39 results about "Gastrointestinal dysfunction" patented technology

The invention discloses application of an agilawood extract in preparation of a medicine for treating Parkinson's disease, and belongs to the technical field of traditional Chinese medicines. According to the present invention, MPTP induced Parkinson's disease mouse subacute model research results show that the agilawood extract can improve Parkinson's disease motor coordination imbalance, cognitive impairment and gastrointestinal dysfunction, the action mechanism and the treatment mechanism of agilawood in treatment of Parkinson's disease are disclosed, and the agilawood extract can provide significant effects for treatment of behavioral diseases of Parkinson's patients, and a theoretical basis is laid for improving the life quality of the Parkinson's disease patient.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound preparation for preventing and treating sepsis based on intestinal treatment and gasification regulation and a preparation method and application of the traditional Chinese medicine compound preparation. The composition is prepared from the following medicinal materials in parts by weight: 3 to 10 parts of rheum officinale, 5 to 10 parts of fructus aurantii, 5 to 10 parts of radix aucklandiae, 10 to 15 parts of fructus gardeniae, 10 to 15 parts of dandelion, 10 to 15 parts of fructus forsythiae, 10 to 15 parts of herba artemisiae scopariae, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of radix paeoniae rubra, 10 to 15 parts of radix salviae miltiorrhizae, 15 to 20 parts of astragalus membranaceus, 10 to 15 parts of rhizoma anemarrhenae, 10 to 15 parts of fructus cannabis, 10 to 15 parts of semen pruni and 3 to 6 parts of raw liquorice. The traditional Chinese medicine compound provided by the invention considers the treatment rules of relaxing bowels, purging heat, promoting qi circulation, removing stagnation, detoxifying, dispersing blood stasis, reinforcing qi, nourishing yin and the like, and also considers the effects of relaxing bowels, regulating qi and supporting healthy qi, various diseases of sepsis patients can be remarkably improved through the synergistic effect of the medicines in the formula, and the traditional Chinese medicine compound especially has an obvious curative effect on gastrointestinal dysfunction. A novel traditional Chinese medicine treatment thought is provided for clinical treatment of sepsis diseases.

The invention discloses a strain for preventing and treating Parkinson's disease as well as a composition, application and a product thereof, and relates to the technical field of microorganisms. The invention provides three strains from human milk, namely lactobacillus helveticus LV-20, plant lactobacillus LPP8 and lactobacillus fermentum PL-15, the invention further provides a composition capable of preventing and treating the Parkinson's disease, and the three strains can well prevent and treat the Parkinson's disease and can be used for preventing and treating the Parkinson's disease. The composition can significantly improve dyskinesia (such as static tremor, muscle stiffness, movement retardation, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive disorder, relieve sleep disorder, inhibit neuroinflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, and improve the curative effect. As probiotics or synbiotics, products for treating and preventing Parkinson's disease have a wide application prospect.

The application discloses a composition, which comprises hydrolyzed protein; the hydrolyzed protein comprises hydrolyzed whey protein and hydrolyzed casein protein, the weight ratio of the hydrolyzed whey protein and the hydrolyzed casein protein is (70-95):(5-30), the amino acid nitrogen content in the hydrolyzed protein is (1.0-3.0) g / 100 g, the proportion of protein hydrolysate with a relative molecular mass distribution <1000 in the hydrolyzed protein is 34-70%, the peptide content (calculated on a dry basis) in the hydrolyzed protein is not less than 33 g / 100 g, and the total free amino acid content in the hydrolyzed protein is not less than 1 g / 100 g. The composition can effectively treat diarrhea and is suitable for people with gastrointestinal dysfunction and severe patients with diarrhea symptoms.

The invention discloses a newborn nasal feeding fixing frame, and relates to the technical field of medical instruments. The stomach tube fixing device comprises a box body, a connecting tube, limiting mechanisms and a stomach tube fixing mechanism, the limiting mechanisms are fixed to the front side and the rear side of the outer side wall of one side of the box body, the connecting tube is inserted into the other side wall of the box body, the stomach tube fixing mechanism is arranged at the outer end of the connecting tube in a sleeving mode, and a flow control valve is arranged on the connecting tube and arranged in the box body. A pumping pump is fixed to the inner side wall of one side of the box body, a water outlet of the pumping pump is connected with the connecting pipe, and a liquid inlet pipe is connected to a water inlet of the pumping pump. When the stomach tube is conveniently fixed, the injection speed is controlled, sudden increase of contents in the stomach of a child patient cannot be caused, gastrointestinal dysfunction cannot be caused, abdominal distension, vomiting and other complications are reduced, and the stomach tube has the advantages of being reasonable in arrangement, low in manufacturing cost and the like.

The invention relates to a traditional Chinese medicine composition for conditioning postoperative patients after radical treatment of colon cancer and a sachet preparation of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 to 10 parts of cortex cinnamomi, 5 to 10 parts of radix angelicae, 15 to 20 parts of raw radix astragali seu hedysari, 15 to 20 parts of sandalwood, 3 to 6 parts of radix et rhizoma rhei, 5 to 10 parts of rhizoma nardostachyos, 5 to 10 parts of rhizoma acori graminei, 5 to 10 parts of rhizoma chuanxiong, 5 to 10 parts of radix aucklandiae, 5 to 10 parts of fructus aurantii immaturus, 5 to 10 parts of cortex magnoliae officinalis, 5 to 10 parts of rhizoma atractylodis macrocephalae, 5 to 10 parts of rhizoma atractylodis, 1 to 3 parts of fructus tsaoko, 10 to 15 parts of pericarpium citri reticulatae, 5 to 10 parts of radix polygalae, 10 to 15 parts of herba eupatorii , 5-10 parts of rose, 5-10 parts of lavender, and 5-10 parts of licorice. The traditional Chinese medicine sachet can help patients after the colorectal cancer operation to improve related symptoms, has the effects of promoting qi circulation, relaxing bowel, eliminating cold to stop pain, inducing resuscitation, relieving convulsion and soothing the nerves, and can obviously improve gastrointestinal dysfunction or disorder and other symptoms of the patients after the colorectal cancer operation and promote recovery and balance of gastrointestinal functions when being prepared into the sachet.

The application belongs to the technical field of traditional Chinese medicine, and particularly relates to an external traditional Chinese medicine composition with the effects of promoting qi circulation and dredging bowels, regulating cold and heat, ascending clear and descending turbid, an external traditional Chinese medicine ointment, a preparation method and application. The external traditional Chinese medicine composition is composed of the following raw medicinal materials: dried ginger, cassia twig, fried atractylodes, radix codonopsis, raw rhubarb, goldthread, immature orange fruit, magnolia officinalis, fried pinellia and licorice. The external traditional Chinese medicine composition has the effects of promoting qi circulation and dredging bowels, regulating cold and heat, ascending clear and descending turbid, and has a remarkable curative effect on treating chronic obstructive pulmonary disease combined with gastrointestinal dysfunction, so that the function of the patient's spleen and stomach is recovered, the clinical symptoms of the patient are effectively relieved, and the quality of life is improved, and there is no problem of the patient not being easy to tolerate and the gastrointestinal burden being aggravated.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating co-disease of liver depression and spleen deficiency type depressive state and IBS (irritable bowel syndrome). The composition comprises radix pseudostellariae, poria cocos, raw coix seeds, fingered citron, polygala tenuifolia, roasted rhizoma atractylodis macrocephalae, lotus seed pulp, mint, roses, lilies, raw fructus gardeniae, fermented soybeans and raw hawthorn fruits. Liver soothing, depression relieving, spleen strengthening and heart nourishing are taken as core treatment rules, heat clearing, restlessness relieving, digestion promoting and stagnation removing are also taken, and the complex pathogenesis that the two are causal to each other is formed for gastrointestinal dysfunction caused by emotional discomfort. The formula is characterized in that the three internal organs of the heart, the liver and the spleen are treated at the same time, the four methods of tonifying, dredging, clearing and eliminating are used at the same time, balance is achieved between qi regulating and healthy qi supporting, and the formula is suitable for patients suffering from complex heart and body diseases with low mood, anxiety, dysphoria, insomnia, amnesia, abdominal fullness, inappetence, loose stool or loose stagnation.

The invention provides a traditional Chinese medicine composition for treating phlegm-heat internal disturbance type heart-body co-disease and a preparation method of the traditional Chinese medicine composition. Comprising 9 g of ginger processed pinellia, 6 g of immature bitter orange, 20 g of bamboo shavings, 10 g of poria cocos, 10 g of dried orange peel, 9 g of polygala tenuifolia, 20 g of fried spina date seed, 15 g of albizia flower, 15 g of vine of multiflower knotweed, 10 g of angelica sinensis, 10 g of radix rehmanniae, 10 g of fingered citron, 12 g of hawthorn and 6 g of honey-fried licorice root. The invention further relates to a preparation method of the traditional Chinese medicine composition for treating the phlegm-heat internal disturbance type heart-body co-disease. According to the formula disclosed by the invention, interaction among the components is utilized, and the components have the effects of soothing the nerves, relieving depression, nourishing yin and blood (Chinese angelica and radix rehmanniae), regulating qi, harmonizing the stomach, tonifying the spleen (poria cocos) and the like; the traditional Chinese medicine composition can comprehensively improve insomnia, anxiety, palpitation, gastrointestinal dysfunction, fatigue and other symptoms represented by climacteric syndrome, workplace hypertension people or chronic fatigue syndrome patients.

1. Name of the product in this design: External gastrointestinal pacing therapy device. 2. Purpose of this design: To relieve and eliminate symptoms of gastrointestinal dysfunction. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction and application thereof. The traditional Chinese medicine enema composition for treating postoperative gastrointestinal dysfunction is prepared from the following raw materials: fried semen raphani, fructus aurantii stir-fried with bran, fried fructus aurantii immaturus, raw liquorice, radix paeoniae alba, rheum officinale, rhizoma zingiberis, codonopsis pilosula, bupleurum chinense, ginger-processed cortex magnoliae officinalis and lignum dalbergiae odoriferae. The prescription is based on the core theories of'six internal organs are used for dredging ', 'qi movement is caused by rising and falling' and'healthy energy is strengthened and attacks evil 'in the traditional Chinese medicine, and the prescription aims to dredge triple jiao, smooth qi movement, dredge the internal organs, purge turbidity and strengthen the healthy energy. The whole formula takes'dredging and descending 'as a main component, 'ascending and dispersing' as an auxiliary component and'tonifying 'as an assistant component, so that a precise compatibility system with simultaneous ascending and descending and simultaneous purgation and tonification is formed. The traditional Chinese medicine enema composition is remarkable in clinical curative effect, low in recurrence rate and free of adverse reaction, the preparation process is simple and easy to implement and easy to popularize and apply, and the traditional Chinese medicine enema composition has good social benefits and economic benefits.

The application belongs to the technical field of traditional Chinese medicines, and provides a compound traditional Chinese medicine and application thereof in preparation of a medicine for preventing and treating postoperative gastrointestinal dysfunction. The compound traditional Chinese medicine is composed of radix codonopsis extract, radix bupleuri extract, fructus aurantii extract, radix astragali extract and radix angelicae extract with a mass ratio of 1:3-4:1-2:3-5:2-3. Animal experiments show that the compound traditional Chinese medicine can significantly reverse the decrease of postoperative gastrointestinal motility function, reverse the changes of gastrointestinal hormones VIP and MTL, and help and promote the recovery of postoperative gastrointestinal motility function. The compound traditional Chinese medicine has reasonable formula, is convenient to use, and has a wide application range, and has curative effects on the recovery of postoperative gastrointestinal function caused by various conditions.

The invention provides a composition capable of ventilating, relieving abdominal distension and pain and improving constipation and application, and relates to the technical field of medicines. The composition is prepared from the following components: 30-40 parts of hawthorn, 5-15 parts of malt, 1-5 parts of Chinese yam, 2-10 parts of endothelium corneum gigeriae galli, 5-15 parts of orange peel and 3-10 parts of semen raphani. All the components supplement each other and are indispensable, so that the synergistic effects of ventilating, relieving abdominal distension and pain and improving constipation are achieved. The composition disclosed by the invention has the remarkable effects of ventilating, relieving abdominal distension and pain and improving the gastric emptying rate and the small intestine propulsion rate on postoperative enteroparalysis rats, atropine-induced gastrointestinal dysfunction rats and iodoacetamide intragastric lavage and small platform combined gastrointestinal dysfunction rats; for constipation mice, the traditional Chinese medicine composition has the functions of remarkably reducing the first-grain black defecation time, increasing the defecation grain number and weight, increasing the content of 5-HT and SP in the bodies of the constipation mice, reducing the content of VIP and improving intestines and stomach.

The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15 to 20 parts of fructus alpiniae oxyphyllae, 15 to 20 parts of rhizoma atractylodis macrocephalae, 10 to 15 parts of fructus psoraleae, 15 to 20 parts of poria cocos, 15 to 20 parts of rhizoma dioscoreae, 10 to 15 parts of fructus schizandrae and 5 to 10 parts of fructus amomi rotundus. The traditional Chinese medicine composition disclosed by the invention has the effects of warming the middle warmer and strengthening the spleen, replenishing qi and strengthening the spleen, eliminating dampness and strengthening the spleen, relieving diarrhea with astringents and promoting digestion and arresting vomiting, can regulate various stress gastrointestinal dysfunctions and improve diarrhea by regulating the functions of the spleen and the stomach and promoting digestion and nutrient absorption of the spleen and the stomach, and is relatively good in curative effect. The traditional Chinese medicine composition and feed are mixed for feeding, active ingestion is adopted, the administration route is more flexible and convenient, and the palatability is good.

This invention discloses a liposomal curcumin composition for regulating the gastrointestinal tract and its applications, belonging to the technical fields of food and health food. The composition consists of 60-80nm liposomal curcumin, prebiotics, and cardamom extract. The liposomal curcumin uses food-grade phospholipids to construct a biomimetic bilayer structure with an encapsulation rate ≥80%, ethanol residue ≤0.5‰, a 2-hour release rate <33% in simulated gastric juice, and a 2-hour release rate >80% in simulated intestinal juice at pH 7.4. The cardamom extract is a water or alcohol extract of cardamom, with a content of 10-60mg per serving. This invention achieves targeted sustained release of curcumin into the intestine through precise particle size control, synergistically regulating gut microbiota with prebiotics and enhancing gastrointestinal motility with cardamom extract. It regulates gastrointestinal function from multiple dimensions, including mucosal repair, microbiota balance, and motility improvement. The bioavailability is more than 18 times higher than ordinary curcumin. The product has high safety and good stability and can be prepared in various dosage forms such as oral liquid, solid beverage, soft capsules, or tablets, suitable for daily conditioning in people with gastrointestinal dysfunction.

This invention proposes a traditional Chinese medicine compound for treating ankylosing spondylitis of the kidney-deficiency and damp-heat type accompanied by gastrointestinal dysfunction, along with its preparation method, belonging to the field of traditional Chinese medicine technology. The compound consists of Smilax glabra, Bletilla striata, Paris polyphylla, Geranium wilfordii, Dioscorea hypoglauca, Patrinia scabiosaefolia, Dipsacus asper, Drynaria fortunei, Pyrola rotundifolia, Clematis chinensis, Pheretima aspergillum, Lycopodium clavatum, Corydalis yanhusuo, Paeonia lactiflora, Atractylodes macrocephala (fried), Coix lacryma-jobi (raw), Aucklandia lappa, and Glycyrrhiza uralensis. This invention combines these herbs to achieve a synergistic effect, collectively clearing heat and dampness, strengthening the spleen and kidneys, and unblocking the meridians. The overall formula addresses both strengthening the body's foundation and eliminating pathogenic factors, ensuring unobstructed meridian flow and relieving arthralgia. This compound has the functions of clearing heat and dampness, strengthening the spleen and kidneys, and unblocking the meridians. It offers a short treatment course, rapid efficacy, low recurrence rate after cure, few side effects, and is inexpensive and convenient to use for treating ankylosing spondylitis with gastrointestinal dysfunction.

The invention provides a composition with the functions of regulating intestinal tracts in a targeted manner and blocking glycolipid absorption and application of the composition in health care products, special meals or nutritional meals, and belongs to the technical field of functional foods or health care products. The composition provided by the invention comprises chia seeds, xylooligosaccharide, polydextrose, konjac powder, isomaltooligosaccharide, fucoidin, citrus fibers, inulin, sodium citrate, potassium sorbate, stevioside, apple concentrated juice, orange concentrated clear juice, lemon concentrated juice, passion flower concentrated juice and blueberry concentrated juice. The composition has the effects of regulating intestinal functions and blocking glycolipid absorption. The invention further provides a preparation method of the composition and application of the composition in preparation of drugs, health care products, special meals or nutritional meals. The invention further provides special meals suitable for patients with diabetes or gastrointestinal dysfunction. The composition or the special meal provided by the invention can regulate the activity of alpha-glucosidase and intestinal microecology in a targeted manner, and meanwhile, optimizes blood sugar, blood fat and metabolic health.

The invention discloses a traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15 to 24 parts of bupleurum chinense, 9 to 15 parts of radix scutellariae slices, 20 to 30 parts of parched white paeony root, 20 to 30 parts of bran-fried immature bitter orange, 9 to 15 parts of ginger processed pinellia, 15 to 20 parts of ginger processed officinal magnolia bark, 10 to 20 parts of fresh ginger, 6 to 10 parts of mirabilite, 10 to 15 parts of Chinese date, 15 to 20 parts of polyporus umbellatus, 15 to 30 parts of rheum officinale, 20 to 30 parts of herba lycopi, 15 to 20 parts of semen lepidii, 10 to 20 parts of semen armeniacae amarae, 10 to 15 parts of earthworm, 20 to 30 parts of rhizoma alismatis and 0.5 to 1 part of euphorbia kansui powder. The traditional Chinese medicine composition provided by the invention has the effects of relaxing bowels, removing heat, resolving Shaoyang, relieving asthma, dispersing blood stasis and dredging collaterals, can effectively relieve clinical symptoms such as abdominal distension, abdominal pain, gastrointestinal dysfunction and the like of AP patients, reduces serum inflammation indexes and improves pancreatic functions.

The application discloses a traditional Chinese medicine composition for treating sepsis gastrointestinal dysfunction and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises A medicinal liquid, and the A medicinal liquid is prepared from the following components in parts by weight: 15 parts by weight of ginseng, 9 parts by weight of rhubarb, 15 parts by weight of angelica, 30 parts by weight of alisma, 6 parts by weight of fried licorice, 15 parts by weight of bitter orange fruit, 15 parts by weight of magnolia, 6 parts by weight of platycodon, 15 parts by weight of snake gourd, 30 parts by weight of atractylodes and 780 parts by weight of water. The traditional Chinese medicine composition can effectively relieve gastrointestinal symptoms of constipation and abdominal distension type sepsis gastrointestinal dysfunction, reduce intra-abdominal pressure, improve blood supply of intra-abdominal organs, improve lung compliance and cardiac return blood volume, reduce systemic inflammatory response, protect intestinal mucosal barrier function and improve microcirculation disorder.

The invention discloses a traditional Chinese medicine composition for treating gastrointestinal dysfunction during chemotherapy of gastric cancer. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 9-15 parts of inula flower, 9-15 parts of bamboo shavings, 3-9 parts of flos caryophylli, 6-15 parts of kaki calyx, 6-15 parts of lignum dalbergiae odoriferae, 15-20 parts of betel nut, 15-20 parts of pericarpium arecae, 15-20 parts of combined spicebush root, 20-30 parts of semen raphani, 15-20 parts of immature bitter orange and 9-15 parts of prepared rhubarb. The traditional Chinese medicine composition is prepared into the acupoint application. In addition, the invention further discloses application of the traditional Chinese medicine composition, the traditional Chinese medicine composition is ground into fine powder, the fine powder is blended into paste with a solvent, or the mixture is prepared into ointment, pills or cakes, or the traditional Chinese medicine decoction is decocted into ointment, or the medicine powder is dispersed on the plaster, and then the plaster is directly applied to the Shenque acupoint, the Zusanli acupoints on the two sides and the Neiguan acupoints on the two sides. The traditional Chinese medicine composition has a good treatment effect on gastrointestinal dysfunction of gastric cancer patients during chemotherapy.

The invention relates to a preparation for treating acute plateau gastrointestinal dysfunction as well as a preparation method and application of the preparation, active ingredients in a pharmaceutical composition are extracted through a supercritical carbon dioxide fluid extraction technology on the basis of a formula for tonifying middle-Jiao and Qi, and a reagent or a reagent composition suitable for oral administration and / or patch is further prepared. The reagent or the reagent composition is suitable for gastrointestinal dysfunction caused by rapid plateau entry.

To provide the use of an intestinal audio analysis device for predicting gastrointestinal dysfunction prior to any clinical signs or symptoms occurring.SOLUTION: An intestinal audio analysis device is provided which has a patient interface adapted to attach to a surface of a patient's abdomen for a duration of time after surgery. The invention provides devices and methods for predicting the risk and likelihood of post-operative gastrointestinal dysfunction based on regression analysis of multiple spectral events related to intestinal sounds, with decreased or eliminated falsely elevated values of those events due to ambient noise.SELECTED DRAWING: Figure 17

The application discloses strains for preventing and treating Parkinson's disease and compositions, applications and products thereof, and relates to the technical field of microorganisms.The application provides three strains of human milk origin, namely Lactobacillus helveticus LV-20, Lactobacillus plantarum LPP8 and Lactobacillus fermentum PL-15.The application also provides a composition capable of preventing and treating Parkinson's disease.The three strains can preferably prevent and treat Parkinson's disease.The composition can significantly improve motor dysfunction (such as static tremor, muscle rigidity, bradykinesia, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive impairment, relieve sleep disorders, inhibit neural inflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, improve constipation and regulate intestinal flora composition, and has a wide application prospect as a probiotic or synbiotic product for treating and preventing Parkinson's disease.

The present disclosure provides methods related to treating or preventing gastrointestinal dysfunction in a subject in need thereof, which include the use of a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor. The disclosure also provides pharmaceutical compositions comprising a DGAT1 inhibitor, or pharmaceutically acceptable salts or esters thereof, useful for the treatments described herein.

The invention discloses a traditional Chinese medicine composition for treating sepsis gastrointestinal dysfunction and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises a liquid medicine A, wherein the liquid medicine A is prepared from the following components in parts by weight: 15 parts of ginseng, 9 parts of rheum officinale, 15 parts of angelica sinensis, 30 parts of rhizoma alismatis, 6 parts of honey-fried licorice root, 15 parts of immature bitter orange, 15 parts of mangnolia officinalis, 6 parts of platycodon grandiflorum, 15 parts of trichosanthes kirilowii maxim, 30 parts of bighead atractylodes rhizome and 780 parts of water. The traditional Chinese medicine composition can effectively relieve gastrointestinal symptoms of constipation and abdominal distension type sepsis gastrointestinal dysfunction, relieve pressure in the abdominal cavity, improve blood supply of visceral organs in the abdominal cavity, improve lung compliance and return blood volume, relieve inflammatory response of the whole body, protect the intestinal mucosa barrier function and improve microcirculation disturbance.

The invention discloses a Clostridium strain with a prevention or treatment effect on neurodegenerative brain diseases and an application of the Clostridium strain. The Clostridium strain provided by the invention has a neuroprotective effect, has a remarkable improvement effect in animal models of degenerative brain diseases such as Parkinson's disease and Alzheimer's disease, and has the effects of relieving dyskinesia and non-dyskinesia in the animal models of Parkinson's disease, including cognitive impairment, gastrointestinal dysfunction and the like; therefore, the strain can be effectively applied to foods and medicines for preventing or treating neurodegenerative brain diseases including Parkinson's disease, Alzheimer's disease, cognitive function impairment and the like.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an external traditional Chinese medicine composition and an external traditional Chinese medicine ointment with the effects of promoting the circulation of qi, relaxing bowels, regulating cold and heat, ascending lucidity and descending turbid, and a preparation method and application of the external traditional Chinese medicine composition and the external traditional Chinese medicine ointment. The external traditional Chinese medicine composition is prepared from the following raw materials: rhizoma zingiberis, cassia twig, roasted rhizoma atractylodis macrocephalae, codonopsis pilosula, raw rhubarb, coptis chinensis, immature bitter orange, mangnolia officinalis, rhizoma pinelliae preparata and honey-fried licorice root. The external traditional Chinese medicine composition has the effects of promoting qi circulation, relaxing bowel, regulating cold and heat, ascending lucidity and descending turbid, has a remarkable curative effect in the aspect of treating chronic obstructive pulmonary disease complicated with gastrointestinal dysfunction, recovers the spleen and stomach functions of a patient, effectively relieves clinical symptoms of the patient, improves life quality, and does not have the problems that the patient is not easy to tolerate and gastrointestinal burden is aggravated.

The invention relates to the technical field of medical treatment, in particular to gastrointestinal dysfunction treatment equipment based on awn needle therapy, which comprises a moving plate, a steering assembly is fixedly connected to the bottom of the moving plate, a working disc is fixedly connected to the bottom of the steering assembly, and a needle storage box is fixedly connected to the bottom of the working disc. And the top of the needle storage box is fixedly connected with a rotating motor. According to the gastrointestinal dysfunction treatment equipment based on the awn needle therapy, accurate positioning and intelligent operation are achieved, it is ensured that treatment is safe and efficient, the equipment detects the treatment part in real time through the scanner, and by combining with a multi-freedom-degree positioning system composed of a steering assembly, a working disc, a rotating motor and the like, acupuncture points can be accurately positioned. The awn needle is automatically taken, fixed and punctured by the telescopic rod I, the needle fixing sleeve and other parts, so that the dependence on the personal manipulation of an operator is greatly reduced, the personal error is avoided, the treatment process is standardized and precise, and the operation safety and the treatment efficiency are remarkably improved.

The present disclosure provides methods related to treating or preventing gastrointestinal dysfunction in a subject in need thereof, which include the use of a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor. The disclosure also provides pharmaceutical compositions comprising a DGAT1 inhibitor, or pharmaceutically acceptable salts or esters thereof, useful for the treatments described herein.

The integrated therapeutic instrument comprises a therapeutic instrument body and an abdomen fixing piece connected with the therapeutic instrument body, an acupoint stimulation disc is arranged on one face of the therapeutic instrument body, a traditional Chinese medicine hot compress disc is arranged on the other face of the therapeutic instrument body, and the acupoint stimulation disc and the traditional Chinese medicine hot compress disc can turn over relative to the abdomen fixing piece. The acupoint stimulation disc comprises a driving mechanism and a massage disc, the driving mechanism is used for driving the massage disc to rotate, the traditional Chinese medicine hot compress disc comprises a heating piece and a traditional Chinese medicine bag which is matched with the heating piece and can be exposed out of the therapeutic apparatus body, and the therapeutic apparatus body can be further electrically connected with an application polar plate. After a patient wears the therapeutic apparatus main body through the abdomen fixing part, acupoint stimulation or traditional Chinese medicine hot compress function can be independently used for precise treatment, or alternate combined treatment is achieved by turning over and switching the treatment surface, use is convenient and easy, and the therapeutic apparatus has good clinical application value for promoting early rehabilitation of postoperative gastrointestinal dysfunction of the patient.