35 results about "Stomatitis" patented technology

The present disclosure relates to a herbo-mineral kit for alleviating adverse effects of chemotherapy resulting into improved quality of life of patients. The herbo-mineral kit comprises a first container containing Padmakadi Ghrut (PDG) in a thick, viscous form; a second container containing Mouktikyukta Kamdudha Vati (MKD) in a solid dosage form; a third container containing Praval Pishti Vati (PPV) in a solid dosage form; and a fourth container containing Ananta vati in a solid dosage form. The herbo-mineral kit of the present disclosure can be used for alleviating adverse effects of chemotherapy such as nausea, vomiting, constipation, diarrhea, stomatitis, and skin discoloration in cancer treatment. Use of the herbo-mineral kit of the present disclosure may prove to be beneficial in all types of cancers and diseases for which chemotherapy is treatment of choice.

The invention belongs to the field of molecular biological detection, and particularly relates to a composition and a method for joint detection and distinguishing of feline calicivirus, feline herpes virus, feline leukemia virus and feline human immunodeficiency virus, and application of the composition and the method. According to the combined detection composition provided by the invention, four targets can be simultaneously detected in one-time sample detection through a multiple fluorescent RPA detection technology, the on-machine detection process can be completed within 30 minutes, and the detection method has the characteristics of high flux, short time and low cost. The invention greatly solves the problems of difficult and pain points in the industries of long time, low sensitivity, poor specificity and the like in the current cat stomatitis pathogen identification, improves the accurate and rapid detection of cat stomatitis diseases, and provides a simple and efficient detection reagent and method for scientific research and clinical detection of suspected cat stomatitis diseases.

The invention relates to the technical field of traditional Chinese medicine processing, and discloses a radish cream extraction method, which at least comprises: S1, respectively crushing radish and mirabilite, adding water, and uniformly mixing to obtain a mixture; s2, placing the mixture obtained in the step S1 in an environment with the temperature of 0-20 DEG C and the relative humidity of 1-60%; and S3, after the frost is separated out in the S2, collecting until the frost is separated out. According to the invention, the process for preparing the radish cream from the mirabilite is researched for the first time, and a basis is provided for production and clinical research significance of glucosinolate and sulforaphane in radishes and establishment of quality standards of the radish cream. The main component of the radish cream is recrystallized Na2SO4. 10H2O, and the result is obtained through experimental verification. The radishes and the mirabilite have a synergistic effect, so that the medicine is purer, and the effects of relieving swelling and pain and clearing away heat and toxic materials are enhanced. The radish cream is used for treating sore throat, mouth and tongue sores, swelling and aching of gum, acute and chronic pharyngolaryngitis, tonsillitis, stomatitis and oral ulcer symptoms.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a residual barley oropharynx combined traditional Chinese medicine extract in preparation of a medicine for treating stomatitis. The invention provides application of a herba houttuyniae extract, a radix astragali extract and a fructus forsythiae extract in preparation of a medicine for treating stomatitis, wherein the stomatitis is herpangina. The herba houttuyniae extract, the radix astragali extract and the fructus forsythiae extract are combined with the herba houttuyniae extract, the radix astragali extract and the fructus forsythiae extract. The herba houttuyniae and radix astragali seu hedysari oral pharynx mixture is combined with the herba houttuyniae extract, the radix astragali seu hedysari extract and the fructus forsythiae extract, so that the synergistic interaction effect of the medicines can be fully exerted, the overall regulation advantage of the combined medicines is exerted, and the herpangina of children is effectively treated.

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

The invention discloses an oral care composition and a preparation method thereof, and belongs to the technical field of oral antibacterial agents. Comprising 50-80 parts of a traditional Chinese medicine extract, 10-20 parts of a humectant, 5-50 parts of water and 0-20 parts of an auxiliary material, the traditional Chinese medicine comprises the following components in parts by weight: 30-50 parts of honeysuckle, 10-30 parts of herba violae, 10-30 parts of dandelion, 10-30 parts of folium isatidis, 1-10 parts of golden cypress, 1-10 parts of radix sophorae flavescentis, 1-10 parts of scutellaria baicalensis and 5-20 parts of mint. The traditional Chinese medicine extracts in a specific proportion are adopted, oral bacteria can be inhibited in daily nursing, breath can be cleared, and oral cancer can be effectively prevented. When serious oral cavity diseases such as stomatitis, oral mucosa hyperemia and edema occur, the traditional Chinese medicine can relieve pain and diminish inflammation, rapidly diminish swelling and effectively treat diseases.

A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.

The invention relates to a benvimod oral-soluble film composition, a preparation method thereof and application of the benvimod oral-soluble film composition in medicine, the benvimod oral-soluble film composition comprises an active component, a film-forming material and a plasticizer, and the active component is selected from one or more of benvimod, pharmaceutically acceptable salts of benvimod, clathrate compounds of benvimod and compounds of benvimod. The invention particularly relates to application of the oral soluble film composition in preparation of medicines for treating and / or preventing oral related diseases, and the oral related diseases are preferably selected from stomatitis, dental ulcer, oral herpes, gingivitis and periodontal diseases. The oral soluble film composition provided by the invention has the advantages of being thin in thickness, good in taste, stable in property, capable of being instantly dissolved in the oral cavity and high in absorption speed.

The invention discloses a temperature-sensitive hydrogel and a preparation method and application thereof, the temperature-sensitive hydrogel comprises the following components: a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, hyaluronic acid (HA) and selenium nanoparticles (SeNPs), the mass concentration of the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer in the hydrogel is 15-30%, the mass concentration of the hyaluronic acid is 0.2-1.0%, the mass concentration of the selenium nanoparticles (SeNPs) in the hydrogel is 0.5-1.5%, and the mass concentration of the selenium nanoparticles (SeNPs) in the hydrogel is 0.5-1.5%. The mass concentration of the selenium nanoparticles is 0.6-4%, and the balance is deionized water. The injectable temperature-sensitive hydrogel combines the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, the HA and the SeNPs, has good biocompatibility, can be injected to a focus part and form gel in situ, and can realize slow and continuous release of selenium nanoparticles, prolong the antioxidant action time and improve the local concentration, so that the injectable temperature-sensitive hydrogel can be used for preparing the selenium nano-particles. The anti-oxidation effect is achieved, and the effect on treating inflammatory bowel diseases (IBD), osteoarthritis (OA), stomatitis diseases such as periodontitis and the like is better.

A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.

The special eucommia feed preparation device comprises a bottom plate, side frames are fixedly connected to the two sides of the top end of the bottom plate, hydraulic cylinders are fixedly installed in the middles of the top ends of the inner walls of the two side frames, a mixing box is fixedly connected to the top ends of the two hydraulic cylinders, and a feeding shell is fixedly communicated with the top of the mixing box; a crushing mechanism is installed in the feeding shell, a first gear motor is fixedly installed in the middle of the top end of the material mixing box, a transmission shell is fixedly connected to the top end of the inner wall of the material mixing box, and the two ends of the two sides of the bottom end of the transmission shell are rotationally connected with rotating shafts through first bearings. According to the device, clotted agkistrodon halys feed can be crushed, uneven mixing of the clotted agkistrodon halys feed and eucommia ulmoides extract is avoided, the eucommia ulmoides leaf extract can be rapidly, effectively and evenly added into the agkistrodon halys feed, the mixed eucommia ulmoides feed can be extruded at a constant speed, and filling is more convenient.

Provided are methods of determining whether a mammalian subject having an inflammatory condition (e.g., an oral inflammatory condition) will respond positively to mesenchymal stem cell (MSC) therapy, as well as method of treating such inflammatory conditions by administering MSCs.

The invention discloses a chemotherapy auxiliary nursing device for the oncology department, relates to the technical field of chemotherapy auxiliary nursing equipment, and provides the following scheme that the chemotherapy auxiliary nursing device comprises an oral necrotic tissue removal mechanism and a phlebitis protection patch, and an oral lesion prevention and treatment mechanism is arranged on the front side of the oral necrotic tissue removal mechanism; the oral necrotic tissue removing mechanism comprises a rotary base joint, a mechanical shoulder joint fixed to the top end of the rotary base joint and a mechanical elbow joint rotationally connected with the top end of the mechanical shoulder joint through a joint motor. According to the technical scheme, the dressing piece located in the intravenous infusion area is arranged, the dressing piece has the local hot compress effect, and meanwhile, the inner side of the dressing piece is smeared with the love-therapeutic cream, so that symptom relieving and recovery are facilitated; in addition, a patient oral necrotic tissue removing mechanism is arranged, a necrotic tissue area is repeatedly washed and removed, and then medicine applying is conducted, so that stomatitis, oral erosion and necrosis on the oral mucosa are prevented, treated and nursed.

This invention relates to a colloidal gold test strip for detecting sheep pox virus antibodies, its preparation method, and its application. First, this invention prepares recombinant 122 protein, which exhibits significant antigenicity and immunogenicity, making it a good target for diagnosing sheep pox virus. Second, this invention prepares a colloidal gold test strip for detecting sheep pox virus antibodies. The test strip has a PVC base plate with a sample pad, a gold-labeled pad, a nitrocellulose membrane, and an absorbent pad arranged sequentially. The gold-labeled pad is coated with gold-labeled recombinant 122 protein. The test strip of this invention can simultaneously detect antibodies against sheep pox virus, bovine nodular dermatosis virus, and goat pox virus, with sensitivities of 1:128, 1:128, and 1:64, respectively. It shows no cross-reactivity with bovine viral diarrhea virus, foot-and-mouth disease virus type O, foot-and-mouth disease virus type A, sheep stomatitis virus, brucellosis, and Escherichia coli, exhibiting good specificity and a diagnostic concordance rate of 93%.

The invention provides an injection for treating cat stomatitis through oral soft tissue injection. The active ingredients of the injection comprise glucocorticoid and B vitamins, and also comprise mesenchymal stem cells at the same time. According to the invention, the mesenchymal stem cells, the glucocorticoid and the vitamin B are combined as the active ingredient of the injection for biological medicine preparation for the first time, so that the long-term effect and stability of the inflammation inhibition and tissue repair functions of the mesenchymal stem cells are fully exerted, and meanwhile, the characteristic of quick inflammation inhibition effect of the glucocorticoid is utilized; the defects that glucocorticoid is large in side effect after being used for a long time and the condition is repeated after medicine withdrawal are overcome, so that the treatment effect on stomatitis is remarkably improved, and the treatment period is greatly shortened; furthermore, the active ingredients are creatively injected into soft tissues of the oral cavity of an affected cat in a multi-point micro-injection manner in an oral soft tissue injection manner, and a better treatment effect is realized by utilizing low-dose and short-term mesenchymal stem cells and glucocorticoid, so that the technical difficulty in treating the cat stomatitis is overcome.

The present application relates to canine and feline FcRn antagonists comprising canine or feline Fc fragment polypeptides that reduce or block binding of canine or feline FcRn to canine or feline IgG autoantibodies, and the use of these FcRn antagonists in treating canine or feline subjects suffering from autoantibody associated autoimmune disorders, such as pemphigus, bullous pemphigoid, lupus erythematosus, and stomatitis.

The invention belongs to the field of medical nursing consumables, and particularly relates to a preparation method and application of a drug-loaded bee cocoon biological membrane. The drug-loaded bee cocoon biological membrane has good tensile strength and adhesive force, can be attached to the oral mucosa part, releases drugs in artificial saliva for not less than 4 hours, and does not degrade in the artificial saliva for 30 days; the drug-loaded bee cocoon biological membrane prepared by the method has good biocompatibility, can successfully load Kangfuxin drugs and slowly release the drugs, is convenient to carry, use and replace in daily life, does not influence the safety of the biological membrane to oral mucosa, and is suitable for home nursing and inter-diagnosis treatment of oral ulcers such as radioactive stomatitis, chemotherapeutic stomatitis and the like.

The present invention relates to recombinant oncolytic viruses comprising a vesicular stomatitis virus (VSV), wherein the glycoprotein (G protein) of VSV is deleted; and which comprises a modified fusion protein (F protein) of Newcastle disease virus (NDV); and the hemagglutinin neuraminidase (HN) protein of NDV. The present invention further relates to nucleic acids encoding for the recombinant oncolytic virus and vectors comprising the nucleic acids. The present invention further relates to pharmaceutical compositions comprising the rVSV of the invention, the nucleic acid or the vector, further to uses as gene delivery tool and / or for tumor detection. The present invention further relates to the recombinant oncolytic vesicular stomatitis virus (VSV) for use in medicine, in particular for the diagnosis, prevention and / or treatment of cancer.

The invention provides application of self-gelling powder in preparation of a medicine for preventing and treating radiation-induced oral mucositis, and belongs to the technical field of medicines. The invention provides an application of self-gelling powder in preparation of a medicine for preventing and treating radiation-induced oral mucositis, the self-gelling powder is prepared from a nutgall extract and carboxymethyl chitosan through gelation, freeze drying and crushing in sequence, and the mass ratio of the nutgall extract to the carboxymethyl chitosan is (1-5): 6. The self-gel powder disclosed by the invention is good in safety and low in cost, has an excellent prevention and treatment effect on radiation-induced oral mucositis caused by head and neck radiotherapy, and can reduce the generation of inflammatory factors after radiation; the self-gel powder has a good antibacterial effect and can prevent secondary infection caused by oral mucosa injury after head and neck radiotherapy; meanwhile, the self-gelling powder becomes gel when encountering water in the oral cavity, and mechanical protection can be provided for the damaged mucous membrane surface of a patient.

This invention discloses a filling production line for an anti-drip oral spray, relating to the field of filling production line technology. It includes a filling platform, a mounting plate fixedly connected to the side wall of the filling platform, a support rod fixedly connected to the upper surface of the mounting plate, a lifting plate slidably connected to the outer surface of the support rod, and an injection pipe fixedly connected to the end of the lifting plate away from the support rod. An injection head is fixedly connected to the lower end of the injection pipe, and a dripping liquid collection mechanism is provided on the injection head. The dripping liquid collection mechanism includes a rotating shaft that automatically drives a collection box to move below the injection head during the injection head's upward movement to collect the liquid dripping from inside the injection head. This not only prevents liquid from dripping onto the filling platform and affecting its operation, keeping the filling platform and working environment clean and tidy, and improving worker comfort, but also avoids liquid waste by collecting the dripping liquid, thereby reducing overall production costs.

The present invention provides compositions and methods for treating stomatitis diarrhea.

The invention provides application of an HIF-2alpha inhibitor in preparation of a medicine for treating hypoxia-related stomatitis bone loss diseases. Experiments provided by the invention show that HIF-2alpha activates the expression of a key gene Camk4 for promoting osteoclast differentiation under the hypoxia condition, and the osteoclast differentiation promoting effect of the Camk4 is exerted; and the HIF-2 alpha inhibitor can be used for remarkably inhibiting osteoclast differentiation. Therefore, the HIF-2 alpha inhibitor can be used for treating the hypoxia-related stomatitis bone loss disease, and is expected to remarkably improve the treatment effect of the stomatitis bone loss disease when being used as an oral cavity-related treatment or prevention medicine.

The invention relates to a stomatitis composition based on micro-crosslinked polyethylene glycol lysozyme and a preparation method and application of a preparation of the stomatitis composition, and the stomatitis composition comprises the following components in parts by mass: polyethylene glycol carboxyl activated ester, polyethylene glycol, chitosan and lysozyme. According to the invention, by virtue of a microstructure formed by micro-crosslinking of polyethylene glycol carboxyl activated ester and lysozyme, the retention time of the lysozyme is prolonged, and the defect that single lysozyme is easy to lose is overcome. On one hand, after part of sites of polyethylene glycol carboxyl activated ester are crosslinked with lysozyme, the rest non-crosslinked activated ester sites continue to be crosslinked with protein in oral mucosa, so that a polyethylene glycol lysozyme complex is fixed on tissues, and the retention efficiency of lysozyme is enhanced; on the other hand, by means of the entrapment effect of the polymer microstructure, the risk that the lysozyme is scoured due to direct contact with saliva can be reduced, and the retention time of the lysozyme is remarkably prolonged.

Base material arrangements having at least two layers can accommodate the addition of antifungal material (nanofiller), such as in denture base resin without significantly compromising the mechanical properties and / or translucency of the base material arrangements. Antifungal agents such as nanosilver and nanozirconia can be used to modify a surface layer of the material arrangements, such as the denture base, to overcome certain known shortcomings of the modified materials, e.g., typical acrylic resins containing nanosilver and nanozirconia.

The lucid ganoderma and mesona chinensis preparation is prepared from the following raw materials in proportion: 100g to 1000g of lucid ganoderma powder, 80g to 800g of mesona chinensis (mesona chinensis) powder, 80g to 800g of rhizoma polygonati powder, 60g to 600g of astragalus membranaceus powder, 40g to 400g of dandelion powder, 40g to 400g of herba cepbalanoplosis segeti powder, 20g to 200g of fructus gardeniae powder and 20g to 200g of honeysuckle flower powder. Sometimes, a small amount of bitter gourd, poria cocos, Chinese yam, rhizoma imperatae, day lily and liquorice can be added as auxiliary materials to expand the application range. The preparation can clear away heat and toxic materials, improve the immunity of the human body, prevent and resist cancers, reduce blood pressure, reduce blood sugar and reduce blood fat, and has good treatment effects on uremia, nephritis, hepatitis B, liver cirrhosis, gall-stone, cholecystitis, cough, asthma, pulmonary heart disease, stomatitis, pharyngitis, enteritis, insomnia, haemorrhoids, cervical spondylosis, lumbar spondylosis and cardia-cerebrovascular diseases.

A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.

The ganoderma and astragalus preparation is made of the following proportioned raw materials, and the ganoderma and astragalus preparation is made of: ganoderma 5kg-50kg, astragalus 4kg-40kg, poria cocos 4kg-40kg, dried ginger 2kg-20kg, dandelion 2kg-20kg, cassia seed 2kg-20kg, cistanche 2kg-20kg, apricot kernel 2kg-20kg, and is prepared in a certain proportion. The preparation can clear heat and resolve toxins, promote blood circulation and remove blood stasis, improve human immunity, prevent and resist cancer, treat hepatitis B, reduce blood pressure, reduce blood sugar, reduce fat, treat skin diseases, cervical spondylosis, lumbar spondylosis, and has a good therapeutic effect on hepatitis, stomatitis, pharyngitis, nephritis, hemorrhoids, visual impairment, and cardiovascular and cerebrovascular diseases caused by diabetes. The preparation can be developed into a medicine or a food with medicinal properties.

The application discloses a traditional Chinese medicine composition for preventing and treating cat stomatitis and a preparation method and application thereof, and comprises the following components in parts by weight: liquorice 2-20 parts, honeysuckle 4-10 parts, ophiopogon 4-10 parts, root of red peony 4-8 parts, scrophularia 4-8 parts, coptis 4-8 parts, radix codonopsitis 4-8 parts and jujube 4-8 parts. The liquorice, scrophularia and coptis in the traditional Chinese medicine composition have the effects of clearing heat and detoxifying, clearing heat and drying dampness, and have certain anti-inflammatory effect; the honeysuckle has the effects of clearing heat and detoxifying and dispelling wind-heat, the ophiopogon has the effects of nourishing yin and generating fluid and moistening lung and clearing heart, the root of red peony has the effects of clearing heat and cooling blood and activating blood and resolving stasis, can achieve the effects of nourishing yin and activating blood and improving metabolism of the body, the radix codonopsitis has the effects of tonifying spleen and lung, nourishing blood and generating fluid, the jujube has the effects of tonifying middle and replenishing qi, nourishing blood and tranquilizing, can regulate immunity of the body, reduce stress of the cat and promote recovery of the disease. Thus, the cat stomatitis is controlled, and problems of decreased appetite, reduced weight, painful eating and lack of spirit of the cat caused by the stomatitis are improved.

The claimed technical solution relates to the field of pharmaceutics and to dosage forms for expanding the existing range of medicaments based on a gramicidin S-containing pharmaceutical substance for use in inhibiting bacterial infections in a local inflammation site in the human oral cavity and in increasing the effectiveness of treatment of inflammatory infectious diseases of the oral cavity, specifically alveolitis, pharyngitis, periodontal disease, gingivitis and stomatitis, and further relates to methods for organizing said dosage forms. The present dosage form for inhibiting bacterial infections, which is based on a pharmaceutical substance containing gramicidin S, chitosan and hydroxypropyl-β-cyclodextrin, additionally contains a film-forming agent in the form of collagen, and a plasticizer, wherein the dosage form is produced in the form of a biodegradable buccal film having a thickness of 33-37 μm, an aqueous-extract pH of 6.8-7.2 and a T50 index for gramicidin S in relation to human erythrocytes of 24-26 mkg / ml and is capable of prolonged release of gramicidin S. The components of the biodegradable buccal film are present in the following proportions: 2-4 wt% gramicidin S; 30-24 wt% chitosan; 10-15 wt% collagen; 28-32 wt% hydroxypropyl-β-cyclodextrin; 30-25 wt% plasticizer. The claims include 2 independent claims and 8 dependent claims.

The invention belongs to the technical field of biological medicine, and particularly relates to application of a mouse nerve growth factor in preparation of a medicine for treating animal inflammation and the medicine. Wherein the application refers to the application of the mouse nerve growth factor in preparation of drugs for treating animal inflammation including chronic gingival stomatitis, and the active ingredient of the drugs is the mouse nerve growth factor; the medicine has the function of treating animal inflammations including chronic gingival stomatitis; the medicine for treating chronic gingival stomatitis of animals is prepared by using simple and easily available mouse nerve growth factors as active substances, the curative effect is remarkable, and the living quality of sick cats is finally improved.