74 results about "Mucositis" patented technology

Disclosed herein are methods and compositions for preventing or reducing adverse events associated with administration of a RAS(ON) inhibitors. Thus, disclosed are compositions and methods for treating or preventing RAS(ON) inhibitor therapy-associated rash or mucositis. The methods involve administering a compound that binds to cyclophilin A (CypA) to compete with a RAS(ON) inhibitor for CypA binding, thereby reducing tri-complex formation in non-tumor tissues. These approaches may improve the tolerability of RAS(ON) inhibitor therapies without compromising efficacy.

The invention relates to the technical field of data processing, in particular to a risk prediction model construction method for oral mucositis nursing, and the method comprises the steps: obtaining the data of all patients seeing a doctor; according to each risk factor of the patient under all the risk levels, obtaining an influence degree of the risk factor on the assessment risk level, and screening out a key risk factor of each risk level; according to the influence degree of each risk factor on all the assessment risk levels, the importance degree of each risk factor is obtained, and all important risk factors are screened out; and according to the key risk factors and the important risk factors of each risk level, constructing an oral mucositis risk prediction model. According to the method, the oral mucositis risk prediction model is constructed by analyzing historical patient data, so that the severity of the oral mucositis of the patient after chemotherapy is accurately predicted, and corresponding prevention and nursing are provided for the patient.

The invention belongs to the technical field of medical materials, and discloses an external gel material for treating oral mucositis and a preparation method of the external gel material. The gel is temperature-sensitive slow-release antibacterial gel, adopts safe components, has a temperature-sensitive characteristic, is in a sol state in a low-temperature state, is convenient to smear, can be converted into a gel state when the temperature is close to the body temperature of a human body, can be tightly attached to an oral mucosa, is good in adhesiveness to the oral mucosa, can also slowly release drugs, and has relatively strong antibacterial performance; the repair and regeneration of oral mucosa epithelial tissues can be promoted. The gel can effectively act on the treatment process of oral diseases, is also suitable for daily oral care, and provides guarantee for oral health.

The invention relates to an adipose-derived stem cell and exosome composition for mucosal inflammation and an application of the adipose-derived stem cell and exosome composition. The composition is composed of a hybrid nano-vesicle and a pulsatilla chinensis exosome compound in a mass ratio of 1: 1. The hybrid nanovesicles are prepared by fusing adipose-derived stem cell exosomes and lipidosome and modifying honey polysaccharide, and the pulsatilla chinensis exosome compound is loaded with interleukin 23 peptidomimetic, polyethylene glycol, black scale quantum dots and camptothecin. The composition has the functions of efficient anti-inflammation, immunoregulation, precise targeting and tissue repair, and meanwhile, the curative effect is enhanced through photo-thermal synergistic treatment. The preparation method comprises the steps of exosome extraction by a density gradient centrifugation method, liposome fusion and surface modification. The composition is suitable for treating mucosal inflammation such as inflammatory bowel disease and oral mucositis, has the advantages of high stability, good biocompatibility and the like, and provides a safe and effective novel treatment strategy for clinic.

The invention discloses supramolecular hydrogel and microneedle patch for treating oral mucositis and a preparation method and application thereof, and belongs to the technical field of biological medicine, and the supramolecular hydrogel for treating oral mucositis comprises the following raw materials: guanosine, a potassium hydroxide solution containing metal ion soluble salt and phenylboronic acid lactone drugs. The raw material of the microneedle patch further comprises a water-soluble backing solution. The supramolecular hydrogel or microneedle patch for treating oral mucositis integrates antibacterial, anti-inflammatory, antioxidant and angiogenesis promoting functions, and has a remarkable effect of promoting healing of chemotherapeutic oral mucosal lesion.

Peptides and methods of use thereof, are disclosed for use in treating various diseases and disorders, including inflammation, pain, oral mucositis, oral lesions, and cancer. The peptides modulate the activity of the transcription factor NF κB.

The invention discloses a traditional Chinese medicine compound composition with an effect of preventing and treating radioactive injury as well as a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-15 parts of American ginseng, 3-6 parts of sea-buckthorn and 10-30 parts of rhizoma polygonati. The composition is proportioned and optimized according to the theory of treatment based on syndrome differentiation, and the medicines are combined to achieve the effects of tonifying qi, activating blood and nourishing yin. Clinical experiment results show that the traditional Chinese medicine compound composition provided by the invention has a remarkable effect of preventing and treating radioactive injury, particularly has a remarkable curative effect in the aspects of improving oral mucositis, dry mouth, weakness, sleep disorder and the like after radiotherapy, and is safe in clinical medication.

The invention discloses a construction method of a leukemia patient hematopoietic stem cell transplantation concurrent oral mucositis risk prediction model, which comprises the following steps: estimating a sample size by adopting an EPV principle, and collecting enough acute leukemia patients for hematopoietic stem cell transplantation treatment cases, basic information, clinical symptoms, hematology indexes and outcome indexes including cases are collected, data arrangement and statistical analysis are carried out by using SAS9.4, risk factors are obtained, and Plt; and the risk factor variable of 0.05 is incorporated into a multi-factor Cox regression model, a risk prediction model is constructed, and visualization is realized. Through verification, the model is stable. The data source of the model has the characteristics of being easy to obtain, objective in index and small in influence on patients, and the model is more suitable for clinical first-line medical staff to monitor oral mucositis.

The invention discloses a traditional Chinese medicine compound for preventing or treating digestive tract mucositis caused by targeted drugs, which is prepared from the following components in parts by weight: 2-4 parts of fructus evodiae, 5-7 parts of marmor serpentinatum, 5-7 parts of geranium wilfordii, 5-7 parts of persimmon frost and 2-4 parts of rhizoma kaempferiae, preferably 3: 6: 6: 6: 3. The preparation method is water decoction and concentration. The compound has the effects of eliminating cold to stop pain, supporting yang to stop diarrhea, dispersing blood stasis, stopping bleeding and the like, obviously reduces the index of diarrhea caused by TKI and the score of oral mucositis, and is suitable for complication management of targeted therapy of NSCLC patients in the stage IV. An orthogonal test verifies scientificity of the formula, and the formula has safety and effectiveness.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

The present invention relates to a method for preparing a coating composition comprising an anti-infective agent for the controlled release of said anti-infective agent, and to a coating composition or coated substrate obtainable by said method. Such coating compositions are particularly useful in the dental field for the treatment or prevention of inflammatory processes, such as mucositis or peri-implantitis, preferably peri-implantitis.

The invention relates to the technical field of medicine, in particular to polypeptide and application thereof in preparation of medicine for treating oral mucosa diseases. The polypeptide disclosed by the invention can be used for treating recurrent aphthous oral ulceration and oral mucositis caused by anti-tumor treatment. The polypeptide disclosed by the invention has a remarkable treatment effect, can promote ulcer healing, and is dose-dependent and time-dependent; the polypeptide is high in safety, a degradation product is natural amino acid, and the polypeptide has a wide application prospect.

Mucoadhesive microgel compositions, which include an active agent (such as HB-EGF), are provided. Aspects of the invention include a microgel comprising a crosslinked poly(ethylene glycol) methyl ether methacrylate polymer comprising a mucoadhesive functionality. Also provided are methods of making and using the mucoadhesive microgel compositions, e.g., in therapeutic applications. In one embodiment, HB-EGF loaded mucoadhesive microgel compositions are provided, e.g., for prevention or treatment of mucositis conditions, such as therapy induced oral mucositis conditions.

Composition for use for the treatment and / or prevention of infections or lesions of the (oral) mucosa, in particular originating from at least one selected the group consisting of: perleche; scarlet fever; pharyngitis; acute necrotising ulcerative mucositis; impetigo contagiosa; chelitis glandularis apostem atosa; gingivostomatitis herpetica; herpes simplex; herpes stabistis recidivans; herpes zoster; hand-foot-mouth; human papilloma virus; HIV; oral candidiasis; oral lichen planus; lichen ruber planus; leukoplakia, erythroplakia; methicillin-resistant staphylococcus aureus; gingivitis / periodontitis; mucositis / peri- implantitis; alveolar osteolytis; wherein the composition comprises or consists of the following components: (a) polyhexanide (PHMB); (b) an organic or inorganic buffer different from a); (c) further additives; (d) optionally water.

A composition contains β-glucan and is used for preventing and / or treating hormone-dependent dermatitis, skin mucositis or other skin inflammatory diseases.

The invention relates to the technical field of oral cavity and skin health care, and particularly discloses a cream for promoting oral mucosa skin healing, the cream comprises the following raw materials by weight: 5-10% of a functional component, 5-10% of a repairing component, 5-8% of an emulsifier, 3-5% of a stabilizer, 20-30% of a matrix, and the balance deionized water; the functional component comprises a kiwi fruit extracting solution; the repairing component comprises hyaluronic acid; the emulsifier is mixed stearate; the technical problems that an existing cream is single in function, and complex requirements of multiple stages and multiple targets in the oral mucosa and skin healing process are difficult to meet at the same time are solved; the obtained cream can be simultaneously suitable for healing of skin and oral mucosa, and is suitable for healing of skin wounds such as burns, scalds, scratches and the like; treating dermatitis, eczema and other skin inflammations; the traditional Chinese medicine composition can be used for treating oral mucosa such as oral ulcer, oral mucositis, thrush, erosive oral lichen planus and the like, and has a wide application prospect.

Compositions and methods for treating cutaneous radiation injury (CRI), including radiation dermatitis, radiation proctopathy, or oral mucositis, employing one or more functional inhibitor of acid sphingomyelinase (FIASMA).

The invention belongs to the technical field of medicines, and particularly relates to an agaricus blazei murill extract and application thereof in treating intestinal mucositis. The invention provides application of an agaricus blazei murill extract FA-2-b-beta in preparation of a medicine for preventing, treating and / or relieving intestinal mucositis. The FA-2-b-beta can obviously improve 5-FU induced intestinal mucositis, obviously promote human intestinal epithelial cell proliferation, recover intestinal barriers and resist toxic and side effects of chemotherapy.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related oral mucositis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix rehmanniae recen, 6-12 parts of radix ophiopogonis, 6-12 parts of radix scrophulariae, 6-12 parts of honeysuckle, 6-12 parts of fructus forsythiae, 3-7 parts of radix scutellariae, 1-3 parts of lotus plumule, 3-7 parts of mint and 3-7 parts of borneol. The composition has the effects of nourishing yin, clearing heat, astringing sores and promoting tissue regeneration, and clinical tests prove that the composition can remarkably reduce the occurrence rate of chemotherapy-related oral mucositis of hematological malignancy patients, relieve the damage degree of oral mucosa, shorten the lasting time of ulcer and pain and effectively improve clinical symptoms of traditional Chinese medicine, and is high in safety.

The present invention relates to the field of medical technology, and discloses the use of aconite polysaccharide in the preparation of drugs for treating inflammatory bowel disease and intestinal mucositis. The present invention conducts a series of studies on aconite polysaccharide using a mouse model, and finds that aconite polysaccharide can significantly improve the intestinal microbial diversity of mice, and at the same time, can improve intestinal flora disorder and make it tend to normal, and provides a new use of aconite polysaccharide-the use in the preparation of drugs for treating inflammatory bowel disease and intestinal mucositis. For example, aconite polysaccharide is used for drug treatment of ulcerative colitis mouse model and 5-Fu-induced intestinal mucositis mouse model, and both can significantly improve their pathological damage.

The invention discloses dendrobium huoshanense compound granules as well as a preparation method and a quality detection method thereof, and belongs to the technical field of traditional Chinese medicine preparations. Dendrobium huoshanense, radix rehmanniae recen, radix ophiopogonis and liquorice are used as a formula, granules are selected as a medicine carrying form, the advantages of maintaining property and flavor tropism of each medicine, mainly treating functions, being relatively large in medicine carrying capacity, easy to dissolve, quick in effect taking and simple and convenient in process are exerted, and a decoction process, a concentration drying process and a granulation process in pharmacy are optimized; the preparation method which is simple and convenient in granulation, high in yield and high in stability is obtained, and the obtained compound granules are uniform in granules, small in angle of repose and relatively good in flowability. Quality control experiment results show that the dendrobium huoshanense compound granules prepared according to the preparation method provided by the invention are high in content of effective components such as total flavonoids and rehmannia D, the process is stable, and technical support is provided for treatment of oral mucositis.

The invention discloses an effective part for chemoradiotherapy-induced oral mucositis in traditional Chinese medicinal material white flower and a preparation process of the effective part. The effective part is identified as a flavonoid component through standard substance spectrogram comparison. Tests prove that the production process of the effective part is practical and feasible, and the total flavonoids in the finally obtained extracting solution are greater than or equal to 50%. Besides, pharmacodynamic studies show that the effective part has a remarkable bacteriostasis effect on staphylococcus aureus, escherichia coli and candida albicans, the bacteriostasis rate is larger than or equal to 80%, the effective part has a remarkable treatment effect on rat oral mucosa acute inflammation caused by chemoradiotherapy, and the application prospect of the effective part in the adaptation disease is shown.

Compositions and methods for treating cutaneous radiation injury (CRI), including radiation dermatitis, radiation proctopathy, or oral mucositis, utilizing one or more functional inhibitors of acid sphingomyelinase (FIASMA).

The invention relates to application of a composition taking taurine as a main active ingredient in preparation of a medicine for promoting mucous membrane healing. Water is used as a solvent, the taurine oral liquid contains 0.1 wt%-40wt% of taurine, 0.01 wt%-1wt% of amino acid, 0.01 wt%-0.5 wt% of vitamin, a protective agent, a bacteriostatic agent, a preservative, a swelling and pain relieving agent and the like. Through verification, the composition disclosed by the invention is prepared into oral spray, fine mist particles of 10-70 microns generated by a spray instrument show a good treatment effect on radiation-induced oral mucositis, and also have a good healing promoting effect on normal oral mucosa tissues after an alveolar surgery.

The invention discloses an oral mucositis prevention gargling device for a patient, and relates to the technical field of medical instruments, the oral mucositis prevention gargling device comprises a liquid storage unit composed of a first cylinder and a second cylinder; the liquid conveying pump is mounted at the inner bottom of the first cylinder body and is connected to the gargling spray head through a liquid conveying pipeline; wherein a sealing disc is arranged in the second cylinder body, and the sealing disc divides the interior of the second cylinder body into an upper functional chamber and a lower negative pressure chamber; the four-way pipe is mounted on a top plate of the second barrel; the negative pressure pump is mounted in the negative pressure cavity and connected to the first connector of the four-way pipe through a negative pressure pipeline; the partition plate is fixed to the top of the sealing disc and divides the functional cavity into a washing cavity on one side and a collecting cavity on the other side, through the designed backwashing device, backwashing can be conducted on a pipeline, accumulated impurities are removed, the pipeline is recovered to be smooth, the blocking risk is reduced, and the continuity of the treatment process is guaranteed.

The invention belongs to the field of animal models, and particularly relates to a zebrafish embryo model for 5-FU side effect research and a construction method and an evaluation method thereof. The construction method comprises the following steps: selecting zebrafish embryos for later use; and putting the zebrafish embryo into a culture hole, and then adding 5-FU for modeling treatment, thereby finishing the construction of the zebrafish embryo model for 5-FU side effect research. The 5-FU induced intestinal mucositis model is constructed by adopting a 3-5-day zebrafish embryo and analyzing information such as the survival rate, the travel trajectory, the intestinal morphology and ROS fluorescent living imaging of zebrafish, and the 5-FU induced intestinal mucositis model has the advantages of being simple in observation index, easy to observe, simple to operate, capable of saving operation time, convenient, rapid, high in efficiency and the like. The method has the characteristics of simple operation, high cost, cheaper mouse model, qualitative and quantitative properties and the like, and is suitable for high-throughput screening of 5-FU induced intestinal mucositis model drugs.

In particular, methods for treating inflammatory dysfunction of the oral mucosa are provided herein that include the step of topically administering an effective amount of riciniferatoxin (RTX). This disclosure is aimed at meeting this need and / or providing other benefits. A method of topically administering RTX to a subject in need thereof for treating inflammatory dysfunction of the oral mucosa is provided herein. This disclosure is based in part on the recognition that oral topical administration of RTX for treating inflammatory dysfunction of the oral mucosa can not only provide effective pain relief, but also treat the underlying neurogenic inflammation.

The invention discloses a gargle administration device for radiation-induced oral mucositis mice, which is characterized by comprising an operation table, a mouse fixing mechanism is arranged on one side of the table top of the operation table, and a mouse administration mechanism is arranged on the other side of the operation table; a mouse opening mechanism is arranged in the middle of the operation table and located between the mouse fixing mechanism and the drug delivery mechanism; the mouse mouth opening mechanism comprises a pair of mouth opening pliers capable of adjusting the mouth opening degree and fixing the mouth opening degree, the mouse drug delivery mechanism comprises a mouthwash drug delivery pipe and a negative pressure suction pipe, and the mouthwash drug delivery pipe and the negative pressure suction pipe can be subjected to angle and height adjustment through an adjusting mechanism. The mouse fixing mechanism and the mouse mouth opening mechanism can stably fix a mouse, meanwhile, the mouth opening clamp is adopted to open the oral cavity of the mouse, and therefore the automatic drug delivery process without manually fixing the mouse by an experimenter is achieved. The consistency and accuracy of operation are improved, and the risk that an experimenter is bitten is reduced.

Peptides and methods of use thereof, are disclosed for use in treating various disease and disorders, including inflammation, pain, oral mucositis, oral lesions, and cancer. The peptides modulate the activity of the transcription factor NF κB.

The invention relates to a compound medicine for treating oral mucositis caused by luconobutuzumab and a preparation method of the compound medicine, and the compound medicine realizes the comprehensive curative effects of resisting inflammation, easing pain and promoting mucosal repair through combination of traditional Chinese medicines and western medicines and synergism of multi-ethnic medicines. The compound medicine is prepared from the following components in parts by weight: 0.1 to 0.5 part of recombinant human epidermal growth factor, 0.5 to 2.0 parts of lidocaine, 0.01 to 0.1 part of vitamin B12, 1.0 to 5.0 parts of astragalus polysaccharide, 0.5 to 3.0 parts of honeysuckle chlorogenic acid, 0.2 to 1.5 parts of glycyrrhizic acid, 0.1 to 1.0 part of crocin, 0.3 to 2.0 parts of saussurea involucrata flavone, 0.2 to 1.8 parts of paris polyphylla saponin and 0.4 to 2.5 parts of sculellaria barbata flavone. The compound provided by the invention is suitable for tumor patients receiving treatment of luconatobutuzumab, is especially suitable for patients suffering from I-III grade oral mucositis, can be used as a hospital preparation or new drug development, and has wide clinical application and market prospects.