60 results about "Oral lichen planus" patented technology

The invention discloses a pharmaceutical composition for treating oral lichen planus, which is prepared from the following raw materials in parts by weight: 10-60 parts of rhizoma anemarrhenae, 5-50 parts of phellodendron bark, 5-50 parts of radix rehmanniae preparata, 5-50 parts of cornel, 3-30 parts of Chinese yam and 3-30 parts of rhizoma alismatis. The invention also discloses a preparation method and application of the pharmaceutical composition. The pharmaceutical composition has the advantages of novel formula, simple components, low cost, obvious curative effect, no toxic or side effect, low tendency to generating tolerance and the like, and provides a new medicine option for clinically treating patients with oral lichen planus.

The invention relates to mouthwash prepared in a Chinese medical formula, and has the functions of replenishing qi, strengthening the spleen, tonifying the kidney, soothing the nerves, clearing the heat, detoxicating, clearing the damp, reducing the cellular immune response, the capillary permeability and the inflammatory exudates, and improving the immunity of the organism. The invention has the advantages of good treatment effect, high cure rate and no recurrence fundamentally; and the oral drug not only has good preventive effect, but also has good therapeutic effect.

The invention discloses a biological type drug membrane and a preparation method thereof. The main components of the biological type drug membrane are leaven and additives including film-forming material, plasticizer, aromatic and so on. The making process flow of the drug membrane is as follows: firstly the slurry of the film-forming material is prepared; inactivated leaven and the additives are added and evenly mixed, and then the processes of deaeration, coating, drying, deciduation and packing are carried out. Compared with the prior art, by adopting the leaven as the main component, the drug membrane not only plays a role of protecting a wound surface but also improves the nutrient metabolism of oral mucosa, protects various cell injuries and enhances body immunity. In addition, the drug membrane has the characteristics of small volume and light weight and is also more convenient for being easy to be packed, stored, transported, carried over and used. The biotype-drug membrane is mainly used for treating various congestion, erosion and ulcerous lesion. And the biological type drug membrane has good effect on treating recurring Aphthous ulcer and oral lichen planus (congestive and erosive type).

The invention provides a single preparation and compound preparation using halometasone as main constituent. The weight ratio of halometasone in pharmaceuticals is 0.0001-50%. The pharmaceuticals can be made into jellies, supensoid agent, liquor and pulvis, and the like, which are administrated in a percutaneous way. The preparation is suitable for dermatitis, eczema, vitligo, psoriasis, hives, rhinitis, lupus sebaceous, lichen planus and asthma, etc. The invention has the advantages of high healing rate, high safety and high promotional value.

The invention relates to a Chinese traditional medicine composition for treating stomatitis, which consists of the following Chinese herbal medicine materials in part by weight: 8 to 9 parts of honeysuckle flower, 8 to 12 parts of plaster stone, 4 parts of natural indigo, 4 parts of borneol, 3 to 9 parts of coptis root, 4 parts of frankincense and 3 to 7 parts of Chinese angelica. The invention can treat various forms of stomatitis, including ulcerous stomatitis, herpetic stomatitis, mycotic stomatitis, oral lichen planus and the like, and has a remarkable curative effect. In particular, the invention has the best curative effect on ulcerous stomatitis. Meanwhile, the Chinese traditional medicine composition also has a remarkable curative effect on body surface ulcers, bedsore, diabetic foot ulcers, erosion and wounds. The invention has the advantages of low cost, cheapness, safety, reliability, convenient use and remarkable effect, and is popular with patients.

The invention relates to a drug for treating oral lichen planus, and particularly relates to a traditional Chinese medicine composition made of a plant Chinese herbal medicine as a raw material for treating oral lichen planus. The traditional Chinese medicine composition is characterized by comprising the following crude drugs by weight: 13-19g of honeysuckle, 13-19g of astragalus membranaceus, 10-15g of curcuma zedoary, 10-15g of ligusticum wallichii, 10-15g of coptidis rhizome, 10-15g of caulis sargentodoxae, 10-15g of pinellia ternate, 15-25g of codonopsis pilosula, 3-9g of typhae pollen, and 3-9g of radix glycyrrhizae. The traditional Chinese medicine composition has the beneficial effects that each component of the traditional Chinese medicine adopts a natural traditional Chinese medicine material, so that the traditional Chinese medicine composition is simple in configuration, wide in drug source, and low in cost, has a synergistic effect in drug effect, has the effects of invigorating the spleen and replenishing qi, clearing heat and eliminating dampness, clearing away heat and toxic materials, activating blood circulation and removing blood stasis, dispelling wind and relieving pain and the like, and is significant in effect on treatment of the oral lichen planus.

The invention discloses a traditional Chinese medicine preparation for treating oral mucosa lesions. The traditional Chinese medicine preparation consists of the following raw materials in parts by weight: 10-100 parts of scutellaria baicalensis, 8-80 parts of ligusticum wallichii, 8-80 parts of Angelica sinensis, 8-80 parts of jasmine, 5-60 parts of radix rehmanniae recen, 5-60 parts of semen plantaginis, 5-60 parts of radix curcumae, 5-60 parts of allium macrostemon, 3-30 parts of radix bupleuri, 3-30 parts of felwort and 3-30 parts of codonopsis pilosula. The invention further discloses a preparation method and an application of the traditional Chinese medicine preparation. The experiment proves that the traditional Chinese medicine preparation has good clinical treatment effects on patients suffering from oral mucosa lesions such as oral lichen planus and dental ulcer. The traditional Chinese medicine preparation disclosed by the invention is novel in formula and simple in composition, the price of each main drug is low, the administration cost is low, and the preparation method is easy to operate and controllable in quality and can be suitable for industrial production.

The invention relates to a traditional Chinese medicinal composition for treating oral lichen planus and an application. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 8-16 parts of root of pilose asiabell, 8-16 parts of paniculate swallowworf root, 8-16 parts of plantago asiatica, 20-30 parts of coix seed, 20-30 parts of peach seed, 20-30 parts of yam, 12-20 pars of garter snake and 12-20 pars of rhizoma bletillae. The traditional Chinese medicinal composition provided by the invention has an obvious curative effect of treating oral lichen planus and is high in safety.

The invention belongs to the field of articles of everyday use, and particularly provides toothpaste for preventing and treating oral ulcer as well as a preparation method and application thereof. Thetoothpaste is prepared from an extract of three drugs of herba taraxaci, herba corydalis bungeanae and radix isatidis, a galla chinensis extract, a radix scutellariae extract, a herba clinopodii chinensis extract, a radix ophiopogonis extract, tranexamic acid, allantoin, an accessory and purified water. The toothpaste for preventing and treating the oral ulcer, which is provided by the invention,can be used for effectively treating and/or preventing a recurrent aphthous ulcer and oral lichen planus, and moreover, has favorable stability and foamability.

Oral lichen planus (OLP) is an immunologic disease which can be controlled and cleared by topical application of a composition of triamcinolone acetonide 0.1% and retinoic acid 0.05% in Orabase® on the affected areas of the mucosa, thrice daily for three weeks. The combined therapy is more effective than triamcinolone acetonide alone in Orabase®. By this method, clearance can be maintained by less frequent application or lower concentrations of the composition.

The invention relates to an oral mucosal disease recognition method based on deep learning multi-feature fusion. The method can be used for diagnosing and recognizing oral leukoplakia, oral lichen planus, oral cancer and recurrent oral ulceration, the diagnosis efficiency is improved, and the recognition accuracy is improved. According to the specific scheme, the method comprises the following steps: (1) collecting an oral mucosal disease image through a camera under white light; (2) preprocessing the collected images, (3) extracting texture features of four oral diseases by using a gray level co-occurrence matrix GLCM algorithm, and extracting bottom features of shapes and colors from HOG and HSV images by using a neural network model; (4) performing extraction of high-level features of the RGB image by using an Officientnet network model; (5) performing feature selection by using a Pearson coefficient in combination with a random forest algorithm, and selecting features having a larger relationship with a target value; (6) carrying out classification identification to train the training set; and (7) performing test verification on the trained model by using the divided test set image.

The invention provides an auxiliary marker for identifying diseases. The auxiliary marker consists of decanoyl carnitine, cysteine and bile acid. The invention also provides a construction method of adisease identification model, which comprises the following steps of: firstly, acquiring a training case set, the subjects in the training case set comprising oral lichen planus disease subjects andoral squamous cell carcinoma disease subjects; secondly, collecting serum samples of the subjects, and carrying out ultra-high performance liquid chromatography quadrupole/electrostatic field orbitraptandem high-resolution mass spectrometry analysis on the serum samples to obtain a plurality of differential metabolites of oral lichen planus and oral squamous cell carcinoma; and thirdly, determining decanoyl carnitine, cysteine and bile acid from the plurality of differential metabolites as a disease identification model by utilizing variable weight importance sorting and a subject working characteristic curve. The invention provides a disease identification model which can be used for identifying and distinguishing oral lichen planus and oral squamous cell carcinoma in the early stage andhas the advantages of being minimally invasive and high in accuracy.

The invention relates to a pharmaceutical composition comprising lysozyme, dextranase and an essential oil of a plant belonging to the family Myrtaceae. The composition is preferably formulated, together with other ingredients, as a mouthwash.

The invention also relates to a method for the prevention, treatment and follow-up of pathologies of the oral cavity of infectious, inflammatory, degenerative or autoimmune origin, the method comprising the administration of the composition of the invention to a patient affected by one or more of such pathologies, which are preferably selected in the group consisting of: gingivitis, periodontitis, aphthous stomatitis, herpetic stomatitis, prosthetic stomatitis, recurrent aphthosis, xerostomia, xerostomia due to Sjogren's syndrome, burning mouth syndrome (BMS), oral candidiasis, inflammatory dermatoses such as oral lichen planus, autoimmune disorders of the mucous membranes such as mucous membrane pemphigoid (MMP), graft-versus-host disease, white tongue, migratory glossitis, desquamative gingivitis due to oral lichen planus, herpes and combinations thereof.

The invention relates to the technical field of daily chemicals, and more specifically, the invention relates to a bacteriostatic toothpaste containing bamboo shavings triterpenes, and a preparation method thereof. A natural, healthy, green and safe botanical drug ''bamboo shavings triterpenes'' is used as a raw material, and a friction agent, a phosphate, a solubilizer and the like in the systemare synergized to prepare the natural bacteriostatic toothpaste. The prepared bacteriostatic toothpaste can effectively inhibit the growth of common oral pathogenic bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Candida albicans, Helicobacter pylori, Staphylococcus aureus, and Escherichia coli, can remove some odor-causing bacteria and oral residual odor-causing substrates, and inhibits the increase of cariogenic bacteria, periodontal pathogens, and oral lichen planus pathogens. In the bacteriostatic toothpaste containing bamboo shavings triterpenes of the invention, the friction agent hydrated silica with a special type and tetrasodium pyrophosphate are added, and thereby a biofilm on the tooth surface is removed by mechanical friction and dissociation. The synergy of hydrated silica and tetrasodium pyrophosphate solves the barrier of the prior art.

The invention discloses a ginkgo nutritious powder, which comprises the following steps: making ginkgo fruit, inactivating enzymes, colloidal grinding, and making pulp; the pulp is enzymolyzed by compound enzymes, and licorice, spatholobus, and uncaria , Chuanwu, and Trichosanthes were mixed and crushed, added distilled water, and then added cellulase for enzymolysis to obtain a traditional Chinese medicine enzymatic solution; mixed the enzymatically treated fruit pulp with the traditional Chinese medicine enzymatic solution, sterilized, and added the activated Acetic acid bacteria, the above filtrate was stirred at 30°C for 20 minutes, then heated to 90°C and kept for 5 minutes, then rapidly cooled to 35-40°C, and homogenized by four homogenizers in turn, and the four homogenizers were homogenized. The pressure of the quality machine is 20 MPa, 55 MPa, 25 MPa and 50 MPa in sequence, and then spray drying is carried out to obtain powdery particles at last. The invention has good taste and good therapeutic effect on oral lichen planus.

The invention relates to the field of a traditional Chinese medicine, in particular to an externally applied traditional Chinese medicine for treating oral lichen planus, which is prepared from the following raw material medicines by weight parts: 30g of radix astragali, 15g of radix zanthoxyli, 5g of resina draconis, 15g of borax, 1g of cinnabar and 2g of radix glycyrrhizae; and the medicines are ground and screened by a screen of 100-120 meshes to obtain fine powder, and then the fine powder is filled into a bottle to further use after being sterilized at high temperature. According to the externally applied traditional Chinese medicine, the local drug delivery is carried out, the function is direct and both principal and secondary aspects of disease are treated, so that the externally applied traditional Chinese medicine has the characteristics of short course of treatment, definite curative effect and uneasy relapse; and the cure rate reaches up to 89.29% and the effective ratio reaches up to 96.25%.

The invention provides a medical composition for treating oral mucosa diseases. The medical composition is prepared from the following raw material medicines in parts by weight of 5-50 parts of radixbupleuri, 3-30 parts of rhizoma cimicifugae, 8-80 parts of radix astragali, 3-30 parts of poria cocos, 3-30 parts of ginseng, 3-30 parts of radix glycyrrhizae preparata, 3-30 parts of swordlike atractylodes rhizomes, 3-30 parts of bighead atractylodes rhizomes, 3-30 parts of fructus aurantii, 3-30 parts of rhizoma coptidis, 3-30 parts of radix scutellariae, 3-30 parts of cinnamon and 5-50 parts ofherba cistanches. The invention also further discloses a preparation method and purpose of the medical composition. The traditional Chinese medicine composition provided by the invention is novel informula and simple in composition, has the advantages of being low in cost, notable in treatment effects, free from toxic and side effects and the like, tolerance is not easy to produce, and a new medication selection is provided for clinical treatment of the oral mucosa diseases of oral lichen planus, dental ulcer or chronic periodontitis and the like.

The invention provides ITS primers for amplifying OLP Candida albicans characteristic sequences. The invention is characterized in that: the primers are ITS-1:5'-GGAAGTAAAAGTCGTAACAAGG-3', ITS-2:5'-GCTGCGTTCTTCATCGATGC-3'. The beneficial effects of the invention are mainly as follows: ITS primers for amplifying OLP Candida albicans characteristic sequences are provided, and the ITS primers provides a basis for genotyping of OLP Candida albicans, genuinely provides a reliable basis for the formulation of timely and effective clinical control measures at the gene level and lays a foundation for indepth research on Monilia molecular epidemiology.

The invention discloses a pharmaceutical composition for treating oral patches stria diseases. The pharmaceutical composition is composed of the following raw materials in parts by weight: 5 to 80 parts of rhizoma atractylodis, 5 to 80 parts of bighead atractylodes rhizome, 5 to 80 parts of cimicifuga foetida, 3 to 60 parts of ligusticum wallichii, 3 to 60 parts of myrrh, 3 to 60 parts of peach seed, 3 to 60 parts of round cardamom, 3 to 60 parts of balloonflower root, and 3 to 60 parts of curcuma rhizome. The invention further discloses a preparation method and applications of the pharmaceutical composition. The provided pharmaceutical composition has a good curative effect on oral patches stria diseases such as oral lichen planus, oral leukoplakia, oral erythroplakia, and the like. The pharmaceutical has the advantages of novel formula, simple composition, low cost, prominent curative effect, no side or toxic effect, and difficult generation of drug resistance, and is a novel clinical choice for the patients of oral lichen planus, oral leukoplakia, or oral erythroplakia.

The invention discloses a pharmaceutical composition for treating oral lichen planus and application of the pharmaceutical composition. The composition is prepared from traditional Chinese medicinal raw materials and excipients. The traditional Chinese medicinal raw materials comprise the following components in parts by weight: 25-40 parts of radix scrophulariae, 25-40 parts of monthly rose, 12-20 parts of dried rehamnnia root and 5-12 parts of willow root. The pharmaceutical composition is used for treating oral lichen planus in an external application way; after medicating for 4 weeks, the damage area of mucous membrane of the patient is obviously reduced and the pain is obviously relieved; the effective rate reaches 94.7%; the curative effect of the pharmaceutical composition is obviously better than the conventional treatment.

The invention relates to a device for detecting oral lichen planus precancerous lesions. The device comprises four protein markers including Golli-MPB, STIM1, FGF19 and FGFR4 and a kit using the fourmarkers as the detection targets and is characterized in that the development stage of the oral lichen planus precancerous lesions is judged according to the mRNA expression quantity of the four markers, and the kit comprises a fluorogenic quantitative PCR reagent, Western-blot, a reverse transcription reagent and a DAB chromogenic reagent. By the device, the oral lichen planus precancerous lesionrisk can be predicted effectively.

The invention belongs to the technical field of traditional Chinese medicines, and especially relates to a traditional Chinese medicine formula for treating oral lichen planus. The formula comprises, by weight, 3-5 parts of Melastoma dodecandrum Lour., 2-3 parts of Osbeckia chinensis L., 2-5 parts of Cassia nomame (Sieb.)Kitag., 3-5 parts of Brassica caulorapa, 3-5 parts of root of Ficus comata Hand.-Mazz., 3-5 parts of root and leaf of Crossostephium chinense (L.) Makino, 3-5 parts of Fewflower Lysionotus Herb, 3-5 parts of Artemisia capillaries, 3-6 parts of dasheen petiole, 2-3 parts of Crotalaria ferruginea Grah. ex Benth., 3-5 parts of Semen Euryales, 2-3 parts of tendrilleaf solomonseal rhizome, and 3-5 parts of Polygonatum sibiricum. The formula adopting traditional Chinese medicine conditioning to invigorate spleen, remove dampness, clear heat, detoxify, invigorate and tonify qi, and has a good treatment effect on oral lichen planus.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine formula for treating oral lichen planus. The traditional Chinese medicine formula is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3-5 parts of wild hyacinth bean, 2-3 parts of aster fastigiatus, 2-5 parts of all-grass of winkled marshweed, 3-5 parts of cuscuta chinensis, 2-3 parts of kohlrabi, 3-5 parts of ficus comata, 3-5 parts of Japanese clover, 3-5 parts of dodartia orientalis linn, 3-5 parts of cuckoo, 3-6 parts of leea macrophylla roxb.ex hornem, 2-3 parts of centipeda minima, 3-5 parts of potentilla discolor, 2-3 parts of hoary bluebellflower, 3-5 parts of cowpea root and 3-5 parts of unpleasant swallowwort herb. The traditional Chinese medicine formula strengthens the spleen, eliminates dampness, clears away heat and toxic materials, strengthens the spleen and replenishes qi through conditioning of the traditional Chinese medicine and has a better effect for treating the oral lichen planus.

The invention relates to a traditional Chinese medicine preparation, a pharmaceutical composition containing the same, and an application of the traditional Chinese medicine preparation and pharmaceutical composition in the preparation of drugs for preventing or treating oral lichen planus. The traditional Chinese medicine preparation comprises the following components in percentage by weight: 8 to 18% of prepared rehmannia root, 5 to 14% of prepared fleece flower root or polygonatum rhizome, 3 to 12% of ligustrum lucidum, 6 to 16% of yerbadetajo herb, 2 to 11% of ligusticum wallichii, 4 to 14% of Chinese yam, 6 to 15% of America ginseng, 6 to 15% of ginseng, 7 to 16% of lucid ganoderma, 5 to 15% of wolfberry, and 3 to 12% of poria cocos. The provided traditional Chinese medicine preparation or pharmaceutical composition containing the same has a prominent preventive and curative effect on oral lichen planus.