Construction method of disease identification model, marker and application thereof

A technology for identifying models and constructing methods, which is applied in the medical field and can solve problems such as the difficult distinction between OSCC and OLP

Active Publication Date: 2021-01-08
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Currently, it is difficult to distinguish OSCC from OLP, so in the early diagnosis of OSCC and the prediction of tumor invasion, better methods are urgently needed to improve diagnosis and treatment

Method used

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  • Construction method of disease identification model, marker and application thereof
  • Construction method of disease identification model, marker and application thereof
  • Construction method of disease identification model, marker and application thereof

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Embodiment Construction

[0032] Various exemplary embodiments of the present invention are now described in detail, which should not be construed as limitations of the invention, but rather as more detailed descriptions of certain aspects, features, and embodiments of the invention.

[0033] It should be understood that the terminology described in the present invention is only used to describe specific embodiments, and is not used to limit the present invention. In addition, regarding the numerical ranges in the present invention, it should be understood that the upper and lower limits of the range and every intermediate value therebetween are specifically disclosed. Each smaller range between any stated value or intervening value in a stated range and any other stated value or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded from the range.

[0034] Unless defined otherwise, all tech...

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Abstract

The invention provides an auxiliary marker for identifying diseases. The auxiliary marker consists of decanoyl carnitine, cysteine and bile acid. The invention also provides a construction method of adisease identification model, which comprises the following steps of: firstly, acquiring a training case set, the subjects in the training case set comprising oral lichen planus disease subjects andoral squamous cell carcinoma disease subjects; secondly, collecting serum samples of the subjects, and carrying out ultra-high performance liquid chromatography quadrupole/electrostatic field orbitraptandem high-resolution mass spectrometry analysis on the serum samples to obtain a plurality of differential metabolites of oral lichen planus and oral squamous cell carcinoma; and thirdly, determining decanoyl carnitine, cysteine and bile acid from the plurality of differential metabolites as a disease identification model by utilizing variable weight importance sorting and a subject working characteristic curve. The invention provides a disease identification model which can be used for identifying and distinguishing oral lichen planus and oral squamous cell carcinoma in the early stage andhas the advantages of being minimally invasive and high in accuracy.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for constructing a disease identification model, markers and applications thereof, in particular to a method for establishing a model for identification of oral lichen planus and oral squamous cell carcinoma, markers and applications. Background technique [0002] Oral lichen planus (OLP) is a common oral mucosal disease with a high incidence in oral mucosal diseases, with certain gender and age distribution characteristics, most commonly affecting middle-aged women. Its lesions progress slowly and can cause great pain, and these lesions rarely resolve spontaneously. Oral mucosal lesions of OLP often occur symmetrically, and can occur in any part of the lips, cheeks, tongue, floor of the mouth, etc., and are most common in the cheeks, mostly with white or off-white patterns, which enlarge and combine to form a reticular, Circular and dendritic patterns can also form wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G16H50/50
CPCG01N30/88G01N2030/8813G16H50/50
Inventor 赵红宇孙志李希博薛鹏李娜刘丽伟李春燊辛明哲
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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