130 results about "Pharmaceutical industry" patented technology

This invention discloses a highly efficient asymmetric synthesis method for aryl propionic acid drug molecules. The method uses racemic aldehydes as substrates and thiamine pyrophosphate-dependent enzymes as biocatalysts. Electrolysis is performed in a diaphragm-free electrolytic cell under conditions of an external redox dielectric and constant current, in a buffer salt solution and nitrogen atmosphere. This method achieves dynamic kinetic oxidation of aldehydes via bioelectrocatalysis, enabling the high-efficiency and high enantioselectivity synthesis of aryl propionic acid drug molecules. The method eliminates the need for redox agents and additives, is simple to operate, operates under mild reaction conditions, and is green and sustainable. This invention applies bioelectrocatalysis to asymmetric synthesis, providing a green and efficient new enzymatic synthetic route for the asymmetric synthesis of aryl propionic acid drug molecules, which has significant application prospects in the pharmaceutical industry.

The utility model discloses an anti-blocking filling machine for capsule medicine preparation and belongs to the technical field of medicine production. A medicine inlet is formed in the upper end of the shell, a stirring mechanism is arranged in the shell and fixedly connected with an anti-blocking mechanism, the anti-blocking mechanism is arranged in a conveying pipe, the conveying pipe is fixedly communicated with the upper end of the shell, a discharging port is formed in the lower end of the conveying pipe, an electronic valve is arranged on the discharging port, and the outer wall of the lower end of the conveying pipe is fixedly connected with a connecting frame. The connecting frame is fixedly connected with the fixing plate, the fixing plate is provided with a filling mechanism, and the filling mechanism corresponds to the discharging port. By means of the unique design and working principle, the capsule medicine preparation device has the remarkable advantages of being efficient in stirring, excellent in anti-blocking performance, accurate in filling, easy and convenient to operate, wide in application and the like, and efficient, reliable and automatic capsule medicine preparation equipment is provided for the pharmaceutical industry.

This invention provides specific sequence nucleic acid molecules and their applications as PDRNs, relating to the field of biotechnology. This invention yields novel specific sequence nucleic acid molecules with deterministic sequences, stable biological activity, and stable product quality. The PDRNs with these specific sequences are non-cytotoxic, exhibit high safety, and have broad application prospects. Furthermore, this invention is the first to discover that specific sequence PDRNs, compared to extracted PDRNs, significantly promote VEGF expression and effectively repair cell damage, providing a novel skincare and repair ingredient for the cosmetics and pharmaceutical industries. This invention also provides a simple method for preparing specific sequence PDRNs, suitable for widespread application and industrial production.

This invention belongs to the field of pharmaceutical drying technology and discloses a pharmaceutical drying and automatic lifting mixing device based on negative pressure fluidization, including a machine body, a lifting cylinder, and a second waste gas guide channel. In use, the invention drives the spiral lifting blades through a waste gas power transmission component, achieving automatic lifting and discharge of the dried material. This eliminates the need for manual transfer, reducing operator workload, improving production efficiency, and avoiding material contamination during transfer, thus meeting the clean production requirements of the pharmaceutical industry. Simultaneously, the pneumatic reciprocating lifting component drives the periodic lifting and lowering of the material plate, continuously agitating the material during the drying process. This breaks the limitations of static drying in existing equipment, ensuring that the material is uniformly exposed to hot air from all directions. This avoids problems such as uneven heating, clumping, and incomplete drying caused by material accumulation, guaranteeing the drying quality of pharmaceutical materials and preventing the destruction of active ingredients.

This utility model relates to a cleanroom air conditioning and dust removal system, belonging to the field of cleanroom technology in the pharmaceutical industry. The system includes a combined cleanroom air conditioning unit, a bag filter, an air supply duct network, a high-efficiency filter air outlet, a return air duct network, a dust removal exhaust hood, a dust removal static pressure box, a dust concentration sensor, and a controller. The bag filter is rigidly connected to the air conditioning unit side-by-side and fixed to the floor of the equipment room, eliminating interference from the equipment to the cleanroom. The outlet of the bag filter is directly connected to the mixing section of the air conditioning unit through the return air duct network, forcibly reusing the dust-removed air as return air. The dust concentration sensor is embedded in the inner wall of the dust removal static pressure box, directly exposed to the dust-laden airflow channel. This application significantly reduces the air conditioning cooling and heating load by physically reducing the demand for fresh air; the centralized layout of the equipment room frees up space in the cleanroom, improving the convenience of operation and maintenance; and the closed-loop dust collection and multi-stage filtration ensure the stability of cleanliness levels D and above.

This application discloses a method and device for aligning pharmaceutical entity data based on multimodal feature fusion. The method includes: acquiring multi-source data records containing entity name, first identity identifier, second identity identifier, related person information, and address information; constructing a core identity feature tuple composed of the entity name and dual identity identifiers to perform a first-level analysis; when the first-level analysis result is a partial mismatch, performing a second-level analysis based on the consistency of related person information and semantic proximity of addresses to determine whether the records point to the same entity; and merging and updating data determined to be from the same entity based on the date of the valid certificate. This application effectively addresses the unique "separation of licenses and permits" and information inconsistency issues in the pharmaceutical industry, significantly improving the accuracy and automation level of entity data alignment.

The group of inventions relates to the field of medicine, pharmacology and the chemical and pharmaceutical industry and includes an improved method for producing (10S, 13S, 16R, 17R)-17-hydroxy-10,13,16-trimethyl-17-propanoyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3-one (compound of formula (I)) and the use thereof for industrial batch, semi-continuous and continuous chemical production. Also described is a method for producing an intermediate compound, Vamorolone Acetate. The method for producing the compound of formula (I) is carried out according to the schema depicted. The production method makes it possible to produce the compound of formula (I) with a purity suitable for the use thereof in a finished dosage form for subjects requiring treatment for Duchenne muscular dystrophy. Thus, the technical results of the present invention consist in an improved production method which results in: a high yield and chemical purity, including stereoisomeric purity, of the compound of formula (I) and intermediate products in the synthesis of the compound of formula (I), which are suitable for use in a finished dosage form for subjects requiring treatment for Duchenne muscular dystrophy; the adaptability of the synthesis of the compound of formula (I) to industrial production; environmentally-friendly production; and a decrease in the formation of undesirable by-products.

Cleaning-in-place (CIP) systems utilize membrane filters for purifying liquid substances in many industries, including but not limited to, the dairy industry, breweries, pharmaceutical industry, and the food industry. These membrane filters undergo a rigorous cleaning process that despite cleaning can leave foulants on the membranes which hamper filter effectiveness. In addition to the cleaning, enzymes can be applied to the membranes to remove foulants and restore filtering effectiveness. However, introduction of enzymes into these CIP systems can be problematic if enzymes remain after cleaning. This disclosure provides a system and methods to mimic the membrane modules and verify that a correct inactivation procedure occurred. The systems and methods include a separate membrane sample so that no membrane modules need be removed to verify full enzyme inactivation.

The application discloses a kind of methyl aspartate lyase EcMAL mutant and its preparation method and application, belong to enzyme engineering technical field.The methyl aspartate lyase EcMAL mutant is any one of mutant EcMAL-M1, mutant EcMAL-M2, mutant EcMAL-M3 and mutant EcMAL-M4.The application is obtained methyl aspartate lyase EcMAL mutant by the mutation of the 329th, 331st, 361st and 365th amino acid sites of methyl aspartate lyase combined with high-throughput screening method.The mutant changes the previous recombinant enzyme only L-aspartic acid production status, so that it is possible to produce D-aspartic acid with methyl aspartate lyase as biological catalyst, and it is expected to be used in pharmaceutical industry.

The utility model provides a system for processing high hardness concentrated salt water of pharmaceutical industry, including front end processing unit, electrochemistry removes hard unit, tubular membrane equipment, weak acid resin removes hard unit and evaporimeter. Front end processing unit is used to pretreatment to pharmaceutical wastewater, electrochemistry removes hard unit with front end processing unit connection, and electrochemistry removes hard unit produces flocculating agent for gathering suspended particles through electrode, tubular membrane equipment is used to filter to the pharmaceutical wastewater after electrochemistry removes hard unit processing, weak acid resin removes hard unit is used to remove calcium magnesium ion to the pharmaceutical wastewater after tubular membrane equipment filtration, evaporimeter is used to evaporate to the concentrated water of weak acid resin removes hard unit export. The utility model provides a system for processing high hardness concentrated salt water of pharmaceutical industry, aims at can solve the problem that evaporimeter heat exchange pipe is scaled seriously in the process of treating pharmaceutical wastewater in prior art and leads to evaporimeter life reduction.

1. The name of the design product: photoelectric liquid level sensor (RLG1224Q1A). 2. The use of the design product: the design product is mainly used in the production, storage and transportation process of various liquid tanks and tanks in chemical industry, petrochemical industry, chemical fiber industry, chemical fertilizer industry, food industry, pharmaceutical industry, transportation industry and military industry. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to the technical field of endoscope protective sleeve production, and discloses endoscope protective sleeve production equipment with a broken material detection function, which comprises a rack, a feeding module is arranged at the front end of the rack, a sleeve forming processing module is arranged at the rear end of the rack, and a conveying system for conveying a film is assembled on the rack. The feeding module comprises two feeding rollers which are distributed up and down, the design that the double-station up-down layout is combined with the material waiting station deflection is adopted, the double feeding rollers can achieve alternate feeding, the material waiting station is located below the equipment, the feeding rollers can deflect towards the outer side of the rack during material waiting, an operator can complete replacement of a large-weight film roll in an open area, and the replacement efficiency is improved. Meanwhile, the deflected material supplementing area is completely isolated from a production operation area, the risk that the deflected material supplementing area makes contact with a high-speed running component in the operation process is avoided, and the dual requirements of the pharmaceutical industry for operation convenience and safety are synchronously met.

Cleaning-in-place (CIP) systems utilize membrane filters for purifying liquid substances in many industries, including but not limited to, the dairy industry, breweries, pharmaceutical industry, and the food industry. These membrane filters undergo a rigorous cleaning process that despite cleaning can leave foulants on the membranes which hamper filter effectiveness. In addition to the cleaning, enzymes can be applied to the membranes to remove foulants and restore filtering effectiveness. However, introduction of enzymes into these CIP systems can be problematic if enzymes remain after cleaning. This disclosure provides a system and methods to mimic the membrane modules and verify that a correct inactivation procedure occurred. The systems and methods include a separate membrane sample so that no membrane modules need be removed to verify full enzyme inactivation.

The invention discloses a drug curative effect evaluation method and system using industrial big data, and relates to the technical field of pharmaceutical industry data analysis, and the method comprises the following steps: obtaining equipment process data and equipment residual data of a target object; performing double-clock fault-tolerant synchronous processing on the equipment process data to generate synchronous time sequence data, and performing quality evaluation on the synchronous time sequence data; and performing process slicing on the synchronous time sequence data, generating a process feature vector based on self-supervised window coding, and performing weight mapping and adjacency transmission processing on the process feature vector to generate a cumulative contribution matrix. According to the scheme, a linkage mechanism of the sensitivity table and the transfer coefficient is established, so that the process contribution matrix can reflect the dynamic change of the residual effect in real time, the dynamic transfer rule of equipment residues among different processes can be accurately captured, and meanwhile, the interference of low-quality data on the calculation process is eliminated through confidence correction.

The invention discloses a blister tray feeding and discharging device and a packaging production line, and relates to the technical field of feeding device tray feeding and discharging. The bubble cap feeding and discharging mechanism is used for supplying the bubble caps to the bubble cap transferring mechanism and recycling the bubble cap trays. Through automatic lifting of the object carrier, automatic clamping and pushing of the limiting clamping plate and automatic transferring of the second-stage conveying frame, ordered circulation of tray feeding, bubble cap transferring and tray recycling is achieved, full-process semi-automation of bubble cap supplying and tray recycling is achieved, frequent manual intervention is not needed, and the production efficiency is improved. Operators only need to be responsible for material supplement, equipment inspection and finished product collection, and do not need to participate in high-strength and repeated manual transfer, putting and other operations, so that the production efficiency is greatly improved, the labor intensity is greatly reduced, meanwhile, direct contact between workers and materials is reduced, the drug pollution risk is reduced, the production operation environment is improved, and the production cost is reduced. The clean production requirement of the pharmaceutical industry is met.

This invention belongs to the field of intelligent training technology in the pharmaceutical industry, and provides a non-contact virtual-real interactive simulation system and method for GMP drug production. It includes: a login authentication module for authenticating trainees' identities based on the virtual-real interactive simulation platform; after successful authentication, trainees can select a training mode; a startup module for activating a motion capture module and a real-time evaluation module after the virtual-real interactive simulation platform detects the selected training mode; a recognition module for capturing and recognizing trainees' actions in real time based on the motion capture module, and synchronizing with the virtual scene of a high-fidelity drug production line model in the training mode to obtain virtual environment feedback; a compliance judgment module for determining whether the trainee's operational compliance based on the virtual environment feedback exceeds a preset compliance level based on the real-time evaluation module; and a report generation module for recording training data under virtual environment feedback and generating an evaluation report stored in a database. This improves training efficiency.

This invention relates to the field of talent training quality assessment technology in medical and pharmaceutical colleges, and discloses a big data closed-loop assessment system for talent training quality in medical and pharmaceutical colleges. The system includes: a data acquisition module to collect multi-source training data; a preprocessing and fusion module to construct a talent training quality dataset; a big data closed-loop assessment module containing three-level indicator construction, multi-dimensional assessment, and result analysis units to complete the assessment and generate personalized reports; an intelligent feedback module to push and visualize the assessment results; a training optimization module to adapt rigid constraints and transform them into optimization measures; and a system iteration module to ensure the assessment system is updated synchronously with the pharmaceutical industry. This invention constructs a full-link closed loop, solving problems such as assessment disconnect and low accuracy, improving the quality of talent training and its industry adaptability, and adapting to the characteristics of medical and pharmaceutical college training.

The utility model belongs to the technical field of pharmaceutical mixing, and particularly relates to a pharmaceutical mixing batch feeder which comprises supporting legs and a mixing cylinder arranged at the tops of the supporting legs, a telescopic assembly is arranged at the top of the mixing cylinder, a pneumatic pushing mixing assembly is arranged on the telescopic assembly, and the pneumatic pushing mixing assembly comprises a support arranged at the telescopic end of the telescopic assembly. A movable ring is installed at the bottom of the support, a sealing cavity is formed in the movable ring, a first elastic assembly is arranged on the inner wall of the bottom of the sealing cavity, a movable sealing ring is arranged on the first elastic assembly, and a first L-shaped guide pipe and a second L-shaped guide pipe which communicate with the sealing cavity are arranged at the bottom of the movable ring. According to the device, through a unique pneumatic pushing structure, the pushing mixing plate can perform bidirectional alternate movement, compared with a traditional single-direction stirring or mixing mode, pharmaceutical raw materials can be turned over more comprehensively, mixing dead angles are reduced, the pharmaceutical raw materials with different components are mixed more uniformly, and the quality stability of drugs is improved.

The present invention relates to medicine and the pharmaceutical industry, and more particularly to agents capable of inhibiting inflammatory processes, and even more particularly to agents that have an antimicrobial, sorptive, angioprotective and wound-healing effect on local inflammatory processes of the skin and soft tissues, for use in surgery, traumatology and dermatology. What is proposed in the present invention is a combination including dexpanthenol, methyluracil and chloramphenicol, and also a pharmaceutical composition based thereon.

The utility model relates to a water cooling conveyor belt device for pharmaceutical industry, which comprises a conveying device, a driving device, a support mechanism and a water tank, the driving device is mounted on one side of the conveying device, the support mechanism is fixed at the bottom of the conveying device, the conveying device comprises a conveying belt and a support frame, a support rod is mounted in the support frame, and the water tank is fixed on the conveying belt. The water tank is placed on the supporting rod and connected with an external circulating water channel. According to the scheme, the water tank is installed in the conveying belt, the upper surface of the water tank is attached to the inner side of the conveying belt and used for heat exchange with the temperature generated by operation on the conveying belt, and therefore the water cooling effect is achieved. Compared with the prior art, the requirement for processing area temperature control in the pharmaceutical industry can be lowered, the temperature difference between the upper face and the lower face of medicine is reduced as much as possible, and the medicine production quality is guaranteed.

The invention relates to the technical field of pressure protection in the pharmaceutical industry, and particularly discloses a pressure protection system and method which are used for solving the problems that in the prior art, parts of a breather valve fall off due to high-frequency vibration, online cleaning and sterilization (CIP / SIP) are not supported, and sanitation compliance is insufficient. The system comprises a breather valve, a tank body and a gas supply device, the breather valve adopts a valve disc assembly design without a lower fastener, the valve disc is allowed to move vertically through a guide mechanism, and the opening pressure is set through a counterweight adjusting mechanism, so that the breather valve is resistant to high-frequency vibration and prevents parts from loosening. The system supports on-line CIP and SIP operations, does not need to disassemble components, and can automatically maintain the inert gas micro-pressure environment in the tank. The invention further provides a pressure protection method which comprises the steps of providing a breather valve, setting pressure parameters and executing online cleaning and sterilization. The device safety and sanitation compliance are improved, and the device is particularly suitable for a pharmaceutical cleaning system.

This application relates to a filter press for easy waste residue cleaning, and pertains to the technical field of solid-liquid separation equipment in the pharmaceutical industry. It includes a frame assembly, a filter plate assembly installed inside the frame assembly, a drive assembly mounted on top of the frame assembly, a cleaning assembly installed inside the drive assembly, and a collection assembly installed inside the frame assembly. A discharge port is installed on the left side of the collection assembly. The drive assembly includes a square bracket, the interior of which is installed outside the frame assembly. A motor is fixedly connected to the front of the square bracket, a rotating rod is fixedly connected to the drive end of the motor, and a sprocket is fixedly connected to the exterior of the rotating rod. This invention enables the cleaning of waste residue from the filter press, thereby reducing downtime caused by waste residue cleaning, increasing equipment operating time, and improving production efficiency.

The invention relates to a pharmaceutical composition, in the form of an orodispersible powder, comprising simethicone and alverine citrate and its manufacturing process; a pharmaceutical composition, in dry form, containing simethicone and its manufacturing process; and a pharmaceutical composition, in granular form, comprising alverine citrate and its manufacturing process. The pharmaceutical composition comprising a mixture of alverine citrate and simethicone according to the invention includes granules composed of simethicone adsorbed onto a powdered solid support; granules containing grains containing alverine citrate, these granules being coated on their external surface with a film of a masking agent; and pharmaceutically acceptable excipients comprising at least one flavoring, and / or at least one acidifier, and / or at least one sweetener, and / or at least one lubricating / anti-aggregating agent, and / or at least one bulking agent.The invention has applications in the pharmaceutical industry.

The invention provides a chromone bisindole derivative as well as a preparation method and application thereof. According to the derivative, a chromone ketone ester compound with different substituted benzene rings is used as a raw material, the 3-site of the compound is structurally modified, and the compound and indole are subjected to an addition reaction to successfully synthesize 21 chromone bis-indole derivatives. The derivative contains chromone and indole dominant skeletons, has various biological activities, and especially has an outstanding anti-tumor effect. The method has the advantages of simple operation, short reaction time, high yield, easily available raw materials, good air stability and wide applicability, can provide a compound source for biological activity screening, and has important application value for drug screening and pharmaceutical industry.

The utility model discloses a dead-corner-free thermal static drain valve, and belongs to the technical field of steam pipeline equipment. The drain valve is mainly composed of an upper cover, a valve seat, a hoop, a screen partition plate, a spring, a temperature-sensitive bag and a sealing gasket, a mounting groove with a slope and a water outlet are formed in the valve seat, the temperature-sensitive bag is made of a temperature-sensitive induction material and is provided with a ball sealing structure, and temperature response control is achieved through a spring pressing mechanism. All stainless steel materials are creatively adopted to construct a main body structure, and a high-temperature-resistant flexible sealing gasket and an anti-residual slope design are matched, so that sanitation dead angles are effectively eliminated. According to the working principle, the water outlet is automatically opened and closed through the thermal expansion and cold contraction characteristics of the temperature-sensitive bag, and intelligent switching between steam blocking and condensate water discharging is achieved. The device has the characteristics of compact structure, reliable sealing, high corrosion resistance and the like, and is particularly suitable for steam systems with high sanitary requirements in the pharmaceutical industry and the like.

The application relates to the technical field of capsule weighing, and discloses an automatic weighing device for capsule production, which comprises a bottom plate, two parallel installation plates fixedly connected to the bottom plate, a feeding box for placing capsules, the feeding box being located between the two installation plates and fixedly connected with the installation plates, a movement assembly arranged in the feeding box, a plurality of communication pipelines communicated with the bottom surface of the feeding box and matched with the capsules in inner diameter, a rotating bin fixedly installed between the two installation plates, the rotating bin being communicated with the communication pipelines at the top, a distribution assembly rotatably arranged in the rotating bin, a plurality of discharge ports arranged at the bottom of the rotating bin, and a discharge assembly located below the rotating bin and communicated with the discharge ports. The application realizes precise static weighing of single capsules and continuous automatic production, significantly improves the weighing accuracy and production efficiency, and meets the production requirements of the pharmaceutical industry in terms of large scale and sterility.

The utility model relates to the technical field of quality detection in the pharmaceutical industry, discloses a manual lamp inspection auxiliary tool for pre-filled syringe liquid dosage form products, and aims to improve the lamp inspection efficiency and reduce the labor cost. The tool comprises a clamping body composed of two oppositely arranged clamping plates, and clamping force is applied between the clamping plates through a torsional spring. The clamping plate is provided with a clamping part, and the clamping part is provided with a flexible material or a clamping head, so that a plurality of pre-filled syringes can be clamped at one time. And a detachable combined structure is adopted between the clamping part and the clamping plate. And the front end of the clamping part is provided with the LED lighting device with adjustable brightness, so that the detection precision is improved. The inner sides of the clamping plates are coated with anti-static coatings, and static interference is prevented. And the clamping block is provided with a buffer pad and a stepped groove to adapt to different bottleneck sizes and protect bottle bodies. And due to the arrangement of the opening part and the grasping part, the product can be conveniently clamped and turned over. The device is simple in structure and convenient to operate, the efficiency of manual lamp inspection is remarkably improved, and the device is suitable for large-scale production and quality inspection of pre-filled syringes.

This invention provides a type of yeast called *Saccharomyces clavatum*, characterized in that the *Saccharomyces clavatum* is: *Saccharomyces clavatum* (… Saccharomycopsis fibuligera AMCC 32248, preservation number CCTCC NO: M 20251908. Enzyme activity phenotypic screening, carbon source utilization analysis, and quantitative enzyme activity detection showed that this strain possesses highly efficient β-glucosidase activity; further analysis of key genes related to β-glucosidase... BGL1 Specific functional sequences were extracted and identified. Enzyme production conditions were optimized using response surface methodology, resulting in a significant increase in enzyme activity compared to before optimization. In a simulated fermentation system, this strain significantly promoted the production of specific acids, esters, aldehydes, alcohols, and other volatile flavor compounds. Its enzyme production characteristics and flavor regulation capabilities provide a new technical solution for addressing issues such as low hydrolysis efficiency of glycosides and insufficient flavor release in fermentation systems, showing potential applications in the food, brewing, feed, and pharmaceutical industries.

1. The name of the design product: square cover (D40). 2. The use of the design product: the design product is used for the cover of toothpaste, cosmetic, and ointment hose, and is applied to the toothpaste, cosmetic, and pharmaceutical industry. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention discloses a fully automatic bottle cap pressing and assembly production line, belonging to the technical field of bottle cap assembly equipment. It includes a bottle cap feeder, a bottle cap sorting machine connected to the discharge end of the feeder, a bottle cap drilling and pressing machine corresponding to the qualified bottle cap discharge end of the sorting machine, and an automatic gasket feeding mechanism on one side of the drilling and pressing machine. It also includes a bottle cap pressing and assembly controller. The feeder and sorter automatically feed and sort bottle caps. Qualified bottle caps with the cap opening facing upwards are conveyed to the drilling and pressing machine, which automatically completes drilling, pressing, and sorting processes sequentially. This significantly improves the processing accuracy, production efficiency, and automation level of bottle cap and sealing gasket assembly. Under the control of the bottle cap pressing and assembly controller, human intervention is greatly reduced, and the product defect rate can be controlled to an extremely low level, fully meeting the stringent packaging safety requirements of the food and pharmaceutical industries.