 0.01% of liquid phytase. Compared with an original product, the ecological health care type carp complete expanded compound feed disclosed by the invention has the characteristics of fastness in carp growth, low feed coefficient, few plant diseases, low mortality rate, a small quantity of used medicament, low incidence of fish hypoxia, low eutrophication of water quality and the like, and can realize a green and ecological development way for sustainable development of healthy cultivation and ecological cultivation of aquiculture.

An herbal extract which induces immune cells to produce interferon and activates Toll-like receptors and a preparation method thereof are provided. The herbal extract is extracted from an effective amount of raw material including Glycyrrhizae Radix, Bupleuri Radix, Scutellariae Radix, Schisandrae Fructus and Paeoniae Rubra Radix. Glycyrrhizae Radix, Bupleuri Radix, Scutellariae Radix, Schisandrae Fructus and Paeoniae Rubra Radix have a weight ratio of 1-5:1-5:1-5:1-3:1-3.

The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

The invention relates to a composition comprising an effective amount of at least one of the strains selected from the group consisting of Lactobacillus plantarum CECT 7527,Lactobacillus plantarum CECT 7528, and Lactobacillus plantarum CECT 7529, These new strains have good probiotic features and are useful for the prevention and / or the treatment of cardiovascular disorders.

A disclosed preparation method for sea cucumber polypeptide for promoting postoperation wound healing is characterized by comprising technological steps of pretreatment, heating denaturation, cooling fragmentation, heating enzyme-killing, coarse filtration and alcohol precipitation, vacuum condensation, standing precipitation, filtering and freeze drying. The prepared sea cucumber has good immunoloregulation effect on body, also has extremely substantial wound healing promotion effect, and is capable of promoting wound to heal 4-5 days early, and the healed wound is flat and no scar is left.

The invention relates to a preparation method of a feed additive, in particular to a preparation method of a cordyceps feed additive. According to the method, the cordyceps feed additive is prepared from cordyceps sinensis anamorphic strains of paecilomyces hepialid for inclined plane culture, liquid fermentation, solid fermentation and later-stage curing process, the cordyceps feed additive is different from microbial viable preparations and is different from ordinary cordyceps products, the defects of products in the prior art are overcome, the effect ingredients of the cordyceps is remained to the maximum degree, in addition, grain bran powder in production raw materials of products are converted into bifidus factors through microorganism via the degradation process in the specific high-temperature sterilization process, the animal growth can be preferably promoted, the feed conversion rate is improved, the cost is reduced, in addition, the animal immunity and the disease resistance can be improved on the premise of not using medicine or using little medicine, the survival rate is improved, and the cost is reduced.

The invention provides compound nutrient powder suitable for tumor treatment. The main components include broccoli seed extract, yeast beta-glucan, nutrient-enriched yeast, acerola cherry powder and inulin, and the auxiliary components are selected from one of, or a plurality of, or all of the following components: whey protein powder, collagen powder, soybean protein powder, broccoli powder, asparagus powder, corn flour, yam flour, agaricus blazei powder, crystalline fructose, maltitol, stevioside and acesulfame potassium. The beneficial effects of the compound nutrient powder are as follows: a formula which combines the broccoli seed extract, the yeast beta-glucan, the nutrient-enriched yeast, the acerola cherry powder and the inulin can effectively realize the function of each component and is helpful for each component to work together so as to increase immunity and help to treat the tumors. The invention also provides a preparation method based on the compound nutrient powder suitable for tumor treatment.

A detoxicating synergistic Chinese medicine for radiotherapy or chemicotherapy is prepared from astragalus root, wolfberry fruit and ganoderma. Its advantage is high curative effect.

The invention discloses a microbe multi-functional health care nutritive rice; the preparation process thereof comprising following steps: immersing paddy in water; drying the water on the husk of the paddy; spraying edible fungi seed liquid on the paddy surface; letting the paddy subject to fungi cultivating, sunning or drying; finally shelling the paddy to obtain the product; wherein the edible fungi seed liquid per milliliter contains 40 to 55 mycelial pellets; the edible fungi seed liquid comprises Pleurotus ostieatus seed liquid, selenium-enriched Pleurotus ostieatus seed liquid, germanium-enriched Pleurotus ostieatus seed liquid, Hericium erimaceus seed liquid, Poria cocos pleurotus ostieatus seed liquid and Agrocybe salicacola seed liquid, which are respectively spayed on the surface of paddy to produce different rice; the microbe multi-functional health care nutritive rice is one of such rice or the mixture of two or more of such rice, with the protein content being three or four times that of the ordinary rice. The microbe multi-functional health care nutritive rice has the advantages of anti-fatigue, anti-aging, enhancing immunity, anti-tumor and promoting intelligence.

The invention relates to an application of PD-L1 gene modified bone marrow mesenchymal stem cells in graft rejection. According to the invention, immune state can be regulated and graft rejection can be inhibited, significant guidance in clinical application of xenogeneic organ transplantation is provided, foundation for inducing peripheral immune tolerance is established, and application prospect is broad.

The invention provides a pig IFNalpha1-Fc encoding gene optimized according to a silkworm reaction system, a fusion protein expressed by the pig IFNalpha1-Fc encoding gene and a method for expressing pig IFNalpha1-Fc fusion protein by utilizing a silkworm bioreactor and belongs to the field of biologic gene engineering. As a non-specific broad spectrum antiviral biological agent, a pig interferon alpha 1 has a wide medical prospect, and but being similar to most gene engineering veterinary medicines, the pig interferon alpha 1 has the problems of underproduction, expensive price, irregular quality and short action time. According to the Pig IFNalpha1-Fc fusion protein, a silkworm expression system is used for expressing an optimized pig IFNalpha1-Fc fusion gene to obtain a target protein with relatively high expression efficiency and relatively strong activity. Besides, according to the pig IFNalpha1-Fc fusion protein provided by the invention, the action time of the pig interferon alpha 1 is prolonged, the integral immune adjustment effect is enhanced, and the later-period purification is facilitated, so that the mass production of pig IFNalpha1-Fc fusion protein preparations is realized by utilizing a gene engineering method, and conditions for developing novel feeds containing the fusion proteins are created.

The invention discloses a compound nutrition tartar sauce and a preparation method thereof. The tartar sauce mainly comprises raw materials of suma, selenium-rich mushrooms and garlic, wherein per 100 g of tartar sauce contains 200 mug organic selenium and 1,600 mg Alpha-linolenic acid. The preparation method comprises the following steps: (1) preparing selenium-rich mushroom powder, (2) preparing suma paste, (3) preparing mashed garlic, (4) selecting a flavoring agent and auxiliary material, (5) confirming a flavoring agent recipe, and (6) preparing the tartar sauce. Proved by the research, the reasonable match of the suma paste, the selenium-rich mushroom powder and the mashed garlic can play a stronger nutrition and health care function in aspects of adjusting fat metabolism, enhancing immune adjustment, reducing hyperlipemia and low density lipoprotein cholesterin, expelling plumbum and detoxifying and protecting the liver and the angiocarpy. The compound nutrition tartar sauce, provided by the invention, has a compound nutrition function, is fresh and tasty, enriches the dish taste of the users, promotes the body health of the users, and is suitable for cooking Chinese dishes.

The invention relates to a clinical nutrition formula special for diseases of respiratory system. The clinical nutrition formula comprises protein, fat, carbohydrate, dietary fiber, macro-element, microelement, lipid-soluble vitamin, water soluble vitamin, diet essence, homologous medicinal and diet components, natural plant compound and new resource food. The invention also relates to a preparation method for the clinical nutrition formula. The method comprises the following steps: preparing all the components into powder in advance; performing alcohol extracting, water extracting, concentrating and spray-drying on the homologous medicinal and diet components, thereby acquiring powder; preparing the vitamins and fat into powder in the manner of microencapsulation treatment; or adopting a wet process for performing emulsifying, homogenizing and spray-drying on all the components, thereby acquiring the powder. Through the screening and matching of the components, the nutrition formula provided by the invention can supply comprehensive and sufficient nutrition support to the patient suffering from the diseases of respiratory system, so that the body immunity can be promoted, a certain effect for improving the nutrition state, respiratory function and life quality of the patient can be achieved and a better condition is established for treating the diseases.

This invention discloses a nonspecific compound polysaccharides immune milk,which is formulated from the following raw materials, by weight,0.3 to 60 parts of fungi polysaccharides, 0.9 to 15 parts of plant polysaccharides, 35 to 1000 parts of functional oligosaccharides, 8000 to 10000 parts of skim cow milk or skim sheep milk. This invention extends the connotation and the extension of immune milk, solves some problems of immune milk produced by local immunity and / or systemic immunity, such as high cost, high operational difficulty, long period and anaphylaxis, has the obvious function of immune regulation, promotes the body resistance to diseases, has good health effect to the people who is weak and liable to have cold. The nonspecific compound polysaccharides immune milk of this invention has a steady character, no risk of anaphylaxis, simple processing technology,is easy to produce on a large scale and has great developmental prospect.