Improvements in
fluid volume measurement systems are disclosed for a pneumatically actuated
diaphragm pump in general, and a
peritoneal dialysis cycler using a pump cassette in particular. Pump
fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections of the apparatus being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a
pump chamber of a
diaphragm pump are also disclosed, in this case using a one-chamber
ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the
pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during
pulse width modulation control of the heater. Improvements are also disclosed in the application of negative pressure during a drain phase in
peritoneal dialysis therapy, and to control the amount of intraperitoneal
fluid accumulation during a therapy. Improvements in efficiency are also disclosed in the movement of fluid into and out of a two-pump cassette and heater bag of a
peritoneal dialysis cycler, and in the synchronization of the operation of two or more pumps in a peritoneal
dialysis cycler or other
fluid handling devices using a multi-pump arrangement.