The invention belongs to the technical field of biomedical materials, and particularly relates to a high-stability injectable
soft tissue filling material and a preparation method and application thereof. The
soft tissue filling material disclosed by the invention is prepared by mixing an amphiphilic degradable polyether-
polyester copolymer with water and annealing; the annealing
process conditions are as follows: under the protection of
inert gas, pressurizing to 1.0-5.0 bar, heating to 110-158 DEG C, slowly cooling to
room temperature under the condition of maintaining the pressure, and finally reducing the pressure to standard
atmospheric pressure. Through experimental tests, the
soft tissue filling material has the excellent properties of
high concentration, high particle size and
viscosity, good preparation stability, good stability among process batches, good needle passing property, no need of a
sterilization process, good safety, long-term retention effect
in vivo, capability of promoting collagen generation of
skin tissues and the like; good application effects are realized in the fields of
wound healing, tissue filling and / or repairing,
wrinkle removal, anti-aging and the like.