55 results about "Mucositis" patented technology

Disclosed herein are methods and compositions for preventing or reducing adverse events associated with administration of a RAS(ON) inhibitors. Thus, disclosed are compositions and methods for treating or preventing RAS(ON) inhibitor therapy-associated rash or mucositis. The methods involve administering a compound that binds to cyclophilin A (CypA) to compete with a RAS(ON) inhibitor for CypA binding, thereby reducing tri-complex formation in non-tumor tissues. These approaches may improve the tolerability of RAS(ON) inhibitor therapies without compromising efficacy.

The invention relates to an adipose-derived stem cell and exosome composition for mucosal inflammation and an application of the adipose-derived stem cell and exosome composition. The composition is composed of a hybrid nano-vesicle and a pulsatilla chinensis exosome compound in a mass ratio of 1: 1. The hybrid nanovesicles are prepared by fusing adipose-derived stem cell exosomes and lipidosome and modifying honey polysaccharide, and the pulsatilla chinensis exosome compound is loaded with interleukin 23 peptidomimetic, polyethylene glycol, black scale quantum dots and camptothecin. The composition has the functions of efficient anti-inflammation, immunoregulation, precise targeting and tissue repair, and meanwhile, the curative effect is enhanced through photo-thermal synergistic treatment. The preparation method comprises the steps of exosome extraction by a density gradient centrifugation method, liposome fusion and surface modification. The composition is suitable for treating mucosal inflammation such as inflammatory bowel disease and oral mucositis, has the advantages of high stability, good biocompatibility and the like, and provides a safe and effective novel treatment strategy for clinic.

The invention discloses supramolecular hydrogel and microneedle patch for treating oral mucositis and a preparation method and application thereof, and belongs to the technical field of biological medicine, and the supramolecular hydrogel for treating oral mucositis comprises the following raw materials: guanosine, a potassium hydroxide solution containing metal ion soluble salt and phenylboronic acid lactone drugs. The raw material of the microneedle patch further comprises a water-soluble backing solution. The supramolecular hydrogel or microneedle patch for treating oral mucositis integrates antibacterial, anti-inflammatory, antioxidant and angiogenesis promoting functions, and has a remarkable effect of promoting healing of chemotherapeutic oral mucosal lesion.

The invention discloses a traditional Chinese medicine compound composition with an effect of preventing and treating radioactive injury as well as a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-15 parts of American ginseng, 3-6 parts of sea-buckthorn and 10-30 parts of rhizoma polygonati. The composition is proportioned and optimized according to the theory of treatment based on syndrome differentiation, and the medicines are combined to achieve the effects of tonifying qi, activating blood and nourishing yin. Clinical experiment results show that the traditional Chinese medicine compound composition provided by the invention has a remarkable effect of preventing and treating radioactive injury, particularly has a remarkable curative effect in the aspects of improving oral mucositis, dry mouth, weakness, sleep disorder and the like after radiotherapy, and is safe in clinical medication.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

The present invention relates to a method for preparing a coating composition comprising an anti-infective agent for the controlled release of said anti-infective agent, and to a coating composition or coated substrate obtainable by said method. Such coating compositions are particularly useful in the dental field for the treatment or prevention of inflammatory processes, such as mucositis or peri-implantitis, preferably peri-implantitis.

Mucoadhesive microgel compositions, which include an active agent (such as HB-EGF), are provided. Aspects of the invention include a microgel comprising a crosslinked poly(ethylene glycol) methyl ether methacrylate polymer comprising a mucoadhesive functionality. Also provided are methods of making and using the mucoadhesive microgel compositions, e.g., in therapeutic applications. In one embodiment, HB-EGF loaded mucoadhesive microgel compositions are provided, e.g., for prevention or treatment of mucositis conditions, such as therapy induced oral mucositis conditions.

Composition for use for the treatment and / or prevention of infections or lesions of the (oral) mucosa, in particular originating from at least one selected the group consisting of: perleche; scarlet fever; pharyngitis; acute necrotising ulcerative mucositis; impetigo contagiosa; chelitis glandularis apostem atosa; gingivostomatitis herpetica; herpes simplex; herpes stabistis recidivans; herpes zoster; hand-foot-mouth; human papilloma virus; HIV; oral candidiasis; oral lichen planus; lichen ruber planus; leukoplakia, erythroplakia; methicillin-resistant staphylococcus aureus; gingivitis / periodontitis; mucositis / peri- implantitis; alveolar osteolytis; wherein the composition comprises or consists of the following components: (a) polyhexanide (PHMB); (b) an organic or inorganic buffer different from a); (c) further additives; (d) optionally water.

A composition contains β-glucan and is used for preventing and / or treating hormone-dependent dermatitis, skin mucositis or other skin inflammatory diseases.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related oral mucositis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix rehmanniae recen, 6-12 parts of radix ophiopogonis, 6-12 parts of radix scrophulariae, 6-12 parts of honeysuckle, 6-12 parts of fructus forsythiae, 3-7 parts of radix scutellariae, 1-3 parts of lotus plumule, 3-7 parts of mint and 3-7 parts of borneol. The composition has the effects of nourishing yin, clearing heat, astringing sores and promoting tissue regeneration, and clinical tests prove that the composition can remarkably reduce the occurrence rate of chemotherapy-related oral mucositis of hematological malignancy patients, relieve the damage degree of oral mucosa, shorten the lasting time of ulcer and pain and effectively improve clinical symptoms of traditional Chinese medicine, and is high in safety.

The invention discloses an effective part for chemoradiotherapy-induced oral mucositis in traditional Chinese medicinal material white flower and a preparation process of the effective part. The effective part is identified as a flavonoid component through standard substance spectrogram comparison. Tests prove that the production process of the effective part is practical and feasible, and the total flavonoids in the finally obtained extracting solution are greater than or equal to 50%. Besides, pharmacodynamic studies show that the effective part has a remarkable bacteriostasis effect on staphylococcus aureus, escherichia coli and candida albicans, the bacteriostasis rate is larger than or equal to 80%, the effective part has a remarkable treatment effect on rat oral mucosa acute inflammation caused by chemoradiotherapy, and the application prospect of the effective part in the adaptation disease is shown.

Compositions and methods for treating cutaneous radiation injury (CRI), including radiation dermatitis, radiation proctopathy, or oral mucositis, utilizing one or more functional inhibitors of acid sphingomyelinase (FIASMA).

The invention relates to application of a composition taking taurine as a main active ingredient in preparation of a medicine for promoting mucous membrane healing. Water is used as a solvent, the taurine oral liquid contains 0.1 wt%-40wt% of taurine, 0.01 wt%-1wt% of amino acid, 0.01 wt%-0.5 wt% of vitamin, a protective agent, a bacteriostatic agent, a preservative, a swelling and pain relieving agent and the like. Through verification, the composition disclosed by the invention is prepared into oral spray, fine mist particles of 10-70 microns generated by a spray instrument show a good treatment effect on radiation-induced oral mucositis, and also have a good healing promoting effect on normal oral mucosa tissues after an alveolar surgery.

The invention discloses an oral mucositis prevention gargling device for a patient, and relates to the technical field of medical instruments, the oral mucositis prevention gargling device comprises a liquid storage unit composed of a first cylinder and a second cylinder; the liquid conveying pump is mounted at the inner bottom of the first cylinder body and is connected to the gargling spray head through a liquid conveying pipeline; wherein a sealing disc is arranged in the second cylinder body, and the sealing disc divides the interior of the second cylinder body into an upper functional chamber and a lower negative pressure chamber; the four-way pipe is mounted on a top plate of the second barrel; the negative pressure pump is mounted in the negative pressure cavity and connected to the first connector of the four-way pipe through a negative pressure pipeline; the partition plate is fixed to the top of the sealing disc and divides the functional cavity into a washing cavity on one side and a collecting cavity on the other side, through the designed backwashing device, backwashing can be conducted on a pipeline, accumulated impurities are removed, the pipeline is recovered to be smooth, the blocking risk is reduced, and the continuity of the treatment process is guaranteed.

Peptides and methods of use thereof, are disclosed for use in treating various disease and disorders, including inflammation, pain, oral mucositis, oral lesions, and cancer. The peptides modulate the activity of the transcription factor NF κB.

The invention relates to a compound medicine for treating oral mucositis caused by luconobutuzumab and a preparation method of the compound medicine, and the compound medicine realizes the comprehensive curative effects of resisting inflammation, easing pain and promoting mucosal repair through combination of traditional Chinese medicines and western medicines and synergism of multi-ethnic medicines. The compound medicine is prepared from the following components in parts by weight: 0.1 to 0.5 part of recombinant human epidermal growth factor, 0.5 to 2.0 parts of lidocaine, 0.01 to 0.1 part of vitamin B12, 1.0 to 5.0 parts of astragalus polysaccharide, 0.5 to 3.0 parts of honeysuckle chlorogenic acid, 0.2 to 1.5 parts of glycyrrhizic acid, 0.1 to 1.0 part of crocin, 0.3 to 2.0 parts of saussurea involucrata flavone, 0.2 to 1.8 parts of paris polyphylla saponin and 0.4 to 2.5 parts of sculellaria barbata flavone. The compound provided by the invention is suitable for tumor patients receiving treatment of luconatobutuzumab, is especially suitable for patients suffering from I-III grade oral mucositis, can be used as a hospital preparation or new drug development, and has wide clinical application and market prospects.

The present invention relates to superoxide dismutase, and uses thereof for preventing or treating mucositis. The superoxide dismutase according to the present invention can be effectively used for treating or improving the inhibition of a proliferation of mucous epithelium cells, which is a side effect of anticancer agents or radiotherapy.

The present application relates to a kind of traditional Chinese medicine composition for treating oral mucositis caused by radiotherapy and chemotherapy, the traditional Chinese medicine composition is composed of effective component and medically acceptable auxiliary materials, characterized in that, the effective component is made of the following weight percentage of raw medicinal materials: Shihuchu 33-41%, Shengdi 20-24%, Maidong 20-24%, Shengancao 17-20%.The traditional Chinese medicine composition described in the present application has the effect of benefiting stomach, generating fluid, nourishing yin and clearing heat, and the effect of treating oral mucositis caused by radiotherapy and chemotherapy is remarkable.

The application belongs to the technical field of biological medicine, and discloses a kind of pharmaceutical composition for oral mucositis and preparation method thereof.The pharmaceutical composition is composed of traditional Chinese medicine extract component 55~70wt% and chemical component 30~45wt%, traditional Chinese medicine extract component is composed of white and extract 30~44wt%, Huangqin extract 20~28wt%, Huangqi extract 15~22wt%, Huanglian extract 8~15wt%, borneol 3~5wt%, and chemical component is composed of sodium hyaluronate 25~38wt%, D-panthenol 22~30wt%, allantoin 18~25wt%, dipotassium glycyrrhizinate 15~22wt%.The traditional Chinese medicine extract component in the application follows the compatibility principle of monarch, minister, assistant and messenger, and has integrated treatment effect of anti-inflammatory, repair, pain relief and infection prevention after being matched with chemical component, can significantly reduce the level of inflammation factor of oral mucositis, and significantly shorten the healing time of oral mucositis.

The invention provides an oral mucositis cryotherapy apparatus, and belongs to the technical field of oral mucositis cryotherapy. In order to solve the problems that in the prior art, the cold compress effect is poor, cooling liquid is inconvenient to recycle, and conditions before and after cold compress are difficult to check, the cold compress therapeutic apparatus comprises a therapeutic apparatus body, a storage battery and a control panel, the storage battery and the control panel are arranged in the therapeutic apparatus body, and a button is installed on the upper surface of the control panel. A semiconductor chilling plate is attached to the lower surface of the cooling bin, and a threaded rod is rotationally connected into the therapeutic apparatus body. The oral mucositis cold compress device plays an auxiliary and convenient role in oral mucositis cryotherapy, can be quickly adjusted, and monitors the cold compress temperature and effect during oral mucositis cryotherapy.

A method of treating acne, of treating UV or radiation induced injury, of reducing the appearance of scars, and / or of treating mucositis, including topically applying a composition including CAPE to a human or other mammal in need thereof, in a therapeutically effective amount and / or from about 1% to about 50% CAPE by weight.

This application relates to the field of nanomedicine technology, and in particular to a selenium-containing nanoparticle, its preparation method, and its application in drugs for treating inflammatory mucosal diseases. The selenium-containing nanoparticle has a core comprising zero-valent selenium or ferrous selenide, and a shell comprising at least one of polyserotonin, dopamine, and sodium alginate; the two are bonded together by C-Se covalent bonds to form a stable organic-inorganic nanocomposite. This selenium-containing nanoparticle overcomes the bottlenecks of traditional selenium nanoparticles, such as easy aggregation and poor retention, and achieves synergistic enhancement of antioxidant, anti-inflammatory, and antibacterial functions. When applied to the treatment of inflammatory mucosal diseases, it can effectively treat inflammatory mucosal diseases in complex environments, such as oral mucositis, based on the "seed-soil" synergistic treatment concept, by synergistically regulating the triple mechanism of "epithelial cells (seeds)," "immune microenvironment (soil)," and "local flora."

The invention relates to the technical field of nursing knowledge base construction, in particular to a construction method of a chemotherapy-related oral mucositis nursing knowledge base. The method comprises the steps of firstly obtaining a knowledge base and access data; further obtaining an initial index weight according to the recent access trend and the total access frequency of each keyword in combination with the distribution of the keywords in the clinical nursing data; further obtaining nursing pertinence according to the difference between clinical nursing data related to each keyword in combination with a recovery effect; and finally, fusing the initial index weight and nursing pertinence to obtain a final index weight of each keyword. According to the scheme, the keyword index weight is dynamically optimized by fusing the universality, the timeliness and the nursing pertinence of the keywords, wide requirements and individual curative effects are considered, hot low-efficiency word deficiency is avoided, and the retrieval accuracy and the application value of the database are improved.

The utility model relates to the technical field of oral cavity cooling, in particular to a cooling device for preventing and treating radiation-induced oral mucositis, which comprises a heat conducting seat, a heat conducting cavity is arranged in the heat conducting seat, a heat conducting pipe is mounted in the heat conducting cavity, and an extension plate is fixed on one side of the heat conducting seat; the dismounting mechanism is located between the heat conduction pipe and the heat conduction seat, and the dismounting mechanism comprises a protection assembly, a connection assembly, a circulation assembly and a control assembly; through the arrangement of the disassembly and assembly mechanism, the heat conduction pipe and the cooling seat can be separated, the heat conduction pipe is convenient to disassemble, a heat conduction cavity in the heat conduction seat is convenient to maintain and clean, and the condition of accumulation of bacteria or viruses is avoided, so that the risk of infection is reduced, and the flexibility of the device is greatly improved; and meanwhile, the problem that a heat conduction pipe in a traditional device is inconvenient to maintain and repair is solved, when the heat conduction pipe is damaged, the whole device does not need to be replaced, and the use cost is saved.

The invention discloses application of a prognosis nutritional index in preparation of an amitinib-related oral mucositis risk assessment kit, and relates to the technical field of medical diagnosis and risk assessment. The invention provides an application of a prognosis nutritional index in preparation of an amitinib-related oral mucositis risk assessment kit. The prognosis nutrition index is divided into four quartile intervals: Q1 (10.10 to 46.90), Q2 (46.91 to 50.65), Q3 (50.66 to 55.20) and Q4 (55.21 to 320.80). Large sample retrospective analysis proves that the PNI and the amitinib related oral mucositis risk are in significant negative correlation, the OM risk is reduced by about 1% every time the PNI is increased by 1 unit, stability is kept in multi-factor regression, tendency score matching and subgroup analysis, and the risk assessment accuracy is high. The method is high in clinical applicability, low in cost, easy and convenient to operate and suitable for primary hospitals and high-load medical environments, and the PNI is calculated based on conventional blood detection indexes.

The present application relates to the technical field of medical dressings, in particular to an external use gel for preventing oral mucositis caused by chemotherapy, and a preparation method, which adopts a combination of catechol group modified polymers and an acidic anti-crosslinking system, and through the dual inhibition of catechol group oxidation by acidic pH and antioxidants in a brown bottle, the gel is stored as a flowable liquid for a long time, after being sprayed to the oral cavity, the catechol group is triggered to rapidly oxidize and crosslink, forming a solid gel film, which physically protects the oral ulcer site, and cooperates with a heat conduction functional system to greatly improve the heat conduction performance of the gel, enabling the cold quantity of cryotherapy to be uniformly transmitted to the superficial tissue of the oral mucosa, without the need for the tongue to push the ice block to move, thereby reducing the pain of the patient, and solving the problem of uneven cooling of existing cryotherapy.

The invention belongs to the field of biological medicine, and particularly relates to a curcumin compound, a preparation method, application and a pharmaceutical composition of the curcumin compound. The curcumin compound (Cur-VE-Zn) is prepared, and the solubility of the curcumin-Zn compound can be improved and the toxicity of the curcumin-Zn compound can be reduced by adding vitamin E or a derivative thereof, so that the Cur-VE-Zn is low in cytotoxicity and good in biological safety; according to the curcumin compound disclosed by the invention, the effect of treating radiation-induced oral mucositis is achieved by removing active oxygen, relieving inflammatory response, promoting mucosal repair and reducing DNA damage. The curcumin compound is used as a main component to prepare the temperature-sensitive hydrogel, the medicine utilization rate is increased, targeted delivery of the curcumin compound in the oral mucosa is achieved, a better treatment effect is further shown, a new strategy is provided for treatment of radiation-induced oral mucositis, and the hydrogel has good application prospects.

The invention provides ruthenium-curcumin-based nano-enzyme, a preparation method thereof and application of the ruthenium-curcumin-based nano-enzyme in radiation-induced oral mucositis, and belongs to the technical field of biological medicine. The method comprises the following steps: mixing a ruthenium source methanol solution and a dispersant methanol solution to obtain a ruthenium source dispersion liquid; and mixing the ruthenium source dispersion liquid, curcumin and o-phenylenediamine, carrying out a self-assembly reaction under a stirring condition, and carrying out solid-liquid separation and dialysis to obtain the ruthenium-curcumin-based nano-enzyme. Experiments prove that the ruthenium-curcumin-based nano-enzyme has SOD, CAT, OH and O2 <-> removal performance, inhibits endoplasmic reticulum stress and reduces mitochondrial calcium overload, so that oxidation circulation from endoplasmic reticulum to mitochondria is blocked, and radiation-induced oral mucositis is treated.

The invention relates to the field of biomedical materials, and discloses injectable self-healing hydrogel for treating radiation-induced oral ulceration as well as a preparation method and application of the injectable self-healing hydrogel. The hydrogel provided by the invention is OCC / CDots / EGCG composite hydrogel, the OCC basic hydrogel is used as a carrier, and Vc-PEI-CDots and EGCG are loaded through a process. The composite hydrogel has an injectable characteristic, has strong antibacterial and in-vitro oxidation resistance, and has a remarkable healing promoting function. Animal experiments show that the hydrogel can effectively promote RIOM wound healing, the expression is epithelial continuous recovery, cell apoptosis reduction, and up-regulation of expression of migration promoting protein VIM and key antioxidant enzyme GPX3 in tissues, and a novel and efficient biomedical material selection is provided for treatment of clinical radiation-induced oral ulcerative mucositis.