The invention discloses a rice overgrowth-controlling, lodging-resistant and yield-increasing agent and an application thereof. The rice overgrowth-controlling, lodging-resistant and yield-increasing agent mainly comprises a plant growth regulator and a fertilizer, wherein the regulator is brassinolide and paclobutrazol or uniconazol, and the fertilizer is one or combination of more than two of substances containing N/P/K/B/Zn/Ca/Cu/Fe/Mn/Mo/Me/S/Cl/Si and other elements, such as urea, potassium dihydrogen phosphate, diammonium phosphate, calcium carbonate, potassium nitrate, silicon fertilizer, zinc sulfate, ferrous sulfate, potassium chloride, boric acid, borax, copper sulfate, ferrous sulfate, molybdenum fertilizer, magnesium sulfate, potassium sulfate, manganese sulfate and rare earth fertilizer. The rice overgrowth-controlling, lodging-resistant and yield-increasing agent has good safety and can effectively shorten the length between neck-panicle nodes and top second nodes of rice and enhance lodging resistance of rice; simultaneously, the rice overgrowth-controlling, lodging-resistant and yield-increasing agent can not affect safe dates of full heading and the grain number per spike of rice, prolong the service life of functional leaf of rice, improve the seed setting rate and the 1000-grain weight of rice and significantly affect the yield of rice. The rice overgrowth-controlling, lodging-resistant and yield-increasing agent is suitable for various types of rice, including conventional rice, hybrid rice and super hybrid rice, and has the advantages of low cost and high performance-price ratio.