Probe type online three-dimensional imaging detection system and probe type online three-dimensional imaging detection method

A technology of three-dimensional imaging and detection system, which is applied in the direction of analyzing materials and instruments, and can solve the problems of weak image processing function and unsatisfactory image quality.

Active Publication Date: 2014-02-05
PHARMAVISION QINGDAO INTELLIGENT TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing products and prototype systems are not ideal for many complex system

Method used

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  • Probe type online three-dimensional imaging detection system and probe type online three-dimensional imaging detection method
  • Probe type online three-dimensional imaging detection system and probe type online three-dimensional imaging detection method
  • Probe type online three-dimensional imaging detection system and probe type online three-dimensional imaging detection method

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Experimental program
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Effect test

Embodiment 1

[0112] like figure 1 , 2 , shown in 3, a kind of probe-type online stereoscopic imaging detection system, comprises the crystal growth reactor 1 that the crystal to be measured is housed, is arranged on the three-dimensional imaging probe inside the crystal reactor, wherein the three-dimensional imaging probe comprises a fixed solid angle Two cameras 2, 3 and a light source, the lenses of the cameras 2 and 3 are central telescopic lenses, and the imaging is clearer; the blade stirrer 6 is arranged in the crystal growth reactor; the system also includes a light source and a strobe control for controlling the work of the light source 4, a computer 5 for processing the image collected by the three-dimensional imaging probe and a display connected to the computer, the light source is connected with the strobe controller 4 and the computer 5, wherein the three-dimensional imaging probe is used to obtain the 2D image of the crystal sample Transmission to the computer 5, the compute...

Embodiment 2

[0115] like Figure 4 , 5 , the present embodiment has the same structure as embodiment 1 except the following features:

[0116] like Figure 4 A reflective disc 12 is arranged under the glass window 11 of the three-dimensional imaging probe, and the gap between the reflective disc 12 and the glass window 11 forms a slurry flow channel 13 . For fast-moving crystals and when the concentration of crystals in the reactor is high, the slurry flow channel can "rectify" the crystals in the solution, and the crystals pass through the slurry flow channel in sequence, which can improve the quality of the collected 2D images.

Embodiment 3

[0118] like Figure 5 , the present embodiment has the same structure as embodiment 1 except the following features:

[0119] The bottom of the three-dimensional imaging probe is provided with a tapered end 13 . In order to facilitate the insertion of the probe into the small size crystallization reactor.

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Abstract

The invention discloses a probe type online three-dimensional imaging detection system which comprises a crystal growth reactor, a three-dimensional imaging probe, a light source and a strobe controller, a computer for processing an image, and a display, wherein the three-dimensional imaging probe is used for transmitting a 2D image to the computer; the computer is used for firstly deleting a background by using a splitting technology and then identifying corresponding points and lines from the 2D image by using an angle/edge/line detection technology; for few angles/lines which are detected difficultly, indistinct angles/lines are predicted/estimated by using molecule modeling and a crystal shape model on the basis of the obtained angles and lines, 3D image reconstruction is realized by using the determined points and lines, then particle description characteristics of 3D crystals are obtained by combining with solution parameters measured online, and finally, the control and the amplification of a crystallization process in a reactor are realized by using a crystalline form grain number balancing model and computational fluid mechanics. The system and the method provided by the invention are capable of directly acquiring the image from the solution and realizing the reconstruction of the 3D crystalline form, and are high in image processing speed.

Description

technical field [0001] The invention relates to the research and application field of crystal growth, in particular to a probe-type online stereo imaging detection system and method. Background technique [0002] Particle shape is recognized as extremely important for many solid form pharmaceuticals, biopharmaceuticals, human health products and specialty chemicals. For example, in the pharmaceutical industry, morphology can affect important properties such as dry powder density, cohesion, and flowability, which can have a significant impact on a company's ability to transform drug particles into finished products. In addition, crystal form can affect the solubility of a drug, potentially affecting the biological properties of the finished product and, in extreme cases, lead a company to de-license drug manufacturing. Despite its significant potential importance, direct measurements of particle shape have been rather limited, relying heavily on off-line instrumental methods...

Claims

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Application Information

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IPC IPC(8): G01N15/00
Inventor 王学重马才云刘晶晶
Owner PHARMAVISION QINGDAO INTELLIGENT TECH LTD
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