11 results about "Stomatitis" patented technology

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

The invention discloses a temperature-sensitive hydrogel and a preparation method and application thereof, the temperature-sensitive hydrogel comprises the following components: a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, hyaluronic acid (HA) and selenium nanoparticles (SeNPs), the mass concentration of the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer in the hydrogel is 15-30%, the mass concentration of the hyaluronic acid is 0.2-1.0%, the mass concentration of the selenium nanoparticles (SeNPs) in the hydrogel is 0.5-1.5%, and the mass concentration of the selenium nanoparticles (SeNPs) in the hydrogel is 0.5-1.5%. The mass concentration of the selenium nanoparticles is 0.6-4%, and the balance is deionized water. The injectable temperature-sensitive hydrogel combines the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, the HA and the SeNPs, has good biocompatibility, can be injected to a focus part and form gel in situ, and can realize slow and continuous release of selenium nanoparticles, prolong the antioxidant action time and improve the local concentration, so that the injectable temperature-sensitive hydrogel can be used for preparing the selenium nano-particles. The anti-oxidation effect is achieved, and the effect on treating inflammatory bowel diseases (IBD), osteoarthritis (OA), stomatitis diseases such as periodontitis and the like is better.

The special eucommia feed preparation device comprises a bottom plate, side frames are fixedly connected to the two sides of the top end of the bottom plate, hydraulic cylinders are fixedly installed in the middles of the top ends of the inner walls of the two side frames, a mixing box is fixedly connected to the top ends of the two hydraulic cylinders, and a feeding shell is fixedly communicated with the top of the mixing box; a crushing mechanism is installed in the feeding shell, a first gear motor is fixedly installed in the middle of the top end of the material mixing box, a transmission shell is fixedly connected to the top end of the inner wall of the material mixing box, and the two ends of the two sides of the bottom end of the transmission shell are rotationally connected with rotating shafts through first bearings. According to the device, clotted agkistrodon halys feed can be crushed, uneven mixing of the clotted agkistrodon halys feed and eucommia ulmoides extract is avoided, the eucommia ulmoides leaf extract can be rapidly, effectively and evenly added into the agkistrodon halys feed, the mixed eucommia ulmoides feed can be extruded at a constant speed, and filling is more convenient.

This invention relates to a colloidal gold test strip for detecting sheep pox virus antibodies, its preparation method, and its application. First, this invention prepares recombinant 122 protein, which exhibits significant antigenicity and immunogenicity, making it a good target for diagnosing sheep pox virus. Second, this invention prepares a colloidal gold test strip for detecting sheep pox virus antibodies. The test strip has a PVC base plate with a sample pad, a gold-labeled pad, a nitrocellulose membrane, and an absorbent pad arranged sequentially. The gold-labeled pad is coated with gold-labeled recombinant 122 protein. The test strip of this invention can simultaneously detect antibodies against sheep pox virus, bovine nodular dermatosis virus, and goat pox virus, with sensitivities of 1:128, 1:128, and 1:64, respectively. It shows no cross-reactivity with bovine viral diarrhea virus, foot-and-mouth disease virus type O, foot-and-mouth disease virus type A, sheep stomatitis virus, brucellosis, and Escherichia coli, exhibiting good specificity and a diagnostic concordance rate of 93%.

The invention provides application of self-gelling powder in preparation of a medicine for preventing and treating radiation-induced oral mucositis, and belongs to the technical field of medicines. The invention provides an application of self-gelling powder in preparation of a medicine for preventing and treating radiation-induced oral mucositis, the self-gelling powder is prepared from a nutgall extract and carboxymethyl chitosan through gelation, freeze drying and crushing in sequence, and the mass ratio of the nutgall extract to the carboxymethyl chitosan is (1-5): 6. The self-gel powder disclosed by the invention is good in safety and low in cost, has an excellent prevention and treatment effect on radiation-induced oral mucositis caused by head and neck radiotherapy, and can reduce the generation of inflammatory factors after radiation; the self-gel powder has a good antibacterial effect and can prevent secondary infection caused by oral mucosa injury after head and neck radiotherapy; meanwhile, the self-gelling powder becomes gel when encountering water in the oral cavity, and mechanical protection can be provided for the damaged mucous membrane surface of a patient.

This invention discloses a filling production line for an anti-drip oral spray, relating to the field of filling production line technology. It includes a filling platform, a mounting plate fixedly connected to the side wall of the filling platform, a support rod fixedly connected to the upper surface of the mounting plate, a lifting plate slidably connected to the outer surface of the support rod, and an injection pipe fixedly connected to the end of the lifting plate away from the support rod. An injection head is fixedly connected to the lower end of the injection pipe, and a dripping liquid collection mechanism is provided on the injection head. The dripping liquid collection mechanism includes a rotating shaft that automatically drives a collection box to move below the injection head during the injection head's upward movement to collect the liquid dripping from inside the injection head. This not only prevents liquid from dripping onto the filling platform and affecting its operation, keeping the filling platform and working environment clean and tidy, and improving worker comfort, but also avoids liquid waste by collecting the dripping liquid, thereby reducing overall production costs.

The invention provides application of an HIF-2alpha inhibitor in preparation of a medicine for treating hypoxia-related stomatitis bone loss diseases. Experiments provided by the invention show that HIF-2alpha activates the expression of a key gene Camk4 for promoting osteoclast differentiation under the hypoxia condition, and the osteoclast differentiation promoting effect of the Camk4 is exerted; and the HIF-2 alpha inhibitor can be used for remarkably inhibiting osteoclast differentiation. Therefore, the HIF-2 alpha inhibitor can be used for treating the hypoxia-related stomatitis bone loss disease, and is expected to remarkably improve the treatment effect of the stomatitis bone loss disease when being used as an oral cavity-related treatment or prevention medicine.

The application discloses a traditional Chinese medicine composition for preventing and treating cat stomatitis and a preparation method and application thereof, and comprises the following components in parts by weight: liquorice 2-20 parts, honeysuckle 4-10 parts, ophiopogon 4-10 parts, root of red peony 4-8 parts, scrophularia 4-8 parts, coptis 4-8 parts, radix codonopsitis 4-8 parts and jujube 4-8 parts. The liquorice, scrophularia and coptis in the traditional Chinese medicine composition have the effects of clearing heat and detoxifying, clearing heat and drying dampness, and have certain anti-inflammatory effect; the honeysuckle has the effects of clearing heat and detoxifying and dispelling wind-heat, the ophiopogon has the effects of nourishing yin and generating fluid and moistening lung and clearing heart, the root of red peony has the effects of clearing heat and cooling blood and activating blood and resolving stasis, can achieve the effects of nourishing yin and activating blood and improving metabolism of the body, the radix codonopsitis has the effects of tonifying spleen and lung, nourishing blood and generating fluid, the jujube has the effects of tonifying middle and replenishing qi, nourishing blood and tranquilizing, can regulate immunity of the body, reduce stress of the cat and promote recovery of the disease. Thus, the cat stomatitis is controlled, and problems of decreased appetite, reduced weight, painful eating and lack of spirit of the cat caused by the stomatitis are improved.

The invention discloses a folium isatidis pet stomatitis spray and a preparation method thereof, and belongs to the technical field of pet supplies. The preparation method of the folium isatidis pet stomatitis spray comprises the following steps: A1, preparing a folium isatidis extract concentrated solution; a2, soybean protein isolate is mixed with the stevia rebaudiana extract, the folium isatidis extract concentrated solution and glycerin, and a water phase is prepared; a3, mixing sunflower seed oil, astaxanthin, curcumin and xanthophyll to prepare an oil phase; and A4, mixing and homogenizing the water phase and the oil phase to obtain the folium isatidis pet stomatitis spray. The prepared folium isatidis pet stomatitis spray is safe and non-irritant, and can effectively inhibit key pathogenic bacteria of pet stomatitis.

The invention belongs to the technical field of biological medicines, and particularly relates to application of fucoxanthin in preparation of a medicine for preventing and treating chemotherapy-induced stomatitis. Experiments show that the fucoxanthin has a protective effect on chemotherapeutic drugs and LPS-induced stomatitis, and specifically, the fucoxanthin has a protective effect on the stomatitis induced by the chemotherapeutic drugs and the LPS-induced stomatitis, and the expression quantity of barrier proteins Occludin and ZO-1 is increased; and the content of epithelial mesenchymal transition (EMT) related protein is reduced. The fucoxanthin is high in safety, wide in source, low in cost and very suitable for being applied to prevention and treatment of stomatitis. The invention not only provides a new drug source for the treatment of stomatitis, but also opens up a new field for the application of the fucoxanthin.

A curable composite material containing nanodiamonds, denture bases and other dental prosthetics made from the composite material and methods for treating dental stomatitis using these prosthetics.