492 results about "Pharmaceutical industry" patented technology

The invention discloses fermented lactobacillus mucus NJ-10 and application thereof in preparation of rare ginsenoside-rich metagen through fermentation conversion, and relates to the field of probiotic fermentation. The lactobacillus fermentum NJ-10 is preserved in the China Center for Type Culture Collection on February 25, 2025, and the preservation number of the lactobacillus fermentum NJ-10 is CCTCC (China Center for Type Culture Collection) NO: M 2025300. According to the present invention, the fermentation lactobacillus mucus NJ-10 capable of producing beta-glucosidase, which is subjected to autonomous separation and identification, can be used for fermentation and conversion of ginseng stem and leaf saponin, and then is subjected to post-generation preparation in a high-temperature and high-pressure steam manner, such that the beta-glucosidase producing beta-glucosidase can be produced, and the beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase producing beta-glucosidase can be produced. According to the method, ginseng stem and leaf saponin is converted through two-step fermentation to prepare the postbiotic fermentation product rich in rare ginsenoside, resource utilization of non-medicinal parts of ginseng is expanded, and the postbiotic fermentation product has wide application prospects in the fields of food industry, pharmaceutical industry, cosmetics, animal breeding and the like.

A gripper for industrial manipulators includes a body, inside which an electric motor is housed, and a turnable portion is constrained to the body. Jaws movable toward and away from each other to hold and release a piece are present on the turnable portion. The electric motor is intended for imparting rotations to the turnable portion while the piece is held between the jaws. A pneumatic actuator, for example a piston, controls the opening of the jaws to release the piece. The electric actuator and the pneumatic actuator remain separate and do not interact while the electric actuator is on. Vice-versa, the electric actuator and the pneumatic actuator are integral while the pneumatic actuator is active. The gripper is particularly adapted for being used in inspection systems of the carousel type, for checking the quality of containers and vials in the pharmaceutical industry.

The invention discloses a drug production safety robot inspection method, which comprises the following steps: acquiring multi-source heterogeneous data of a drug production safety state in real time, including environment sensor data, intelligent video data and equipment operation parameters; based on the multi-source heterogeneous data, constructing and dynamically updating a production safety risk assessment model; according to the production safety risk assessment model, a self-adaptive inspection task is generated and adjusted, and the task defines an inspection target, a path, a period and an execution maneuvering terminal; scheduling the maneuvering terminal to execute the inspection task, driving the multi-mode AI potential safety hazard identification engine by the returned safety state data and outputting an identification result; and an identification result is fed back to the production safety risk assessment model to form closed-loop control. The invention also discloses an intelligent inspection system for pharmaceutical production safety. According to the invention, prospective risk early warning, self-adaptive task scheduling and closed-loop self-optimization can be realized, so that higher requirements of the modern pharmaceutical industry on personnel safety, public health and compliance production can be met.

The invention belongs to the technical field of membranes, and discloses a preparation method and application of a small-aperture amination-polyamide roll type ultrafiltration membrane, a polyamide layer is subjected to amination treatment by using DETA (diethylenetriamine), the electronegativity of the surface of the membrane is changed by optimizing the concentration of DETA, the charge property of the surface of the membrane is optimized, and the electronegativity of the surface of the membrane is reduced, so that the ultrafiltration membrane is prepared. Therefore, the influence of the electrostatic repulsion effect on the rejection rate is reduced, and the separation performance of the membrane on small-molecular organic matters / inorganic salts is improved. The preparation method is simple to operate and low in cost. The prepared small-aperture amination-polyamide roll type ultrafiltration membrane can be used for recycling RO concentrated water in the field of printing and dyeing wastewater treatment and the application fields of purification and decoloration of macromolecules such as protein, polypeptide and drugs in the pharmaceutical industry.

The invention relates to a big data analysis technology-based process impurity and degraded impurity relationship analysis method, which comprises the following steps of: calculating correlation coefficients among process impurities, typical impurity variables and degraded impurities through a canonical correlation analysis method; and constructing a transfer relationship among various impurities, typical impurity variables and various degraded impurities through correlation coefficient screening, so as to judge the correlation degree between the process impurities and the degraded impurities. The analysis method provided by the invention comprehensively analyzes the impurity formation rule of the medicine in the production, storage and use processes, deeply excavates the correlation between process impurities and degraded impurities, reveals the internal relevance of different impurities, not only helps to guide the direction of impurity spectrum research, but also helps to improve the quality of the medicine. Scientific basis is provided for control of key impurities of drugs and process optimization, the safety and effectiveness of the drugs are improved, and further development of pharmaceutical science and pharmaceutical industry is promoted.

The invention relates to daily chemical and pharmaceutical industries, in particular to a guanidyl-containing carboxymethyl chitosan quaternary ammonium salt derivative as well as a preparation method and application thereof. The chemical structural formula of the guanidyl-containing carboxymethyl chitosan quaternary ammonium salt derivative is shown in the specification. The prepared guanidyl carboxymethyl chitosan-containing quaternary ammonium salt derivative has good antioxidant activity and can be applied to preparation of an antioxidant, the preparation method is simple, convenient and efficient, the biological activity of chitosan is enhanced, the application range of chitosan is widened, and the guanidyl carboxymethyl chitosan-containing quaternary ammonium salt derivative can be widely applied to the fields of cosmetics, functional food and medicine. # imgabs0 #

The invention discloses a whole pharmaceutical factory complex working condition waste gas comprehensive treatment control system, which relates to the technical field of pharmaceutical industry waste gas treatment, and comprises a low-concentration waste gas treatment system, a high-concentration waste gas treatment system, a fuel pretreatment and conveying system, a heat recovery system and a control system of each flow. Waste gas of the low-concentration waste gas treatment system and waste gas of the high-concentration waste gas treatment system come from a plurality of workshops, and the low-concentration waste gas treatment system conducts concentration treatment to obtain high-concentration waste gas which is then conveyed to the high-concentration waste gas treatment system to be treated. The fuel pretreatment and conveying system is responsible for providing fuel meeting the requirement for the high-concentration waste gas treatment system, waste gas is treated by the high-concentration waste gas treatment system, then exhaust gas is subjected to heat recovery through the heat recovery system, and the exhaust gas is used for preheating sewage of the sewage treatment system, analyzing a rotating wheel and the like. Through cooperation of all processing systems, stable, safe, continuous and efficient operation of the system is ensured.

The invention provides a specific sequence nucleic acid molecule and application thereof as a PDRN, and relates to the technical field of biology. A novel nucleic acid molecule with a specific sequence is obtained, and the sequence has certainty, biological activity and stable product quality. The PDRN of the specific sequence does not have cytotoxicity, is high in safety and has a wide application prospect. Moreover, compared with the extracted PDRN, the PDRN with a specific sequence is found for the first time, the product has a remarkable effect of promoting VEGF expression, cell damage can be effectively repaired, and a novel skin-care and repairing functional component is provided for the industries of cosmetics and medicines. The invention further provides a preparation method of the PDRN with the specific sequence, and the preparation method is simple and suitable for popularization, application and industrial production.

The utility model provides a disinfection device for a purified water system in the pharmaceutical industry by using high-concentration ozone water. Comprising a PEM electrolysis type ozone generation device, a gas / water mixing device, a middle isolation tank and a control system, purified water of a purified water storage tank is introduced through a water inlet pipeline and is controllably divided into two paths to respectively enter the middle isolation tank and the gas / water mixing device; pure water stored in the middle isolation tank is respectively communicated with a cathode water tank, an anode water tank and cooling coils of the cathode water tank and the anode water tank in a controlled mode through a submersible pump, ozone at the top of the anode water tank enters a gas / water mixing device through an ozone discharging pipe and an ozone distributor to be mixed with purified water, and ozone water is produced. And the ozone water is output to a purified water system through an ozone water discharge pipe. According to the device, a high-concentration and high-purity ozone gas source is manufactured on site, the concentration of the ozone gas source is larger than or equal to 20% (wt%), and the concentration of mixed ozone water is larger than or equal to 20 mg / L. Compared with an existing pasteurization method and a corona ozone method, the method has the advantages of being easy to operate, low in energy consumption, free of chemical residues and the like.

According to the method for treating the high-concentration organic waste gas in the pharmaceutical industry, a combined direct catalytic oxidation mode is adopted, and condensation at the temperature of 5 DEG C below zero, condensation at the temperature of 15 DEG C below zero, buffering of a buffer tank, heat exchange of heat exchange equipment, CO catalytic oxidation, air cooling of an air cooler and bypass activated carbon adsorption are sequentially carried out; and a front-end LEL detector II is arranged, and when the concentration detected by the front-end LEL detector II is ultrahigh, the activated carbon bypass module is switched to perform bypass emergency treatment.

The invention discloses a preparation method of a dehydroabietic acid cellulose ester (DCE) bonded silica gel stationary phase, which comprises the following steps: firstly, carboxylating the surface of a SiO2 microsphere with a core-shell structure, then carrying out acylating chlorination, and then preparing amphiphilic DCE coated SiO2 solid particles with DCE in a chemical bonding manner. The DCE-SiO2 solid particle has the pore diameter of 5-30nm and the specific surface area of 50-400m < 2 > / g, has the characteristics of intact particle shape, uniform particle size, high mechanical strength, high pressure resistance and the like, and can be used as a liquid chromatographic column filler. The preparation method is simple and convenient, the column pressure is low, the repeatability is good, the chemically modified DCE has a phenanthrene ring skeleton and has good selective separation performance on saponin drugs containing ring structures, and the application prospect in the pharmaceutical industry is wide.

The invention provides a method for detecting the content of liquiritin and glycyrrhizic acid in liquorice decoction pieces based on hyperspectrum, and relates to a method for rapidly and nondestructively predicting the content of index components of the liquorice decoction pieces by using a hyperspectrum technology. The method comprises the following implementation steps: acquiring a hyperspectral image of the liquorice decoction piece, determining the liquid phase content of the liquorice decoction piece, preprocessing the hyperspectral image, establishing a content prediction model, and quickly and nondestructively detecting the liquorice decoction piece. The method comprises the following steps: collecting licorice decoction pieces in a short-wave infrared band by using a hyperspectral imaging technology, determining the contents of liquiritin and glycyrrhizic acid in a collected sample through liquid chromatography, extracting characteristic wavelengths according to the content measurement data, comparing the advantages and disadvantages of different characteristic variable extraction methods and content prediction models, and determining the content of glycyrrhizic acid in the licorice decoction pieces. Therefore, rapid nondestructive detection of the liquiritin and glycyrrhizic acid content in the licorice decoction pieces is realized, an analysis method is provided for rapid grading and screening of the traditional Chinese medicine decoction pieces, digitization, intelligence and greenization of the traditional Chinese medicine industry are promoted, and improvement of the equipment manufacturing level of the pharmaceutical industry is promoted.

The swing arm type rubber plug cleaning machine comprises a machine body, a cleaning tank is arranged in the machine body, a partition plate is arranged in the cleaning tank, an overflow hole is formed in the partition plate, an overflow tank is formed in the cleaning tank through the partition plate, and an overflow water outlet is formed in the side face of the overflow tank. A lifting mechanism is arranged in one side of the machine body and comprises a fixing column. The rubber plug cleaning process comprises the stages of cleaning water overflow cleaning, ultrasonic overflow cleaning and bubbling overflow cleaning, different cleaning modes and time are set in each stage according to different formulas, the cleaning modes and time can be recorded and reports can be formed, residues of fine structures such as rubber plug navel holes and pores can be effectively removed through the multiple cleaning modes, and the cleaning efficiency is improved. The cleanliness reaches the sterile production standard in the pharmaceutical industry; automatic equipment reduces the risk of secondary pollution caused by manual sequence transfer, and conforms to the GMP specification; the equipment can be adapted to rubber plugs with different specifications, and the rubber plugs are not easy to damage.

The invention relates to the technical field of nano-enzyme preparation and application thereof, in particular to nano-enzyme and a preparation method and application thereof in antibiosis, the nano-enzyme is prepared by using ascorbic acid, sodium hydroxide, copper chloride and cobalt chloride as reaction raw materials and adopting a liquid-phase chemical reduction coprecipitation method, and copper-cobalt nano-enzyme is obtained. The diameter of the prepared nano-material is about 3 nm, the nano-material has good peroxidase-like activity, when a substrate hydrogen peroxide is catalyzed, the Michaelis constant KM is 0.93 mM, the maximum reaction rate Vmax is 12.1862 * 10 <-8 > (M.s <-1 >), the mimic enzyme shows good antibacterial performance on escherichia coli and staphylococcus aureus, the bactericidal effect can be achieved by breaking cell walls, and the mimic enzyme has good application prospects. And the minimum inhibitory concentrations of the compounds are respectively 22.5 [mu] g / mL and 5.63 [mu] g / mL. The nano enzyme is simple in preparation method, low in cost and remarkable in antibacterial effect, and has wide application prospects in the fields of medical industry, chemical production and the like.

The invention discloses a pollution source dynamic acquisition and monitoring method and system, relates to the technical field of pollution source dynamic acquisition and monitoring, and solves the problem that a scheme capable of sensing the pollution situation and autonomously optimizing the monitoring frequency is difficult to set in pharmaceutical production. And a dynamic threshold is difficult to set according to the dynamic influence of the environmental variable on the pollution diffusion rule. According to the method, the predicted pollution concentration of the current time period is obtained through the pre-evaluation model; determining the data acquisition frequency of the current time period according to the pollution concentration of the previous time period and the predicted pollution concentration of the current time period; acquiring the pollution concentration of each pollution source in the current time period based on the data acquisition frequency of the current time period; determining an alarm instruction of each pollution source based on the pollution concentration in the current time period, and giving an alarm based on the alarm instruction; according to the invention, environmental risk control can be changed from passive response to active prevention, and technical support is provided for green production and sustainable development of the pharmaceutical industry.

The invention discloses a method for detecting related substances in imaric acid dihydrochloride by HPLC (High Performance Liquid Chromatography), and belongs to the technical field of chemical engineering and pharmacy, the related substances in the imaric acid dihydrochloride are detected by high performance liquid chromatography, a phosphate buffer solution (0.05 mol / L of monopotassium phosphate solution, and pH adjusted to 2.5 by phosphoric acid) is used as a mobile phase A, acetonitrile is used as a mobile phase B, gradient elution is carried out, the flow rate is 1.0 ml / min, the detection wavelength is 250nm, and the detection wavelength is 250nm. The column temperature is 40 DEG C, and the detection wavelength is 235nm; the method can be used for effectively separating and quantitatively detecting imatamide, demethylated imaric acid dihydrochloride, ortho-imaric acid, meta-imaric acid, p-hydroxymethyl benzamide, an intermediate B, p-hydroxymethyl benzoic acid, an imaric acid dimer, p-cyanobenzyl alcohol, p-chloromethyl benzamide, p-toluic acid and p-chloromethyl benzoic acid in the imaric acid dihydrochloride. The method disclosed by the invention is simple and convenient to operate, strong in specificity, high in sensitivity and accuracy, good in linearity and capable of effectively controlling the quality of a p-imaric acid dihydrochloride product.

The invention discloses a preparation method of monodisperse vaterite-shaped calcium carbonate with uniform particle size, which comprises the following steps: 1, mixing lime with an ethanol solution, carrying out digestion reaction, and standing and settling lime slurry after the digestion reaction is finished; 2, carbon dioxide gas is introduced into the lime slurry for a carbonization reaction, vaterite-shaped calcium carbonate is generated, and different composite crystal growth inhibitors are added during carbonization to regulate and control the crystal form of calcium carbonate; and 3, after the carbonization reaction is finished, carrying out suction filtration, drying and crushing to finally obtain the monodisperse vaterite-shaped calcium carbonate with uniform particle size. The raw materials are low in obtaining cost, the preparation process is simple and easy to adjust, the calcium carbonate particles are regular in morphology and uniform in particle size distribution and are monodisperse products, the method for preparing the calcium carbonate with the special morphology is widened, and the prepared vaterite-shaped calcium carbonate is expected to be applied to the special fields such as the food industry and the pharmaceutical industry.

The invention discloses a compound residue detection method, which adopts liquid chromatography (HPLC) to perform quantitative analysis on residual vomitinib on the surface of equipment, can quickly and accurately determine the drug residue, and ensures that the production environment is clean and meets the drug production quality standard. The method comprises the following steps: preparing a solution, collecting a sample by using a wiping method or a leaching method, and preparing a diluent, a reference stock solution, a reference substance solution and a test solution. The chromatographic conditions are that a Thermo C18 chromatographic column is adopted, the detection wavelength is 332 nm, a mobile phase A is a phosphate buffer solution, a mobile phase B is acetonitrile, and the flow velocity is 1.0 ml / min. Through the method, the residual quantity of the vomitinib can be efficiently detected, the thorough cleaning of production equipment is ensured, the cross contamination of medicines is avoided, and the quality control level of the medicines is improved. The method has the advantages of simplicity and convenience in operation, rapidness in detection, high sensitivity and the like, and is widely applicable to detection and control of drug residues in the pharmaceutical industry.

The invention relates to a risk management and decision support method, system and platform for the pharmaceutical industry. The method comprises strategic investment portfolio management, supervision affair, clinical drug development, pharmaceutical economics, investment strategy optimization, risk management, merger and purchase full-duty investigation and stock markets. The system uses artificial intelligence and diverse data from public and private sources, including clinical trials, regulatory decisions, economic data, pharmacological data, and company data. The system integrates a plurality of decision modules for clinical development, such as clinical risk, supervision risk, pharmacological risk and economic risk. This risk factor network generates predictive and normative information for strategic decisions.

The invention belongs to the technical field of plant tissue culture, and particularly relates to an induction method of adventitious roots of cinnamomum camphora. According to the method disclosed by the invention, the adventitious root induction rate of the adventitious root of the cinnamomum camphora is remarkably improved by establishing a sterile system of the cinnamomum camphora, culturing cluster buds and sterile seedlings, promoting rooting of tissue culture seedlings, inhibiting browning, enabling the adventitious buds to extend and inducing the adventitious root through three ways, so that the problems of shortage of borneol resources and high market demand are solved; the method for inducing the adventitious roots of the cinnamomum camphora can be used for industrial production, and sufficient raw materials are provided for extraction of borneol; according to the method, large-scale culture of the adventitious roots of the cinnamomum camphora is achieved, a large number of pharmaceutical raw materials can be obtained at low cost in a short time, and an integrated production system can be formed with the pharmaceutical industry. The technology has important practical significance for promoting the development of the cinnamomum camphora industry, expanding the application of the pharmaceutical field, constructing a rare and endangered traditional Chinese medicinal material breeding technology system and realizing sustainable development and utilization.

A transfer device (2) and a method for transferring at least one functional element (3) into a process chamber (4) are provided, wherein the at least one functional element (3) is arranged interchangeably on an element carrier (5) and the element carrier (5) is transferable from a starting position (6) into an end or working position (7), wherein, in the end or working position (7), the at least one functional element (3) is arranged partly in the process chamber (4) and partly outside the process chamber (4). The invention is therefore particularly suitable for aseptic processes in the pharmaceutical industry, but is not limited to this sphere.

The invention relates to a pharmaceutical composition in the form of orodispersible powder comprising simeticone and alverine citrate, as well as to the method for manufacturing same; to a pharmaceutical composition in dry form containing simeticone and to the method for manufacturing same; and to a pharmaceutical composition in the form of grains comprising alverine citrate and to the method for manufacturing same. The pharmaceutical composition comprising a mixture of alverine citrate and simeticone according to the invention comprises grains composed of simeticone adsorbed onto a powdered solid support, granules containing grains containing alverine citrate, wherein the outer surface of these grains is coated with a film made of a masking agent, and pharmaceutically acceptable excipients comprising at least one flavouring, and / or at least one acidifier, and / or at least one sweetener, and / or at least one lubricating / anti-aggregating agent, and / or at least one filler. The invention is intended for use in the pharmaceutical industry.

The invention relates to a method for producing fermented vegetable oil by a semi-continuous fed-batch fermentation process, which comprises the following steps: firstly, inoculating a strain into a fermentation culture medium for thallus propagation under proper conditions, then mixing with crude vegetable oil according to a certain proportion, fermenting at proper temperature, and discharging part of fermentation liquor after the fermentation index reaches a set value, thereby obtaining the fermented vegetable oil. And returning a water phase containing active thalli to the fermentation tank, and meanwhile, supplementing fresh vegetable oil crude oil with the same mass as the water phase to continue fermentation. And repeating the steps until the time of the acid value of the oil phase of the fermentation liquid reaching the set value exceeds 24 hours or is more than two times of the time of the fermentation reaching the set value after the previous oil supplement, ending the fermentation, and centrifugally separating and purifying the separated oil phase to obtain the fermented vegetable oil. The production efficiency of the fermented vegetable oil can be greatly improved, the single-batch production yield is improved, the stability of the quality of the fermented oil is ensured, the production cost is saved, and the method can be widely applied to the cosmetic and skin care field, the food field or the pharmaceutical industry.

In the pharmaceutical industry, a swinging tablet counting machine is usually used for filling tablets, but the situation that a plurality of tablets are stacked in one tablet counting hole occurs, so that filling difference is caused. The utility model discloses an improved swing tablet counting machine assembly which comprises a tablet counting disc, a discharging disc, a rotating transmission shaft, a power source, a material guiding pipe, a brush and a positioning clamp assembly. The swing tablet counting machine is improved on the basis of a traditional swing tablet counting machine, the position of the brush can be controlled by adjusting the relative position relation of the positioning clamp assemblies, the area of a tablet charging area can be adjusted, meanwhile, redundant tablets can be automatically removed, and therefore the defect that multiple tablets are stacked in one tablet counting hole of the traditional swing tablet counting machine is overcome. The brush and the positioning clamp assembly can be separated from each other, and the device can be suitable for material protection cylinders with different heights, and is simple to overhaul and replace and low in cost.

This invention discloses a highly efficient asymmetric synthesis method for aryl propionic acid drug molecules. The method uses racemic aldehydes as substrates and thiamine pyrophosphate-dependent enzymes as biocatalysts. Electrolysis is performed in a diaphragm-free electrolytic cell under conditions of an external redox dielectric and constant current, in a buffer salt solution and nitrogen atmosphere. This method achieves dynamic kinetic oxidation of aldehydes via bioelectrocatalysis, enabling the high-efficiency and high enantioselectivity synthesis of aryl propionic acid drug molecules. The method eliminates the need for redox agents and additives, is simple to operate, operates under mild reaction conditions, and is green and sustainable. This invention applies bioelectrocatalysis to asymmetric synthesis, providing a green and efficient new enzymatic synthetic route for the asymmetric synthesis of aryl propionic acid drug molecules, which has significant application prospects in the pharmaceutical industry.

1. The name of the product under this design: Magnetic Stirrer (Multi-heating MSM‑H). 2. Purpose of this product design: This product design is an experimental instrument with multiple magnetic stirring stations that can simultaneously stir and mix multiple groups of samples at the same speed. It is used in the petroleum, chemical, biological and pharmaceutical industries. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention relates to a palatable, free-flowing powdered composition derived from Abelmoschus esculentus for enhancing endurance. The composition comprises polysaccharides (5-50%) including rhamnogalacturonans and arabinogalactans; flavonoid glycosides (2-10%) including quercetin 3-O-gentiobioside and isoquercitrin (Okraenduroside); and total carbohydrates (30-70%), along with optional excipients for stability and bioavailability. The composition, when administered to a subject in an appropriate dose, improves running endurance, enhances swimming endurance, improves rate of perceived exertion (RPE), ameliorates severity of fatigue, improves fatigue score, increases peak power, and enhances endurance and muscle performance. The invention also discloses a method of preparation involving aqueous-alcoholic extraction, concentration, and purification to obtain a water-soluble powder. The composition can be formulated into capsules, tablets, powders, and beverages and administered orally at a dose of 100-2000 mg / day. Animal and human studies confirm the efficacy of the composition for enhancing endurance, making it suitable for the nutraceutical, sports nutrition, and pharmaceutical industries.

The utility model discloses an anti-blocking filling machine for capsule medicine preparation and belongs to the technical field of medicine production. A medicine inlet is formed in the upper end of the shell, a stirring mechanism is arranged in the shell and fixedly connected with an anti-blocking mechanism, the anti-blocking mechanism is arranged in a conveying pipe, the conveying pipe is fixedly communicated with the upper end of the shell, a discharging port is formed in the lower end of the conveying pipe, an electronic valve is arranged on the discharging port, and the outer wall of the lower end of the conveying pipe is fixedly connected with a connecting frame. The connecting frame is fixedly connected with the fixing plate, the fixing plate is provided with a filling mechanism, and the filling mechanism corresponds to the discharging port. By means of the unique design and working principle, the capsule medicine preparation device has the remarkable advantages of being efficient in stirring, excellent in anti-blocking performance, accurate in filling, easy and convenient to operate, wide in application and the like, and efficient, reliable and automatic capsule medicine preparation equipment is provided for the pharmaceutical industry.

This invention provides specific sequence nucleic acid molecules and their applications as PDRNs, relating to the field of biotechnology. This invention yields novel specific sequence nucleic acid molecules with deterministic sequences, stable biological activity, and stable product quality. The PDRNs with these specific sequences are non-cytotoxic, exhibit high safety, and have broad application prospects. Furthermore, this invention is the first to discover that specific sequence PDRNs, compared to extracted PDRNs, significantly promote VEGF expression and effectively repair cell damage, providing a novel skincare and repair ingredient for the cosmetics and pharmaceutical industries. This invention also provides a simple method for preparing specific sequence PDRNs, suitable for widespread application and industrial production.